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H-Invitational ID: HIT000058452 Accession number: AB015856 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Cyclic AMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 alpha; Activating transcription factor 6 alpha; ATF6-alpha; Contains: Processed cyclic AMP-dependent transcription factor ATF-6 alpha;
 
 

Transcript original information
Accession number AB015856.1
CAGE tag ID NA
EST ID NA
Clone Number NA
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ATF6) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ATF6);
Sequence data provider NA
Annotation project NA
Length of cDNA 2509[bp] (No. of exon:16)[A:746 T:650 G:534 C:579]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGGAG;  TAGCAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0001253
Genomic location  G-integra Help Chromosome 1
Location 1q23.3
Position 161736084- 161928872
Strand +
Possible duplicated location(s) NA
Gene structure 16 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:22926
KEGG GENES KEGG GENES(22926)
GeneCard GeneCardATF6*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000055894
Predicted CDS 69..2081;  670[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.717

Motif information
ORF

length(670),orf(69:2081)
MGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAAN
ETYENNFDNLDFDLDLMPWESDIWDINNQICTVKDIKAEPQPLSPASSSY
SVSSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGENSNSLSSPEPLKE
DKPVTGSRNKTENGLTPKKKIQVNSKPSIQPKPLLLPAAPKTQTNSSVPA
KTIIIQTVPTLMPLAKQQPIISLQPAPTKGQTVLLSQPTVVQLQAPGVLP
SAQPVLAVAGGVTQLPNHVVNVVPAPSANSPVNGKLSVTKPVLQSTMRNV
GSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKK
ENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNYGPMSMLEQ
DSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKA
LMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRM
TNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYASPR
SYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAINI
NENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFG
SPPAATEATHVVSTIPESLQ*
a.a.
length
InterPro Name
length(65), motif(304:368) 65 IPR004827 Basic-leucine zipper domain [Domain]
length(64), motif(306:369) 64 IPR004827 Basic-leucine zipper domain [Domain]
length(60), motif(307:366) 60 IPR004827 Basic-leucine zipper domain [Domain]
length(15), motif(312:326) 15 IPR004827 Basic-leucine zipper domain [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000058452
H-Inv cluster ID Locus viewHIX0001253
Accession number AB015856.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Cyclic AMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 alpha; Activating transcription factor 6 alpha; ATF6-alpha; Contains: Processed cyclic AMP-dependent transcription factor ATF-6 alpha;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P18850)  [Identity/coverage = 99.701%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 25168279271374983796210564271111583101116320911483355146991591548933416710414ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ATF6
HGNC aliases NA
HGNC name activating transcription factor 6
DDBJ ATF6
UniProt ATF6
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000055894
No. of interaction 22
Interaction partner(s) HIP000023587HIP000025459HIP000025459HIP000028704HIP000031216HIP000034648HIP000034648HIP000054415HIP000069159HIP000069159HIP000076344HIP000078380HIP000078380HIP000085732HIP000105729HIP000105729HIP000112600HIP000112600HIP000120476HIP000136954HIP000136954HIP000251490
