H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000098375 Accession number: BC046497 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Similar to Transcription factor Dp-1; DRTF1-polypeptide 1; DRTF1; E2F dimerization partner 1;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number BC046497.1 CAGE tag ID NA EST ID NA Clone Number IMAGE:4820447 Experimental resources   NBRC ; HGPD ; Sequence data provider NA Annotation project NA Length of cDNA 2446[bp] (No. of exon:4)[A:783 T:689 G:507 C:467] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type Brain, hippocampus Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA Site: 2400(+) Signal: 2383-2387(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) AAGGAG;  CAGAAG;  Transcript quality feature NA Notes NA

AGGGGCAGAGTTTTGAGGCAGAGCTGATCAAGGGAACCTCAACAAACAAC CCCAGCCATGGAGGCGGCGGTGTCTTTGAAGACCCCATGAGAGCATCAAA CAAGGGAGAGAGCCTGGAACAAATCATCGTAGTAAAATGGCGGCAGAGAG CTAGTAATGTGTCTGGAATTGGTGGGTTCTTGGTCGCACTGACTTAAGAA TGAAGCCGCGGACCCTCACGGTGGTGTCTTTGGTGGCTGTTCACCCTTCC ACAGTAAACGTGCTTGGGAAGCAACTTTGCCAAAAGCCTTCGGACAGTCC AGCGTCAACACCGCAAGCCAAGTGGAGGAGAAAAATCTGCGCCTCTTTCT CTCAAGGGATACTTTGTCTCTGGGGTACTTTCTGACCCAGTGGACCCCTG GCAGAAGTAAGCGTGGACTGTGGCTACAGGACCACGCAGAGTCAACACGA ACCGAAGCCAGGCCTTGGCCACGGCAGCTCTGGGGTCCAACCACTTGATC AATGCAGGAAATGCTTTGATGGCAGAATTCTTCCATGGCCAGCTTCTCAT ATTCTCTGGGACAGACACAAACCAAGAAAAATGAGTGTGGCGCAGAATCT GATGTGTCCTTCCTTACCCCGTGCTGGTAGCAAAAAGTATGTCTTGAACT TTTCTTTGTTACACACAGTCTGGGTAATAACAGACTGAAGGAAAACTAAA GAAGCTTGGGAGGCTAAGTTCAATGACAAATGAAGAACTAAGGCAGAGAA AAAAGAGAATTGAGAAAGTGTCTGGGTGTCTGGAGAGGTTGGGGGAATAG AGAGGGAGGAGATATAATTGGCCAGATAACTTGAGAGTGGGAGAGGAGTG CAAACATTATTTTTGAGGCGCTTTGTTGGATATTTAAAATGCACTCCTAC CTTTGGCATTTTCTCAAAAGGCAAGAAAGATTTGTTTTCAATTCTATTTT TCTGCTGGACTGAACCAGTGCCAAGACTGGACCATGTAGGATCCTGGGTT TATTTCAGTTACATAAGCAAACGTTGCTGTGATTTGGAATAGTCAAAGTC ATGAATGTTTCTCAACTTCCATTTTGTCAGCTGCTTGAGTTTCTATTCTG AGAGGTGCTAACTGTGAACATTGTTATTCACTTGTGTTCCCTAAATCACT TTTAATTAGTTTTAATTTGAACCAAGAATGTTCTACTGTTGAAACTATGT CAAGAATGATCAAAAATGAAATTAATAAAGAATTCGCGTCAAAAAAATTT GCACTAATATTACAGTATTTTATAATGTCTATCTCAGCAGAGTCACAGAT AATTTAGAATTTTTAATTTTGTTTTTAAGTGATTTTCCTCAAAGCTATAA TAGCCTTGGTAAAGAGTTTAGTTAAACATTATTTTTCACCTCTCACGCAT TTTGTGTAATGAAATTTTTCTATCATCTTCCAGTGGAATTAATTGCATTG GTGCAAAAAATGCAATCAAATCGATGACTGAATTTAGCCTTTGAAACCTC ACGTCTAGCTGGGATAGTTACTATATTCATTACATACTGAAAAATGATAA GCAGTAAGCTTTTCTGCTAAAAAACTGCCAAAGATAAGTTTTTCAAGGCT CTCAAAATATCCTAAAGCTGACAATACAAGAAATGTTAAAATATTGTTGG AATTTTTAACGGAATCTTCCTTCTCTTCTTTTCCTGTTTAAGACAATAGT AGTTAGTTGTCCACTAATCGTTAATACACGATTTTCTAACAAAGACTTGC ATATCCTTTTGGCTAAAAAGTGGCCAAATATCAGAGAGCTAGAAGTTTGG GAGACAGCCTTTAGTCTTTTCCAAAGCATGTAAGCCCTTTTGAATCATTT TGGGTAAATGGCGAAGATTAAACAGAATTCATAAAGGGTTTCTGATACAT AAGTGGAATGTGCCTGTGAGGACACTACACATGACAATAATCTAAGCATG CTCTCTTTTAGTCCCAAAACGTGTAGAGTAATGTCACATGAAATTTACAG GAGGCCATTGACTTGGACTGAGCTCCTGCACCAGGCCTAACAGACCAAAC CAAAATGGAGTCACTCATGCTGAAGTTCACACCACCAAGCCAAAACTGAG TTGTTTATCCGATCTTCCAAGAAATCAAGAAAGACAGGGAGATAACAGCC CAATCCCCAAACAGGCCAGTTTTTGCTGGCATGATAGGAAGGCCCCTCTG CTTCAAACTTTCCAAAGAAAGTAACTTGGAAACAACCAATCTGCTTTTTG TTCTCCGTTTCTGCTTTCCTCAACCATTTTCTGACCATAAAACCAACATC CTTTGCTCGGCTCATGGGAACATTCATTCTATTTTGTAGAATGAGGTGTT GCCCGATATTCTAGATTTGCAAATAAAAGCCAATTAAGATCTTTAAATTA AAAAAAAAAAAAAAAAAAAAAAAAAAAAACAAAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0002608
Genomic location	Chromosome	2
	Location	2q31.1
	Position	175411869- 175639553
	Strand	+
Possible duplicated location(s)		NA
Gene structure		4 exon(s)
Database links	RefSeq	NA
	Ensembl	ENST00000412835;  ENST00000442996;
	Entrez Gene	NA
	KEGG GENES	NA
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000138589 Predicted CDS 200..385;  61[aa];  Orientation:+2;  Codon Adaptation Index (CAI). 0.666

