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H-Invitational ID: HIT000335634 Accession number: BC096346 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number BC096346.3 CAGE tag ID NA EST ID NA Clone Number MGC:117042 IMAGE:40008964 Experimental resources   NBRC ; HGPD ; Antibody (ITGAM) ; Catalog (ITGAM); Sequence data provider NA Annotation project NA Length of cDNA 3645[bp] (No. of exon:30)[A:820 T:763 G:1012 C:1050] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type PCR rescued clones Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) TAGCAG;  Transcript quality feature NA Notes NA

TGGTTCCTCAGTGGTGCCTGCAACCCCTGGTTCACCTCCTTCCAGGTTCT GGCTCCTTCCAGCCATGGCTCTCAGAGTCCTTCTGTTAACAGCCTTGACC TTATGTCATGGGTTCAACTTGGACACTGAAAACGCAATGACCTTCCAAGA GAACGCAAGGGGCTTCGGGCAGAGCGTGGTCCAGCTTCAGGGATCCAGGG TGGTGGTTGGAGCCCCCCAGGAGATAGTGGCTGCCAACCAAAGGGGCAGC CTCTACCAGTGCGACTACAGCACAGGCTCATGCGAGCCCATCCGCCTGCA GGTCCCCGTGGAGGCCGTGAACATGTCCCTGGGCCTGTCCCTGGCAGCCA CCACCAGCCCCCCTCAGCTGCTGGCCTGTGGTCCCACCGTGCACCAGACT TGCAGTGAGAACACGTATGTGAAAGGGCTCTGCTTCCTGTTTGGATCCAA CCTACGGCAGCAGCCCCAGAAGTTCCCAGAGGCCCTCCGAGGGTGTCCTC AAGAGGATAGTGACATTGCCTTCTTGATTGATGGCTCTGGTAGCATCATC CCACATGACTTTCGGCGGATGAAGGAGTTTGTCTCAACTGTGATGGAGCA ATTAAAAAAGTCCAAAACCTTGTTCTCTTTGATGCAGTACTCTGAAGAAT TCCGGATTCACTTTACCTTCAAAGAGTTCCAGAACAACCCTAACCCAAGA TCACTGGTGAAGCCAATAACGCAGCTGCTTGGGCGGACACACACGGCCAC GGGCATCCGCAAAGTGGTACGAGAGCTGTTTAACATCACCAACGGAGCCC GAAAGAATGCCTTTAAGATCCTAGTTGTCATCACGGATGGAGAAAAGTTT GGCGATCCCTTGGGATATGAGGATGTCATCCCTGAGGCAGACAGAGAGGG AGTCATTCGCTACGTCATTGGGGTGGGAGATGCCTTCCGCAGTGAGAAAT CCCGCCAAGAGCTTAATACCATCGCATCCAAGCCGCCTCGTGATCACGTG TTCCAGGTGAATAACTTTGAGGCTCTGAAGACCATTCAGAACCAGCTTCG GGAGAAGATCTTTGCGATCGAGGGTACTCAGACAGGAAGTAGCAGCTCCT TTGAGCATGAGATGTCTCAGGAAGGCTTCAGCGCTGCCATCACCTCTAAT GGCCCCTTGCTGAGCACTGTGGGGAGCTATGACTGGGCTGGTGGAGTCTT TCTATATACATCAAAGGAGAAAAGCACCTTCATCAACATGACCAGAGTGG ATTCAGACATGAATGATGCTTACTTGGGTTATGCTGCCGCCATCATCTTA CGGAACCGGGTGCAAAGCCTGGTTCTGGGGGCACCTCGATATCAGCACAT CGGCCTGGTAGCGATGTTCAGGCAGAACACTGGCACGTGGGAGTCCAACG CTAATGTCAAGGGCACCCAGATCGGCGCCTACTTCGGGGCCTCCCTCTGC TCCGTGGACGTGGACAGCAACGGCAGCACCGACCTGGTCCTCATCGGGGC CCCCCATTACTACGAGCAGACCCGAGGGGGCCAGGTGTCCGTGTGCCCCT TGCCCAGGGGGAGGGCTCGGTGGCAGTGTGATGCTGTTCTCTACGGGGAG CAGGGCCAACCCTGGGGCCGCTTTGGGGCAGCCCTAACAGTGCTGGGGGA CGTAAATGGGGACAAGCTGACGGACGTGGCCATTGGGGCCCCAGGAGAGG AGGACAACCGGGGTGCTGTTTACCTGTTTCACGGAACCTCAGGATCTGGC ATCAGCCCCTCCCATAGCCAGCGGATAGCAGGCTCCAAGCTCTCTCCCAG GCTCCAGTATTTTGGTCAGTCACTGAGTGGGGGCCAGGACCTCACAATGG ATGGACTGGTAGACCTGACTGTAGGAGCCCAGGGGCACGTGCTGCTGCTC AGGTCCCAGCCAGTACTGAGAGTCAAGGCAATCATGGAGTTCAATCCCAG