BIND 153784;  153785; 
DIP NA
MINT NA
HPRD 00145;  01861;  01908;  01961;  02482;  02788;  02992;  03399;  05633;  07340;  16752; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:22926
KEGG GENES KEGG GENES(22926)
GeneCard GeneCardATF6*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function sequence-specific DNA binding (GO:0043565);  transcription factor activity (GO:0003700); 
Biological process regulation of transcription, DNA-dependent (GO:0006355); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT nuclear; 
Target P Other
SOSUI membrane protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
274 327 1sknP 1e-04 22.6 53/100 a.37.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA051115; 
Affymetrix
GeneChip
HG-Focus 203952_at; 
HG-U133 203952_at; 
HG-U133A 203952_at; 
HG-U133A_2 203952_at; 
HG-U133B NA
HG-U133_Plus_2 203952_at; 
HG-U95 338_at; 
HG-U95A 338_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2363921;  2363922;  2363923;  2363925;  2363928;  2363929;  2363931;  2363933;  2363934;  2363938;  2363940;  2363951;  2363955;  2363956;  2363957;  2363960;  2363961;  2363966;  2363978;  2363979;  2441017;  2441037; 
HuGeneFL AF005887_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P62907; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P62907; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) AK036335 MGI:2400756 G-integraG-integra
Orthology Bos sp. (Cow) ENSBTAT00000006888 G-integraG-integra
Orthology Equus sp. (Horse) ENSECAT00000023918 G-integraG-integra
Orthology Gallus sp. (Chicken) ENSGALT00000040110 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000020862 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000000715 G-integraG-integra
Orthology Danio sp. (Zebrafish) NM_001110519 G-integraG-integra
Orthology Rattus sp. (Rat) XM_001076843 G-integraG-integra
Orthology Macaca sp. (Macaque) XM_001118153 G-integraG-integra
Orthology Pan sp. (Chimpanzee) XM_001174215 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001369506 G-integraG-integra
Orthology Canis sp. (Dog) XM_545777 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
32 .. 32 A/G rs60394665 + 5'UTR
60 .. 60 A/G rs182701901 + 5'UTR
85 .. 85 G/T rs200220130 + CDS Nonsynonymous[Gly6Val]
115 .. 115 G/T rs112863172 + CDS Nonsynonymous[Ser16Ile]
127 .. 127 T/C rs35284289 + CDS Nonsynonymous[Phe20Ser]
135 .. 135 C/T rs149825732 + CDS Synonymous[Leu23Leu]
173 .. 173 T/C rs2070151 + CDS Synonymous[Leu35Leu]
204 .. 204 T/C rs151136116 + CDS Synonymous[Leu46Leu]
217 .. 217 A/G rs56394151 + CDS Nonsynonymous[Asn50Ser]
267 .. 267 A/G/T rs1058405 + CDS
269 .. 269 G/A rs1135982 + CDS Nonsynonymous[Met67Ile]
311 .. 311 T/C rs138607905 + CDS Synonymous[Cys81Cys]
313 .. 313 C/T rs144743551 + CDS Nonsynonymous[Thr82Ile]
338 .. 338 C/T rs2271013 - CDS Synonymous[Pro90Pro]
376 .. 376 C/T rs199848647 + CDS Nonsynonymous[Ser103Leu]
377 .. 377 A/G rs2271012 - CDS Synonymous[Ser103Ser]
384 .. 384 C/T rs150872316 + CDS Nonsynonymous[Arg106Trp]
385 .. 385 G/C rs149683955 + CDS Nonsynonymous[Arg106Pro]
394 .. 394 A/G rs2271011 - CDS Nonsynonymous[Asp109Gly]
428 .. 428 G/A rs141465868 + CDS Synonymous[Glu120Glu]
447 ^ 448 -/A rs34354288 + CDS
454 .. 454 T/G rs150831546 + CDS Nonsynonymous[Met129Arg]
490 .. 490 G/A rs61801254 + CDS Nonsynonymous[Ser141Asn]
493 .. 493 T/C rs147573850 + CDS Nonsynonymous[Leu142Pro]
501 .. 501 C/G rs2070150 + CDS Nonsynonymous[Pro145Ala]
502 .. 502 C/T rs201470370 + CDS Nonsynonymous[Pro145Leu]
