H-InvDB x AHG DB
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H-InvDB_8.3 released on March 26, 2013.
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H-Invitational ID: HIT000192217 Accession number: L13779 Created date: 26-Mar-2013 Last modified: 20-Apr-2012
Definition: Similar to Hyaluronidase PH-20; Hyal-PH20; EC=3.2.1.35; Hyaluronoglucosaminidase PH-20; Sperm adhesion molecule 1; Sperm surface protein PH-20; Precursor;
 
 

Transcript original information
Accession number L13779.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider NA
Annotation project NA
Length of cDNA 1675[bp] (No. of exon:8)[A:446 T:505 G:352 C:372]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type testis
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature N-truncated
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGCAG; 
Transcript quality feature Truncation; 
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0007042
Genomic location  G-integra Help Chromosome 7
Location 7q31.32
Position 123594330- 123668755
Strand +
Possible duplicated location(s) NA
Gene structure 8 exon(s)
Database links RefSeq NM_003117;  NM_153189;  NM_001174044;  NM_001174045;  NM_001174046; 
Ensembl ENST00000223028;  ENST00000340011;  ENST00000402183;  ENST00000413927;  ENST00000439500;  ENST00000460182;  ENST00000472838;  ENST00000476892; 
Entrez Gene Entrez Gene ID:6677; 
KEGG GENES KEGG GENES(6677); 
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000012869
Predicted CDS 1..828;  275[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.71

Motif information
ORF

length(275),orf(1:828) GSCFNVEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREA IRVSKIPDAKSPLPVFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASG IVIWGTLSIMRSMKSCLLLDNYMETILNPYIINVTLAAKMCSQVLCQEQG VCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGKPTLEDLEQFSEKFYC SCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQIFYNAS PSTLSATMFIDLCDLYLVPTSYLIL* 		a.a.
length		 InterPro Name
length(263), motif(1:263) 263 IPR018155 Hyaluronidase [Family]
length(139), motif(1:139) 139 IPR018155 Hyaluronidase [Family]
length(133), motif(1:133) 133 IPR017853 Glycoside hydrolase, catalytic core [Domain]
length(133), motif(1:133) 133 IPR013785 Aldolase-type TIM barrel [Domain]
length(263), motif(1:263) 263 IPR001439 Glycoside hydrolase, family 56, sperm surface protein PH20 [Family]
length(15), motif(11:25) 15 IPR018155 Hyaluronidase [Family]
length(14), motif(116:129) 14 IPR018155 Hyaluronidase [Family]
length(16), motif(169:184) 16 IPR001439 Glycoside hydrolase, family 56, sperm surface protein PH20 [Family]
length(15), motif(184:198) 15 IPR001439 Glycoside hydrolase, family 56, sperm surface protein PH20 [Family]
length(15), motif(203:217) 15 IPR001439 Glycoside hydrolase, family 56, sperm surface protein PH20 [Family]
length(15), motif(220:234) 15 IPR001439 Glycoside hydrolase, family 56, sperm surface protein PH20 [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000192217
H-Inv cluster ID Locus viewHIX0007042
Accession number L13779.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Similar to Hyaluronidase PH-20; Hyal-PH20; EC=3.2.1.35; Hyaluronoglucosaminidase PH-20; Sperm adhesion molecule 1; Sperm surface protein PH-20; Precursor;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P38567)  [Identity/coverage = 100.0%/51.08%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 8234258;  8282124;  8575780;  9288901;  12853948;  21248752;  ALL; 
Gene family/group Gene family H-Inv gene family/group ID HIF0000413
Gene family/group name Putative Hyaluronidase (IPR018155).
Evidence motif (InterPro) ID IPR018155
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ NA
UniProt SPAM1
EC number EC 3.2.1.35hyaluronoglucosaminidase; 
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 00531 :Glycosaminoglycan degradation;  01032 :Glycan structures - degradation; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000012869
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NM_003117;  NM_153189;  NM_001174044;  NM_001174045;  NM_001174046; 
Ensembl ENST00000223028;  ENST00000340011;  ENST00000402183;  ENST00000413927;  ENST00000439500;  ENST00000460182;  ENST00000472838;  ENST00000476892; 
Entrez Gene Entrez Gene ID:6677; 
KEGG GENES KEGG GENES(6677); 
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Putative Hyaluronidase (IPR018155). Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function catalytic activity (GO:0003824);  hyalurononglucosaminidase activity (GO:0004415); 
Biological process fusion of sperm to egg plasma membrane (GO:0007342);  metabolic process (GO:0008152); 

Subcellular localization information  Last modified:20-Apr-2012
WoLF PSORT cytosol;  extracellular;  mitochondria;  Other; 
Target P Other
SOSUI membrane protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:20-Apr-2012
Start End PDB_ID E-value Identity Coverage SCOP_ID
1 22 1fcqA 6e-05 22.7 22/100 c.1.8.9
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:20-Apr-2012
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator		 AceGene AGhsA200911; 
Affymetrix
GeneChip		 HG-Focus 216989_at; 
HG-U133 210536_s_at;  216972_at;  216989_at; 
HG-U133A 210536_s_at;  216972_at;  216989_at; 
HG-U133A_2 210536_s_at;  216972_at;  216989_at; 
HG-U133B NA
HG-U133_Plus_2 210536_s_at;  216972_at;  216989_at; 
HG-U95 35129_at; 
HG-U95A 35129_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3021843;  3021844;  3021845;  3021846;  3021854;  3021856;  3021862;  3021863; 
HuGeneFL S67798_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P111826; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P111826; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:20-Apr-2012
Disease relation Disease name:NA
Related information in OMIM OMIM ID:NA Title:NA
Co-localized orphan diseases OMIM ID:  605635; 
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(6677)
Disease Entrez Gene ID:(6677)
Substance Entrez Gene ID:(6677)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo Viewer;  LEGENDALEGENDA; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
285 .. 285 T/C rs34978112 + CDS Synonymous[Ala95Ala]
323 .. 323 G/A rs35268918 + CDS Nonsynonymous[Ser108Asn]
576 .. 576 G/A rs113698779 + CDS Synonymous[Glu192Glu]
637 .. 637 G/A rs35333278 + CDS Nonsynonymous[Asp213Asn]
647 .. 647 A/T rs75168651 + CDS Nonsynonymous[Asp216Val]
809 .. 809 C/A rs112848378 + CDS Nonsynonymous[Thr270Asn]
815 ^ 816 -/T rs35961309 + CDS
1125 .. 1125 C/A rs76739120 + 3'UTR
1150 .. 1150 T/G rs2896338 + 3'UTR
1404 .. 1404 A/G rs115641800 + 3'UTR
1492 .. 1492 T/- rs35718972 + 3'UTR
1506 .. 1506 T/A rs117572352 + 3'UTR
1506 .. 1506 T/- rs67734863 - 3'UTR
1508 .. 1508 A/T rs116975986 + 3'UTR
1510 .. 1510 G/T rs76756246 + 3'UTR
1649 .. 1649 G/A rs77466997 + 3'UTR
1651 .. 1651 G/A rs78398928 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
MER41B 781 931 -
MIR 1042 1119 -
AluJr 1220 1487 -
AluJr 1544 1655 -
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;