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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000101080 Accession number: D17716 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; EC=2.4.1.155; Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase; GlcNAc-T V; GNT-V; Mannoside acetylglucosaminyltransferase 5; N-acetylglucosaminyl-transferase V;
 
 

Transcript original information
Accession number D17716.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider NA
Annotation project NA
Length of cDNA 2421[bp] (No. of exon:16)[A:674 T:585 G:585 C:577]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type liver
Develpmental stage fetal
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0013383
Genomic location  G-integra Help Chromosome 2
Location 2q21.2-2q21.3
Position 135011830- 135206468
Strand +
Possible duplicated location(s) NA
Gene structure 16 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:4249
KEGG GENES KEGG GENES(4249)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000029338
Predicted CDS 146..2371;  741[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.779
Database links RefSeq NP_002401
UniProt Q09328
CCDS CCDS2171

Motif information
ORF

length(741),orf(146:2371)
MALFTPWKLSSQKLGFFLVTFGFIWGMMLLHFTIQQRTQPESSSMLREQI
LDLSKRYIKALAEENRNVVDGPYAGVMTAYDLKKTLAVLLDNILQRIGKL
ESKVDNLVVNGTGTNSTNSTTAVPSLVALEKINVADIINGAQEKCVLPPM
DGYPHCEGKIKWMKDMWRSDPCYADYGVDGSTCSFFIYLSEVENWCPHLP
WRAKNPYEEADHNSLAEIRTDFNILYSMMKKHEEFRWMRLRIRRMADAWI
QAIKSLAEKQNLEKRKRKKVLVHLGLLTKESGFKIAETAFSGGPLGELVQ
WSDLITSLYLLGHDIRISASLAELKEIMKKVVGNRSGCPTVGDRIVELIY
IDIVGLAQFKKTLGPSWVHYQCMLRVLDSFGTEPEFNHANYAQSKGHKTP
WGKWNLNPQQFYTMFPHTPDNSFLGFVVEQHLNSSDIHHINEIKRQNQSL
VYGKVDSFWKNKKIYLDIIHTYMEVHATVYGSSTKNIPSYVKNHGILSGR
DLQFLLRETKLFVGLGFPYEGPAPLEAIANGCAFLNPKFNPPKSSKNTDF
FIGKPTLRELTSQHPYAEVFIGRPHVWTVDLNNQEEVEDAVKAILNQKIE
PYMPYEFTCEGMLQRINAFIEKQDFCHGQVMWPPLSALQVKLAEPGQSCK
QVCQESQLICEPSFFQHLNKDKDMLKYKVTCQSSELAKDILVPSFDPKNK
HCVFQGDLLLFSCAGAHPRHQRVCPCRDFIKGQVALCKDCL*
a.a.
length
InterPro Name
length(741), motif(1:741) 741 IPR026116 Glycosyltransferase family 18 [Family]
length(136), motif(4:139) 136 IPR027833 Domain of unknown function DUF4525 [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000101080
H-Inv cluster ID Locus viewHIX0013383
Accession number D17716.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript; 
Coding potential  Help Protein coding; 
Definition Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; EC=2.4.1.155; Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase; GlcNAc-T V; GNT-V; Mannoside acetylglucosaminyltransferase 5; N-acetylglucosaminyl-transferase V;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q09328)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence NA
PubMed ID 829203610395745ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ NA
UniProt MGAT5
EC number EC 2.4.1.155alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 00510 :N-Glycan biosynthesis;  01030 :Glycan structures - biosynthesis 1; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000029338
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:4249
KEGG GENES KEGG GENES(4249)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity (GO:0030144); 
Biological process protein amino acid N-linked glycosylation (GO:0006487); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT endoplasmic;  golgi apparatus;  extracellular;  Other; 
Target P signal peptide
SOSUI soluble protein
TMHMM membrane protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA111007;  AGhsB261320; 
Affymetrix
GeneChip
HG-Focus 206720_at; 
HG-U133 206720_at; 
HG-U133A 206720_at; 
HG-U133A_2 206720_at; 
HG-U133B NA
HG-U133_Plus_2 206720_at; 
HG-U95 31313_at; 
HG-U95A 31313_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2506953;  2506954;  2506955;  2506964;  2506980;  2506982;  2506986;  2506987;  2506988;  2506989;  2506991;  2506992;  2507000;  2507021;  2507027;  2507028;  2507030;  2507044;  2507048;  2507049;  2577451;  2577457;  2577484; 
HuGeneFL D17716_at;  X91653_s_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P16743; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P16743; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) AK030402 MGI:2393223 G-integraG-integra
Orthology Danio sp. (Zebrafish) BC117664 G-integraG-integra
