H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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Locus view Protein view G-integra DiseaseInfo Viewer H-ANGEL Evola PPI view Gene Family/Group Hyperlink MS

H-Invitational ID: HIT000489194 Accession number: AK294570 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Similar to Talin-2;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AK294570.1 CAGE tag ID NA EST ID NA Clone Number BRAMY4002147 Experimental resources   NBRC ; HGPD ; Antibody (TLN2) ; Catalog (TLN2); Sequence data provider NA Annotation project NA Length of cDNA 1390[bp] (No. of exon:6)[A:337 T:296 G:394 C:363] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type amygdala Develpmental stage NA

Sequence quality information CDS feature N-truncated Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature Truncation;  Notes NA

ATTGCAGAAACAGAGTTACTGGGGGCTGCAGCATCCATCGAAGCTGCTGC TAAGAAGTTAGAGCAACTGAAGCCAAGAGCAAAACCAAAACAAGCGGATG AGACCCTGGACTTTGAGGAACAGATCTTGGAAGCTGCTAAATCCATTGCT GCTGCCACAAGCGCCCTGGTCAAATCGGCCTCAGCAGCCCAGAGGGAGCT GGTGGCCCAAGGAAAGGTGGGCTCCATCCCTGCCAATGCTGCAGACGACG GACAGTGGTCACAGGGGCTGATTTCTGCTGCCCGGATGGTGGCGGCTGCG ACCAGCAGTCTCTGTGAGGCGGCCAATGCCTCCGTTCAGGGACACGCCAG CGAGGAGAAGCTCATCTCATCTGCCAAGCAGGTCGCCGCTTCCACGGCTC AGCTGCTGGTGGCCTGCAAGGTGAAGGCCGACCAGGATTCAGAGGCCATG AGGCGGCTACAGGTAATGGTCACTGATGCTGGTGGGAAAATACTCCTGTT GGAGCGGGCGGCAGGAAATGCTGTGAAAAGAGCCTCAGACAATCTTGTCC GTGCAGCCCAGAAGGCAGCTTTTGGCAAAGCTGATGACGACGATGTTGTA GTGAAAACCAAGTTTGTGGGGGGCATTGCTCAGATCATCGCCGCCCAGGA AGAAATGCTAAAGAAAGAGCGAGAACTGGAAGAAGCAAGGAAAAAACTGG CCCAAATCCGCCAGCAGCAGTATAAGTTTTTACCCACCGAGCTGAGGGAA GATGAGGGCTAAAGGTGCGAGCCCAGATGGCGAGCCCCAGGGGATGGCCC TGGCTGAACTGGACAGACAGTGTTCCTGAGAGGCTGGGCACTTAGCTGGA AACCGCCCACCTCCCTCCCGGGTGAGCCTGGAGCCCTGCGTGCTTGTTCT CACATCTCTGTCCCGTCGGCACTGGCTGCATGATCGTGATGTCACACGGT ACAATGTCCTACCCACAACTCCTCTGCCGCCTCCCCTCATGCCTCACCGT GTCTCAGGAGAGAGGGGTGCACGTTTCATGGACTGTTACCAACAAAGAAA AGTCAGTATTATGTTGTTCTCAGACACTTTGGCTTTTGTTGGTCCTTCTC TTAGGCCTGCTCCTGGACCTCTTTATGATATTGTGATAGGGAAAAAAATC ATTGACGTCATAGAATATTCTTCTTCCTCTCAGGAGAAGACGGAAGCTGG AGTTGGACATGGTTCATAAAAGCCAGAAACACAAACCCGTGTGGACTCCG GGAGGGTGACTCAGGTCCTCCTTCCATGTCTTGAGCACTGGCTCACCCAG GGGGTGAAAAATTCCCGCCCCTGTTTGCACGCTTTCTTGCCTCCGTGTGT AAGCTCCTTGTACAACCCAGACCCATCTTGTATTTTGTGG

