H-InvDB x AHG DB
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H-InvDB_8.3 released on March 26, 2013.
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H-Invitational ID: HIT000423295 Accession number: AK290498 Created date: 26-Mar-2013 Last modified: 26-Mar-2013
Definition: Cyclic AMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 alpha; Activating transcription factor 6 alpha; ATF6-alpha; Contains: Processed cyclic AMP-dependent transcription factor ATF-6 alpha;
 
 

Transcript original information
Accession number AK290498.1
CAGE tag ID NA
EST ID NA
Clone Number FCBBF3018244
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ATF6) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ATF6);
Sequence data provider NA
Annotation project NA
Length of cDNA 2486[bp] (No. of exon:16)[A:744 T:640 G:533 C:569]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type brain
Develpmental stage fetal
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGGAG;  TAGCAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001253
Genomic location  G-integra Help Chromosome 1
Location 1q23.3
Position 161736110- 161928876
Strand +
Possible duplicated location(s) NA
Gene structure 16 exon(s)
Database links RefSeq NM_007348
Ensembl ENST00000367942ENST00000476437
Entrez Gene Entrez Gene ID:22926
KEGG GENES KEGG GENES(22926)
GeneCard GeneCardATF6*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000192063
Predicted CDS 42..2054;  670[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.72
Database links RefSeq NA
UniProt A8K383
CCDS NA

Motif information
ORF

length(670),orf(42:2054)
MGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAAN
ETYENNFDNLDFDLDLMPWESDIWDINNQICTVKDIKAEPQPLSPASSSY
SVSSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGENSNSLSSPEPLKE
DKPVTGSRNKTENGLTPKKKIQVNSKPPIQPKPLLLPAAPKTQTNSSVPA
KTIIIRTVPTLMPLAKQQPIISLQPAPTKGQTVLLSQPTVVQPQAPGVLP
SAQPVLAVAGGVTQLPNHVVNVVPAPSANSPVNGKLSVTKPVLQSTMRNV
GSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKK
ENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNYGPMSMLEQ
DSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKA
LMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRM
TNNQQKARILQGALEQGSNSQLMAVQYTETTSSISRDSGSELQVYYASPR
SYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAINI
NENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFG
SPPAATEATHVVSTIPESLQ*
a.a.
length
InterPro Name
length(65), motif(304:368) 65 IPR004827 Basic-leucine zipper (bZIP) transcription factor [Domain]
length(64), motif(306:369) 64 IPR004827 Basic-leucine zipper (bZIP) transcription factor [Domain]
length(60), motif(307:366) 60 IPR011616 bZIP transcription factor, bZIP-1 [Domain]
length(15), motif(312:326) 15 IPR004827 Basic-leucine zipper (bZIP) transcription factor [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000423295
H-Inv cluster ID Locus viewHIX0001253
Accession number AK290498.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Cyclic AMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 alpha; Activating transcription factor 6 alpha; ATF6-alpha; Contains: Processed cyclic AMP-dependent transcription factor ATF-6 alpha;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P18850)  [Identity/coverage = 98.955%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 25168279271374983796210564271111583101116320911483355146991591548933416710414ALL
Gene family/group Gene family H-Inv gene family/group ID HIF0001703
Gene family/group name bZIP transcription factor, bZIP-1 (IPR011616).
Evidence motif (InterPro) ID IPR011616
Gene symbol/name HGNC symbol ATF6
HGNC aliases NA
HGNC name activating transcription factor 6
DDBJ NA
UniProt ATF6
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000192063
No. of interaction 15
Interaction partner(s) HIP000024870HIP000032458HIP000033699HIP000050382HIP000055894HIP000058287HIP000075004HIP000079270HIP000081899HIP000099637HIP000103895HIP000107439HIP000114133HIP000254832HIP000350019
BIND 153783;  153784;  153785; 
DIP NA
MINT MINT-19431; 
HPRD 00145;  01861;  01908;  02482;  02788;  02992;  03399;  05633;  07340;  16118;  16752; 
IntAct EBI-3446117;  EBI-3438989;  EBI-3917270;  EBI-3917280;  EBI-3908954;  EBI-3916592;  EBI-852240;  EBI-852192; 
Database links RefSeq NM_007348
Ensembl ENST00000367942ENST00000476437
Entrez Gene Entrez Gene ID:22926
KEGG GENES KEGG GENES(22926)
GeneCard GeneCardATF6*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links bZIP transcription factor, bZIP-1 (IPR011616). Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function sequence-specific DNA binding (GO:0043565);  transcription factor activity (GO:0003700);  protein dimerization activity (GO:0046983); 
Biological process regulation of transcription, DNA-dependent (GO:0006355); 
Cellular component nucleus (GO:0005634); 

Subcellular localization information  Last modified:26-Mar-2013
WoLF PSORT nuclear; 
Target P Other
SOSUI membrane protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:26-Mar-2013
Start End PDB_ID E-value Identity Coverage SCOP_ID
274 327 1sknP 1e-04 22.6 53/100 a.37.1.1
Related H-InvDB links GTOP GTOP

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:26-Mar-2013
Disease relation Disease name:NA
Related information in OMIM OMIM ID:NA Title:NA
Co-localized orphan diseases OMIM ID:  115665116600155600600975605225605606606788606852606928607317607671608543608553608995610320612367612596
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(22926)
Disease Entrez Gene ID:(22926)
Substance Entrez Gene ID:(22926)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo ViewerLEGENDALEGENDA

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
5 .. 5 A/G rs60394665 + 5'UTR
88 .. 88 G/T rs112863172 + CDS Nonsynonymous[Ser16Ile]
100 .. 100 T/C rs35284289 + CDS Nonsynonymous[Phe20Ser]
146 .. 146 T/C rs2070151 + CDS Synonymous[Leu35Leu]
190 .. 190 A/G rs56394151 + CDS Nonsynonymous[Asn50Ser]
240 .. 240 A/G/T rs1058405 + CDS
242 .. 242 G/A rs1135982 + CDS Nonsynonymous[Met67Ile]
311 .. 311 C/T rs2271013 - CDS Synonymous[Pro90Pro]
350 .. 350 A/G rs2271012 - CDS Synonymous[Ser103Ser]
367 .. 367 A/G rs2271011 - CDS Nonsynonymous[Asp109Gly]
420 ^ 421 -/A rs34354288 + CDS
463 .. 463 G/A rs61801254 + CDS Nonsynonymous[Ser141Asn]
474 .. 474 C/G rs2070150 + CDS Nonsynonymous[Pro145Ala]
510 .. 510 T/C rs1135983 + CDS Nonsynonymous[Ser157Pro]
817 .. 817 C/T rs11799951 + CDS Nonsynonymous[Ala259Val]
885 .. 885 G/C rs78561001 + CDS Nonsynonymous[Val282Leu]
902 .. 902 C/T rs16847240 + CDS Synonymous[Ser287Ser]
922 .. 922 A/G rs79010144 + CDS Nonsynonymous[Gln294Arg]
1071 .. 1071 G/C rs2134689 - CDS Nonsynonymous[Glu344Gln]
1116 .. 1116 C/G rs80112842 + CDS Nonsynonymous[Leu359Val]
1120 .. 1120 A/G rs75594989 + CDS Nonsynonymous[Asp360Gly]
1457 .. 1457 C/T rs1135984 + CDS Synonymous[Asn472Asn]
1532 .. 1532 A/T rs1058408 + CDS Synonymous[Ser497Ser]
1910 ^ 1911 -/A rs34529107 + CDS
1937 .. 1937 A/G rs9482 + CDS Synonymous[Ser632Ser]
2083 .. 2083 C/T rs78713669 + 3'UTR
2094 .. 2094 G/A rs76485377 + 3'UTR
2178 .. 2178 G/A rs13401 + 3'UTR
2224 .. 2224 C/G rs17417647 + 3'UTR
2321 .. 2321 T/A rs74579405 + 3'UTR
2381 .. 2381 A/G rs1136046 + 3'UTR
2402 .. 2402 T/C rs112942257 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer