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H-Invitational ID: HIT000383139 Accession number: AB037533 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: Similar to 5-hydroxytryptamine receptor 1F.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AB037533.1 CAGE tag ID NA EST ID NA Clone Number NA Experimental resources   NBRC ; HGPD ; Antibody (HTR1F) ; Catalog (HTR1F); Sequence data provider NA Annotation project NA Length of cDNA 1125[bp] (No. of exon:1)[A:335 T:337 G:229 C:224] Devision HUM Molecular type DNA Library origin Cell type NA Tissue type NA Develpmental stage NA

Sequence quality information CDS feature C-truncated Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

AGCTATATTAATCTTTTAAAACAAAGAAAATGGATTTCTTAAATTCATCT GATCAAAACTTGACCTCAGAGGAACTGTTAAACAGAATGCCATCCAAAAT TCTGGTGTCCCTCACTCTGTCTGGGCTGGCACTGATGACAACAACTATCA ACTCCCTTGTGATCGCTGCAATTATTGTGACCCGGAAGCTGCACCATCCA GCCAATTATTTAATTTGTTCCCTTGCAGTCACAGATTTTCTTGTGGCTGT CCTGGTGATGCCCTTCAGCATTGTGTATATTGTGAGAGAGAGCTGGATTA TGGGGCAAGTGGTCTGTGACATTTGGCTGAGTGTTGACATTACCTGCTGC ACGTGCTCCATCTTGCATCTCTCAGCTATAGCTTTGGATCGGTATCGAGC AATCACAGATGCTGTTGAGTATGCCAGGAAAAGGACTCCAAAGCATGCTG GCATTATGATTACAATAGTTTGGATTATATCTGTTTTTATCTCTATGCCT CCTCTATTCTGGAGGCACCAAGGAACTAGCAGAGATGATGAATGCATCAT CAAGCACGACCACATTGTTTCCACCATTTACTCAACATTTGGAGCTTTCT ACATCCCACTGGCATTGATTTTGATCCTTTACTACAAAATATATAGAGCA GCAAAGACATTATACCACAAGAGACAAGCAAGTAGGATTGCAAAGGAGGA GGTGAATGGCCAAGTCCTTTTGGAGAGTGGTGAGAAAAGCACTAAATCAG TTTCCACATCCTATGTACTAGAAAAGTCTTTATCTGACCCATCAACAGAC TTTGATAAAATTCATAGCACAGTGAGAAGTCTCAGGTCTGAATTCAAGCA TGAGAAATCTTGGAGAAGGCAAAAGATCTCAGGTACAAGAGAACGGAAAG CAGCCACTACCCTGGGATTAATCTTGGGTGCATTTGTAATATGTTGGCTT CCTTTTTTTGTAAAAGAATTAGTTGTTAATGTCTGTGACAAATGTAAAAT TTCTGAAGAAATGTCCAATTTTTTGGCATGGCTTGGGTATCTCAATTCCC TTATAAATCCACTGATTTACACAATCTTTAATGAAGACTTCAAGAAAGCA TTCCAAAAGCTTGTGCGATGTCGAT

Gene structure information

H-Inv cluster ID		HIX0030749
Genomic location	Chromosome	3
	Location	3p11.1
	Position	88039871- 88040995
	Strand	+
Possible duplicated location(s)		NA
Gene structure		1 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	NA
	KEGG GENES	NA
	GeneCard	HTR1F;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000173930 Predicted CDS 30..1125;  365[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.72

MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIV TRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWL SVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWII SVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILIL YYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKS LSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILG AFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIF NEDFKKAFQKLVRCR

Motif information

	a.a. length	InterPro	Name
	365	IPR000450	5-Hydroxytryptamine 1F receptor [Family]
	14	IPR000450	5-Hydroxytryptamine 1F receptor [Family]
	213	IPR017452	GPCR, rhodopsin-like, 7TM [Domain]
	15	IPR000450	5-Hydroxytryptamine 1F receptor [Family]
	25	IPR000276	G protein-coupled receptor, rhodopsin-like [Family]
	308	IPR017452	GPCR, rhodopsin-like, 7TM [Domain]
	307	IPR000276	G protein-coupled receptor, rhodopsin-like [Family]
	9	IPR002231	5-hydroxytryptamine receptor family [Family]
	22	IPR000276	G protein-coupled receptor, rhodopsin-like [Family]
	23	IPR000276	G protein-coupled receptor, rhodopsin-like [Family]
	17	IPR000276	G protein-coupled receptor, rhodopsin-like [Family]
	22	IPR000276	G protein-coupled receptor, rhodopsin-like [Family]
	17	IPR000450	5-Hydroxytryptamine 1F receptor [Family]
	9	IPR002231	5-hydroxytryptamine receptor family [Family]
	24	IPR000276	G protein-coupled receptor, rhodopsin-like [Family]
	20	IPR000450	5-Hydroxytryptamine 1F receptor [Family]
	16	IPR000450	5-Hydroxytryptamine 1F receptor [Family]
	17	IPR000450	5-Hydroxytryptamine 1F receptor [Family]
	19	IPR000450	5-Hydroxytryptamine 1F receptor [Family]
	96	IPR017452	GPCR, rhodopsin-like, 7TM [Domain]
	25	IPR000276	G protein-coupled receptor, rhodopsin-like [Family]
	12	IPR002231	5-hydroxytryptamine receptor family [Family]
	27	IPR000276	G protein-coupled receptor, rhodopsin-like [Family]
	6	IPR002231	5-hydroxytryptamine receptor family [Family]

Gene function information

H-Inv ID		HIT000383139
H-Inv cluster ID		HIX0030749
Accession number		AB037533.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Similar to 5-hydroxytryptamine receptor 1F.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_000857)  [Identity/coverage = 100.0%/99.73%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	HTR1F
	HGNC aliases	"5-hydroxytryptamine (serotonin) receptor 1F"
	HGNC name	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
	DDBJ	HTR1F
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000173930
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	NA
	KEGG GENES	NA
	GeneCard	HTR1F;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	serotonin receptor activity (GO:0004993);  G-protein coupled receptor activity (GO:0004930);
Biological process	G-protein coupled receptor protein signaling pathway (GO:0007186);
Cellular component	integral to membrane (GO:0016021);  integral to plasma membrane (GO:0005887);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	plasma membrane;
Target P	Other
SOSUI	membrane protein
TMHMM	membrane protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 57 .. 57 A/C rs142860258 + CDS Nonsynonymous[Asn10His] 72 .. 72 G/C rs200299083 + CDS Nonsynonymous[Glu15Gln] 104 .. 104 G/A/T rs138692634 + CDS 121 .. 121 C/G rs141238218 + CDS Nonsynonymous[Ser31Cys] 139 .. 139 C/T rs180793593 + CDS Nonsynonymous[Thr37Ile] 164 .. 164 C/T rs111422517 + CDS Synonymous[Ile45Ile] 165 .. 165 G/A rs139622628 + CDS Nonsynonymous[Ala46Thr] 184 .. 184 G/A rs147790807 + CDS Nonsynonymous[Arg52Gln] 184 ^ 185 -/G rs142935523 + CDS 286 .. 286 G/A rs148774926 + CDS Nonsynonymous[Arg86Lys] 288 .. 288 G/C rs151295145 + CDS Nonsynonymous[Glu87Gln] 301 .. 301 T/C rs149733928 + CDS Nonsynonymous[Met91Thr] 356 .. 356 C/T rs150481200 + CDS Synonymous[Cys109Cys] 392 .. 392 G/T rs199724095 + CDS Synonymous[Arg121Arg] 396 .. 396 C/T rs201859991 + CDS AA-STOP[Arg123*] 428 .. 428 G/A rs141186951 + CDS Synonymous[Arg133Arg] 500 .. 500 T/G rs149370975 + CDS Synonymous[Pro157Pro] 557 .. 557 C/T rs1800020 + CDS Synonymous[His176His] 581 .. 581 C/T rs147827549 + CDS Synonymous[Tyr184Tyr] 589 .. 589 T/G rs147206598 + CDS Nonsynonymous[Phe187Cys] 593 .. 593 A/T rs200594949 + CDS Synonymous[Gly188Gly] 611 .. 611 G/A rs200158656 + CDS Synonymous[Leu194Leu] 645 .. 645 A/G rs200052855 + CDS Nonsynonymous[Arg206Gly] 717 .. 717 C/T rs141307791 + CDS Nonsynonymous[Leu230Phe] 718 .. 718 T/C rs200867459 + CDS Nonsynonymous[Leu230Pro] 764 .. 764 T/C rs201820111 + CDS Synonymous[Tyr245Tyr] 794 .. 794 A/G rs142679464 + CDS Synonymous[Ser255Ser] 799 .. 799 A/G rs113447772 + CDS Nonsynonymous[Asp257Gly] 812 .. 812 T/A rs6301 + CDS Synonymous[Ile261Ile] 836 .. 836 G/A rs191093250 + CDS Synonymous[Arg269Arg] 851 .. 851 T/C rs201728270 + CDS Synonymous[His274His] 900 .. 900 G/C rs201702555 + CDS Nonsynonymous[Ala291Pro] 908 .. 908 T/C rs200883374 + CDS Synonymous[Thr293Thr] 1108 .. 1108 A/G rs112317422 + CDS Nonsynonymous[Lys360Arg] 1123 .. 1123 G/A rs183674304 + CDS Nonsynonymous[Arg365Gln]  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;