H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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Locus view Protein view G-integra DiseaseInfo Viewer H-ANGEL Evola PPI view Gene Family/Group Hyperlink MS

H-Invitational ID: HIT000387026 Accession number: BC113573 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Similar to Exportin-4; Exp4;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number BC113573.1 CAGE tag ID NA EST ID NA Clone Number MGC:142133 IMAGE:8322625 Experimental resources   NBRC ; HGPD ; Antibody (XPO4) ; Catalog (XPO4); Sequence data provider NA Annotation project NA Length of cDNA 3452[bp] (No. of exon:22)[A:1039 T:973 G:733 C:707] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type Lung, PCR rescued clones Develpmental stage NA

Sequence quality information CDS feature N-truncated Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

CTCTCAAGGCACCACCTTCCATGGTCAATAATGAACAACGCCAGCATGCA GAGCACATATTCTTATCATTTAGGAAATCAAAATCACCATTTGCAGTTTG CAAGCATATTTTGGAAACTAGTAAAGTGGACTATGTCCTCTTTCAAGCTG CCACAGCCATAATGGAAGCAGTTGTCCGAGAGTGGATTCTCTTGGAAAAA GGTAGCATCGAGTCTCTGCGAACATTCCTTTTAACCTATGTCTTACAAAG GCCCAACCTTCAAAAGTATGTTCGGGAACAGATTCTACTAGCAGTAGCAG TAATTGTAAAAAGAGGATCATTAGATAAATCAATTGACTGCAAAAGCATT TTTCATGAAGTCAGCCAGTTGATTAGTAGTGGCAATCCCACTGTGCAAAC TCTGGCCTGTTCTATTCTGACTGCGCTATTGAGTGAATTTTCAAGTTCAA GTAAAACTAGCAACATTGGATTGAGCATGGAATTCCATGGTAACTGCAAA AGAGTTTTTCAGGAAGAAGACCTTCGTCAGATCTTCATGTTAACTGTTGA AGTTCTGCAGGAGTTCAGCAGGCGGGAAAACCTCAATGCTCAGATGTCTT CAGTATTTCAGCGTTACCTTGCACTCGCCAATCAAGTCTTGAGCTGGAAC TTTCTTCCTCCAAATTTGGGCAGACATTATATAGCTATGTTTGAATCCTC GCAAAATGTGCTGTTGAAGCCAACAGAGTCCTGGCGGGAGACTCTTCTGG ACAGCAGAGTTATGGAGCTTTTCTTCACAGTACATCGAAAAATCAGAGAA GATTCAGATATGGCACAAGATTCTCTGCAGTGCCTTGCCCAGTTAGCTTC TCTTCATGGACCCATCTTCCCAGATGAAGGATCACAAGTTGATTATCTAG CACACTTCATTGAGGGATTACTGAATACTATCAATGGAATTGAAATAGAA GATTCTGAAGCTGTGGGGATCTCCAGCATTATCAGCAACCTGATAACCGT GTTCCCACGAAATGTTTTAACTGCCATTCCAAGTGAACTTTTCTCCTCCT TTGTTAACTGCCTCACACACCTCACTTGTTCTTTTGGGCGAAGTGCTGCA TTGGAAGAAGTGCTTGATAAAGATGACATGGTATACATGGAAGCATATGA TAAATTGTTGGAGTCCTGGTTAACTTTGGTTCAAGATGACAAACATTTCC ATAAAGGCTTTTTTACCCAACATGCAGTTCAAGTTTTCAATTCCTATATT CAGTGCCACCTAGCTGCTCCAGATGGCACAAGAAATTTGACTGCCAATGG TGTGGCCTCTCGTGAGGAGGAAGAAATAAGTGAACTTCAAGAGGATGATC GAGACCAGTTTTCTGATCAACTGGCCAGTGTAGGAATGCTAGGAAGAATT GCTGCAGAACACTGTATACCTCTTCTGACAAGTTTATTAGAAGAAAGAGT AACAAGACTCCATGGTCAGTTACAACGACATCAGCAACAGTTACTTGCTT CACCGGGTTCAAGCACTGTTGACAACAAAATGCTTGATGATCTCTATGAA GATATTCACTGGCTTATTTTAGTTACAGGCTACCTCTTAGCTGATGATAC TCAGGGAGAGACTCCGCTAATACCTCCAGAAATAATGGAATATTCCATTA AGCATTCATCTGAAGTTGACATTAATACAACACTTCAAATTTTGGGATCT CCAGGAGAAAAGGCTTCTTCCATCCCAGGGTACAACAGAACAGATTCTGT GATTAGGCTGTTGTCTGCCATTCTCAGAGTTTCAGAAGTTGAATCTCGAG CAATAAGAGCAGATCTCACTCATCTACTAAGTCCCCAGATGGGCAAAGAT ATTGTTTGGTTTTTAAAACGCTGGGCAAAGACTTATCTCCTGGTGGATGA AAAACTGTATGATCAGATAAGTCTGCCATTCAGTACAGCGTTCGGAGCAG ATACAGAGGGTTCTCAGTGGATAATTGGCTACCTCTTACAAAAAGTCATC AGTAACCTCTCAGTCTGGAGTAGTGAGCAGGACCTTGCAAATGACACTGT GCAGCTCCTTGTCACTTTGGTGGAAAGAAGAGAAAGGGCAAACTTAGTAA TTCAATGTGAGAACTGGTGGAATTTAGCTAAGCAGTTTGCAAGCCGAAGC CCACCTCTTAATTTCTTGTCAAGTCCTGTGCAGAGGACATTGATGAAGGC TCTAGTCTTAGGAGGTTTTGCACATATGGACACAGAAACCAAACAGCAGT ATTGGACAGAGGTTCTTCAGCCACTTCAGCAGCGATTCTTAAGAGTGATA AACCAAGAAAACTTCCAGCAGATGTGTCAGCAAGAGGAAGTCAAGCAGGA AATCACTGCCACACTAGAGGCCCTGTGTGGCATTGCTGAGGCTACCCAGA TTGACAACGTAGCAATCCTGTTTAATTTTTTAATGGACTTCCTTACCAAT TGCATTGGATTGATGGAAGTTTACAAGAATACCCCAGAGACTGTCAATCT CATTATAGAAGTTTTTGTTGAAGTTGCACATAAACAGATATGCTATCTTG GAGAGTCCAAAGCTATGAACTTATATGAAGCCTGCCTTACTTTGTTGCAA GTGTATTCTAAGAATAATTTAGGGCGGCAAAGAATAGATGTTACAGCAGA AGAAGAGCAATACCAAGACCTGCTTCTCATTATGGAACTTCTTACTAACC TGCTGTCAAAAGAATTCATAGATTTCAGTGATACAGATGAAGTGTTTAGA GGACATGAGCCAGGTCAAGCAGCAAACAGATCTGTGTCAGCAGCGGATGT TGTGTTGTATGGAGTAAACCTAATTCTGCCCTTGATGTCACAGGATCTCT TGAAGTTTCCAACCCTTTGTAATCAGTACTACAAATTAATCACATTTATC TGTGAGATTTTTCCTGAAAAAATACCACAGCTTCCTGAGGATCTGTTTAA AAGTCTGATGTACTCCCTAGAATTAGGAATGACATCAATGAGTTCGGAGG TTTGCCAGCTTTGCCTGGAGGCCTTGACACCGTTAGCTGAACAGTGTGCA AAAGCACAAGAAACAGACTCACCACTTTTTCTAGCAACACGGCACTTTCT TAAGCTGGTTTTTGATATGCTGGTTTTGCAAAAGCACAACACAGAGATGA CCACTGCGGCTGGCGAAGCTTTCTACACGTTGGTGTGTTTGCACCAGGCT GAATATTCTGAACTGGTCGAAACATTACTATCAAGTCAGCAAGACCCAGT TATTTACCAGAGATTAGCAGATGCCTTCAACAAGCTCACTGCAAGCAGCA CTCCTCCTACGCTGGATCGGAAGCAGAAGATGGCCTTCTTAAAGAGTTTA GAAGAATTTATGGCAAATGTTGGTGGTCTCCTTTGTGTAAAATAAACAAC AGAACTTTATGCTTAATTTAGATCCTTTCTGCAAAGTGCACTGAATTGCT GA

Gene structure information

H-Inv cluster ID		HIX0011162
Genomic location	Chromosome	13
	Location	13q12.11
	Position	21357804- 21442848
	Strand	-
Possible duplicated location(s)		NA
Gene structure		22 exon(s)
Database links	RefSeq	NM_022459;
	Ensembl	ENST00000255305;  ENST00000400602;  ENST00000456108;  ENST00000465018;  ENST00000490513;  ENST00000543060;
	Entrez Gene	Entrez Gene ID:64328;
	KEGG GENES	KEGG GENES(64328);
	GeneCard	XPO4;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000190825 Predicted CDS 3..3395;  1130[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.674

LKAPPSMVNNEQRQHAEHIFLSFRKSKSPFAVCKHILETSKVDYVLFQAA TAIMEAVVREWILLEKGSIESLRTFLLTYVLQRPNLQKYVREQILLAVAV IVKRGSLDKSIDCKSIFHEVSQLISSGNPTVQTLACSILTALLSEFSSSS KTSNIGLSMEFHGNCKRVFQEEDLRQIFMLTVEVLQEFSRRENLNAQMSS VFQRYLALANQVLSWNFLPPNLGRHYIAMFESSQNVLLKPTESWRETLLD SRVMELFFTVHRKIREDSDMAQDSLQCLAQLASLHGPIFPDEGSQVDYLA HFIEGLLNTINGIEIEDSEAVGISSIISNLITVFPRNVLTAIPSELFSSF VNCLTHLTCSFGRSAALEEVLDKDDMVYMEAYDKLLESWLTLVQDDKHFH KGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEEEISELQEDDR DQFSDQLASVGMLGRIAAEHCIPLLTSLLEERVTRLHGQLQRHQQQLLAS PGSSTVDNKMLDDLYEDIHWLILVTGYLLADDTQGETPLIPPEIMEYSIK HSSEVDINTTLQILGSPGEKASSIPGYNRTDSVIRLLSAILRVSEVESRA IRADLTHLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQISLPFSTAFGAD TEGSQWIIGYLLQKVISNLSVWSSEQDLANDTVQLLVTLVERRERANLVI QCENWWNLAKQFASRSPPLNFLSSPVQRTLMKALVLGGFAHMDTETKQQY WTEVLQPLQQRFLRVINQENFQQMCQQEEVKQEITATLEALCGIAEATQI DNVAILFNFLMDFLTNCIGLMEVYKNTPETVNLIIEVFVEVAHKQICYLG ESKAMNLYEACLTLLQVYSKNNLGRQRIDVTAEEEQYQDLLLIMELLTNL LSKEFIDFSDTDEVFRGHEPGQAANRSVSAADVVLYGVNLILPLMSQDLL KFPTLCNQYYKLITFICEIFPEKIPQLPEDLFKSLMYSLELGMTSMSSEV CQLCLEALTPLAEQCAKAQETDSPLFLATRHFLKLVFDMLVLQKHNTEMT TAAGEAFYTLVCLHQAEYSELVETLLSSQQDPVIYQRLADAFNKLTASST PPTLDRKQKMAFLKSLEEFMANVGGLLCVK*

Motif information

	a.a. length	InterPro	Name
	1092	IPR016024	Armadillo-type fold [Domain]
	157	IPR011989	Armadillo-like helical [Domain]