MKPRTLTVVSLVAVHPSTVNVLGKQLCQKPSDSPASTPQAKWRRKICASF SQGILCLWGTF*

Gene function information

H-Inv ID		HIT000098375
H-Inv cluster ID		HIX0002608
Accession number		BC046497.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		Representative transcript;
Coding potential		Protein coding;
Definition		Similar to Transcription factor Dp-1; DRTF1-polypeptide 1; DRTF1; E2F dimerization partner 1;
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (Q14186)  [Identity/coverage = 86.364%/5.37%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		7739537;  8039504;  8405995;  12004135;  15057823;  15489334;  17531812;  18187866;  18669648;  19007248;  19413330;  19608861;  19690332;  ALL;
Gene family/group	H-Inv gene family/group ID	HIF0000453
	Gene family/group name	Putative Transcription factor DP, subgroup (IPR016556).
	Evidence motif (InterPro) ID	IPR016556
Gene symbol/name	HGNC symbol	NA
	HGNC aliases	NA
	HGNC name	NA
	DDBJ	NA
	UniProt	TFDP1
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000138589
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	ENST00000412835;  ENST00000442996;
	Entrez Gene	NA
	KEGG GENES	NA
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Human curated
Notes		NA
Related H-InvDB links		Putative Transcription factor DP, subgroup (IPR016556). Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	extracellular;  mitochondria;
Target P	signal peptide
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information

Last modified:20-Apr-2012

Tissue-specific expression			NA
Probe information	AceGene		NA
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	NA
		HG-U133A	NA
		HG-U133A_2	NA
		HG-U133B	NA
		HG-U133_Plus_2	NA
		HG-U95	42192_at;
		HG-U95A	NA
		HG-U95B	42192_at;
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2516398;  2516399;  2516426;  2516432;  2587962;  2587963;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	NA
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:NA Title:NA
Co-localized orphan diseases		OMIM ID:  600666;  607329;  609402;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	NA
	Disease	NA
	Substance	NA
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Evolutionary information

Last modified:20-Apr-2012

Relationship	Species	Accession number	MGI	Links
Orthology	Rattus sp. (Rat)	BC099767		G-integra
Orthology	Pan sp. (Chimpanzee)	XM_001141348		G-integra

Phylogenetic tree [View by ATV]	Neighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS (under constraction);

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 59 .. 59 T/C rs73972684 + 5'UTR 81 .. 81 G/A rs80311350 + 5'UTR 128 .. 128 C/G rs9789707 + 5'UTR 166 .. 166 G/C rs9287976 + 5'UTR 314 ^ 315 -/C rs35609919 + CDS 426 .. 426 A/G rs1562957 + 3'UTR 513 .. 513 G/A rs77612995 + 3'UTR 620 .. 620 C/T rs115874652 + 3'UTR 755 .. 755 G/A rs10205439 + 3'UTR 1236 .. 1236 G/A rs1823686 + 3'UTR 1597 .. 1597 G/T rs114723712 + 3'UTR 1729 .. 1729 C/T rs1823687 + 3'UTR 2016 .. 2016 G/C rs113007247 + 3'UTR 2111 .. 2111 G/T rs60180158 + 3'UTR 2200 .. 2200 G/A rs12478595 + 3'UTR 2300 .. 2300 C/T rs112098801 + 3'UTR 2338 .. 2338 A/G rs75821575 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  Type Start End Strand LTR12C 158 227 - LTR54 1982 2402 + Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;