GGAAGTGGCAAGGAATGTATTTGAGTGTAATGATCAGGTGGTGAAAGGCA AGGAAGCCGGAGAGGTCAGAGTCTGCCTCCATGTCCAGAAGAGCACACGG GATCGGCTAAGAGAAGGACAGATCCAGAGTGTTGTGACTTATGACCTGGC TCTGGACTCCGGCCGCCCACATTCCCGCGCCGTCTTCAATGAGACAAAGA ACAGCACACGCAGACAGACACAGGTCTTGGGGCTGACCCAGACTTGTGAG ACCCTGAAACTACAGTTGCCGAATTGCATCGAGGACCCAGTGAGCCCCAT TGTGCTGCGCCTGAACTTCTCTCTGGTGGGAACGCCATTGTCTGCTTTCG GGAACCTCCGGCCAGTGCTGGCGGAGGATGCTCAGAGACTCTTCACAGCC TTGTTTCCCTTTGAGAAGAATTGTGGCAATGACAACATCTGCCAGGATGA CCTCAGCATCACCTTCAGTTTCATGAGCCTGGACTGCCTCGTGGTGGGTG GGCCCCGGGAGTTCAACGTGACAGTGACTGTGAGAAATGATGGTGAGGAC TCCTACAGGACACAGGTCACCTTCTTCTTCCCGCTTGACCTGTCCTACCG GAAGGTGTCCACGCTCCAGAACCAGCGCTCACAGCGATCCTGGCGCCTGG CCTGTGAGTCTGCCTCCTCCACCGAAGTGTCTGGGGCCTTGAAGAGCACC AGCTGCAGCATAAACCACCCCATCTTCCCGGAAAACTCAGAGGTCACCTT TAATATCACGTTTGATGTAGACTCTAAGGCTTCCCTTGGAAACAAACTGC TCCTCAAGGCCAATGTGACCAGTGAGAACAACATGCCCAGAACCAACAAA ACCGAATTCCAACTGGAGCTGCCGGTGAAATATGCTGTCTACATGGTGGT CACCAGCCATGGGGTCTCCACTAAATATCTCAACTTCACGGCCTCAGAGA ATACCAGTCGGGTCATGCAGCATCAATATCAGGTCAGCAACCTGGGGCAG AGGAGCCTCCCCATCAGCCTGGTGTTCTTGGTGCCCGTCCGGCTGAACCA GACTGTCATATGGGACCGCCCCCAGGTCACCTTCTCCGAGAACCTCTCGA GTACGTGCCACACCAAGGAGCGCTTGCCCTCTCACTCCGACTTTCTGGCT GAGCTTCGGAAGGCCCCCGTGGTGAACTGCTCCATCGCTGTCTGCCAGAG AATCCAGTGTGACATCCCGTTCTTTGGCATCCAGGAAGAATTCAATGCTA CCCTCAAAGGCAACCTCTCGTTTGACTGGTACATCAAGACCTCGCATAAC CACCTCCTGATCGTGAGCACAGCTGAGATCTTGTTTAACGATTCCGTGTT CACCCTGCTGCCGGGACAGGGGGCGTTTGTGAGGTCCCAGACGGAGACCA AAGTGGAGCCGTTCGAGGTCCCCAACCCCCTGCCGCTCATCGTGGGCAGC TCTGTCGGGGGACTGCTGCTCCTGGCCCTCATCACCGCCGCGCTGTACAA GCTCGGCTTCTTTAAGCGGCAATACAAGGACATGATGAGTGAAGGGGGTC CCCCGGGGGCCGAACCCCAGTAGCGGCTCCTTCCCGACAGAGCTGCCTCT CGGTGGCCAGCAGGACTCTGCCCAGACCACACGTAGCCCCCAGGCTGCTG GACACGTCGGACAGCGAAGTATCCCCGACAGGACGGGCTTGGGCT

Gene structure information

H-Inv cluster ID		HIX0012987
Genomic location	Chromosome	16
	Location	16p11.2
	Position	31271322- 31343150
	Strand	+
Possible duplicated location(s)		NA
Gene structure		30 exon(s)
Database links	RefSeq	NM_000632;  NM_001145808;
	Ensembl	ENST00000287497;  ENST00000544665;
	Entrez Gene	Entrez Gene ID:3684;
	KEGG GENES	KEGG GENES(3684);
	GeneCard	ITGAM;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000147384 Predicted CDS 65..3523;  1152[aa];  Orientation:+2;  Codon Adaptation Index (CAI). 0.8

MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGSRVVVGA PQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPP QLLACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSD IAFLIDGSGSIIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHF TFKEFQNNPNPRSLVKPITQLLGRTHTATGIRKVVRELFNITNGARKNAF KILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVGDAFRSEKSRQEL NTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEGTQTGSSSSFEHEM SQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFINMTRVDSDMN DAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGTWESNANVKG TQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGR ARWQCDAVLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRG AVYLFHGTSGSGISPSHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVD LTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGE VRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRR QTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVGTPLSAFGNLRP VLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREF NVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESA SSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKAN VTSENNMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRV MQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHT KERLPSHSDFLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGN LSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEPF EVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAE PQ*

Motif information

	a.a. length	InterPro	Name
	51	IPR013519	Integrin alpha beta-propellor [Repeat]
	186	IPR002035	von Willebrand factor, type A [Domain]
	179	IPR002035	von Willebrand factor, type A [Domain]
	50	IPR013519	Integrin alpha beta-propellor [Repeat]
	13	IPR000413	Integrin alpha chain [Family]
	12	IPR000413	Integrin alpha chain [Family]
	21	IPR000413	Integrin alpha chain [Family]
	58	IPR013519	Integrin alpha beta-propellor [Repeat]
	55	IPR013519	Integrin alpha beta-propellor [Repeat]
	25	IPR000413	Integrin alpha chain [Family]
	36	IPR013517	FG-GAP [Repeat]
	55	IPR013519	Integrin alpha beta-propellor [Repeat]
	22	IPR000413	Integrin alpha chain [Family]
	20	IPR000413	Integrin alpha chain [Family]
	387	IPR013649	Integrin alpha-2 [Domain]
	14	IPR000413	Integrin alpha chain [Family]
	20	IPR000413	Integrin alpha chain [Family]
	8	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site [Conserved_site]
	15	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site [Conserved_site]

Gene function information

H-Inv ID		HIT000335634
H-Inv cluster ID		HIX0012987
Accession number		BC096346.3
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (P11215)  [Identity/coverage = 99.826%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		1346576;  1683702;  2454931;  2457584;  2563162;  2833753;  3539202;  7867070;  8419480;  8747460;  9560195;  9687375;  12208882;  15194813;  15489334;  18204446;  18204448;  19159218;  ALL;
Gene family/group	H-Inv gene family/group ID	HIF0000158
	Gene family/group name	Putative Integrin alpha-2 (IPR013649).
