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H-Invitational ID: HIT000078325 Accession number: AF358909 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Potassium channel subfamily K member 16 isoform 2.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AF358909.1 CAGE tag ID NA EST ID NA Clone Number NA Experimental resources   NBRC ; HGPD ; Antibody (KCNK16) ; Catalog (KCNK16); Sequence data provider NA Annotation project NA Length of cDNA 930[bp] (No. of exon:6)[A:175 T:206 G:272 C:277] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type NA Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

ATGCCCAGTGCTGGGCTCTGCAGCTGCTGGGGTGGCCGGGTGCTGCCCCT GCTGCTGGCCTATGTCTGCTACCTGCTGCTCGGTGCCACTATCTTCCAGC TGCTAGAGAGGCAGGCGGAGGCTCAGTCCAGGGACCAGTTTCAGTTGGAG AAGCTGCGCTTCCTGGAGAACTACACCTGCCTGGACCAGTGGGCCATGGA GCAGTTTGTGCAGGTCATCATGGAAGCCTGGGTGAAAGGTGTGAACCCCA AAGGCAACTCTACCAACCCCAGCAACTGGGACTTTGGCAGCAGTTTCTTC TTTGCAGGCACAGTTGTCACTACCATAGGATATGGGAACCTGGCACCCAG CACAGAGGCAGGTCAGGTCTTCTGTGTCTTCTATGCCCTGTTGGGCATCC CGCTTAACGTGATCTTCCTCAACCACCTGGGCACAGGGCTGCGTGCCCAT CTGGCCGCCATTGAAAGATGGGAGGACCGTCCCAGGCGCTCCCAGGTACT GCAAGTCCTGGGCCTGGCTCTGTTCCTGACCCTGGGGACGCTGGTCATTC TCATCTTCCCACCCATGGTCTTCAGCCATGTGGAGGGCTGGAGCTTCAGC GAGGGCTTCTACTTTGCTTTCATCACTCTCAGCACCATTGGCTTTGGGGA CTATGTTGTTGGCACAGACCCCAGCAAGCATTATATCTCAGTGTATCGGA GCCTGGCAGCCATCTGGATCCTCCTGGGCCTGGCGTGGCTGGCGCTGATC CTCCCACTGGGCCCCCTGCTTCTGCACAGATGCTGCCAGCTCTGGCTGCT CAGTCTGAGGCAAGGCTGTGGAGCCAAGGCGGCTCCAGGCAGGAGACCCA GGAGAGGCTCTACAGCAGCAAGAGGAGTCCAAGTCACACCCCAGGACTTC CCCATATCCAAGAAAGGACTGGGAAGCTGA

Gene structure information

H-Inv cluster ID		HIX0032796
Genomic location	Chromosome	6
	Location	6p21.2
	Position	39282778- 39290316
	Strand	-
Possible duplicated location(s)		NA
Gene structure		6 exon(s)
Database links	RefSeq	NM_032115;  NM_001135105;  NM_001135106;  NM_001135107;
	Ensembl	ENST00000373227;  ENST00000373229;  ENST00000425054;  ENST00000437525;  ENST00000507712;
	Entrez Gene	Entrez Gene ID:83795;
	KEGG GENES	KEGG GENES(83795);
	GeneCard	KCNK16;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000086460 Predicted CDS 1..930;  309[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.816 Database links RefSeq NP_115491;  UniProt Q96T55;  CCDS CCDS4843;

MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLE KLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFF FAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAH LAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFS EGFYFAFITLSTIGFGDYVVGTDPSKHYISVYRSLAAIWILLGLAWLALI LPLGPLLLHRCCQLWLLSLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDF PISKKGLGS*

