H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000196909_05 Accession number: M95727 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Similar to HLA class II histocompatibility antigen, DQ alpha 2 chain; DX alpha chain; HLA class II histocompatibility antigen, DQ(6) alpha chain; HLA-DQA1; MHC class II DQA2; Precursor;

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Transcript original information Accession number M95727.1 CAGE tag ID NA EST ID NA Clone Number NA Experimental resources   NBRC ; HGPD ; Sequence data provider NA Annotation project NA Length of cDNA 225[bp] (No. of exon:1)[A:61 T:56 G:57 C:51] Devision NA Molecular type NA Library origin Cell type B-lymphoblastoma Tissue type blood Develpmental stage NA
Sequence quality information CDS feature N/C-truncated Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA	GGTGTAAACTTGTACCAGTCTCACGGTCCCTCTGGCCAGTACACCCATGA ATTTGATGGAGACGAGGAGTTCTACGTGGACCTGGAGACGAAAGAGACTG TCTGGCAGTTGCCTATGTTTAGCAAATTTATAAGTTTTGACCCGCAGAGT GCACTGAGAAATATGGCTGTGGGAAAACACACCTTGGAATTCATGATGAG ACAGTCCAACTCTACCGCTGCTACC

Gene structure information

H-Inv cluster ID		HIX0058177
Genomic location	Chromosome	6_mcf_hap5
	Location	NA
	Position	4050140- 4050364
	Strand	+
Possible duplicated location(s)		HIX0166445;
Gene structure		1 exon(s)
Database links	RefSeq	NM_020056;
	Ensembl	ENST00000241802;
	Entrez Gene	NA
	KEGG GENES	NA
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000013503 Predicted CDS 1..225;  75[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.654

GVNLYQSHGPSGQYTHEFDGDEEFYVDLETKETVWQLPMFSKFISFDPQS ALRNMAVGKHTLEFMMRQSNSTAAT

Motif information

	a.a. length	InterPro	Name
	73	IPR014745	MHC class II, alpha/beta chain, N-terminal [Domain]
	74	IPR011162	MHC classes I/II-like antigen recognition protein [Domain]
	75	IPR001003	MHC class II, alpha chain, N-terminal [Domain]
	74	IPR001003	MHC class II, alpha chain, N-terminal [Domain]

Gene function information

H-Inv ID		HIT000196909_05
H-Inv cluster ID		HIX0058177
Accession number		M95727.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		Representative transcript;
Coding potential		Protein coding;
Definition		Similar to HLA class II histocompatibility antigen, DQ alpha 2 chain; DX alpha chain; HLA class II histocompatibility antigen, DQ(6) alpha chain; HLA-DQA1; MHC class II DQA2; Precursor;
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (P01906)  [Identity/coverage = 98.667%/29.41%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		2513578;  3036828;  3610256;  6584734;  8026991;  8598037;  9036956;  11684289;  14574404;  17241953;  18046453;  19092054;  19533806;  ALL;
Gene family/group	H-Inv gene family/group ID	HIF0000002
	Gene family/group name	Major histocompatibility complex (MHC).
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	NA
	HGNC aliases	NA
	HGNC name	NA
	DDBJ	NA
	UniProt	HLA-DQA2
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000013503
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NM_020056;
	Ensembl	ENST00000241802;
	Entrez Gene	NA
	KEGG GENES	NA
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Human curated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Biological process	antigen processing and presentation (GO:0019882);  immune response (GO:0006955);
Cellular component	membrane (GO:0016020);  MHC class II protein complex (GO:0042613);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	cytosol;  nuclear;  extracellular;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Twilight zone
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Evolutionary information

Last modified:20-Apr-2012

Relationship	Species	Accession number	MGI	Links
Orthology	Mus sp. (Mouse)	AK002532		G-integra
Orthology	Canis sp. (Dog)	ENSCAFT00000001272		G-integra

Phylogenetic tree [View by ATV]	Neighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS (under constraction);