	Evidence motif (InterPro) ID	IPR013649
Gene symbol/name	HGNC symbol	ITGAM
	HGNC aliases	"integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)"
	HGNC name	integrin, alpha M (complement component 3 receptor 3 subunit)
	DDBJ	ITGAM
	UniProt	ITGAM
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000147384
	No. of interaction	353
	Interaction partner(s)	HIP000006735;  HIP000006735;  HIP000010968;  HIP000012085;  HIP000013960;  HIP000014176;  HIP000014859;  HIP000016037;  HIP000016037;  HIP000016130;  HIP000017050;  HIP000019188;  HIP000021316;  HIP000021316;  HIP000021507;  HIP000021507;  HIP000021564;  HIP000021564;  HIP000021848;  HIP000022009;  HIP000022168;  HIP000022258;  HIP000022258;  HIP000022399;  HIP000022399;  HIP000022724;  HIP000022816;  HIP000022995;  HIP000022999;  HIP000023019;  HIP000023206;  HIP000023383;  HIP000023396;  HIP000023507;  HIP000023509;  HIP000023757;  HIP000023764;  HIP000024002;  HIP000024145;  HIP000024523;  HIP000024752;  HIP000025088;  HIP000025088;  HIP000025118;  HIP000025362;  HIP000025475;  HIP000025488;  HIP000026241;  HIP000026779;  HIP000026926;  HIP000027204;  HIP000027524;  HIP000027556;  HIP000027556;  HIP000027617;  HIP000028183;  HIP000028658;  HIP000028658;  HIP000028663;  HIP000029067;  HIP000029067;  HIP000029441;  HIP000029441;  HIP000029465;  HIP000029590;  HIP000029625;  HIP000030345;  HIP000030409;  HIP000030416;  HIP000030416;  HIP000030430;  HIP000030823;  HIP000031126;  HIP000031428;  HIP000032520;  HIP000032569;  HIP000033214;  HIP000033214;  HIP000033528;  HIP000033751;  HIP000033751;  HIP000034022;  HIP000034068;  HIP000034474;  HIP000034818;  HIP000035153;  HIP000035161;  HIP000035579;  HIP000035712;  HIP000035761;  HIP000035968;  HIP000036187;  HIP000036327;  HIP000036625;  HIP000037660;  HIP000037809;  HIP000039387;  HIP000039484;  HIP000039536;  HIP000039538;  HIP000040022;  HIP000040212;  HIP000040283;  HIP000040283;  HIP000041487;  HIP000041759;  HIP000041759;  HIP000041931;  HIP000042178;  HIP000042178;  HIP000043176;  HIP000043629;  HIP000043629;  HIP000044968;  HIP000045142;  HIP000045142;  HIP000045187;  HIP000047777;  HIP000048493;  HIP000048493;  HIP000048656;  HIP000048767;  HIP000048823;  HIP000049068;  HIP000050608;  HIP000051080;  HIP000051499;  HIP000051561;  HIP000052316;  HIP000053428;  HIP000053712;  HIP000054467;  HIP000055399;  HIP000055633;  HIP000056484;  HIP000057276;  HIP000057276;  HIP000057544;  HIP000057544;  HIP000057602;  HIP000057602;  HIP000057659;  HIP000057984;  HIP000058633;  HIP000058692;  HIP000059852;  HIP000059852;  HIP000060137;  HIP000060149;  HIP000060440;  HIP000060701;  HIP000061387;  HIP000062017;  HIP000062017;  HIP000063852;  HIP000064222;  HIP000065702;  HIP000066190;  HIP000066197;  HIP000067145;  HIP000067305;  HIP000067305;  HIP000067787;  HIP000067787;  HIP000067942;  HIP000067942;  HIP000068394;  