H-InvDB_9.0 released on May 27, 2015. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000065665 Accession number: AF069681 Created date: 26-Mar-2013 Last modified: 27-May-2015 Definition: KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein T-Star; Sam68-like mammalian protein 2; SLM-2; Sam68-like phosphotyrosine protein;

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AF069681.1 CAGE tag ID NA EST ID NA Clone Number NA Experimental resources   NBRC ; HGPD ; Sequence data provider NA Annotation project NA Length of cDNA 1557[bp] (No. of exon:9)[A:399 T:303 G:443 C:412] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type testes Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

CTGGCGGGACTGGCGGGGATCGCCGTGGACTGCCTCAGGGGCGCCGCAGC CCGCTCGGCCCGAGGGCCCGCCTAACCGCGCCGCCCGCGCCCGCTCCTCC TCGGCCCGCGCCCGGAGCGCGGGGGCCGCCGGCGCTGGGTACTCGGCGGC CACCGGGGATCGGGGCTGAGCGGTCGGTTCCCGCCCCCGTGCCGCCGCCG CCGCCTTCCGGCCGACCGCCCGGCTTGGCCGCTGCTGCCGCGTCTGGCCC CCGGGTCCCCGCCGCTGGGGGCGCGGGCGGGGTCGGGGGTTGCCGGGCGC CGCCCCCCGTGCGCCTGGAGTCCACATCCCGGGCCCGGCGGCCGGCGAGC ATGGAGGAGAAGTACCTGCCCGAGCTGATGGCGGAGAAGGACTCCCTGGA CCCCTCCTTCACGCACGCCCTGCGCCTGGTGAACCAAGAAATAGAAAAGT TTCAAAAAGGAGAAGGCAAGGATGAAGAAAAGTACATCGATGTGGTGATT AATAAGAACATGAAGCTGGGACAGAAAGTGTTAATTCCCGTAAAACAGTT CCCTAAGTTCAACTTTGTGGGGAAACTTTTGGGTCCACGTGGCAATTCTC TGAAGCGTTTACAAGAAGAAACCTTGACAAAAATGTCCATCCTTGGGAAA GGTTCCATGAGAGACAAGGCCAAGGAAGAAGAGTTGAGGAAAAGTGGAGA AGCGAAGTACTTCCATCTCAATGATGATCTCCATGTTCTCATTGAAGTGT TTGCCCCACCTGCAGAAGCTTATGCCAGGATGGGACATGCTTTGGAAGAA ATCAAAAAGTTCCTCATCCCTGATTATAATGATGAGATCAGGCAAGCACA GCTCCAGGAGTTAACATATTTGAATGGTGGTTCAGAAAATGCAGATGTTC CAGTGGTTCGAGGGAAACCCACCTTGCGTACAAGAGGTGTACCAGCCCCA GCAATAACCAGGGGAAGGGGAGGAGTTACAGCCCGGCCAGTTGGAGTTGT AGTACCACGAGGGACGCCAACTCCCAGAGGAGTCCTGTCCACCCGAGGGC CAGTGAGTCGGGGAAGAGGACTTCTCACTCCCAGAGCAAGAGGAGTCCCC CCAACTGGGTACAGACCTCCACCGCCACCCCCGACACAAGAGACTTATGG AGAATATGACTATGATGATGGATATGGCACTGCTTATGATGAACAGAGTT ATGATTCCTATGATAACAGCTATAGCACCCCAGCCCAAAGTGGTGCTGAT TACTATGATTACGGACATGGACTCAGTGAGGAGACTTATGATTCCTACGG GCAAGAAGAGTGGACTAACTCAAGACACAAGGCACCTTCAGCGAGGACAG CAAAGGGCGTCTACAGAGACCAGCCATATGGCAGATACTGATTGTACTGT CTGATGTTGTGAAATAGCCAATCTCCACCAGTCCTGTATACTGTTCAAAG TAATTTTTTTCTATGAACAATCCCTTTTTAAATAAATCAAAATGCTTAAA ATCTGAATGGATGGAACTTAAAACTACTTTGTTGAAACATCAACCTGGGT AGAAAAA

Gene structure information

H-Inv cluster ID		HIX0007811
Genomic location	Chromosome	8
	Location	8q24.23
	Position	136469760- 136659493
	Strand	+
Possible duplicated location(s)		NA
Gene structure		9 exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:10656;
	KEGG GENES	KEGG GENES(10656);
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000045606 Predicted CDS 351..1391;  346[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.741 Database links RefSeq NP_006549;  UniProt O75525;  CCDS CCDS6374;

MEEKYLPELMAEKDSLDPSFTHALRLVNQEIEKFQKGEGKDEEKYIDVVI NKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGK GSMRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEE IKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKPTLRTRGVPAP AITRGRGGVTARPVGVVVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVP PTGYRPPPPPPTQETYGEYDYDDGYGTAYDEQSYDSYDNSYSTPAQSGAD YYDYGHGLSEETYDSYGQEEWTNSRHKAPSARTAKGVYRDQPYGRY*

Motif information

	a.a. length	InterPro	Name
	127	IPR004088	K Homology domain, type 1 [Domain]
	99	IPR004087	K Homology domain [Domain]
	122	IPR004088	K Homology domain, type 1 [Domain]

