H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000243889 Accession number: AJ001683 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: NKG2-F type II integral membrane protein; NK cell receptor F; NKG2-F-activating NK receptor;
 
 

Transcript original information
Accession number AJ001683.1
CAGE tag ID NA
EST ID NA
Clone Number B0955
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (KLRC4) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (KLRC4);
Sequence data provider NA
Annotation project NA
Length of cDNA 971[bp] (No. of exon:4)[A:344 T:279 G:170 C:178]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0219819
Genomic location  G-integra Help Chromosome 12
Location 12p13.2
Position 10559983- 10562356
Strand -
Possible duplicated location(s) NA
Gene structure 4 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8302
KEGG GENES KEGG GENES(8302)
GeneCard GeneCardKLRC4*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000080429
Predicted CDS 183..659;  158[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.723
Database links RefSeq NP_038459
UniProt O43908
CCDS CCDS8624

Motif information
ORF

length(158),orf(183:659)
MNKQRGTYSEVSLAQDPKRQQRKLKGNKISISGTKQEIFQVELNLQNASS
DHQGNDKTYHCKGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPCIGVL
EQNNFSLNRRMQKARHCGHCPEEWITYSNSCYYIGKERRTWEERVCWPVL
RRTLICFL*
a.a.
length
InterPro Name
length(64), motif(80:143) 64 IPR016187 C-type lectin fold [Domain]
length(35), motif(109:143) 35 IPR016186 C-type lectin-like [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000243889
H-Inv cluster ID Locus viewHIX0219819
Accession number AJ001683.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript; 
Coding potential  Help Protein coding; 
Definition NKG2-F type II integral membrane protein; NK cell receptor F; NKG2-F-activating NK receptor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (O43908)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 939480795983069683661117519681548933416541075ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol KLRC4
HGNC aliases NA
HGNC name killer cell lectin-like receptor subfamily C, member 4
DDBJ NKG2F
UniProt KLRC4
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000080429
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8302
KEGG GENES KEGG GENES(8302)
GeneCard GeneCardKLRC4*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA


Subcellular localization information  Last modified:27-May-2015
WoLF PSORT cytosol;  mitochondria;  nuclear;  Other; 
Target P Other
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
103 143 1kg0C 3e-07 24.4 41/136 d.169.1.1
116 147 1hq8A 6e-08 37.5 32/123 d.169.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene NA
Affymetrix
GeneChip
HG-Focus 210690_at; 
HG-U133 210690_at; 
HG-U133A 210690_at; 
HG-U133A_2 210690_at; 
HG-U133B NA
HG-U133_Plus_2 210690_at; 
HG-U95 35532_i_at;  35533_f_at; 
HG-U95A 35532_i_at;  35533_f_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3444107;  3444108;  3444109;  3444112;  3444113;  3444132;  3444144; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P218058; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P218058; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
79 .. 79 T/G rs143682578 - 5'UTR
138 .. 138 G/T rs201530762 - 5'UTR
163 .. 163 G/C rs201827978 - 5'UTR
193 .. 193 A/G rs140767143 - CDS Nonsynonymous[Gln4Arg]
194 .. 194 A/G rs147598384 - CDS Synonymous[Gln4Gln]
233 .. 233 A/G rs145150411 - CDS Synonymous[Pro17Pro]
267 .. 267 A/G rs139613925 - CDS Nonsynonymous[Ile29Val]
268 .. 268 T/G rs1841958 - CDS Nonsynonymous[Ile29Ser]
332 .. 332 G/A rs1841957 - CDS Synonymous[Ser50Ser]
423 .. 423 A/T rs148702713 - CDS Nonsynonymous[Ile81Phe]
493 .. 493 A/G rs2617170 - CDS Nonsynonymous[Asn104Ser]
506 .. 506 T/A rs112429327 - CDS Nonsynonymous[Asn108Lys]
526 .. 526 G/A rs201936811 - CDS Nonsynonymous[Arg115His]
534 .. 534 G/A rs201205058 - CDS Nonsynonymous[Gly118Ser]
544 .. 544 C/A rs12308865 - CDS Nonsynonymous[Pro121His]
588 .. 588 A/G rs146507468 - CDS Nonsynonymous[Lys136Glu]
613 .. 613 G/A rs138156966 - CDS Nonsynonymous[Arg144Lys]
615 .. 615 G/A rs146324289 - CDS Nonsynonymous[Val145Ile]
683 .. 683 C/T rs17514000 + 3'UTR
723 .. 723 A/T rs2617168 - 3'UTR
849 .. 849 G/A rs80131636 - 3'UTR
887 ^ 888 -/C rs35219249 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
L1ME3D 710 902 -
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer