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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000056791 Accession number: BX648144 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Talin-2;
 
 

Transcript original information
Accession number BX648144.1
CAGE tag ID NA
EST ID NA
Clone Number DKFZp686I0976
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider Provider:DKFZ/MIPS
Annotation project H-Invitational FLcDNA
Length of cDNA 2125[bp] (No. of exon:9)[A:546 T:483 G:526 C:570]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type human endometrium carcinoma cell line
Develpmental stage adult
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0012315
Genomic location  G-integra Help Chromosome 15
Location 15q22.2
Position 63050789- 63077040
Strand +
Possible duplicated location(s) NA
Gene structure 9 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:83660
KEGG GENES KEGG GENES(83660)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000217474
Predicted CDS 256..1248;  330[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.783

Motif information
ORF

length(330),orf(256:1248)
MLESSSYLIRTARSLAINPKDPPTWSVLAGHSHTVSDSIKSLITSIRDKA
PGQRECDYSIDGINRCIRDIEQASLAAVSQSLATRDDISVEALQEQLTSV
VQEIGHLIDPIATAARGEAAQLGHKVTQLASYFEPLILAAVGVASKILDH
QQQMTVLDQTKTLAESALQMLYAAKEGGGNPKAQHTHDAITEAAQLMKEA
VDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTT
VVKYSKAIAVTAQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAAT
AEPEEVCHLKTPILRCTHTLVPTPGYFFIA*
a.a.
length
InterPro Name
length(306), motif(1:306) 306 IPR015711 Talin-2 [Family]
length(119), motif(91:209) 119 IPR006077 Vinculin/alpha-catenin [Family]
length(75), motif(233:307) 75 IPR006077 Vinculin/alpha-catenin [Family]
length(69), motif(243:311) 69 IPR015009 Vinculin-binding site-containing domain [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000056791
H-Inv cluster ID Locus viewHIX0012315
Accession number BX648144.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Talin-2;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q9Y4G6)  [Identity/coverage = 98.645%/14.52%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 92058411152738112168954124222191657217116964243186696482126946021406692ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ NA
UniProt TLN2
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000217474
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:83660
KEGG GENES KEGG GENES(83660)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function actin filament binding (GO:0051015); 
Biological process cell adhesion (GO:0007155); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT mitochondria;  cytosol;  nuclear;  peroxisome; 
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
89 212 2b0hA1 5e-06 16.9 124/100 a.24.9.2
232 305 2b0hA1 4e-14 63.5 74/100 a.24.9.2
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene NA
Affymetrix
GeneChip
HG-Focus NA
HG-U133 NA
HG-U133A NA
HG-U133A_2 NA
HG-U133B NA
HG-U133_Plus_2 NA
HG-U95 81893_at; 
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D 81893_at; 
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3597205;  3597208;  3597209;  3597211;  3597212;  3597215;  3597216;  3597218;  3597221;  3597222; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 NA
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
5 .. 5 A/- rs113839254 + 5'UTR
12 .. 12 T/C rs12324409 + 5'UTR
13 .. 13 G/A rs7181066 + 5'UTR
39 .. 39 G/A rs117787653 + 5'UTR
98 .. 98 A/C rs139323765 + 5'UTR
120 .. 120 C/T rs146729597 + 5'UTR
126 .. 126 C/T rs148891969 + 5'UTR
127 .. 127 G/A rs143603462 + 5'UTR
162 .. 162 G/A rs148071691 + 5'UTR
206 .. 206 G/A rs141621869 + 5'UTR
207 .. 207 C/A rs74381092 + 5'UTR
254 .. 254 C/T rs150096125 + 5'UTR
272 .. 272 C/T rs190697613 + CDS Nonsynonymous[Ser6Leu]
273 .. 273 G/A rs138708550 + CDS Synonymous[Ser6Ser]
289 .. 289 G/A rs142760429 + CDS Nonsynonymous[Ala12Thr]
292 .. 292 C/T rs200886764 + CDS Nonsynonymous[Arg13Cys]
303 .. 303 C/T rs147498967 + CDS Synonymous[Ala16Ala]
435 .. 435 C/T rs140087396 + CDS Synonymous[Ile60Ile]
436 .. 436 G/A rs149627024 + CDS Nonsynonymous[Asp61Asn]
438 .. 438 T/C rs144384637 + CDS Synonymous[Asp61Asp]
457 .. 457 C/T rs202059168 + CDS Nonsynonymous[Arg68Trp]
465 .. 465 C/T rs148806117 + CDS Synonymous[Ile70Ile]
506 .. 506 C/T rs147117916 + CDS Nonsynonymous[Thr84Met]
551 .. 551 C/T rs142261304 + CDS Nonsynonymous[Ser99Leu]
555 .. 555 G/C rs35946975 + CDS Synonymous[Val100Val]
567 .. 567 C/T rs139582651 + CDS Synonymous[Ile104Ile]
579 .. 579 C/T rs201384963 + CDS Synonymous[Ile108Ile]
588 .. 588 C/T rs139364010 + CDS Synonymous[Ile111Ile]
601 .. 601 C/T rs146711240 + CDS Nonsynonymous[Arg116Trp]
602 .. 602 G/A rs200045232 + CDS Nonsynonymous[Arg116Gln]
603 .. 603 G/T rs140291112 + CDS Synonymous[Arg116Arg]
631 .. 631 G/A rs201711971 + CDS Nonsynonymous[Val126Met]
672 .. 672 C/T rs200925755 + CDS Synonymous[Ala139Ala]
686 .. 686 C/T rs149940780 + CDS Nonsynonymous[Ala144Val]
744 .. 744 C/G rs200255870 + CDS Synonymous[Leu163Leu]
756 .. 756 C/T rs150770826 + CDS Synonymous[Ala167Ala]
763 .. 763 A/T rs200011295 + CDS Nonsynonymous[Met170Leu]
834 .. 834 C/T rs145072613 + CDS Synonymous[Ala193Ala]
835 .. 835 G/A rs141816570 + CDS Nonsynonymous[Ala194Thr]
849 .. 849 G/A rs145732508 + CDS Synonymous[Lys198Lys]
864 .. 864 C/T rs113320595 + CDS Synonymous[Asp203Asp]
876 .. 876 G/A rs141182921 + CDS Synonymous[Thr207Thr]
879 .. 879 G/A rs146956888 + CDS Synonymous[Leu208Leu]
924 .. 924 C/T rs200962160 + CDS Synonymous[Asp223Asp]
925 .. 925 G/A rs138052939 + CDS Nonsynonymous[Ala224Thr]
934 .. 934 G/A rs200375758 + CDS Nonsynonymous[Glu227Lys]
974 ^ 975 -/A rs36019073 + CDS
981 .. 981 A/T rs141936748 + CDS Synonymous[Gly242Gly]
985 .. 985 T/A rs150674208 + CDS Nonsynonymous[Phe244Ile]
988 .. 988 G/T rs138929602 + CDS Nonsynonymous[Val245Phe]
995 .. 995 A/G rs149434344 + CDS Nonsynonymous[Tyr247Cys]
1033 .. 1033 G/A rs141920011 + CDS Nonsynonymous[Val260Met]
1040 .. 1040 C/T rs146289948 + CDS Nonsynonymous[Ala262Val]
1063 .. 1063 G/A rs7182971 + CDS Nonsynonymous[Val270Ile]
1068 .. 1068 T/A rs144235392 + CDS Synonymous[Thr271Thr]
1107 .. 1107 C/A rs145593887 + CDS Synonymous[Thr284Thr]
1149 .. 1149 A/G rs148751789 + CDS Synonymous[Ala298Ala]
1201 .. 1201 T/C rs148879771 + CDS Nonsynonymous[Cys316Arg]
1431 .. 1431 C/T rs1498128 - 3'UTR
1447 .. 1447 T/A rs142612537 + 3'UTR
1500 .. 1500 T/C rs181181580 + 3'UTR
1532 .. 1532 A/T rs186892762 + 3'UTR
1538 .. 1538 T/G rs151076036 + 3'UTR
1649 .. 1649 T/C rs141286996 + 3'UTR
1746 .. 1746 C/T rs145019917 + 3'UTR
1965 .. 1965 T/G rs2133090 - 3'UTR
2095 .. 2095 A/C rs115579885 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer