H-InvDB x AHG DB
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H-InvDB_8.3 released on March 26, 2013.
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H-Invitational ID: HIT000293029 Accession number: CR613834 Created date: 26-Mar-2013 Last modified: 20-Apr-2012
Definition: Similar to Catalase; EC=1.11.1.6;
 
 

Transcript original information
Accession number CR613834.1
CAGE tag ID NA
EST ID NA
Clone Number CS0DI065YO16
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (CAT) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (CAT);
Sequence data provider NA
Annotation project NA
Length of cDNA 1230[bp] (No. of exon:6)[A:368 T:341 G:258 C:263]
Devision HTC
Molecular type mRNA
Library origin Cell type NA
Tissue type Placenta Cot 25-normalized
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature N-truncated
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) GAGCAG; 
Transcript quality feature Truncation; 
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0009550
Genomic location  G-integra Help Chromosome 11
Location 11p13
Position 34478258- 34493575
Strand +
Possible duplicated location(s) NA
Gene structure 6 exon(s)
Database links RefSeq NM_001752; 
Ensembl ENST00000241052;  ENST00000525707;  ENST00000528104;  ENST00000530343;  ENST00000534710; 
Entrez Gene Entrez Gene ID:847; 
KEGG GENES KEGG GENES(847); 
GeneCard GeneCardCAT;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000019760
Predicted CDS 3..635;  210[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.806

Motif information
ORF

length(210),orf(3:635) LNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPDTHRHRLG PNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPS ALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHL KDAQIFIQKKAVKNFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGS HLAAREKANL* 		a.a.
length		 InterPro Name
length(205), motif(1:205) 205 IPR020835 Catalase-like domain, haem-dependent [Domain]
length(184), motif(1:184) 184 IPR020835 Catalase-like domain, haem-dependent [Domain]
length(94), motif(1:94) 94 IPR018028 Catalase-related subgroup [Domain]
length(61), motif(1:61) 61 IPR011614 Catalase, N-terminal [Domain]
length(186), motif(1:186) 186 IPR011614 Catalase, N-terminal [Domain]
length(9), motif(37:45) 9 IPR002226 Catalase [Domain]
length(67), motif(114:180) 67 IPR010582 Catalase-related immune responsive [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000293029
H-Inv cluster ID Locus viewHIX0009550
Accession number CR613834.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Similar to Catalase; EC=1.11.1.6;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P04040)  [Identity/coverage = 100.0%/39.85%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 3755525;  3755526;  6548744;  7882369;  8282800;  10656833;  10666617;  11134921;  11728823;  12665801;  14702039;  15489334;  16554811;  18083107;  21269460;  ALL; 
Gene family/group Gene family H-Inv gene family/group ID HIF0003469
Gene family/group name Human gene family/group candidate, HIF0003469.
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol CAT
HGNC aliases NA
HGNC name catalase
DDBJ NA
UniProt CAT
EC number NA
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000019760
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NM_001752; 
Ensembl ENST00000241052;  ENST00000525707;  ENST00000528104;  ENST00000530343;  ENST00000534710; 
Entrez Gene Entrez Gene ID:847; 
KEGG GENES KEGG GENES(847); 
GeneCard GeneCardCAT;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Human gene family/group candidate, HIF0003469. Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function catalase activity (GO:0004096);  heme binding (GO:0020037);  iron ion binding (GO:0005506); 
Biological process response to oxidative stress (GO:0006979); 

Subcellular localization information  Last modified:20-Apr-2012
WoLF PSORT cytosol;  nuclear;  mitochondria;  Other; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:20-Apr-2012
Start End PDB_ID E-value Identity Coverage SCOP_ID
1 160 1a4eA 9e-52 35.6 160/488 e.5.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:20-Apr-2012
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator		 AceGene AGhsA181008;  AGhsC100216; 
Affymetrix
GeneChip		 HG-Focus 201432_at; 
HG-U133 201432_at;  211922_s_at; 
HG-U133A 201432_at;  211922_s_at; 
HG-U133A_2 201432_at;  211922_s_at; 
HG-U133B NA
HG-U133_Plus_2 201432_at;  211922_s_at; 
HG-U95 37009_at; 
HG-U95A 37009_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3326416;  3326420;  3326423;  3326428;  3326429;  3326430;  3326431;  3326432;  3326433;  3369116; 
HuGeneFL X04085_rna1_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P105138; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P105138; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:20-Apr-2012
Disease relation Disease name:NA
Related information in OMIM OMIM ID:  115500;  Title: CATALASE
Co-localized orphan diseases OMIM ID:  604499;  607967;  609270;  609470;  611010; 
Disease related mutation MutationView:  115500; 
JRE-1.4.0 or later is required.Download JRE at Sun's web site.
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(847)
Disease Entrez Gene ID:(847)
Substance Entrez Gene ID:(847)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo Viewer;  LEGENDALEGENDA; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
218 .. 218 C/T rs769217 + CDS Synonymous[Asp72Asp]
306 .. 306 C/G/T rs704724 + CDS
527 .. 527 C/T rs17880442 + CDS Synonymous[His175His]
611 .. 611 G/A rs35677492 + CDS Synonymous[Ala203Ala]
640 .. 640 G/A/C/T rs2234940 + 3'UTR
669 .. 669 G/T rs34455645 + 3'UTR
795 .. 795 G/A rs11546300 - 3'UTR
804 .. 804 C/A rs2266619 + 3'UTR
838 .. 838 T/A rs61882274 + 3'UTR
851 ^ 852 -/A rs71787154 + 3'UTR
931 .. 931 C/T rs2266625 + 3'UTR
965 .. 965 A/C rs1050028 + 3'UTR
1071 .. 1071 T/C rs58333953 + 3'UTR
1100 .. 1100 A/G rs2266629 + 3'UTR
1111 .. 1111 A/C rs1050032 + 3'UTR
1179 .. 1179 T/C rs14527 + 3'UTR
1214 .. 1214 A/G rs80205455 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;