HIP000068394;  HIP000069571;  HIP000069593;  HIP000069725;  HIP000069725;  HIP000069780;  HIP000069873;  HIP000070059;  HIP000070198;  HIP000070318;  HIP000070318;  HIP000070585;  HIP000070754;  HIP000071068;  HIP000071706;  HIP000071922;  HIP000072192;  HIP000073044;  HIP000073047;  HIP000074513;  HIP000074943;  HIP000075345;  HIP000075345;  HIP000075847;  HIP000075938;  HIP000076249;  HIP000076337;  HIP000076408;  HIP000076659;  HIP000077740;  HIP000077832;  HIP000077840;  HIP000078069;  HIP000078246;  HIP000078246;  HIP000078745;  HIP000078916;  HIP000079212;  HIP000079391;  HIP000079583;  HIP000080111;  HIP000080111;  HIP000080569;  HIP000080569;  HIP000080779;  HIP000081007;  HIP000081311;  HIP000081572;  HIP000082842;  HIP000082917;  HIP000082917;  HIP000083279;  HIP000085268;  HIP000086239;  HIP000086406;  HIP000086868;  HIP000087878;  HIP000088759;  HIP000089323;  HIP000090133;  HIP000090133;  HIP000090216;  HIP000090291;  HIP000091247;  HIP000091335;  HIP000091335;  HIP000091632;  HIP000091632;  HIP000091711;  HIP000091876;  HIP000093422;  HIP000093967;  HIP000094609;  HIP000095236;  HIP000095872;  HIP000095892;  HIP000096090;  HIP000096235;  HIP000096767;  HIP000097272;  HIP000097662;  HIP000098362;  HIP000098377;  HIP000098623;  HIP000098949;  HIP000099206;  HIP000099419;  HIP000099536;  HIP000099613;  HIP000099690;  HIP000099690;  HIP000101833;  HIP000102236;  HIP000102434;  HIP000102605;  HIP000102613;  HIP000103026;  HIP000103026;  HIP000103413;  HIP000103838;  HIP000104077;  HIP000104576;  HIP000104730;  HIP000104744;  HIP000105250;  HIP000105556;  HIP000105556;  HIP000106438;  HIP000107831;  HIP000108418;  HIP000108418;  HIP000108490;  HIP000108945;  HIP000108985;  HIP000109262;  HIP000109916;  HIP000110189;  HIP000110189;  HIP000110503;  HIP000111125;  HIP000114363;  HIP000115247;  HIP000115247;  HIP000115330;  HIP000116249;  HIP000116767;  HIP000116907;  HIP000116907;  HIP000117036;  HIP000125414;  HIP000127450;  HIP000134428;  HIP000135672;  HIP000135672;  HIP000136584;  HIP000137017;  HIP000141707;  HIP000144372;  HIP000146969;  HIP000147025;  HIP000147735;  HIP000155836;  HIP000161718;  HIP000161718;  HIP000161881;  HIP000162096;  HIP000164846;  HIP000166951;  HIP000175698;  HIP000175698;  HIP000183512;  HIP000187121;  HIP000192522;  HIP000193291;  HIP000193655;  HIP000193742;  HIP000195159;  HIP000195950;  HIP000195950;  HIP000208002;  HIP000247450;  HIP000249948;  HIP000250623;  HIP000250906;  HIP000253486;  HIP000256099;  HIP000257735;  HIP000258575;  HIP000259169;  HIP000259467;  HIP000285483;  HIP000298444;  HIP000335268;  HIP000335268;  HIP000337149;  HIP000337322;  HIP000346686;  HIP000347450;  HIP000355064;  HIP000358274;  HIP000358946;  HIP000359612;  HIP000361072;  HIP000381912;  HIP000436145;  HIP000436431;
	BIND	NA
	DIP	102805E;  136891E;  136893E;  136895E;  136896E;  136897E;  136898E;  136899E;  136901E;  179694E;  179695E;  179697E;  179698E;  179700E;  179701E;  179703E;  179704E;  179706E;  179707E;  179708E;  179709E;  179710E;  179711E;  179714E;  179715E;  179716E;  179717E;  179719E;  179721E;  179722E;  179725E;  179726E;  179729E;  179730E;  179733E;  179734E;  179736E;  179737E;  179738E;  179739E;  179741E;  179743E;  179744E;  179746E;  179747E;  179748E;  179750E;  179752E;  179753E;  179754E;  179757E;  179760E;  179762E;  179763E;  179764E;  179765E;  179766E;  179767E;  179768E;  179769E;  179770E;  179771E;  179772E;  179773E;  179775E;  179778E;  179780E;  179781E;  179782E;  179786E;  179787E;  179788E;  179789E;  179790E;  179791E;  179792E;  179793E;  179795E;  179800E;  179802E;  179803E;  179808E;  179809E;  179810E;  179811E;  179812E;  179814E;  179815E;  179817E;  179818E;  179819E;  179820E;  179821E;  179822E;  179824E;  179826E;  179828E;  179829E;  179830E;  179831E;  179832E;  179834E;  179835E;  179836E;  179841E;  179843E;  179845E;  179846E;  179847E;  179850E;  179853E;  179855E;  179856E;  179857E;  179859E;  179861E;  179862E;  179863E;  179864E;  179865E;  179866E;  179869E;  179870E;  179871E;  179872E;  179873E;  179874E;  179876E;  179878E;  179880E;  179881E;  179882E;  179883E;  179884E;  179886E;  179887E;  179888E;  179889E;  179890E;  179893E;  179894E;  179895E;  179898E;  179899E;  179900E;  179902E;  179904E;  179906E;  179907E;  179908E;  179909E;  179910E;  179911E;  179913E;  179914E;  179916E;  179917E;  179921E;  179924E;  179925E;  179926E;  179928E;  179929E;  179930E;  179932E;  179933E;  179936E;  179937E;  179938E;  179939E;  179940E;  179941E;  179942E;  179943E;  179944E;  179945E;  179947E;  179948E;  179949E;  179950E;  179952E;  179956E;  179957E;  179958E;  179960E;  179961E;  179963E;  179964E;  179965E;  179966E;  179967E;  179969E;  179970E;  179972E;  179974E;  57291E;  59384E;  61831E;  65401E;  65402E;  72435E;
	MINT	MINT-1899852;  MINT-1900076;  MINT-1900102;  MINT-1900350;  MINT-1900376;  MINT-1900477;  MINT-1900589;  MINT-1900667;  MINT-1900851;  MINT-1900873;  MINT-1901005;  MINT-1901071;  MINT-1901203;  MINT-1901225;  MINT-1901291;  MINT-1901315;  MINT-1901389;  MINT-1901542;  MINT-1901612;  MINT-7041884;  MINT-7304301;  MINT-7894116;  MINT-7894154;
	HPRD	00017;  00032;  00054;  00146;  00152;  00153;  00185;  00287;  00309;  00405;  00484;  00559;  00664;  00713;  00727;  00808;  00835;  00930;  00945;  01051;  01099;  01226;  01242;  01247;  01291;  01456;  01487;  01684;  01716;  01717;  01771;  01787;  01819;  01852;  01857;  02032;  02050;  02131;  02193;  02226;  02248;  02304;  02305;  02326;  02358;  02421;  02530;  02620;  02658;  02818;  02915;  03014;  03131;  03213;  03343;  03445;  03478;  03488;  03494;  03569;  03691;  03823;  03930;  03968;  03976;  03989;  03990;  04043;  04045;  04131;  04274;  