Gene function information

H-Inv ID		HIT000387026
H-Inv cluster ID		HIX0011162
Accession number		BC113573.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		Representative transcript;  Splicing isoform
Coding potential		Protein coding;
Definition		Similar to Exportin-4; Exp4;
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (Q9C0E2)  [Identity/coverage = 99.823%/98.18%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		10944119;  11214970;  14702039;  15057823;  16449645;  17081983;  17974005;  18669648;  18691976;  19690332;  21269460;  ALL;
Gene family/group	H-Inv gene family/group ID	HIF0001667
	Gene family/group name	Putative Ubiquitin-associated/translation elongation factor EF1B, N-terminal (IPR000449).
	Evidence motif (InterPro) ID	IPR000449
Gene symbol/name	HGNC symbol	XPO4
	HGNC aliases	NA
	HGNC name	exportin 4
	DDBJ	XPO4
	UniProt	XPO4
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000190825
	No. of interaction	5
	Interaction partner(s)	HIP000081634;  HIP000102042;  HIP000112927;  HIP000146236;  HIP000420501;
	BIND	24526;
	DIP	NA
	MINT	NA
	HPRD	07556;  15496;
	IntAct	EBI-2567957;
Database links	RefSeq	NM_022459;
	Ensembl	ENST00000255305;  ENST00000400602;  ENST00000456108;  ENST00000465018;  ENST00000490513;  ENST00000543060;
	Entrez Gene	Entrez Gene ID:64328;
	KEGG GENES	KEGG GENES(64328);
	GeneCard	XPO4;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Human curated
Notes		NA
Related H-InvDB links		Putative Ubiquitin-associated/translation elongation factor EF1B, N-terminal (IPR000449). Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	binding (GO:0005488);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	cytosol;  nuclear;
Target P	Not predicted
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 3 136 1wa5C 2e-05 10.2 128/100 a.118.1.1

Related H-InvDB links GTOP

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:NA Title:NA
Co-localized orphan diseases		OMIM ID:  610158;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(64328)
	Disease	Entrez Gene ID:(64328)
	Substance	Entrez Gene ID:(64328)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Evolutionary information

Last modified:20-Apr-2012

Relationship	Species	Accession number	MGI	Links
Orthology	Gallus sp. (Chicken)	AJ719315		G-integra
Orthology	Mus sp. (Mouse)	AK129430		G-integra
Orthology	Bos sp. (Cow)	ENSBTAT00000004832		G-integra
Orthology	Danio sp. (Zebrafish)	ENSDART00000004108		G-integra
Orthology	Oryzias sp. (Medaka)	ENSORLT00000016468		G-integra
Orthology	Pongo sp. (Orangutan)	ENSPPYT00000006152		G-integra
Orthology	Tetraodon sp. (Tetraodon)	GSTENT00029158001		G-integra
Orthology	Takifugu sp. (Fugu)	SINFRUT00000137142		G-integra
Orthology	Rattus sp. (Rat)	XM_001063318		G-integra
Orthology	Macaca sp. (Macaque)	XM_001085699		G-integra
Orthology	Pan sp. (Chimpanzee)	XM_001148771		G-integra
Orthology	Monodelphis sp. (Opossum)	XM_001366403		G-integra
Orthology	Equus sp. (Horse)	XM_001488990		G-integra
Orthology	Canis sp. (Dog)	XM_534538		G-integra

Phylogenetic tree [View by ATV]	Neighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS (under constraction);

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 153 .. 153 A/C rs75894660 - CDS Nonsynonymous[Thr51Pro] 287 .. 287 A/G rs61737207 - CDS Synonymous[Leu95Leu] 385 .. 385 A/G rs17320607 - CDS Nonsynonymous[Asn128Ser] 547 .. 547 T/C rs75491924 - CDS Nonsynonymous[Val182Ala] 722 .. 722 A/G rs34938233 - CDS Synonymous[Pro240Pro] 1020 .. 1020 A/C rs76608841 - CDS Nonsynonymous[Thr340Pro] 1214 .. 1214 T/- rs35001993 - CDS 1290 .. 1290 A/G rs9552285 - CDS Nonsynonymous[Thr430Ala] 1570 ^ 1571 -/T rs35241770 - CDS 2048 .. 2048 T/C rs9579954 - CDS Synonymous[Thr682Thr] 2175 .. 2175 C/T rs61762964 - CDS Nonsynonymous[Pro725Ser] 2342 .. 2342 C/A rs75620499 - CDS Synonymous[Val780Val] 2634 .. 2634 A/T rs117470697 - CDS Nonsynonymous[Ile878Leu] 3017 .. 3017 G/A rs35518636 - CDS Synonymous[Leu1005Leu] 3072 .. 3072 C/A rs1133141 + CDS Nonsynonymous[Pro1024Thr] 3164 .. 3164 C/G rs117269843 - CDS Synonymous[Gly1054Gly] 3166 .. 3166 A/G rs116989674 - CDS Nonsynonymous[Glu1055Gly]  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;