Orthology Macaca sp. (Macaque) ENSMMUT00000014783 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000005464 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000014874 G-integraG-integra
Orthology Tetraodon sp. (Tetraodon) GSTENT00013473001 G-integraG-integra
Orthology Rattus sp. (Rat) L14284 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000158222 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001363507 G-integraG-integra
Orthology Equus sp. (Horse) XM_001489097 G-integraG-integra
Orthology Pan sp. (Chimpanzee) XM_515802 G-integraG-integra
Orthology Canis sp. (Dog) XM_541015 G-integraG-integra
Orthology Bos sp. (Cow) XM_617768 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
109 .. 109 G/T rs200509590 + 5'UTR
210 .. 210 G/A rs138863444 + CDS Nonsynonymous[Gly22Asp]
285 .. 285 G/A rs141403771 + CDS Nonsynonymous[Arg47His]
365 .. 365 G/A rs138982519 + CDS Nonsynonymous[Ala74Thr]
401 .. 401 C/G rs143677470 + CDS Nonsynonymous[Leu86Val]
449 .. 449 T/G rs150662712 + CDS Nonsynonymous[Ser102Ala]
450 .. 450 C/T rs199721773 + CDS Nonsynonymous[Ser102Leu]
493 .. 493 A/G rs200048384 + CDS Synonymous[Ser116Ser]
499 .. 499 C/T rs116123889 + CDS Synonymous[Asn118Asn]
587 .. 587 C/T rs146396288 + CDS Nonsynonymous[Pro148Ser]
664 .. 664 C/T rs149877815 + CDS Synonymous[Tyr173Tyr]
672 .. 672 A/G rs189190982 + CDS Nonsynonymous[Tyr176Cys]
730 .. 730 G/T rs142123342 + CDS Nonsynonymous[Trp195Cys]
763 .. 763 C/T rs147817518 + CDS Synonymous[Pro206Pro]
767 .. 767 G/A rs149741126 + CDS Nonsynonymous[Glu208Lys]
786 .. 786 C/T rs145273807 + CDS Nonsynonymous[Ser214Leu]
792 .. 792 C/T rs201826666 + CDS Nonsynonymous[Ala216Val]
793 .. 793 G/A rs138350444 + CDS Synonymous[Ala216Ala]
794 .. 794 G/A rs200147803 + CDS Nonsynonymous[Glu217Lys]
820 .. 820 C/T rs142313139 + CDS Synonymous[Leu225Leu]
838 .. 838 G/A rs149155318 + CDS Synonymous[Lys231Lys]
841 .. 841 T/C rs138918113 + CDS Synonymous[His232His]
852 .. 852 G/A rs201792962 + CDS Nonsynonymous[Arg236Gln]
853 .. 853 G/A rs200192196 + CDS Synonymous[Arg236Arg]
873 .. 873 G/A rs201224826 + CDS Nonsynonymous[Arg243Gln]
887 .. 887 G/A rs146378528 + CDS Nonsynonymous[Ala248Thr]
897 .. 897 A/G rs199697639 + CDS Nonsynonymous[Gln251Arg]
905 .. 905 A/C rs142027297 + CDS Nonsynonymous[Lys254Gln]
943 .. 943 G/A rs183327629 + CDS Synonymous[Lys266Lys]
945 .. 945 G/A rs150500954 + CDS Nonsynonymous[Arg267Gln]
987 .. 987 C/G rs147380416 + CDS Nonsynonymous[Ser281Cys]
995 .. 995 A/C rs139598273 + CDS Nonsynonymous[Lys284Gln]
1044 .. 1044 A/G rs112377437 + CDS Nonsynonymous[Gln300Arg]
1072 .. 1072 C/T rs201895701 + CDS Synonymous[Tyr309Tyr]
1092 .. 1092 G/A rs147621888 + CDS Nonsynonymous[Arg316Lys]
1111 .. 1111 T/C rs142227919 + CDS Synonymous[Ala322Ala]
1149 .. 1149 G/A rs145359732 + CDS Nonsynonymous[Arg335Gln]
1178 .. 1178 A/G rs140937382 + CDS Nonsynonymous[Ile345Val]
1227 .. 1227 A/G rs200233947 + CDS Nonsynonymous[Lys361Arg]
1247 .. 1247 G/C rs201546855 + CDS Nonsynonymous[Val368Leu]
1273 .. 1273 C/T rs146814728 + CDS Synonymous[Val376Val]
1282 .. 1282 A/G rs34876684 - CDS Synonymous[Ser379Ser]
1338 .. 1338 A/G rs199733445 + CDS Nonsynonymous[Lys398Arg]
1449 .. 1449 G/C rs201296930 + CDS Nonsynonymous[Ser435Thr]
1455 .. 1455 T/C rs148183644 + CDS Nonsynonymous[Ile437Thr]
1576 .. 1576 A/G rs147363895 + CDS Synonymous[Ala477Ala]
1615 .. 1615 C/T rs139534721 + CDS Synonymous[Tyr490Tyr]
1618 .. 1618 G/C rs139580353 + CDS Synonymous[Val491Val]
1626 .. 1626 A/G rs149733032 + CDS Nonsynonymous[His494Arg]
1645 .. 1645 G/C rs148494322 + CDS Synonymous[Arg500Arg]
1702 .. 1702 C/T rs146797944 + CDS Synonymous[Tyr519Tyr]
1735 .. 1735 T/C rs151078098 + CDS Synonymous[Asn530Asn]
1792 .. 1792 C/A rs117206120 + CDS Nonsynonymous[Asp549Glu]
1833 .. 1833 A/G rs199878442 + CDS Nonsynonymous[Gln563Arg]
1862 .. 1862 C/T rs141050390 + CDS Nonsynonymous[Arg573Trp]
1869 .. 1869 A/G rs139862656 + CDS Nonsynonymous[His575Arg]
1972 .. 1972 C/T rs146926321 + CDS Synonymous[Cys609Cys]
2053 .. 2053 C/T rs147167219 + CDS Synonymous[Ser636Ser]
2080 .. 2080 C/T rs148653542 + CDS Synonymous[Pro645Pro]
2227 .. 2227 C/T rs182264209 + CDS Synonymous[Ser694Ser]
2291 .. 2291 G/A rs200390028 + CDS Nonsynonymous[Ala716Thr]
2293 .. 2293 C/A rs2230908 + CDS Synonymous[Ala716Ala]
2365 .. 2365 C/T rs144158856 + CDS Synonymous[Cys740Cys]
2420 .. 2420 C/G rs202011729 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer