H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000493782 Accession number: AK299158 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Similar to Synaptobrevin homolog YKT6; EC=2.3.1.-; Precursor;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AK299158.1 CAGE tag ID NA EST ID NA Clone Number NT2RP3000647 Experimental resources   NBRC ; HGPD ; Antibody (YKT6) ; Catalog (YKT6); Sequence data provider NA Annotation project NA Length of cDNA 1268[bp] (No. of exon:6)[A:296 T:279 G:385 C:308] Devision HUM Molecular type mRNA Library origin Cell type teratocarcinoma Tissue type NA Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature Truncation;  Notes NA

ATCCGGAAGTGGATTGCGAGCCAGGAGGAGGAAGCCGGCGGTGGCCCCGT CAGCAGCCGGCTGCTGAGAGGCCGGTAGGCGGCGGCGGTCCCGAGGGGCG GCGGCCGCGCTGCTCCCTGAGAACGGGTCCCGCAGCTGGGCAGGCGGGCG GCCTGAGGGCGCGGAGCCATGAAGCTGTACAGCCTCAGCGTCCTCTACAA AGGCGAGGCCAAGGTGGTGCTGCTCAAAGCCGCATACGATGTGTCTTCCT TCAGCTTTTTCCAGAGATCCAGCGTTCAGGAATTCATGACCTTCACGAGT CAACTGATTGTGGAGCGCTCATCGAAAGGCACTAGAGCTTCTGTCAAAGA ACAAGACTATCTGTGCCACGTCTACGTCCGGAATGATAGTCTTGCAGGTG TGGTCATTGCTGACAATGAATACCCATCCCGGGTGGCCTTTACCTTGCTG GAGAAGGTACTAGATGAATTCTCCAAGCAAGTCGACAGGATAGACTGGCC AGTAGGATCCCCTGCTACAATCCATTACCCAGCCCTGGATGGTCACCTCA GTAGATACCAGAACCCACGAGAAGCTGATCCCATGACTAAAGTGCAGGCC GAACTAGATGAGACCAAAATCATTCTGGCCCGGAAACAAAACTCATGCTG TGCCATCATGTGATGCAGCCTGCCAGAGGCCCAATGCTGGAATGGCACCA TCATTCACATCAGAACTGCAGCCCCTGGAAAGGAAGAGACAGCCATAGAC GAGGAGCCAGAGTGGGGGCAGACTGGCCATTTTTATTTTGAAGTTCCTGC GAGAAATGGATGGTGGAAGGGTGGCGAATGTTCAAATTCATATGTGTGGT AGTGATTCTTGGAAAGAATTTGAGGTCCCCAAAGGTGTATTTTTGGGCAA ATGAAACCATAAACTCCGACTGGCTTCTGTAGATGCCAAAGGGCTCTTTT TCAGCTAACCCTGGGAAGGCTCTGGGAGGGAGGTCGGAGCCAGCTGTTTC TCGATCTTTGGTATATCTTTGGATCTTATTTGTACATTAATGATATTAAC ACTCCAGTGGGGGGTGGGGAGTCCCTGATGCTAGGGCTGGGGTGGGTGGA GTTTGAAGACTCTTGGGAAAGCCTCTCCTGGGGCCACTGTTGGGGGTGGG AGTGAGCCCACCACAGAGGCCACAGGCAGGCCCCCACTTCAGGCCCAAGG CCTGGGGCGGGGGGAACAGTCACTGGGTCTCAGATTCTGAGACTGTTGTT TAGCTTACCTTTCTGCTA

Gene structure information

H-Inv cluster ID		HIX0006647
Genomic location	Chromosome	7
	Location	7p13
	Position	44240567- 44252488
	Strand	+
Possible duplicated location(s)		NA
Gene structure		6 exon(s)
Database links	RefSeq	NM_006555;
	Ensembl	ENST00000223369;  ENST00000421621;  ENST00000424864;  ENST00000447123;  ENST00000463014;  ENST00000478411;  ENST00000496112;
	Entrez Gene	Entrez Gene ID:10652;
	KEGG GENES	KEGG GENES(10652);
	GeneCard	YKT6;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000252931 Predicted CDS 169..663;  164[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.775 Database links RefSeq NA UniProt B4DR94;  CCDS NA

MKLYSLSVLYKGEAKVVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVER SSKGTRASVKEQDYLCHVYVRNDSLAGVVIADNEYPSRVAFTLLEKVLDE FSKQVDRIDWPVGSPATIHYPALDGHLSRYQNPREADPMTKVQAELDETK IILARKQNSCCAIM*

Motif information

	a.a. length	InterPro	Name
	138	IPR011012	Longin-like [Domain]
	133	IPR010908	Longin [Domain]
	108	IPR010908	Longin [Domain]

Gene function information

H-Inv ID		HIT000493782
H-Inv cluster ID		HIX0006647
Accession number		AK299158.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Similar to Synaptobrevin homolog YKT6; EC=2.3.1.-; Precursor;
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (O15498)  [Identity/coverage = 96.855%/80.3%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		9211930;  15044687;  15215310;  15479160;  15489334;  21269460;  ALL;
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	YKT6
	HGNC aliases	NA
	HGNC name	YKT6 v-SNARE homolog (S. cerevisiae)
	DDBJ	NA
	UniProt	YKT6
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000252931
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NM_006555;
	Ensembl	ENST00000223369;  ENST00000421621;  ENST00000424864;  ENST00000447123;  ENST00000463014;  ENST00000478411;  ENST00000496112;
	Entrez Gene	Entrez Gene ID:10652;
	KEGG GENES	KEGG GENES(10652);
	GeneCard	YKT6;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Biological process	transport (GO:0006810);  vesicle-mediated transport (GO:0016192);
Cellular component	integral to membrane (GO:0016021);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	cytosol;  extracellular;  nuclear;  Other;
Target P	Not predicted
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 1 137 1h8mA 6e-36 32.1 137/140 d.110.4.1

Related H-InvDB links GTOP

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:NA Title:NA
Co-localized orphan diseases		OMIM ID:  605635;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(10652)
	Disease	Entrez Gene ID:(10652)
	Substance	Entrez Gene ID:(10652)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 98 .. 98 G/T rs11540050 + 5'UTR 218 .. 218 T/G rs748870 + CDS Nonsynonymous[Val17Gly] 509 .. 509 C/G rs112426773 + CDS Nonsynonymous[Ser114Cys] 733 .. 733 G/A rs79546049 + 3'UTR 785 .. 785 A/T rs78455736 + 3'UTR 790 .. 790 G/T rs78352778 + 3'UTR 800 .. 800 C/G rs12670584 + 3'UTR 970 .. 971 CT/- rs3840675 - 3'UTR 973 .. 973 T/G rs79911862 + 3'UTR 1089 .. 1089 G/- rs3840673 - 3'UTR 1225 .. 1225 G/T rs11540053 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;