505 .. 505 A/G rs200620848 + CDS Nonsynonymous[Glu146Gly]
537 .. 537 T/C rs1135983 + CDS Nonsynonymous[Ser157Pro]
697 .. 697 C/T rs138321248 + CDS Nonsynonymous[Thr210Met]
748 .. 748 C/G rs146056942 + CDS Nonsynonymous[Pro227Arg]
773 .. 773 G/A rs201567683 + CDS Synonymous[Leu235Leu]
783 .. 783 A/G rs141611945 + CDS Nonsynonymous[Thr239Ala]
810 .. 810 G/A rs189775459 + CDS Nonsynonymous[Val248Ile]
844 .. 844 C/T rs11799951 + CDS Nonsynonymous[Ala259Val]
847 .. 847 G/A rs148549919 + CDS Nonsynonymous[Gly260Glu]
865 .. 865 C/T rs200983247 + CDS Nonsynonymous[Pro266Leu]
872 .. 872 C/T rs146192208 + CDS Synonymous[His268His]
901 .. 901 C/T rs138997959 + CDS Nonsynonymous[Ala278Val]
902 .. 902 G/A rs202091973 + CDS Synonymous[Ala278Ala]
912 .. 912 G/C rs78561001 + CDS Nonsynonymous[Val282Leu]
927 .. 927 T/C rs200145443 + CDS Nonsynonymous[Ser287Pro]
929 .. 929 C/T rs16847240 + CDS Synonymous[Ser287Ser]
949 .. 949 A/G rs79010144 + CDS Nonsynonymous[Gln294Arg]
969 .. 969 G/A rs200990345 + CDS Nonsynonymous[Gly301Ser]
1003 .. 1003 G/A rs148863991 + CDS Nonsynonymous[Arg312His]
1017 .. 1017 C/T rs146640460 + CDS AA-STOP[Arg317*]
1067 .. 1067 G/T rs138069779 + CDS Synonymous[Gly333Gly]
1075 .. 1075 C/T rs141227581 + CDS Nonsynonymous[Ala336Val]
1098 .. 1098 G/C rs2134689 - CDS Nonsynonymous[Glu344Gln]
1104 .. 1104 G/A rs182139828 + CDS Nonsynonymous[Glu346Lys]
1137 .. 1137 C/T rs145066726 + CDS Nonsynonymous[Arg357Trp]
1138 .. 1138 G/A rs141420481 + CDS Nonsynonymous[Arg357Gln]
1147 .. 1147 A/G rs75594989 + CDS Nonsynonymous[Asp360Gly]
1160 .. 1160 A/G rs149651765 + CDS Synonymous[Ser364Ser]
1163 .. 1163 G/C rs140946697 + CDS Nonsynonymous[Glu365Asp]
1289 .. 1289 T/A rs147170108 + CDS Synonymous[Pro407Pro]
1297 .. 1297 G/A rs181923135 + CDS Nonsynonymous[Ser410Asn]
1337 .. 1337 T/C rs151244125 + CDS Synonymous[Ala423Ala]
1343 .. 1343 G/T rs201554630 + CDS Nonsynonymous[Glu425Asp]
1365 .. 1365 A/G rs148600740 + CDS Nonsynonymous[Ile433Val]
1379 .. 1379 C/T rs187088858 + CDS Synonymous[Asn437Asn]
1390 .. 1390 A/G rs207460520 + CDS Nonsynonymous[Tyr441Cys]
1441 .. 1441 C/T rs151155267 + CDS Nonsynonymous[Pro458Leu]
1484 .. 1484 C/T rs1135984 + CDS Synonymous[Asn472Asn]
1519 .. 1519 G/A rs145033970 + CDS Nonsynonymous[Arg484Gln]
1559 .. 1559 A/T rs1058408 + CDS Synonymous[Ser497Ser]
1588 .. 1588 C/A rs201415050 + CDS Nonsynonymous[Thr507Asn]
1608 .. 1608 C/G rs1135987 + CDS Nonsynonymous[Leu514Val]
1641 .. 1641 G/A rs199504598 + CDS Nonsynonymous[Val525Ile]
1662 .. 1662 A/G rs145763916 + CDS Nonsynonymous[Ser532Gly]
1670 .. 1670 C/T rs201527618 + CDS Synonymous[Ile534Ile]
1736 .. 1736 T/G rs193049562 + CDS Nonsynonymous[Phe556Leu]
1786 .. 1786 G/A rs143652365 + CDS Nonsynonymous[Arg573Lys]
1845 .. 1845 A/G rs146909535 + CDS Nonsynonymous[Ile593Val]
1850 .. 1850 G/A rs143219642 + CDS Synonymous[Val594Val]
1925 .. 1925 G/A rs147153714 + CDS Synonymous[Gln619Gln]
1937 ^ 1938 -/A rs34529107 + CDS
1964 .. 1964 A/G rs9482 + CDS Synonymous[Ser632Ser]
2014 .. 2014 T/G rs201204499 + CDS Nonsynonymous[Phe649Cys]
2028 .. 2028 G/A rs144131817 + CDS Nonsynonymous[Ala654Thr]
2110 .. 2110 C/T rs78713669 + 3'UTR
2111 .. 2111 G/A rs191852748 + 3'UTR
2121 .. 2121 G/A rs76485377 + 3'UTR
2187 .. 2187 G/A rs148286684 + 3'UTR
2192 .. 2192 A/G rs141867476 + 3'UTR
2205 .. 2205 G/A rs13401 + 3'UTR
2251 .. 2251 C/G rs17417647 + 3'UTR
2348 .. 2348 T/A rs74579405 + 3'UTR
2408 .. 2408 A/G rs1136046 + 3'UTR
2429 .. 2429 T/C rs112942257 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer