H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

Home Quick guide Navi BLAST Site map Download Contact us Help

Locus view Protein view G-integra DiseaseInfo Viewer H-ANGEL Evola PPI view Gene Family/Group Hyperlink MS

H-Invitational ID: HIT000100293 Accession number: BT007373 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Similar to E3 ubiquitin-protein ligase TRIM63.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number BT007373.1 CAGE tag ID NA EST ID NA Clone Number GH00013X1.0 Experimental resources   NBRC ; HGPD ; Antibody (TRIM63) ; Catalog (TRIM63); Sequence data provider NA Annotation project NA Length of cDNA 1041[bp] (No. of exon:7)[A:272 T:203 G:303 C:263] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type NA Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) CAGGAG;  Transcript quality feature NA Notes NA

ATGGATTATAAGTCGAGCCTGATCCAGGATGGGAATCCCATGGAGAACTT GGAGAAGCAGCTGATCTGCCCTATCTGCCTGGAGATGTTTACCAAGCCAG TGGTCATCTTGCCGTGCCAGCACAACCTGTGCCGGAAGTGTGCCAATGAC ATCTTCCAGGCTGCAAATCCCTACTGGACCAGCCGGGGCAGCTCAGTGTC CATGTCTGGAGGCCGTTTCCGCTGCCCCACCTGCCGCCACGAGGTGATCA TGGATCGTCACGGAGTGTACGGCCTGCAGAGGAACCTGCTGGTGGAGAAC ATCATCGACATCTACAAACAGGAGTGCTCCAGTCGGCCGCTGCAGAAGGG CAGTCACCCCATGTGCAAGGAGCACGAAGATGAGAAAATCAACATCTACT GTCTCACGTGTGAGGTGCCCACCTGCTCCATGTGCAAGGTGTTTGGGATC CACAAGGCCTGCGAGGTGGCCCCATTGCAGAGTGTCTTCCAGGGACAAAA GACTGAACTGAATAACTGTATCTCCATGCTGGTGGCGGGGAATGACCGTG TGCAGACCATCATCACTCAGCTGGAGGATTCCCGTCGAGTGACCAAGGAG AACAGTCACCAGGTAAAGGAAGAGCTGAGCCAGAAGTTTGACACGTTGTA TGCCATCCTGGATGAGAAGAAAAGTGAGTTGCTGCAGCGGATCACGCAGG AGCAGGAGGAAAAGCTTAGCTTCATCGAGGCCCTCATCCAGCAGTACCAG GAGCAGCTGGACAAGTCCACAAAGCTGGTGGAAACTGCCATCCAGTCCCT GGACGAGCCTGGGGGAGCCACCTTCCTCTTGACTGCCAAGCAACTCATCA AAAGCATTGTGGAAGCTTCCAAGGGCTGCCAGCTGGGGAAGACAGAGCAG GGCTTTGAGAACATGGACTTCTTTACTTTGGATTTAGAGCACATAGCAGA CGCCCTGAGAGCCATTGACTTTGGGGCAGCTGAAGATGATGAGGATGACG ATGTCGATACCAAGAAGCAGAAGACCGACGAGGATGACTAG

Gene structure information

H-Inv cluster ID		HIX0000284
Genomic location	Chromosome	1
	Location	1p36.11
	Position	26383664- 26393985
	Strand	-
Possible duplicated location(s)		NA
Gene structure		7 exon(s)
Database links	RefSeq	NM_032588;
	Ensembl	ENST00000374272;  ENST00000483052;
	Entrez Gene	Entrez Gene ID:84676;
	KEGG GENES	KEGG GENES(84676);
	GeneCard	TRIM63;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000043956 Predicted CDS 1..1041;  346[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.852 Database links RefSeq NA UniProt Q6NR77;  CCDS NA

MDYKSSLIQDGNPMENLEKQLICPICLEMFTKPVVILPCQHNLCRKCAND IFQAANPYWTSRGSSVSMSGGRFRCPTCRHEVIMDRHGVYGLQRNLLVEN IIDIYKQECSSRPLQKGSHPMCKEHEDEKINIYCLTCEVPTCSMCKVFGI HKACEVAPLQSVFQGQKTELNNCISMLVAGNDRVQTIITQLEDSRRVTKE NSHQVKEELSQKFDTLYAILDEKKSELLQRITQEQEEKLSFIEALIQQYQ EQLDKSTKLVETAIQSLDEPGGATFLLTAKQLIKSIVEASKGCQLGKTEQ GFENMDFFTLDLEHIADALRAIDFGAAEDDEDDDVDTKKQKTDEDD*

Gene function information

H-Inv ID		HIT000100293
H-Inv cluster ID		HIX0000284
Accession number		BT007373.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Similar to E3 ubiquitin-protein ligase TRIM63.
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (NP_115977)  [Identity/coverage = 95.349%/98.02%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	HIF0001508
	Gene family/group name	Zinc finger, C3HC4 RING-type (IPR018957).
	Evidence motif (InterPro) ID	IPR018957
Gene symbol/name	HGNC symbol	TRIM63
	HGNC aliases	"ring finger protein 28", "tripartite motif-containing 63"
	HGNC name	tripartite motif containing 63
	DDBJ	NA
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000043956
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NM_032588;
	Ensembl	ENST00000374272;  ENST00000483052;
	Entrez Gene	Entrez Gene ID:84676;
	KEGG GENES	KEGG GENES(84676);
	GeneCard	TRIM63;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Zinc finger, C3HC4 RING-type (IPR018957). Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	nuclear;  cytosol;  golgi apparatus;  mitochondria;  peroxisome;  plasma membrane;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 1 120 1jm7A 2e-09 24.0 100/103 g.44.1.1 119 169 2d8uA1 7e-21 100.0 51/51 g.43.1.1

Related H-InvDB links GTOP

Gene expression information

Last modified:20-Apr-2012

Tissue-specific expression			muscle/heart;
Probe information	AceGene		AGhsB050521;
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	NA
		HG-U133A	NA
		HG-U133A_2	NA
		HG-U133B	NA
		HG-U133_Plus_2	NA
		HG-U95	NA
		HG-U95A	NA
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2402541;  2402542;  2402543;  2402545;  2402548;  2402549;  2402550;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	NA
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:NA Title:NA
Co-localized orphan diseases		OMIM ID:  115665;  116600;  155600;  600975;  605225;  605606;  606788;  606852;  606928;  607317;  607671;  608543;  608553;  608995;  610320;  612367;  612596;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(84676)
	Disease	Entrez Gene ID:(84676)
	Substance	Entrez Gene ID:(84676)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 12 .. 12 G/A rs3795690 + CDS Synonymous[Lys4Lys] 135 .. 135 G/C rs61760891 - CDS Synonymous[Arg45Arg] 162 .. 162 T/G rs41284327 - CDS Synonymous[Ala54Ala] 263 .. 263 G/C rs41284325 - CDS Nonsynonymous[Gly88Ala] 267 .. 267 G/T rs35123100 + CDS Synonymous[Val89Val] 306 .. 306 C/T rs34009998 + CDS Synonymous[Ile102Ile] 625 .. 625 C/T rs35131871 + CDS Synonymous[Leu209Leu] 645 .. 645 G/A rs117577030 - CDS Synonymous[Thr215Thr] 709 .. 709 G/A rs2275950 + CDS Nonsynonymous[Glu237Lys] 805 .. 805 G/A rs61749355 - CDS Nonsynonymous[Glu269Lys] 980 .. 980 C/G rs112224658 - CDS Nonsynonymous[Ala327Gly] 982 .. 982 G/A rs112552852 - CDS Nonsynonymous[Glu328Lys]  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;