H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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Locus view Protein view G-integra DiseaseInfo Viewer H-ANGEL Evola PPI view Gene Family/Group Hyperlink MS

H-Invitational ID: HIT000067464 Accession number: AF086790 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Aconitase, mitochondrial-like family protein.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AF086790.1 CAGE tag ID NA EST ID NA Clone Number NA Experimental resources   NBRC ; HGPD ; Sequence data provider NA Annotation project NA Length of cDNA 2215[bp] (No. of exon:0)[A:590 T:468 G:562 C:595] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type liver Develpmental stage NA

Sequence quality information CDS feature N-truncated Kozak sequence NA PolyA Site: 2197(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

AAATTATGCATACCCTGGAGTTCTTCTGATTGGCACTGACTCCCACACCC CCAATGGTGGTGGCCTAGGAGGCATCTCGATTGGAGTAGGGGGTCGTGAT CGTGTGGATGTCATGGCTGGGATCCCCTGCGAGTTGAAGTGTACCAAGGT GATTGCGATGAAGCTGACAGGCTCCCTCTCTGGTTGGACCTCACCCAAAG ATGTGATCCTGAAAGTGGCAGGAATCCTGACAGTAAAAGGTGGTACAGGT GCCATTGTAGAATACCATGGGCCTGGTGTCGACTCCATCTCCTGCACGGG CATGGCAACAATCTGCAACATGGGTGCAGAAATTGGGGCCACCACATCAG TGTTCCCATACAATCACAGGATGAAGAAGTACCTGAGCAAGACTGGCCGA GCAGACATTGCCAGTCTACGTGAAGAATTCAAGGATCACCTAGTGCCTGA CCCTGGCTGCCAGTATGACCAAGTGATTGAAATTAACCTCAATGAGCTAA AGCCACATATCAATGGACCTTTTACCCCTGACTTGGCTCACCCAGTAGCA GAAGTGGGCACTGTGGCAGAGAAGGAAGGTTGGCCTCTGGACATCAGAGT GGGTTTGATTGGCAGCTGCACCAATTCAAGCTATGAGGATATGGGACGGT CAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGACTCAAGTGCAAGTCC CAGTTCACCATCACACCAGGCTCTGAGCAGATCCGCGCCACCATTGAGCG GGATGGCTATGCACAGATCCTGAGGGATGTGGGAGGCATTGTTTTGGCCA ATGCCTGTGGCCCTTGCATTGGCCAGCGGGACAGAAAGGACATCAAGAAG GGGGAGAAGAATACAATGGTCACTTCCTACAACAGGAACTTCACAGGCCG CAATGACGCTTTCCCTGAGACCCATGCTTTTGTCACATCCCCAGAGATTG TCACAGCCCTGGCCATTGCAGGAACCCTTAAGTTCAACCCAGAAACCGAC TTCTTGACAGGCAAGGATGGCAAGAAGTTCAAGCTGGAAGCTCCAGATGC AGATGAGCTTCCCCGATCGAGCTTTGACCCAGGGCAGGACACCTACCAGC AACCCCCCAAGGACAGCAGTGGGCAGCGGGTAGACGTGAGCCCTACCAGC CAGCGCCTGCAGCTCTTGGAGCCTTTTGACAAGTGGGACGGCAAAGACCT GGAGGACCTGCAAATCCTCATCAAGGTCAAAGGGAAGTGCACCACCGACC ACATTTCTGCTGCGTTCCCCTGGCTCAAGTTCCGTGGACATCTGGACAAC ATCTCTAATAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGC CAACTCCGTGCGTAATGCTGTCACCCAGGAGTTTGGCCCTGTGCCTGACA CTGCTCGATACTACAAGAAACATGGCATCAGGTGGGTGGTGATTGGAGAC GAGAACTATGGTGAAGGCTCAAGCCGGGAACATGCAGCACTGGAGCCTCG CCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCATG AGACGATTAAGAAACAGGGCTTGCTGCCCCTCACCTTTGCTGACCCCTCT GACTACAACAAGATCCATCCAGTGGACAAACTGACTATTCAAGGCCTGAA GGACTTTGCCCCTGGCAAGCCTCTGAAATGCATCATCAAGCACCCTAATG GGACCCAGGAAACCATCCTCTTGAACCACACCTTCAATGAGACCCAGATC GAATGGTTCCGTGCAGGCAGTGCCCTAAACAGGATGAAGGAGCTGCAGCA ATAAGGAAGGTCCCGGCAAGCTGGCTGTCATGTCCCACTCTGGACCCACT CTGGACCCTGCTGGATGTCAGAAGTACAGGTCCGTGTGCATCCTCAGAGC CAGAGCTGGTCTATCCAGCATGGCCTAGCTCTGAGATGACGACCAGACCT GCTTCCTGCTCTCTCCATCCTCAGCCACTGAGTGATCCACCGTGGAGGGC ACTTGAGATTAAGTCCCAGCCCCTGCCTTTCAGCTTGGTTCTTCCTTCAA AAATGCCATGCAACCTGTATTTATTTTTAATGACAGCACTCCCTCTAAAA AAAAGTTTTCATCCTGCCTGATCATTTCACTGGTGGCTGAAGGATTTTAG AGAACCTTTGTTCTCATAAGAAAAAAAAAAAGCCAAATCCATTGACAAAA AAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0044052
Genomic location	Chromosome	UM
	Location	NA
	Position	NA
	Strand	NA
Possible duplicated location(s)		NA
Gene structure		exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	NA
	KEGG GENES	NA
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000118408 Predicted CDS 2..1804;  600[aa];  Orientation:+2;  Codon Adaptation Index (CAI). 0.816 Database links RefSeq NA UniProt O75944;  CCDS NA

NYAYPGVLLIGTDSHTPNGGGLGGISIGVGGRDRVDVMAGIPCELKCTKV IAMKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTG MATICNMGAEIGATTSVFPYNHRMKKYLSKTGRADIASLREEFKDHLVPD PGCQYDQVIEINLNELKPHINGPFTPDLAHPVAEVGTVAEKEGWPLDIRV GLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIER DGYAQILRDVGGIVLANACGPCIGQRDRKDIKKGEKNTMVTSYNRNFTGR NDAFPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPDA DELPRSSFDPGQDTYQQPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKDL EDLQILIKVKGKCTTDHISAAFPWLKFRGHLDNISNNLLIGAINIENGKA NSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPR HLGGRAIITKSFARIHETIKKQGLLPLTFADPSDYNKIHPVDKLTIQGLK DFAPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ *

Motif information

	a.a. length	InterPro	Name
	600	IPR015937	Aconitase/isopropylmalate dehydratase [Family]
	49	IPR015931	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [Domain]
	600	IPR006248	Aconitase, mitochondrial-like [Family]
	376	IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha [Domain]
	323	IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha [Domain]
	14	IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha [Domain]
	16	IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha [Domain]
	112	IPR015932	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 [Domain]
	14	IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha [Domain]
	14	IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha [Domain]
	172	IPR015931	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 [Domain]
	15	IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha [Domain]
	17	IPR018136	Aconitase family, 4Fe-4S cluster binding site [Binding_site]
	12	IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha [Domain]
	14	IPR018136	Aconitase family, 4Fe-4S cluster binding site [Binding_site]
	14	IPR001030	Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha [Domain]
	221	IPR015928	Aconitase/3-isopropylmalate dehydratase, swivel [Domain]
	216	IPR015928	Aconitase/3-isopropylmalate dehydratase, swivel [Domain]
	128	IPR000573	Aconitase A/isopropylmalate dehydratase small subunit, swivel [Domain]

Gene function information

H-Inv ID		HIT000067464
H-Inv cluster ID		HIX0044052
Accession number		AF086790.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		Representative transcript;
Coding potential		Protein coding;
Definition		Aconitase, mitochondrial-like family protein.
Similarity category		Category: IPR domain containing protein(Category III).
		InterPro domain (IPR006248) -containing protein.
Experimental evidence		NA
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	NA
	HGNC aliases	NA
	HGNC name	NA
	DDBJ	ACON
	UniProt	NA
EC number		EC 4.2.1.3aconitate hydratase;
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		00020 :Citrate cycle (TCA cycle);  00630 :Glyoxylate and dicarboxylate metabolism;  00720 :Reductive carboxylate cycle (CO2 fixation);
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000118408
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	NA
	KEGG GENES	NA
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Human curated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	aconitate hydratase activity (GO:0003994);  4 iron, 4 sulfur cluster binding (GO:0051539);
Biological process	tricarboxylic acid cycle (GO:0006099);  metabolic process (GO:0008152);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	cytosol;  mitochondria;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 1 339 1acoA2 e-108 94.4 339/527 c.83.1.1 340 560 1acoA1 5e-59 95.5 221/226 c.8.2.1

Related H-InvDB links GTOP

Gene expression information

Last modified:20-Apr-2012

Tissue-specific expression			NA
Probe information	AceGene		NA
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	217307_at;  217311_at;
		HG-U133A	217307_at;  217311_at;
		HG-U133A_2	217307_at;  217311_at;
		HG-U133B	NA
		HG-U133_Plus_2	217307_at;  217311_at;
		HG-U95	31434_at;
		HG-U95A	31434_at;
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	3958959;  3958971;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	A_24_P579439;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;