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H-Invitational ID: HIT000497125 Accession number: AK302501 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Pogo transposable element with ZNF domain isoform 5.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AK302501.1 CAGE tag ID NA EST ID NA Clone Number TESTI4009243 Experimental resources   NBRC ; HGPD ; Antibody (POGZ) ; Catalog (POGZ); Sequence data provider NA Annotation project NA Length of cDNA 4414[bp] (No. of exon:18)[A:1128 T:1051 G:1072 C:1163] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type testis Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) CAGAAG;  CAGGAG;  Transcript quality feature NA Notes NA

AAGGTCCCTTTAAGGCGACGGCGCCTTCCTCGGGTCAGACTACCGGCGGC GACGACCACGGGAGCATGGCGGACACCGACCTGTTCATGGAATGTGAGGA GGAGGAGTTGGAGCCATGGCAGAAAATCAGTGATGTCATTGAGGACTCTG TAGTTGAAGATTATAATTCAGTGGATAAAACTACCACAGCTGGCAATCCT TTGGTCCAGCAAGGTGGACAGCCACTCATCCTGACCCAGAATCCAGCCCC AGGTCTGGGCACAATGGTTACTCAACCAGTATTGAGGCCTGTTCAGGTCA TGCAGAATGCCAATCATGTGACTAGTTCCCCTGTGGCCTCACAACCAATA TTTATCACTACGCAGGGATTTCCTGTAAGGAATGTCCGGCCTGTACAAAA TGCAATGAATCAGGTTGGGATTGTGCTGAACGTACAGCAAGGCCAAACGG TTAGACCAATTACACTAGTTCCAGCCCCAGGTACCCAGTTTGTTAAGCCG ACAGTTGGAGTTCCACAAGTGTTCTCCCAGATGACCCCTGTGGGGCCAGG CTCCACAATGCCTGTGAGGCCCACCACCAACACCTTCACCACCGTCATCC CGGCCACTCTTACCATTCGAAGCACCGTCCCACAGTCCCAGTCCCAGCAG ACCAAGTCCACTCCCAGCACTTCTACCACTCCCACTGCCACACAGCCAAC CTCACTGGGGCAACTAGCTGTTCAGTCTCCAGGCCAGTCAAACCAGACCA CGAATCCCAAGCTAGTGAGCATTGCCAGCTTTGTCACTGTGAAGCGACCT GGTGTTACAGGCGAAAATAGCAATGAAGTGGCCAAATTGGTGAATACCCT TAACACCATCCCTTCCCTGGGCCAGAGTCCTGGGCCAGTGGTGGTGTCCA ACAACAGCTCTGCTCATGGCTCTCAAAGAACCAGCGGACCTGAGTCTTCA ATGAAAGTGACCTCTTCCATCCCAGTATTTGACCTCCAGGATGGTGGACG