H-InvDB x AHG DB
Transcript view
H-InvDB_8.3 released on March 26, 2013.
Search by for Advanced Search
Home Quick guide Navi BLAST Site map Download Contact us Help
Locus viewLocus view Protein view Protein view G-integraG-integra DiseaseInfo ViewerDiseaseInfo Viewer H-ANGELH-ANGEL EvolaEvola PPI viewerPPI view Gene Family/GroupGene Family/Group Hyperlink managemnet system (All databases)Hyperlink MS
H-Invitational ID: HIT000497077 Accession number: AK302453 Created date: 26-Mar-2013 Last modified: 20-Apr-2012
Definition: Similar to Methylglutaconyl-CoA hydratase, mitochondrial; EC=4.2.1.18; AU-specific RNA-binding enoyl-CoA hydratase; AU-binding protein/enoyl-CoA hydratase; Precursor;
 
 

Transcript original information
Accession number AK302453.1
CAGE tag ID NA
EST ID NA
Clone Number TESTI4005570
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (AUH) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (AUH);
Sequence data provider NA
Annotation project NA
Length of cDNA 1076[bp] (No. of exon:7)[A:246 T:285 G:299 C:246]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type testis
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0018470
Genomic location  G-integra Help Chromosome 9
Location 9q22.31
Position 94056665- 94124177
Strand -
Possible duplicated location(s) NA
Gene structure 7 exon(s)
Database links RefSeq NM_001698; 
Ensembl ENST00000303617;  ENST00000375731;  ENST00000422391;  ENST00000473695;  ENST00000475023;  ENST00000478465; 
Entrez Gene Entrez Gene ID:549; 
KEGG GENES KEGG GENES(549); 
GeneCard GeneCardAUH;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000255827
Predicted CDS 7..774;  255[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.685
Database links RefSeq NA
UniProt B4DYI6; 
CCDS NA

Motif information
ORF

length(255),orf(7:774) MAAAVAAAPGALGSLHAGGARLVAACSAWLCPGLRLPGSLAGRRAGPAIW AQGWVPAAGGPAPKRGYSSEMKTEDELRVRHLEEENRGIVVLGINRAYGK NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMS SSEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAA SSAKMGLVETKLAIIPGGVTSSTEVLNPSKSSMKIGIIIFQTPVNIDILA SSHES* 		a.a.
length		 InterPro Name
length(129), motif(92:220) 129 IPR001753 Crotonase, core [Domain]
length(21), motif(176:196) 21 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site [Conserved_site]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000497077
H-Inv cluster ID Locus viewHIX0018470
Accession number AK302453.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Methylglutaconyl-CoA hydratase, mitochondrial; EC=4.2.1.18; AU-specific RNA-binding enoyl-CoA hydratase; AU-binding protein/enoyl-CoA hydratase; Precursor;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q13825)  [Identity/coverage = 100.0%/63.72%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 7892223;  11738050;  12434311;  12655555;  15164053;  15489334;  21269460;  ALL; 
Gene family/group Gene family H-Inv gene family/group ID HIF0001091
Gene family/group name Crotonase, core (IPR001753).
Evidence motif (InterPro) ID IPR001753
Gene symbol/name HGNC symbol AUH
HGNC aliases "AU RNA-binding protein/enoyl-Coenzyme A hydratase", "AU RNA binding protein/enoyl-Coenzyme A hydratase"
HGNC name AU RNA binding protein/enoyl-CoA hydratase
DDBJ NA
UniProt AUH
EC number NA
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000255827
No. of interaction 1
Interaction partner(s) HIP000110574; 
BIND NA
DIP 87762E; 
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NM_001698; 
Ensembl ENST00000303617;  ENST00000375731;  ENST00000422391;  ENST00000473695;  ENST00000475023;  ENST00000478465; 
Entrez Gene Entrez Gene ID:549; 
KEGG GENES KEGG GENES(549); 
GeneCard GeneCardAUH;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Crotonase, core (IPR001753). Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function catalytic activity (GO:0003824); 
Biological process metabolic process (GO:0008152); 

Subcellular localization information  Last modified:20-Apr-2012
WoLF PSORT extracellular;  mitochondria;  endoplasmic;  Other; 
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:20-Apr-2012
Start End PDB_ID E-value Identity Coverage SCOP_ID
74 221 1hzdA 1e-24 86.5 148/266 c.14.1.3
Related H-InvDB links GTOP GTOP

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:20-Apr-2012
Disease relation Disease name: 3-methylglutaconic aciduria, type I (250950); 
Related information in OMIM OMIM ID:  600529;  Title: AU-SPECIFIC RNA-BINDING PROTEIN
Co-localized orphan diseases OMIM ID:  156240;  606613;  610438; 
Disease related mutation MutationView:  600529; 
JRE-1.4.0 or later is required.Download JRE at Sun's web site.
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(549)
Disease Entrez Gene ID:(549)
Substance Entrez Gene ID:(549)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo Viewer;  LEGENDALEGENDA; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
11 .. 11 C/G rs13302733 - CDS Nonsynonymous[Ala2Gly]
17 .. 17 C/G rs13302727 - CDS Nonsynonymous[Ala4Gly]
83 .. 83 G/A rs74484860 - CDS Nonsynonymous[Cys26Tyr]
194 .. 194 C/A rs11549739 + CDS Nonsynonymous[Pro63Gln]
356 .. 356 C/A rs79838368 - CDS Nonsynonymous[Ala117Asp]
489 .. 489 A/C rs7874056 - CDS Synonymous[Ile161Ile]
595 .. 595 C/T rs121434636 + CDS AA-STOP[Arg197*]
628 .. 628 G/A rs61758733 - CDS Nonsynonymous[Val208Ile]
844 .. 844 T/A rs117124319 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
Tigger1 657 887 -
AluSc 890 1073 -
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;