H-InvDB x AHG DB
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H-InvDB_8.3 released on March 26, 2013.
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H-Invitational ID: HIT000432572 Accession number: AK313706 Created date: 26-Mar-2013 Last modified: 20-Apr-2012
Definition: SH2 domain-containing protein 2A; SH2 domain-containing adapter protein; T cell-specific adapter protein; TSAd; VEGF receptor-associated protein;
 
 

Transcript original information
Accession number AK313706.1
CAGE tag ID NA
EST ID NA
Clone Number KIDNE2013687
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (SH2D2A) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (SH2D2A);
Sequence data provider NA
Annotation project NA
Length of cDNA 1304[bp] (No. of exon:8)[A:273 T:204 G:370 C:457]
Devision HTC
Molecular type mRNA
Library origin Cell type NA
Tissue type kidney
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGCAG;  CAGGAG; 
Transcript quality feature Truncation; 
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001177
Genomic location  G-integra Help Chromosome 1
Location 1q23.1
Position 156776970- 156786634
Strand -
Possible duplicated location(s) NA
Gene structure 8 exon(s)
Database links RefSeq NM_003975;  NM_001161441;  NM_001161442;  NM_001161443;  NM_001161444; 
Ensembl ENST00000368198;  ENST00000368199;  ENST00000392306;  ENST00000468744;  ENST00000486350;  ENST00000495306; 
Entrez Gene Entrez Gene ID:9047; 
KEGG GENES KEGG GENES(9047); 
GeneCard GeneCardSH2D2A;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000198375
Predicted CDS 135..1304;  389[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.843
Database links RefSeq NA
UniProt B2R9A4; 
CCDS NA

Motif information
ORF

length(389),orf(135:1304) MEFPLAQICPQGSHEAPIPTFSTFQITDMTRRSCQNLGYTAASPQAPEAA SSTGNAERAEEVPGEGSLFLQAETRAWFQKTQAHWLLQHGAAPAWFHGFI TRREAERLLEPKPQGCYLVRFSESAVTFVLTYRSRTCCRHFLLAQLRDGR HVVLGEDSAHARLQDLLLHYTAHPLSPYGETLTEPLARQTPEPAGLSLRT EESNFGSKSQGPNPQYSPIIKQGQAPVPMQKEGAGEKEPSQLLRPKPPIP AKPQLPPEVYTIPVPRHRPAPRPKPSNPIYNEPDEPIAFYAMGRGSPGEA PSNIYVEVEDEGLPATLGHPVLRKSWSRPVPGGQNTGGSQLHSENSVIGQ GPPLPHQPPPAWRHTLPHNLSRQVLQDRGQAWLPLGPPQ* 		a.a.
length		 InterPro Name
length(84), motif(93:176) 84 IPR000980 SH2 motif [Domain]
length(99), motif(95:193) 99 IPR000980 SH2 motif [Domain]
length(15), motif(95:109) 15 IPR000980 SH2 motif [Domain]
length(92), motif(95:186) 92 IPR000980 SH2 motif [Domain]
length(76), motif(95:170) 76 IPR000980 SH2 motif [Domain]
length(11), motif(114:124) 11 IPR000980 SH2 motif [Domain]
length(15), motif(159:173) 15 IPR000980 SH2 motif [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000432572
H-Inv cluster ID Locus viewHIX0001177
Accession number AK313706.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition SH2 domain-containing protein 2A; SH2 domain-containing adapter protein; T cell-specific adapter protein; TSAd; VEGF receptor-associated protein;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q9NP31)  [Identity/coverage = 99.486%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 9468509;  10692392;  15489334;  15592455;  16710414;  18669648;  ALL; 
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol SH2D2A
HGNC aliases "SH2 domain protein 2A"
HGNC name SH2 domain containing 2A
DDBJ NA
UniProt SH2D2A
EC number NA
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000198375
No. of interaction 10
Interaction partner(s) HIP000022415;  HIP000024723;  HIP000039154;  HIP000039705;  HIP000042847;  HIP000042847;  HIP000054999;  HIP000100100;  HIP000136585;  HIP000149073; 
BIND NA
DIP 185121E; 
MINT MINT-64472; 
HPRD 01614;  02625;  03555;  03659; 
IntAct EBI-3928276;  EBI-2678701;  EBI-2678596;  EBI-734126; 
Database links RefSeq NM_003975;  NM_001161441;  NM_001161442;  NM_001161443;  NM_001161444; 
Ensembl ENST00000368198;  ENST00000368199;  ENST00000392306;  ENST00000468744;  ENST00000486350;  ENST00000495306; 
Entrez Gene Entrez Gene ID:9047; 
KEGG GENES KEGG GENES(9047); 
GeneCard GeneCardSH2D2A;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function protein binding (GO:0005515); 

Subcellular localization information  Last modified:20-Apr-2012
WoLF PSORT cytosol;  nuclear; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:20-Apr-2012
Start End PDB_ID E-value Identity Coverage SCOP_ID
92 189 2cs0A1 2e-15 39.8 98/106 d.93.1.1
Related H-InvDB links GTOP GTOP

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:20-Apr-2012
Disease relation Disease name:NA
Related information in OMIM OMIM ID:NA Title:NA
Co-localized orphan diseases OMIM ID:  115665;  116600;  155600;  600975;  605225;  605606;  606788;  606852;  606928;  607317;  607671;  608543;  608553;  608995;  610320;  612367;  612596; 
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(9047)
Disease Entrez Gene ID:(9047)
Substance Entrez Gene ID:(9047)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo Viewer;  LEGENDALEGENDA; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
33 .. 33 C/T rs72698634 - 5'UTR
60 .. 60 G/T rs12753240 - 5'UTR
60 .. 61 GA/TT rs34770558 - 5'UTR
61 .. 61 A/T rs12738727 - 5'UTR
66 .. 66 C/T rs4348714 - 5'UTR
289 .. 289 G/A rs926103 + CDS Nonsynonymous[Ser52Asn]
535 .. 535 G/A rs11556220 + CDS Nonsynonymous[Ser134Asn]
697 .. 697 G/A rs61731562 - CDS Nonsynonymous[Arg188Gln]
841 .. 841 A/G rs76643780 - CDS Nonsynonymous[Glu236Gly]
874 ^ 875 -/T rs34624011 - CDS
948 .. 948 C/T rs12072861 - CDS Nonsynonymous[Arg272Cys]
1013 .. 1013 C/T rs41313896 - CDS Synonymous[Gly293Gly]
1034 .. 1034 C/G rs12071857 - CDS Synonymous[Ala300Ala]
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;