04285;  04343;  04451;  04472;  04494;  04646;  04690;  04745;  04885;  05009;  05055;  05668;  05763;  05831;  06120;  06362;  06771;  06982;  07273;  07294;  07429;  07529;  07535;  07536;  07591;  07760;  08439;  08493;  08564;  08912;  08930;  08950;  09047;  09059;  09060;  09141;  09162;  09218;  09283;  09424;  09430;  09435;  09466;  09482;  09690;  09870;  10065;  10199;  10293;  10452;  10510;  10937;  10986;  11177;  11501;  11655;  11745;  11769;  11897;  11899;  11901;  12011;  12432;  12473;  13657;  13711;  13723;  14371;  14528;  15225;  15412;  15452;  15905;  16018;  16055;  16070;  16145;  16310;  16540;  16687;  17137;  17439;  17637;  17871;  18128;
	IntAct	EBI-2314011;  EBI-631774;  EBI-631917;  EBI-2313974;  EBI-2313879;  EBI-2313978;  EBI-2314003;  EBI-2313982;  EBI-2310636;  EBI-2313959;  EBI-1394886;  EBI-2307988;  EBI-2216065;  EBI-2313999;  EBI-2216050;  EBI-1174649;  EBI-2216076;  EBI-2313990;  EBI-2313986;  EBI-1174324;  EBI-1394926;  EBI-1174455;  EBI-1394922;  EBI-1394910;  EBI-1394894;  EBI-2314019;  EBI-631715;  EBI-631703;  EBI-396959;  EBI-631746;  EBI-375679;  EBI-2314015;  EBI-375669;  EBI-2603356;  EBI-2314681;  EBI-2584952;  EBI-2584939;  EBI-2584946;  EBI-389541;  EBI-300976;  EBI-389576;  EBI-3647662;  EBI-375665;  EBI-389472;  EBI-3647640;  EBI-389429;  EBI-301421;  EBI-375689;  EBI-632151;  EBI-525167;  EBI-631973;  EBI-398049;  EBI-877197;  EBI-631595;  EBI-631939;  EBI-632068;  EBI-632030;  EBI-632008;  EBI-632139;  EBI-632078;  EBI-398110;  EBI-770345;  EBI-525002;  EBI-704591;  EBI-877168;  EBI-770052;  EBI-769098;  EBI-704679;  EBI-770539;  EBI-877135;  EBI-770442;  EBI-524892;  EBI-776423;  EBI-80771;  EBI-80768;  EBI-80408;  EBI-631223;  EBI-924062;  EBI-631587;  EBI-525174;  EBI-630996;  EBI-924000;  EBI-630980;  EBI-631094;  EBI-877394;  EBI-877347;  EBI-631055;  EBI-877215;  EBI-631033;  EBI-631008;  EBI-631026;  EBI-631581;  EBI-631283;  EBI-631396;  EBI-924074;  EBI-924107;  EBI-978148;  EBI-631316;  EBI-976976;  EBI-924562;  EBI-631378;  EBI-631387;  EBI-991110;  EBI-987325;  EBI-998522;  EBI-2313943;  EBI-2313887;  EBI-2313883;  EBI-2028240;  EBI-1965337;  EBI-1394973;
Database links	RefSeq	NM_000632;  NM_001145808;
	Ensembl	ENST00000287497;  ENST00000544665;
	Entrez Gene	Entrez Gene ID:3684;
	KEGG GENES	KEGG GENES(3684);
	GeneCard	ITGAM;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Putative Integrin alpha-2 (IPR013649). Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Biological process	cell adhesion (GO:0007155);
Cellular component	integrin complex (GO:0008305);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	extracellular;  plasma membrane;  peroxisome;  Other;
Target P	signal peptide
SOSUI	membrane protein
