H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000432417_05 Accession number: AK313551 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: HLA class II histocompatibility antigen, DO alpha chain precursor.

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Transcript original information Accession number AK313551.1 CAGE tag ID NA EST ID NA Clone Number PEBLM2004856 Experimental resources   NBRC ; HGPD ; Antibody (HLA-DOA) ; Catalog (HLA-DOA); Sequence data provider NA Annotation project NA Length of cDNA 782[bp] (No. of exon:4)[A:146 T:161 G:219 C:256] Devision NA Molecular type NA Library origin Cell type peripheral blood mononuclear cells (HPBMC5939) Tissue type NA Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

GACTGATTTGATTAAAGCACCAGAGTGTAATGGCCCTCAGAGCAGGGCTG GTCCTGGGGTTCCACACCCTGATGACCCTCCTGAGCCCGCAGGAGGCAGG GGCCACCAAGGCTGACCACATGGGCTCCTACGGACCCGCCTTCTACCAGT CTTACGGCGCCTCGGGCCAGTTCACCCATGAATTTGATGAGGAACAGCTG TTCTCTGTGGACCTGAAGAAAAGCGAGGCCGTGTGGCGTCTGCCTGAGTT TGGTGACTTTGCCCGCTTTGACCCGCAGGGCGGGCTGGCCGGCATCGCCG CAATCAAAGCCCATCTGGACATCCTGGTGGAGCGCTCCAACCGCAGCAGA GCCATCAACGTGCCTCCACGGGTGACCGTGCTCCCCAAGTCTCGGGTGGA GCTGGGCCAGCCCAACATCCTCATCTGCATCGTGGACAACATCTTCCCCC CTGTGATCAATATCACCTGGCTGCGCAACGGCCAAACTGTCACTGAGGGA GTGGCCCAGACCAGCTTCTATTCCCAGCCTGACCATTTGTTCCGCAAGTT CCACTACCTGCCCTTCGTGCCCTCAGCCGAGGACGTCTATGACTGCCAGG TGGAGCACTGGGGCCTGGATGCGCCACTCCTCAGGCATTGGGAGCTCCAG GTGCCTATTCCACCACCAGATGCCATGGAGACCCTGGTCTGTGCCCTGGG CCTGGCCATCGGCCTGGTGGGCTTCCTCGTGGGCACCGTCCTCATCATCA TGGGCACATATGTGTCCAGTGTCCCCAGGTAA

Gene structure information

H-Inv cluster ID		HIX0058180
Genomic location	Chromosome	6_qbl_hap6
	Location	NA
	Position	4206948- 4209435
	Strand	-
Possible duplicated location(s)		HIX0184190;  HIX0166906;
Gene structure		4 exon(s)
Database links	RefSeq	NA
	Ensembl	ENST00000374813;  ENST00000383225;  ENST00000383226;  ENST00000418857;  ENST00000432150;  ENST00000444109;  ENST00000465107;  ENST00000465500;  ENST00000466497;  ENST00000467465;  ENST00000468742;  ENST00000474066;  ENST00000474803;  ENST00000477987;  ENST00000484149;  ENST00000485411;  ENST00000485901;  ENST00000487893;  ENST00000489297;  ENST00000490045;  ENST00000490305;  ENST00000491304;  ENST00000492557;  ENST00000492839;  ENST00000494729;  ENST00000495532;  ENST00000497431;
	Entrez Gene	Entrez Gene ID:3111;
	KEGG GENES	KEGG GENES(3111);
	GeneCard	HLA-DOA;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000029856 Predicted CDS 30..782;  250[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.872 Database links RefSeq NP_002110;  UniProt P06340;  CCDS CCDS4763;

MALRAGLVLGFHTLMTLLSPQEAGATKADHMGSYGPAFYQSYGASGQFTH EFDEEQLFSVDLKKSEAVWRLPEFGDFARFDPQGGLAGIAAIKAHLDILV ERSNRSRAINVPPRVTVLPKSRVELGQPNILICIVDNIFPPVINITWLRN GQTVTEGVAQTSFYSQPDHLFRKFHYLPFVPSAEDVYDCQVEHWGLDAPL LRHWELQVPIPPPDAMETLVCALGLAIGLVGFLVGTVLIIMGTYVSSVPR *

Motif information

	a.a. length	InterPro	Name
	77	IPR014745	MHC class II, alpha/beta chain, N-terminal [Domain]
	84	IPR011162	MHC classes I/II-like antigen recognition protein [Domain]
	82	IPR001003	MHC class II, alpha chain, N-terminal [Domain]
	81	IPR001003	MHC class II, alpha chain, N-terminal [Domain]
	115	IPR013783	Immunoglobulin-like fold [Domain]
	81	IPR007110	Immunoglobulin-like [Domain]
	81	IPR003597	Immunoglobulin C1-set [Domain]
	72	IPR003597	Immunoglobulin C1-set [Domain]
	7	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site [Conserved_site]

Gene function information

H-Inv ID		HIT000432417_05
H-Inv cluster ID		HIX0058180
Accession number		AK313551.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		Representative transcript;  Splicing isoform
Coding potential		Protein coding;
Definition		HLA class II histocompatibility antigen, DO alpha chain precursor.
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (NP_002110)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	HIF0000002
	Gene family/group name	Major histocompatibility complex (MHC).
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	HLA-DOA
	HGNC aliases	NA
	HGNC name	major histocompatibility complex, class II, DO alpha
	DDBJ	NA
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000029856
	No. of interaction	7
	Interaction partner(s)	HIP000026960;  HIP000027891;  HIP000039637;  HIP000080397;  HIP000108285;  HIP000163972;  HIP000436308;
	BIND	NA
	DIP	NA
	MINT	MINT-65765;
	HPRD	05457;  10322;  17943;
	IntAct	EBI-735034;  EBI-3943844;  EBI-2559511;
Database links	RefSeq	NA
	Ensembl	ENST00000374813;  ENST00000383225;  ENST00000383226;  ENST00000418857;  ENST00000432150;  ENST00000444109;  ENST00000465107;  ENST00000465500;  ENST00000466497;  ENST00000467465;  ENST00000468742;  ENST00000474066;  ENST00000474803;  ENST00000477987;  ENST00000484149;  ENST00000485411;  ENST00000485901;  ENST00000487893;  ENST00000489297;  ENST00000490045;  ENST00000490305;  ENST00000491304;  ENST00000492557;  ENST00000492839;  ENST00000494729;  ENST00000495532;  ENST00000497431;
	Entrez Gene	Entrez Gene ID:3111;
	KEGG GENES	KEGG GENES(3111);
	GeneCard	HLA-DOA;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Human curated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Biological process	antigen processing and presentation (GO:0019882);  immune response (GO:0006955);
Cellular component	membrane (GO:0016020);  MHC class II protein complex (GO:0042613);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	extracellular;  peroxisome;  endoplasmic;  Other;
Target P	signal peptide
SOSUI	membrane protein
TMHMM	membrane protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.