Gene structure information

H-Inv cluster ID		HIX0012315
Genomic location	Chromosome	15
	Location	15q22.2
	Position	63112720- 63133437
	Strand	+
Possible duplicated location(s)		NA
Gene structure		6 exon(s)
Database links	RefSeq	NM_015059;
	Ensembl	ENST00000306829;  ENST00000467297;  ENST00000472902;  ENST00000474847;  ENST00000489129;  ENST00000494733;
	Entrez Gene	Entrez Gene ID:83660;
	KEGG GENES	KEGG GENES(83660);
	GeneCard	TLN2;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000357875 Predicted CDS 1..762;  253[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.758

IAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQILEAAKSIA AATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARMVAAA TSSLCEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAM RRLQVMVTDAGGKILLLERAAGNAVKRASDNLVRAAQKAAFGKADDDDVV VKTKFVGGIAQIIAAQEEMLKKERELEEARKKLAQIRQQQYKFLPTELRE DEG*

Motif information

	a.a. length	InterPro	Name
	253	IPR015710	Talin-related [Family]
	244	IPR002558	I/LWEQ [Domain]
	226	IPR002558	I/LWEQ [Domain]
	212	IPR002558	I/LWEQ [Domain]
	205	IPR002558	I/LWEQ [Domain]

Gene function information

H-Inv ID		HIT000489194
H-Inv cluster ID		HIX0012315
Accession number		AK294570.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Similar to Talin-2;
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (Q9Y4G6)  [Identity/coverage = 100.0%/9.36%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		9205841;  11527381;  12168954;  12422219;  15302935;  16572171;  16964243;  17081983;  18083107;  18669648;  19413330;  19608861;  21269460;  ALL;
Gene family/group	H-Inv gene family/group ID	HIF0004216
	Gene family/group name	Human gene family/group candidate, HIF0004216.
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	TLN2
	HGNC aliases	NA
	HGNC name	talin 2
	DDBJ	NA
	UniProt	TLN2
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000357875
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NM_015059;
	Ensembl	ENST00000306829;  ENST00000467297;  ENST00000472902;  ENST00000474847;  ENST00000489129;  ENST00000494733;
	Entrez Gene	Entrez Gene ID:83660;
	KEGG GENES	KEGG GENES(83660);
	GeneCard	TLN2;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Human gene family/group candidate, HIF0004216. Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	actin binding (GO:0003779);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	cytosol;  mitochondria;  nuclear;  Other;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 1 89 1r0dA 2e-17 37.8 74/194 a.216.1.1

Related H-InvDB links GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 163 .. 163 G/A rs62004656 + CDS Nonsynonymous[Ala55Thr] 264 .. 264 G/A rs8038919 + CDS Synonymous[Gln88Gln] 294 .. 294 G/C rs74020685 + CDS Synonymous[Ala98Ala] 333 .. 333 C/T rs2242380 + CDS Synonymous[Ser111Ser] 421 .. 421 G/T rs78592652 + CDS Nonsynonymous[Val141Leu] 570 .. 570 T/A rs937418 + CDS Synonymous[Ala190Ala] 640 .. 640 G/A rs117251745 + CDS Nonsynonymous[Ala214Thr] 654 .. 654 A/C rs34464964 + CDS Nonsynonymous[Glu218Asp] 668 .. 668 A/G rs117761903 + CDS Nonsynonymous[Glu223Gly] 788 .. 788 C/T rs57314391 + 3'UTR 845 .. 845 G/T rs11633471 + 3'UTR 864 .. 864 C/T rs74978059 + 3'UTR 915 .. 915 G/A rs112547592 + 3'UTR 955 .. 955 T/C rs16945912 + 3'UTR 999 .. 999 G/A rs62007063 + 3'UTR 1079 .. 1079 T/C rs114553369 + 3'UTR 1082 .. 1082 G/A rs16945915 + 3'UTR 1104 .. 1104 G/A rs12914026 + 3'UTR 1155 .. 1155 A/C rs62007064 + 3'UTR 1387 .. 1387 G/C rs79165205 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;