TMHMM	membrane protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 149 337 1bho1 2e-36 100.0 189/189 c.62.1.1 311 615 1jv2A4 6e-42 27.0 300/438 b.69.8.1 616 771 1jv2A1 1e-26 20.1 154/160 b.1.15.1 773 921 1jv2A2 1e-27 15.9 138/139 b.1.15.1 921 1099 1jv2A3 1e-31 17.0 176/190 b.1.15.1

Related H-InvDB links GTOP

Gene expression information

Last modified:20-Apr-2012

Tissue-specific expression			NA
Probe information	AceGene		AGhsB211308;
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	205785_at;
		HG-U133A	205785_at;
		HG-U133A_2	205785_at;
		HG-U133B	NA
		HG-U133_Plus_2	205785_at;
		HG-U95	NA
		HG-U95A	NA
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	3656991;  3656992;  3656993;  3656994;  3656995;  3656997;  3656998;  3656999;  3657000;  3657001;  3657002;  3657004;  3657005;  3657006;  3657007;  3657011;  3657012;  3657013;  3657014;  3657015;  3657017;  3657018;  3657020;  3657023;  3657025;  3657026;  3657028;  3657029;  3657030;  3657031;  3657033;  3657034;  3688340;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	NA
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name: {Systemic lupus erythematous, association with susceptibility to, 6} (609939);
Related information in OMIM		OMIM ID:  120980;  Title: INTEGRIN, ALPHA-M
Co-localized orphan diseases		OMIM ID:  156850;  605013;  605021;  606668;  607339;  608558;  608903;  610260;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(3684)
	Disease	Entrez Gene ID:(3684)
	Substance	Entrez Gene ID:(3684)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 27 .. 27 C/T rs41408845 + 5'UTR 294 .. 294 G/A rs1143679 + CDS Nonsynonymous[Arg77His] 745 .. 745 G/A rs41499844 + CDS Synonymous[Thr227Thr] 939 .. 939 G/A rs61755176 + CDS Nonsynonymous[Arg292His] 1017 .. 1017 T/A rs61755177 + CDS Nonsynonymous[Phe318Tyr] 1093 .. 1093 C/A rs3087444 + CDS Nonsynonymous[Ser343Arg] 1386 .. 1386 C/T rs11861251 + CDS Nonsynonymous[Thr441Met] 1399 .. 1399 C/T rs79658154 + CDS Synonymous[Asn445Asn] 1530 .. 1530 G/- rs34543155 - CDS 1569 .. 1569 G/A rs79206973 + CDS Nonsynonymous[Arg502Gln] 1843 .. 1843 C/A rs77434675 + CDS Synonymous[Leu593Leu] 1865 .. 1865 C/T rs8056264 + CDS Synonymous[Leu601Leu] 2008 .. 2008 C/T rs1143681 + CDS Synonymous[Ala648Ala] 2188 .. 2188 C/A rs118095734 + CDS Synonymous[Thr708Thr] 2545 .. 2545 C/A rs3087445 + CDS Synonymous[Ser827Ser] 2561 .. 2561 A/C rs78048000 + CDS Nonsynonymous[Thr833Pro] 2563 .. 2563 G/A rs1143682 + CDS Synonymous[Thr833Thr] 2637 .. 2637 C/T rs1143683 + CDS Nonsynonymous[Ala858Val] 2814 .. 2814 T/G rs76323106 + CDS Nonsynonymous[Leu917Arg] 2824 .. 2824 G/A rs116037476 + CDS Synonymous[Pro920Pro] 2917 .. 2917 G/T rs61758333 + CDS Nonsynonymous[Met951Ile] 3063 .. 3063 C/A rs41321249 + CDS Nonsynonymous[Thr1000Asn] 3241 .. 3241 C/G rs80070764 + CDS Synonymous[Thr1059Thr] 3427 .. 3427 C/T rs1143677 + CDS Synonymous[Ala1121Ala] 3500 .. 3500 C/T rs1143678 + CDS Nonsynonymous[Pro1146Ser]  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;