Gene function information

H-Inv ID		HIT000065665
H-Inv cluster ID		HIX0007811
Accession number		AF069681.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein T-Star; Sam68-like mammalian protein 2; SLM-2; Sam68-like phosphotyrosine protein;
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (O75525)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		10077576;  10332027;  10564820;  10749975;  11714634;  11741900;  15163637;  15489334;  15901763;  19561594;  19608861;  ALL;
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	NA
	HGNC aliases	NA
	HGNC name	NA
	DDBJ	T-Star
	UniProt	KHDRBS3
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000045606
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:10656;
	KEGG GENES	KEGG GENES(10656);
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	nucleic acid binding (GO:0003676);  RNA binding (GO:0003723);

Subcellular localization information

Last modified:27-May-2015

WoLF PSORT	cytosol;  nuclear;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:27-May-2015

Start End PDB_ID E-value Identity Coverage SCOP_ID 8 67 3d19A2 7e-08 8.3 60/130 a.29.13.1 55 176 1k1gA 2e-15 31.4 118/122 d.51.1.1

Related H-InvDB links GTOP

Gene expression information

Last modified:27-May-2015

Tissue-specific expression			NA
Probe information	AceGene		AGhsB020320;
	Affymetrix GeneChip	HG-Focus	209781_s_at;
		HG-U133	209781_s_at;
		HG-U133A	209781_s_at;
		HG-U133A_2	209781_s_at;
		HG-U133B	NA
		HG-U133_Plus_2	209781_s_at;
		HG-U95	31786_at;
		HG-U95A	31786_at;
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	3117385;  3117386;  3117387;  3117388;  3117399;  3117400;  3117403;  3117404;  3117406;  3117412;  3117420;  3117431;  3117432;  3117433;  3117434;  3117435;  3155043;  3155047;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	A_23_P257335;
		Whole Human Genome Oligo Microarray:PGID247	A_23_P257335;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 175 .. 175 C/T rs11550913 + 5'UTR 308 .. 308 C/G rs201121717 + 5'UTR 407 .. 407 C/T rs147742474 + CDS Synonymous[Ser19Ser] 438 .. 438 G/A rs191294793 + CDS Nonsynonymous[Glu30Lys] 482 .. 482 G/A rs142274678 + CDS Synonymous[Lys44Lys] 530 .. 530 G/C rs141052238 + CDS Synonymous[Val60Val] 539 .. 539 C/T rs190397357 + CDS Synonymous[Pro63Pro] 729 ^ 730 -/C rs34597682 + CDS 815 .. 815 C/T rs16905401 + CDS Synonymous[Leu155Leu] 823 .. 823 A/G rs201758637 + CDS Nonsynonymous[Asp158Gly] 830 .. 830 T/C rs145472431 + CDS Synonymous[Asn160Asn] 928 .. 928 G/A rs200509558 + CDS Nonsynonymous[Arg193His] 969 .. 969 G/C rs200026165 + CDS Nonsynonymous[Gly207Arg] 988 .. 988 C/T rs148841356 + CDS Nonsynonymous[Pro213Leu] 991 .. 991 T/C rs143501901 + CDS Nonsynonymous[Val214Ala] 1015 .. 1015 C/T rs150971318 + CDS Nonsynonymous[Thr222Met] 1016 .. 1016 G/A rs140999731 + CDS Synonymous[Thr222Thr] 1041 .. 1041 A/G rs201184278 + CDS Nonsynonymous[Thr231Ala] 1070 .. 1070 A/G rs199816214 + CDS Synonymous[Gly240Gly] 1084 .. 1084 G/A rs201822878 + CDS Nonsynonymous[Arg245Lys] 1104 .. 1104 A/G rs144816427 + CDS Nonsynonymous[Thr252Ala] 1144 .. 1144 C/T rs199983279 + CDS Nonsynonymous[Thr265Ile] 1147 .. 1147 A/G rs201017593 + CDS Nonsynonymous[Tyr266Cys] 1228 .. 1228 C/T rs138747212 + CDS Nonsynonymous[Thr293Ile] 1262 .. 1262 C/T rs141874778 + CDS Synonymous[Tyr304Tyr] 1263 .. 1263 G/A rs150184893 + CDS Nonsynonymous[Gly305Arg] 1268 .. 1268 T/C rs202041702 + CDS Synonymous[His306His] 1307 .. 1307 A/G rs143154338 + CDS Synonymous[Glu319Glu] 1325 .. 1325 A/G rs149365116 + CDS Synonymous[Arg325Arg] 1342 .. 1342 C/T rs201292624 + CDS Nonsynonymous[Ala331Val] 1343 .. 1343 G/A rs201329239 + CDS Synonymous[Ala331Ala] 1358 .. 1358 C/A/T rs144732287 + CDS 1359 .. 1359 G/A rs138429826 + CDS Nonsynonymous[Val337Ile] 1369 .. 1369 A/C rs202045003 + CDS Nonsynonymous[Asp340Ala] 1451 .. 1451 T/C rs3210857 + 3'UTR 1490 .. 1490 A/G rs3184618 + 3'UTR 1551 ^ 1552 -/A rs34118572 + 3'UTR 1552 .. 1552 G/A rs1128066 + 3'UTR 1553 ^ 1554 -/A rs59580956 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;