GAAAATATGTCCACGATGTAATGCTCAATTTCGTGTTACTGAAGCTTTGA GAGGTCACATGTGTTACTGTTGCCCAGAAATGGTTGAATACCAGAAGAAA GGAAAGTCCCTGGATTCAGAACCCAGTGTCCCATCAGCAGCAAAGCCCCC ATCCCCTGAGAAAACAGCTCCTGTTGCTTCCACACCCTCTTCTACACCTA TTCCTGCTCTGTCACCGCCTACCAAAGTACCAGAACCAAATGAGAACGTG GGCGATGCCGTCCAGACCAAACTCATTATGCTTGTAGATGACTTCTACTA TGGACGGGATGGTGGCAAAGTAGCCCAGCTCACAAATTTCCCTAAGGTCG CCACATCTTTCCGATGCCCACATTGTACCAAAAGGCTAAAAAACAATATT CGATTCATGAACCATATGAAACACCACGTAGAACTCGATCAGCAGAACGG TGAGGTAGATGGTCACACTATCTGCCAGCACTGTTACCGCCAGTTTTCTA CTCCCTTCCAGCTTCAGTGCCACTTGGAAAATGTTCATAGTCCCTATGAA TCTACTACCAAGTGCAAGATCTGTGAATGGGCGTTTGAAAGTGAGCCACT ATTTCTCCAGCATATGAAGGATACTCATAAGCCTGGAGAGATGCCTTATG TTTGCCAGGTGTGTCAATATCGCTCCTCACTCTACTCTGAGGTAGATGTC CATTTTCGGATGATCCATGAGGATACCCGGCATCTGCTCTGCCCTTATTG CCTGAAGGTCTTCAAAAATGGCAATGCATTCCAACAGCATTACATGAGGC ACCAGAAGAGAAATGTTTATCACTGCAACAAATGCCGGCTGCAGTTTCTC TTTGCCAAGGACAAAATTGAACACAAGCTTCAACACCATAAAACCTTCCG TAAACCCAAGCAGCTGGAGGGCTTGAAACCAGGCACCAAGGTGACAATCC GGGCTTCCCGAGGGCAGCCACGAACTGTTCCTGTATCCTCTAATGATACA CCTCCCAGCGCCTTGCAGGAGGCAGCACCGCTGACCTCCTCAATGGACCC TCTGCCTGCCTTCCTTTATCCCCCTGTCCAGCGCAGCATCCAGAAGAGAG CTGTTAGGAAAATGAGTGTCATGGGCCGGCAGACATGCCTGGAGTGCAGC TTCGAGATCCCAGACTTCCCTAATCATTTCCCTACTTACGTACACTGCTC TCTGTGTCGCTATAGCACCTGCTGTTCTCGAGCTTATGCCAACCACATGA TCAACAATCATGTTCCACGGAAGAGCCCCAAGTATTTGGCTTTGTTTAAA AATTCTGTGAGTGGAATCAAGCTGGCCTGCACTTCATGTACCTTTGTTAC CTCTGTGGGCGATGCTATGGCCAAGCATTTGGTATTCAACCCCTCTCACA GATCCAGCAGCATCCTGCCACGGGGACTCACTTGGATAGCTCACTCAAGG CATGGCCAGACTCGTGACCGAGTGCATGACCGGAACGTGAAGAATATGTA CCCTCCTCCTTCCTTCCCCACTAACAAAGCTGCCACTGTGAAATCTGCGG GGGCCACCCCAGCTGAGCCTGAAGAGCTACTAACTCCCTTAGCCCCAGCA CTCCCATCACCAGCCTCAACTGCAACCCCACCACCAACCCCCACTCACCC GCAGGCTTTAGCCCTTCCACCGCTGGCTACAGAGGGAGCCGAATGTCTGA ATGTTGATGATCAGGATGAAGGGAGCCCAGTCACCCAAGAACCTGAGCTA GCATCAGGTGGTGGTGGTAGTGGTGGAGTTGGCAAAAAGGAGCAGCTGTC TGTGAAGAAGCTTCGAGTAGTACTGTTTGCTCTATGCTGCAATACAGAAC AGGCAGCTGAACACTTCCGAAATCCCCAGCGACGTATTCGCCGTTGGCTT CGACGTTTCCAGGCCTCCCAGGGGGAGAATCTAGAGGGCAAATATCTGAG CTTTGAGGCAGAAGAGAAACTGGCTGAGTGGGTGCTAACCCAGCGCGAAC AACAGCTACCTGTAAATGAGGAGACCTTGTTCCAGAAGGCCACCAAAATA GGACGTTCTTTGGAAGGGGGGTTTAAGATCTCCTATGAGTGGGCTGTGCG TTTCATGCTGCGGCACCACCTGACTCCCCATGCCCGGCGAGCTGTGGCCC ACACCCTACCTAAGGATGTAGCAGAGAATGCAGGACTCTTCATTGATTTT GTACAACGGCAGATTCACAACCAGGACTTACCCTTGTCTATGATTGTGGC TATTGATGAGATCTCTTTGTTCCTGGATACAGAGGTGCTGAGCAGTGATG ATCGAAAGGAGAATGCCCTGCAGACAGTGGGCACAGGGGAACCTTGGTGT GATGTAGTCCTAGCCATTCTGGCAGATGGCACTGTCCTTCCCACCCTGGT TTTCTACAGAGGGCAGATGGATCAGCCTGCTAACATGCCAGACTCCATAT TGCTAGAGGCAAAGGAGAGTGGCTACAGTGATGACGAGATCATGGAGCTG TGGTCAACTCGAGTGTGGCAGAAGCACACAGCTTGCCAGCGCAGCAAAGG CATGCTTGTGATGGACTGTCATCGCACTCACTTGTCAGAAGAGGTACTGG CTATGCTTAGTGCCTCTAGCGCTTTGCCTGCAGTGGTCCCAGCAGGCTGT AGCTCCAAAATTCAGCCATTAGATGTATGCATCAAAAGAACTGTCAAGAA CTTCCTGCATAAAAAATGGAAGGAACAGGCTCGGGAAATGGCAGATACTG CATGTGATTCTGATGTCCTGCTTCAGCTGGTGCTTGTCTGGCTGGGTGAA GTGCTAGGTGTCATTGGGGACTGTCCAGAGCTAGTTCAGCGCTCCTTCCT GGTGGCTAGTGTTCTGCCTGGCCCCGATGGCAACATTAACTCACCTACAA GAAATGCTGACATGCAGGAGGAGCTAATTGCCTCCCTAGAGGAGCAACTG AAGCTGAGTGGGGAACATTCTGAGTCTTCCACTCCACGACCCAGATCATC TCCTGAAGAGACAATTGAGCCTGAAAGTCTTCACCAGCTCTTTGAGGGTG AAAGTGAGACCGAGTCTTTCTATGGCTTTGAAGAAGCTGACCTAGATCTG ATGGAGATTTGAGTGTTGGGGTCATGAGGGGGTGTGGAGTGGGGGTGGGA ACATGTGAGGGAGGGTAAAGGGGCTTAGGGAAAAGGGGGCATACCAGGTG GGGTATTTGGTTTCTATTTTTTAATTTTATACCACCACTCCCCCCTGAAG TTGACTTACACTTCCCTGTGGATTTGTGGATTAATTAGGAAAACCAATAG TAATCACGTCTGAGCCAAGGAGCTGGCCCATTGGTCATTCACTTCTGCTA AAAACAGGTTTTTGTGACTTTTTTTTTTTTAAATTTAAATCACTGTGTTT GGTATTTTTCTGAC

Gene structure information

H-Inv cluster ID		HIX0001060
Genomic location	Chromosome	1
	Location	1q21.3
	Position	151376975- 151431691
	Strand	-
Possible duplicated location(s)		NA
Gene structure		18 exon(s)
Database links	RefSeq	NM_015100;  NM_145796;  NM_207171;  NM_001194937;  NM_001194938;
	Ensembl	ENST00000271715;  ENST00000358476;  ENST00000361398;  ENST00000368863;  ENST00000392723;  ENST00000409503;  ENST00000437847;  ENST00000439756;  ENST00000441516;  ENST00000450842;  ENST00000467287;  ENST00000476128;  ENST00000482678;  ENST00000485040;  ENST00000491586;  ENST00000492528;  ENST00000495253;  ENST00000497787;  ENST00000529669;  ENST00000531094;  ENST00000533351;  ENST00000533461;  ENST00000540984;
	Entrez Gene	Entrez Gene ID:23126;
	KEGG GENES	KEGG GENES(23126);
	GeneCard	POGZ;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000255872 Predicted CDS 66..4112;  1348[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.758 Database links RefSeq NA UniProt B4DYL9;  CCDS NA

MADTDLFMECEEEELEPWQKISDVIEDSVVEDYNSVDKTTTAGNPLVQQG GQPLILTQNPAPGLGTMVTQPVLRPVQVMQNANHVTSSPVASQPIFITTQ GFPVRNVRPVQNAMNQVGIVLNVQQGQTVRPITLVPAPGTQFVKPTVGVP QVFSQMTPVGPGSTMPVRPTTNTFTTVIPATLTIRSTVPQSQSQQTKSTP STSTTPTATQPTSLGQLAVQSPGQSNQTTNPKLVSIASFVTVKRPGVTGE NSNEVAKLVNTLNTIPSLGQSPGPVVVSNNSSAHGSQRTSGPESSMKVTS SIPVFDLQDGGRKICPRCNAQFRVTEALRGHMCYCCPEMVEYQKKGKSLD SEPSVPSAAKPPSPEKTAPVASTPSSTPIPALSPPTKVPEPNENVGDAVQ TKLIMLVDDFYYGRDGGKVAQLTNFPKVATSFRCPHCTKRLKNNIRFMNH MKHHVELDQQNGEVDGHTICQHCYRQFSTPFQLQCHLENVHSPYESTTKC KICEWAFESEPLFLQHMKDTHKPGEMPYVCQVCQYRSSLYSEVDVHFRMI HEDTRHLLCPYCLKVFKNGNAFQQHYMRHQKRNVYHCNKCRLQFLFAKDK IEHKLQHHKTFRKPKQLEGLKPGTKVTIRASRGQPRTVPVSSNDTPPSAL QEAAPLTSSMDPLPAFLYPPVQRSIQKRAVRKMSVMGRQTCLECSFEIPD FPNHFPTYVHCSLCRYSTCCSRAYANHMINNHVPRKSPKYLALFKNSVSG IKLACTSCTFVTSVGDAMAKHLVFNPSHRSSSILPRGLTWIAHSRHGQTR DRVHDRNVKNMYPPPSFPTNKAATVKSAGATPAEPEELLTPLAPALPSPA STATPPPTPTHPQALALPPLATEGAECLNVDDQDEGSPVTQEPELASGGG GSGGVGKKEQLSVKKLRVVLFALCCNTEQAAEHFRNPQRRIRRWLRRFQA SQGENLEGKYLSFEAEEKLAEWVLTQREQQLPVNEETLFQKATKIGRSLE GGFKISYEWAVRFMLRHHLTPHARRAVAHTLPKDVAENAGLFIDFVQRQI HNQDLPLSMIVAIDEISLFLDTEVLSSDDRKENALQTVGTGEPWCDVVLA ILADGTVLPTLVFYRGQMDQPANMPDSILLEAKESGYSDDEIMELWSTRV WQKHTACQRSKGMLVMDCHRTHLSEEVLAMLSASSALPAVVPAGCSSKIQ PLDVCIKRTVKNFLHKKWKEQAREMADTACDSDVLLQLVLVWLGEVLGVI GDCPELVQRSFLVASVLPGPDGNINSPTRNADMQEELIASLEEQLKLSGE HSESSTPRPRSSPEETIEPESLHQLFEGESETESFYGFEEADLDLMEI*

Motif information

	a.a. length	InterPro	Name
	23	IPR015880	Zinc finger, C2H2-like [Domain]
	28	IPR007087	Zinc finger, C2H2-type [Domain]
	21	IPR007087	Zinc finger, C2H2-type [Domain]
	24	IPR015880	Zinc finger, C2H2-like [Domain]
	29	IPR007087	Zinc finger, C2H2-type [Domain]
	22	IPR007087	Zinc finger, C2H2-type [Domain]
	24	IPR015880	Zinc finger, C2H2-like [Domain]
	22	IPR007087	Zinc finger, C2H2-type [Domain]
	24	IPR015880	Zinc finger, C2H2-like [Domain]
	23	IPR015880	Zinc finger, C2H2-like [Domain]
	21	IPR007087	Zinc finger, C2H2-type [Domain]
	23	IPR015880	Zinc finger, C2H2-like [Domain]
	22	IPR007087	Zinc finger, C2H2-type [Domain]
	24	IPR015880	Zinc finger, C2H2-like [Domain]
	26	IPR015880	Zinc finger, C2H2-like [Domain]
	71	IPR006600	Pogo transposase / Cenp-B / PDC2, DNA-binding HTH domain [Domain]
	64	IPR009057	Homeodomain-like [Domain]
	65	IPR006600	Pogo transposase / Cenp-B / PDC2, DNA-binding HTH domain [Domain]
	61	IPR004906	Pogo transposase / Cenp-B / PDC2, subgroup, DNA-binding HTH domain [Domain]
	52	IPR012287	Homeodomain-related [Domain]
	167	IPR004875	DDE superfamily endonuclease, CENP-B-like [Family]

Gene function information

H-Inv ID		HIT000497125
H-Inv cluster ID		HIX0001060
Accession number		AK302501.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;  Splicing isoform
Coding potential		Protein coding;
Definition		Pogo transposable element with ZNF domain isoform 5.
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (NP_001181867)  [Identity/coverage = 99.777%/100.0%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	POGZ
	HGNC aliases	NA
	HGNC name	pogo transposable element with ZNF domain
	DDBJ	NA
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000255872
	No. of interaction	14
	Interaction partner(s)	HIP000028337;  HIP000031158;  HIP000031158;  HIP000035264;  HIP000049028;  HIP000049614;  HIP000051481;  HIP000055698;  HIP000079462;  HIP000090938;  HIP000090938;  HIP000091701;  HIP000097588;  HIP000249922;
	BIND	NA
	DIP	112059E;  40120E;  688E;  689E;  690E;  691E;  692E;
	MINT	MINT-2858666;
	HPRD	01428;  02502;  03434;  04090;  04419;  04556;  06121;  08361;  09470;
	IntAct	EBI-765648;  EBI-955814;
Database links	RefSeq	NM_015100;  NM_145796;  NM_207171;  NM_001194937;  NM_001194938;
	Ensembl	ENST00000271715;  ENST00000358476;  ENST00000361398;  ENST00000368863;  ENST00000392723;  ENST00000409503;  ENST00000437847;  ENST00000439756;  ENST00000441516;  ENST00000450842;  ENST00000467287;  ENST00000476128;  ENST00000482678;  ENST00000485040;  ENST00000491586;  ENST00000492528;  ENST00000495253;  ENST00000497787;  ENST00000529669;  ENST00000531094;  ENST00000533351;  ENST00000533461;  ENST00000540984;
	Entrez Gene	Entrez Gene ID:23126;
	KEGG GENES	KEGG GENES(23126);
	GeneCard	POGZ;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	DNA binding (GO:0003677);  zinc ion binding (GO:0008270);  nucleic acid binding (GO:0003676);
Biological process	regulation of transcription (GO:0045449);
Cellular component	nucleus (GO:0005634);  intracellular (GO:0005622);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	nuclear;  plasma membrane;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 434 633 1fgjA 7e-15 5.6 197/499 a.138.1.3 959 1017 1hlvA2 8e-14 30.5 59/65 a.4.1.7 1119 1148 2oyoA1 2e-04 26.7 30/186 a.152.1.3

Related H-InvDB links GTOP

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:NA Title:NA
Co-localized orphan diseases		OMIM ID:  115665;  116600;  155600;  600975;  605225;  605606;  606788;  606852;  606928;  607317;  607671;  608543;  608553;  608995;  610320;  612367;  612596;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(23126)
	Disease	Entrez Gene ID:(23126)
	Substance	Entrez Gene ID:(23126)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 60 .. 60 G/A rs12125310 - 5'UTR 282 .. 282 T/C rs111818924 - CDS Synonymous[Leu73Leu] 809 .. 809 A/G rs115103475 - CDS Synonymous[Thr248Thr] 969 .. 969 A/G rs114367083 - CDS Nonsynonymous[Ile302Val] 1428 .. 1428 G/T rs77833954 - CDS Nonsynonymous[Val455Leu] 1486 .. 1486 A/C rs77094536 - CDS Nonsynonymous[Tyr474Ser] 1531 ^ 1532 -/A rs34001433 - CDS 1646 .. 1646 T/A rs35441120 + CDS Synonymous[Pro527Pro] 1729 .. 1729 G/A rs72996036 - CDS Nonsynonymous[Arg555Gln] 2135 .. 2135 A/G rs111313602 - CDS Synonymous[Thr690Thr] 2594 .. 2594 C/T rs75839466 - CDS Synonymous[Ala843Ala] 2792 .. 2792 G/A rs113903415 - CDS Synonymous[Glu909Glu] 3051 .. 3051 G/T rs12023222 - CDS AA-STOP[Gly996*] 3176 .. 3176 G/A rs116755407 - CDS Synonymous[Glu1037Glu] 3255 .. 3255 G/T rs77042047 - CDS Nonsynonymous[Asp1064Tyr] 3974 .. 3974 G/T rs35198305 + CDS Nonsynonymous[Glu1303Asp] 3983 .. 3983 T/G rs1571294 - CDS Synonymous[Thr1306Thr] 4142 .. 4142 G/C/A rs6667714 - 3'UTR 4187 .. 4187 G/A rs117727823 - 3'UTR 4369 .. 4369 T/- rs71775079 - 3'UTR 4373 .. 4373 T/- rs71759095 - 3'UTR 4381 .. 4381 A/T rs116518827 - 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;