H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

Home Quick guide Navi BLAST Site map Download Contact us Help

Locus view Protein view G-integra DiseaseInfo Viewer H-ANGEL Evola PPI view Gene Family/Group Hyperlink MS

H-Invitational ID: HIT000101512 Accession number: D49400 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: V-type proton ATPase subunit F; V-ATPase subunit F; V-ATPase 14 kDa subunit; Vacuolar proton pump subunit F;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number D49400.1 CAGE tag ID NA EST ID NA Clone Number NA Experimental resources   NBRC ; HGPD ; Antibody (ATP6V1F) ; Catalog (ATP6V1F); Sequence data provider NA Annotation project NA Length of cDNA 680[bp] (No. of exon:2)[A:138 T:164 G:174 C:204] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type brain Develpmental stage fetus

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

AGTTTCAGTGGCTTCTGGTGCTCTAGGGTGAGCTCTGCCCGGCTGCAGGG ATGGCGGGGAGGGGTAAGCTCACCGCAGTGATCGGAGACGAGGACACGGT GACTGGTTTCCTGCTGGGCGGCATAGGGGAGCTTAACAAGAACCGCCATC CCAATTTCCTGGTGGTGGAGAAGGATACAACCATCAATGAGATCGAAGAC ACTTTCCGGCAATTTCTAAACCGGGATGACATTGGCATCATCCTCATCAA CCAGTACATCGCAGAGATGGTGCGGCATGCCCTGGACGCCCACCAGCAGT CCATCCCCGCTGTCCTGGAGATCCCCTCCAAGGAGCACCCATATGACGCC GCCAAGGACTCCATCCTGCGCAGGGCCAGGGGCATGTTCACTGCCGAAGA CCTGCGCTAGGGGACTCCTCATAGCCCTCAGCCCTTCCCTCGTTTCCAGG CCTCTCCCCAGGCTTGCCATCAGCCTTCTTTACTTTTTGAGCCTCTGATT TCCAATTCCCTGCTCCTTCCCACTCCATTAAGAGGCTAGGTGAGGCGCTT CTAGGTTGCTGGGGCTCTGCTGGTTAAGGAACAGGAAGCCTGACCATCTC CCTCCACTACCTCTTCCCTGTGCTGTTACACAGTGTCATTGTTGATGTTA AATTAAAGTCATATTCTTGCTTCTCTCCAG

Gene structure information

H-Inv cluster ID		HIX0033667
Genomic location	Chromosome	7
	Location	7q32.1
	Position	128502910- 128505902
	Strand	+
Possible duplicated location(s)		NA
Gene structure		2 exon(s)
Database links	RefSeq	NM_004231;  NM_001198909;
	Ensembl	ENST00000249289;  ENST00000492758;
	Entrez Gene	Entrez Gene ID:9296;
	KEGG GENES	KEGG GENES(9296);
	GeneCard	ATP6V1F;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000027841 Predicted CDS 51..410;  119[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.852

MAGRGKLTAVIGDEDTVTGFLLGGIGELNKNRHPNFLVVEKDTTINEIED TFRQFLNRDDIGIILINQYIAEMVRHALDAHQQSIPAVLEIPSKEHPYDA AKDSILRRARGMFTAEDLR*

Gene function information

H-Inv ID		HIT000101512
H-Inv cluster ID		HIX0033667
Accession number		D49400.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		V-type proton ATPase subunit F; V-ATPase subunit F; V-ATPase 14 kDa subunit; Vacuolar proton pump subunit F;
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (Q16864)  [Identity/coverage = 99.16%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		8581736;  15489334;  21269460;  ALL;
Gene family/group	H-Inv gene family/group ID	HIF0002542
	Gene family/group name	ATPase, V1 complex, subunit F, eukaryotic (IPR005772).
	Evidence motif (InterPro) ID	IPR005772
Gene symbol/name	HGNC symbol	ATP6V1F
	HGNC aliases	NA
	HGNC name	ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
	DDBJ	NA
	UniProt	ATP6V1F
EC number		EC 3.6.1.3adenosinetriphosphatase;
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		00230 :Purine metabolism;
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000027841
	No. of interaction	13
	Interaction partner(s)	HIP000031904;  HIP000031904;  HIP000033722;  HIP000040212;  HIP000045212;  HIP000079362;  HIP000089323;  HIP000095593;  HIP000095593;  HIP000098362;  HIP000103276;  HIP000116600;  HIP000193291;
	BIND	180328;  301689;  301696;  301698;  301726;
	DIP	NA
	MINT	MINT-8007070;
	HPRD	00783;  01967;  06120;
	IntAct	NA
Database links	RefSeq	NM_004231;  NM_001198909;
	Ensembl	ENST00000249289;  ENST00000492758;
	Entrez Gene	Entrez Gene ID:9296;
	KEGG GENES	KEGG GENES(9296);
	GeneCard	ATP6V1F;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		ATPase, V1 complex, subunit F, eukaryotic (IPR005772). Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	cytosol;  nuclear;  cytoskeleton;  extracellular;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 9 108 2d00A1 1e-25 20.5 88/104 c.149.1.1

Related H-InvDB links GTOP

Gene expression information

Last modified:20-Apr-2012

Tissue-specific expression			NA
Probe information	AceGene		AGhsA201222;
	Affymetrix GeneChip	HG-Focus	201527_at;
		HG-U133	201527_at;
		HG-U133A	201527_at;
		HG-U133A_2	201527_at;
		HG-U133B	NA
		HG-U133_Plus_2	201527_at;
		HG-U95	37395_at;
		HG-U95A	37395_at;
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	3023213;  3023219;  3023220;  3413342;
		HuGeneFL	D49400_at;
	Agilent	Human 1A Oligo Microarray:PGID215	A_23_P93623;
		Whole Human Genome Oligo Microarray:PGID247	A_23_P93623;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:NA Title:NA
Co-localized orphan diseases		OMIM ID:  605635;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(9296)
	Disease	Entrez Gene ID:(9296)
	Substance	Entrez Gene ID:(9296)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 12 .. 12 C/T rs11547837 + 5'UTR 17 .. 17 G/T rs75593211 + 5'UTR 39 .. 39 C/T rs113816833 + 5'UTR 73 .. 73 C/T rs1804887 + CDS Nonsynonymous[Thr8Ile] 121 .. 121 G/T rs10958 + CDS Nonsynonymous[Gly24Val] 164 .. 164 G/C rs112994393 + CDS Synonymous[Val38Val] 288 .. 288 G/A rs73459264 + CDS Nonsynonymous[Ala80Thr] 309 .. 309 G/A rs11547835 + CDS Nonsynonymous[Ala87Thr] 339 .. 339 C/A rs11547836 + CDS Nonsynonymous[Pro97Thr] 393 .. 393 G/C rs1804889 + CDS Nonsynonymous[Ala115Pro] 442 .. 442 G/T rs1804888 + 3'UTR 551 .. 551 C/T rs1050684 + 3'UTR 601 .. 601 C/T rs3580 - 3'UTR 616 .. 616 C/T rs15498 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;