Gene function information

H-Inv ID		HIT000078325
H-Inv cluster ID		HIX0032796
Accession number		AF358909.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		Representative transcript;  Splicing isoform
Coding potential		Protein coding;
Definition		Potassium channel subfamily K member 16 isoform 2.
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (NP_115491)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	HIF0000156
	Gene family/group name	Putative Ion transport 2 (IPR013099).
	Evidence motif (InterPro) ID	IPR013099
Gene symbol/name	HGNC symbol	KCNK16
	HGNC aliases	NA
	HGNC name	potassium channel, subfamily K, member 16
	DDBJ	KCNK16
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000086460
	No. of interaction	3
	Interaction partner(s)	HIP000046840;  HIP000065282;  HIP000182418;
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	12179;
	IntAct	EBI-1142735;
Database links	RefSeq	NM_032115;  NM_001135105;  NM_001135106;  NM_001135107;
	Ensembl	ENST00000373227;  ENST00000373229;  ENST00000425054;  ENST00000437525;  ENST00000507712;
	Entrez Gene	Entrez Gene ID:83795;
	KEGG GENES	KEGG GENES(83795);
	GeneCard	KCNK16;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Human curated
Notes		NA
Related H-InvDB links		Putative Ion transport 2 (IPR013099). Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	plasma membrane;
Target P	signal peptide
SOSUI	membrane protein
TMHMM	membrane protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 89 120 1orqC 2e-06 31.2 32/223 f.14.1.1

Related H-InvDB links GTOP

Gene expression information

Last modified:20-Apr-2012

Tissue-specific expression			endocrine_exocrine;
Probe information	AceGene		AGhsB051122;
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	234554_at;
		HG-U133A	NA
		HG-U133A_2	NA
		HG-U133B	234554_at;
		HG-U133_Plus_2	234554_at;
		HG-U95	NA
		HG-U95A	NA
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2952931;  2952938;  2952939;  2952943;  2952944;  2952945;  2952946;  2952948;  2952952;  2952953;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	A_23_P253503;
		Whole Human Genome Oligo Microarray:PGID247	A_23_P253503;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:NA Title:NA
Co-localized orphan diseases		OMIM ID:  122550;  143400;  604519;  608545;  610294;  611724;  612558;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(83795)
	Disease	Entrez Gene ID:(83795)
	Substance	Entrez Gene ID:(83795)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Evolutionary information

Last modified:20-Apr-2012

Relationship	Species	Accession number	MGI	Links
Orthology	Bos sp. (Cow)	ENSBTAT00000030656		G-integra
Orthology	Canis sp. (Dog)	ENSCAFT00000002431		G-integra
Orthology	Oryzias sp. (Medaka)	ENSORLT00000022262		G-integra
Orthology	Pongo sp. (Orangutan)	ENSPPYT00000019278		G-integra
Orthology	Tetraodon sp. (Tetraodon)	GSTENT00019936001		G-integra
Orthology	Takifugu sp. (Fugu)	SINFRUT00000138269		G-integra
Orthology	Rattus sp. (Rat)	XM_001063888		G-integra
Orthology	Macaca sp. (Macaque)	XM_001117141		G-integra
Orthology	Gallus sp. (Chicken)	XM_001235223		G-integra
Orthology	Monodelphis sp. (Opossum)	XM_001379411		G-integra
Orthology	Equus sp. (Horse)	XM_001500661		G-integra
Orthology	Mus sp. (Mouse)	XM_138942		G-integra
Orthology	Danio sp. (Zebrafish)	XM_688902		G-integra

Phylogenetic tree [View by ATV]	Neighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS (under constraction);

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 117 .. 117 G/A rs3734619 - CDS Synonymous[Ala39Ala] 145 .. 145 T/A rs112232325 - CDS Nonsynonymous[Leu49Met] 261 .. 261 T/C rs61750316 - CDS Synonymous[Ser87Ser] 303 .. 303 T/C rs61751240 - CDS Synonymous[Phe101Phe] 423 .. 423 C/T rs111983106 - CDS Synonymous[Asn141Asn] 456 .. 456 C/T rs79043904 - CDS Synonymous[Ala152Ala] 483 .. 483 C/T rs116802366 - CDS Synonymous[Pro161Pro] 514 .. 514 C/G rs61745897 - CDS Nonsynonymous[Leu172Val] 622 .. 622 A/C rs41273132 - CDS Nonsynonymous[Ile208Leu] 645 .. 645 T/C rs9462527 - CDS Synonymous[Phe215Phe] 696 .. 696 T/C rs3734618 - CDS Synonymous[Tyr232Tyr] 813 .. 813 A/G rs112112869 - CDS Synonymous[Gln271Gln] 831 .. 831 G/A rs9471065 - CDS Synonymous[Ala277Ala] 902 .. 902 C/A rs11756091 - CDS Nonsynonymous[Pro301His]  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;