H-InvDB x AHG DB
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H-Invitational ID: HIT000251060 Accession number: AY208943 Created date: 26-Mar-2013 Last modified: 20-Apr-2012
Definition: Mitochondrial ornithine transporter 2.
 
 

Transcript original information
Accession number AY208943.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (SLC25A2) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (SLC25A2);
Sequence data provider NA
Annotation project NA
Length of cDNA 1338[bp] (No. of exon:1)[A:319 T:361 G:347 C:311]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0031997
Genomic location  G-integra Help Chromosome 5
Location 5q31.3
Position 140682203- 140683540
Strand -
Possible duplicated location(s) NA
Gene structure 1 exon(s)
Database links RefSeq NM_031947; 
Ensembl ENST00000239451; 
Entrez Gene Entrez Gene ID:83884; 
KEGG GENES KEGG GENES(83884); 
GeneCard GeneCardSLC25A2;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000069782
Predicted CDS 109..1014;  301[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.721
Database links RefSeq NP_114153; 
UniProt Q9BXI2; 
CCDS CCDS4258; 

Motif information
ORF

length(301),orf(109:1014) MKSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDC FLKTYAQVGLRGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDK QAKLSDLQTAAAGSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSH NTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGGYELSRSFFAS GRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFI GTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEA Y* 		a.a.
length		 InterPro Name
length(286), motif(4:289) 286 IPR001993 Mitochondrial substrate carrier [Family]
length(85), motif(7:91) 85 IPR018108 Mitochondrial substrate/solute carrier [Repeat]
length(294), motif(8:301) 294 IPR001993 Mitochondrial substrate carrier [Family]
length(85), motif(10:94) 85 IPR018108 Mitochondrial substrate/solute carrier [Repeat]
length(94), motif(104:197) 94 IPR018108 Mitochondrial substrate/solute carrier [Repeat]
length(93), motif(107:199) 93 IPR018108 Mitochondrial substrate/solute carrier [Repeat]
length(92), motif(206:297) 92 IPR018108 Mitochondrial substrate/solute carrier [Repeat]
length(87), motif(207:293) 87 IPR018108 Mitochondrial substrate/solute carrier [Repeat]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000251060
H-Inv cluster ID Locus viewHIX0031997
Accession number AY208943.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript; 
Coding potential  Help Protein coding; 
Definition Mitochondrial ornithine transporter 2.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_114153)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Experimental evidence Protein evidence
PubMed ID NA
Gene family/group Gene family H-Inv gene family/group ID HIF0000021
Gene family/group name Putative Mitochondrial substrate carrier (IPR001993).
Evidence motif (InterPro) ID IPR001993
Gene symbol/name HGNC symbol SLC25A2
HGNC aliases NA
HGNC name solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2
DDBJ ORNT2
UniProt NA
EC number NA
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000069782
No. of interaction 22
Interaction partner(s) HIP000034130;  HIP000034709;  HIP000046840;  HIP000071011;  HIP000085125;  HIP000085125;  HIP000087949;  HIP000088916;  HIP000095929;  HIP000098568;  HIP000102384;  HIP000111022;  HIP000114715;  HIP000146054;  HIP000148859;  HIP000163436;  HIP000163436;  HIP000181513;  HIP000258560;  HIP000336703;  HIP000336703;  HIP000339211; 
BIND NA
DIP 50758E;  50759E;  50760E;  50761E;  50763E;  50764E;  50765E;  50767E;  50768E;  50769E;  50770E;  50771E;  50774E;  50775E;  50778E;  99489E;  99490E; 
MINT NA
HPRD 05889;  09440;  12179;  12692; 
IntAct EBI-882652;  EBI-1143317;  EBI-1141484; 
Database links RefSeq NM_031947; 
Ensembl ENST00000239451; 
Entrez Gene Entrez Gene ID:83884; 
KEGG GENES KEGG GENES(83884); 
GeneCard GeneCardSLC25A2;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Human curated
Notes NA
Related H-InvDB links Putative Mitochondrial substrate carrier (IPR001993). Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function binding (GO:0005488); 
Biological process transport (GO:0006810); 
Cellular component membrane (GO:0016020); 

Subcellular localization information  Last modified:20-Apr-2012
WoLF PSORT cytosol;  extracellular;  mitochondria;  plasma membrane;  Other; 
Target P Other
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:20-Apr-2012
Start End PDB_ID E-value Identity Coverage SCOP_ID
7 198 1okcA 1e-29 17.5 219/292 f.42.1.1
259 289 1okcA 1e-29 17.5 219/292 f.42.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:20-Apr-2012
Tissue-specific expression  H-ANGEL placenta/testis/ovary; 
Probe
information DNAProbeLocator		 AceGene NA
Affymetrix
GeneChip		 HG-Focus NA
HG-U133 224166_at; 
HG-U133A NA
HG-U133A_2 NA
HG-U133B 224166_at; 
HG-U133_Plus_2 224166_at; 
HG-U95 57269_at; 
HG-U95A NA
HG-U95B 57269_at; 
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2878631;  2878632;  2878633;  2878634; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P92650; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P92650; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:20-Apr-2012
Disease relation Disease name:NA
Related information in OMIM OMIM ID:NA Title:NA
Co-localized orphan diseases OMIM ID:  601888;  608850;  611091;  612554;  612571; 
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(83884)
Disease Entrez Gene ID:(83884)
Substance Entrez Gene ID:(83884)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo Viewer;  LEGENDALEGENDA; 

Evolutionary information  Evola Help Last modified:20-Apr-2012
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) AK077159 MGI:2392896 G-integraG-integra
Orthology Equus sp. (Horse) ENSECAT00000005452 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000003883 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000018480 G-integraG-integra
Orthology Tetraodon sp. (Tetraodon) GSTENT00022132001 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000134315 G-integraG-integra
Orthology Rattus sp. (Rat) XM_001065727 G-integraG-integra
Orthology Macaca sp. (Macaque) XM_001092357 G-integraG-integra
Orthology Pan sp. (Chimpanzee) XM_527046 G-integraG-integra
Orthology Canis sp. (Dog) XM_544307 G-integraG-integra
Orthology Bos sp. (Cow) XM_586265 G-integraG-integra
Phylogenetic tree [View by ATV]
 Neighbor-joining (phb) 
Related H-InvDB links EvolaEvola;  dN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
14 .. 14 T/A rs77201699 - 5'UTR
276 .. 276 T/C rs11952797 - CDS Synonymous[Ala56Ala]
299 .. 299 A/G rs115876844 - CDS Nonsynonymous[Tyr64Cys]
399 .. 399 A/G rs79139730 - CDS Synonymous[Gly97Gly]
548 .. 548 C/T rs34663948 + CDS Nonsynonymous[Ala147Val]
583 .. 583 G/T rs10075302 - CDS Nonsynonymous[Gly159Cys]
650 .. 650 T/G rs3749779 + CDS Nonsynonymous[Val181Gly]
784 .. 784 G/A/T rs3749780 + CDS
867 .. 867 C/T rs3749781 + CDS Synonymous[Leu253Leu]
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;