H-InvDB x AHG DB
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H-InvDB_8.3 released on March 26, 2013.
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H-Invitational ID: HIT000321629_03 Accession number: X17653 Created date: 26-Mar-2013 Last modified: 20-Apr-2012
Definition: Fc-gamma-receptor IIB; Fragment;
 
 

Transcript original information
Accession number X17653.1
CAGE tag ID NA
EST ID NA
Clone Number pFcR13
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (FCGR2C) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (FCGR2C);
Sequence data provider NA
Annotation project NA
Length of cDNA 1309[bp] (No. of exon:7)[A:324 T:312 G:318 C:355]
Devision NA
Molecular type NA
Library origin Cell type NA
Tissue type placenta
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGCAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001249
Genomic location  G-integra Help Chromosome 1
Location 1q23.3
Position 161632962- 161647708
Strand +
Possible duplicated location(s) NA
Gene structure 7 exon(s)
Database links RefSeq NM_004001;  NM_001002273;  NM_001002274;  NM_001002275;  NM_001190828; 
Ensembl ENST00000236937;  ENST00000358671;  ENST00000367960;  ENST00000367961;  ENST00000367962;  ENST00000403078;  ENST00000428605;  ENST00000452001;  ENST00000480308;  ENST00000485778; 
Entrez Gene Entrez Gene ID:2213; 
KEGG GENES KEGG GENES(2213); 
GeneCard GeneCardFCGR2C;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000057068
Predicted CDS 70..945;  291[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.793

Motif information
ORF

length(291),orf(70:945) MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKA VLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYR FKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVL RCHSWKDKPLVKVTFFQNGKSKKFSRSIPNFSIPQANHSHSGDYHCTGNI GYTLYSSKPVTITVQAPSSSPMGIIVAVVIGIAVAAIVAAVGALIYCRKK RISANSTNPDEADKVGAENTITYSLLMHPDALEEPDDQNRI* 		a.a.
length		 InterPro Name
length(82), motif(47:128) 82 IPR013783 Immunoglobulin-like fold [Domain]
length(80), motif(48:127) 80 IPR007110 Immunoglobulin-like [Domain]
length(74), motif(56:129) 74 IPR003599 Immunoglobulin subtype [Domain]
length(59), motif(62:120) 59 IPR003598 Immunoglobulin subtype 2 [Domain]
length(83), motif(131:213) 83 IPR007110 Immunoglobulin-like [Domain]
length(85), motif(133:217) 85 IPR013783 Immunoglobulin-like fold [Domain]
length(79), motif(137:215) 79 IPR003599 Immunoglobulin subtype [Domain]
length(61), motif(143:203) 61 IPR003598 Immunoglobulin subtype 2 [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000321629_03
H-Inv cluster ID Locus viewHIX0001249
Accession number X17653.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Fc-gamma-receptor IIB; Fragment;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q8IZV7)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 12215903;  ALL; 
Gene family/group Gene family H-Inv gene family/group ID HIF0000234
Gene family/group name Immunoglobulin-like (IPR007110).
Evidence motif (InterPro) ID IPR007110
Gene symbol/name HGNC symbol FCGR2C
HGNC aliases "Fc fragment of IgG, low affinity IIc, receptor for (CD32)"
HGNC name Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
DDBJ hFcRII-C
UniProt FCGR2B
EC number NA
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000057068
No. of interaction 18
Interaction partner(s) HIP000022009;  HIP000024649;  HIP000035818;  HIP000036574;  HIP000040764;  HIP000041413;  HIP000042124;  HIP000044618;  HIP000044897;  HIP000059017;  HIP000059017;  HIP000069004;  HIP000082878;  HIP000086431;  HIP000086431;  HIP000134584;  HIP000134584;  HIP000176149; 
BIND 185360;  258420;  258897; 
DIP NA
MINT MINT-4052274;  MINT-4052302;  MINT-4052327;  MINT-4052351;  MINT-7255483;  MINT-7255549;  MINT-7255586;  MINT-7255609;  MINT-7255636; 
HPRD 00510;  01140;  02209;  05407;  05431;  06782;  08493;  09052;  09175;  12275; 
IntAct EBI-2695793;  EBI-3221844; 
Database links RefSeq NM_004001;  NM_001002273;  NM_001002274;  NM_001002275;  NM_001190828; 
Ensembl ENST00000236937;  ENST00000358671;  ENST00000367960;  ENST00000367961;  ENST00000367962;  ENST00000403078;  ENST00000428605;  ENST00000452001;  ENST00000480308;  ENST00000485778; 
Entrez Gene Entrez Gene ID:2213; 
KEGG GENES KEGG GENES(2213); 
GeneCard GeneCardFCGR2C;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Immunoglobulin-like (IPR007110). Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA


Subcellular localization information  Last modified:20-Apr-2012
WoLF PSORT extracellular;  plasma membrane;  endoplasmic;  Other; 
Target P signal peptide
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:20-Apr-2012
Disease relation Disease name:NA
Related information in OMIM OMIM ID:NA Title:NA
Co-localized orphan diseases OMIM ID:  115665;  116600;  155600;  600975;  605225;  605606;  606788;  606852;  606928;  607317;  607671;  608543;  608553;  608995;  610320;  612367;  612596; 
Disease related mutation
JRE-1.4.0 or later is required.Download JRE at Sun's web site.
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(2213)
Disease Entrez Gene ID:(2213)
Substance Entrez Gene ID:(2213)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo Viewer;  LEGENDALEGENDA; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
87 .. 87 C/T rs6681090 + CDS Synonymous[Phe6Phe]
197 .. 197 C/T rs59388251 + CDS Nonsynonymous[Thr43Ile]
238 .. 238 C/T rs10917661 + CDS AA-STOP[Gln57*]
258 .. 258 G/A rs5017568 + CDS Synonymous[Gln63Gln]
317 .. 317 A/C rs5017567 + CDS Nonsynonymous[Gln83Pro]
405 .. 405 G/A rs6665610 + CDS Synonymous[Thr112Thr]
527 .. 527 A/G rs61731480 + CDS Nonsynonymous[His153Arg]
576 .. 576 A/C rs112318761 + CDS Synonymous[Gly169Gly]
678 .. 678 G/A rs2298022 + CDS Synonymous[Thr203Thr]
683 .. 683 A/T rs1050499 + CDS Nonsynonymous[Tyr205Phe]
764 .. 764 T/C rs1050501 + CDS Nonsynonymous[Ile232Thr]
903 .. 903 C/T rs115842547 + CDS Synonymous[His278His]
914 .. 914 T/C rs61804185 + CDS Nonsynonymous[Leu282Pro]
962 .. 962 T/C rs72554670 + 3'UTR
966 ^ 967 -/T rs36068674 + 3'UTR
1041 .. 1041 G/T rs115589169 + 3'UTR
1131 .. 1131 A/G rs1043 + 3'UTR
1135 .. 1135 G/A rs844 + 3'UTR
1149 .. 1149 T/G rs1050519 + 3'UTR
1161 .. 1161 C/T rs60519172 + 3'UTR
1211 .. 1211 A/G rs77142736 + 3'UTR
1289 .. 1289 G/C rs1050522 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;