H-InvDB x AHG DB
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H-InvDB_8.3 released on March 26, 2013.
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H-Invitational ID: HIT000056301 Accession number: BX647654 Created date: 26-Mar-2013 Last modified: 20-Apr-2012
Definition: Similar to Talin-2;
 
 

Transcript original information
Accession number BX647654.1
CAGE tag ID NA
EST ID NA
Clone Number DKFZp451B1011
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (TLN2) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (TLN2);
Sequence data provider Provider:DKFZ/MIPS; 
Annotation project H-Invitational FLcDNA
Length of cDNA 4819[bp] (No. of exon:28)[A:1200 T:959 G:1335 C:1325]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type human spinal cord
Develpmental stage adult
Mini-G
Sequence quality information
CDS feature N-truncated
Kozak sequence NA
PolyA Site: 6419(+) Signal: 6395-6399(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron 775-2390[bp];
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0012315
Genomic location  G-integra Help Chromosome 15
Location 15q22.2
Position 63032644- 63133685
Strand +
Possible duplicated location(s) NA
Gene structure 28 exon(s)
Database links RefSeq NM_015059; 
Ensembl ENST00000306829;  ENST00000467297;  ENST00000472902;  ENST00000474847;  ENST00000489129;  ENST00000494733; 
Entrez Gene Entrez Gene ID:83660; 
KEGG GENES KEGG GENES(83660); 
GeneCard GeneCardTLN2;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000338102
Predicted CDS 427..3927;  1166[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.776

Motif information
ORF

length(1166),orf(427:3927) RGCWTILMNLLVTSLTLTALRVMENSKVLGESMAGISQNAKTGDLPAFGE CVGIASKALCGLTEAAAQAAYLVGISDPNSQAGHQGLVDPIQFARANQAI QMACQNLVDPGSSPSQVLSAATIVAKHTSALCNACRIASSKTANPVAKRH FVQSAKEVANSTANLVKTIKALDGDFSEDNRNKCRIATAPLIEAVENLTA FASNPEFVSIPAQISSEGSQAQEPILVSAKTMLESSSYLIRTARSLAINP KDPPTWSVLAGHSHTVSDSIKSLITSIRDKAPGQRECDYSIDGINRCIRD IEQASLAAVSQSLATRDDISVEALQEQLTSVVQEIGHLIDPIATAARGEA AQLGHKVTQLASYFESLILAAVGVASKILDHQQQMTVLDQTKTLAESALQ MLYAAKEGGGNPKAQHTHDAITEAAQLMKEAVDDIMVTLNEAASEVGLVG GMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVKYSKAIAVTAQEMMTKS VTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTRVQDLGH GCIFLVQKAGALQVCPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGT QACITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKA LVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPE TQVVLINAIKDVAKALSDLISATKGAASKPVDDPSMYQLKGAAKVMVTNV TSLLKTVKAVEDEATRGTRALEATIECIKQELTVFQSKDVPEKTSSPEES IRMTKVITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFH PDVSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKR VAGAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQ LKPRAKPKQADETLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGK ... 		a.a.
length		 InterPro Name
length(1145), motif(22:1166) 1145 IPR015711 Talin [Family]
length(1145), motif(22:1166) 1145 IPR015710 Talin-related [Family]
length(147), motif(139:285) 147 IPR006077 Vinculin/alpha-catenin [Family]
length(137), motif(309:445) 137 IPR006077 Vinculin/alpha-catenin [Family]
length(136), motif(463:598) 136 IPR006077 Vinculin/alpha-catenin [Family]
length(125), motif(474:598) 125 IPR015009 Vinculin-binding site-containing domain [Domain]
length(138), motif(625:762) 138 IPR006077 Vinculin/alpha-catenin [Family]
length(240), motif(918:1157) 240 IPR002558 I/LWEQ [Domain]
length(211), motif(956:1166) 211 IPR002558 I/LWEQ [Domain]
length(197), motif(961:1157) 197 IPR002558 I/LWEQ [Domain]
length(190), motif(966:1155) 190 IPR002558 I/LWEQ [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000056301
H-Inv cluster ID Locus viewHIX0012315
Accession number BX647654.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Talin-2;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q9Y4G6)  [Identity/coverage = 99.758%/49.1%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 9205841;  11527381;  12168954;  12422219;  15302935;  16572171;  16964243;  17081983;  18083107;  18669648;  19413330;  19608861;  21269460;  ALL; 
Gene family/group Gene family H-Inv gene family/group ID HIF0004216
Gene family/group name Human gene family/group candidate, HIF0004216.
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol TLN2
HGNC aliases NA
HGNC name talin 2
DDBJ NA
UniProt TLN2
EC number NA
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000338102
No. of interaction 1
Interaction partner(s) HIP000146718; 
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct EBI-4496344; 
Database links RefSeq NM_015059; 
Ensembl ENST00000306829;  ENST00000467297;  ENST00000472902;  ENST00000474847;  ENST00000489129;  ENST00000494733; 
Entrez Gene Entrez Gene ID:83660; 
KEGG GENES KEGG GENES(83660); 
GeneCard GeneCardTLN2;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Human gene family/group candidate, HIF0004216. Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function actin binding (GO:0003779);  structural molecule activity (GO:0005198); 
Biological process cell adhesion (GO:0007155); 
Cellular component actin cytoskeleton (GO:0015629); 

Subcellular localization information  Last modified:20-Apr-2012
WoLF PSORT mitochondria;  extracellular;  cytosol;  Other; 
Target P signal peptide
SOSUI membrane protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:20-Apr-2012
Start End PDB_ID E-value Identity Coverage SCOP_ID
89 212 2b0hA1 1e-05 16.9 124/136 a.24.9.2
232 367 2b0hA1 4e-25 66.9 136/136 a.24.9.2
455 528 1sj8A2 9e-06 23.0 74/125 a.216.1.1
604 667 1amoA1 2e-04 19.4 62/269 b.43.4.1
690 866 1r0dA 1e-47 28.2 177/194 a.216.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:20-Apr-2012
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator		 AceGene AGhsB010603; 
Affymetrix
GeneChip		 HG-Focus NA
HG-U133 212703_at; 
HG-U133A 212703_at; 
HG-U133A_2 212703_at; 
HG-U133B NA
HG-U133_Plus_2 212703_at; 
HG-U95 NA
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3597193;  3597194;  3597198;  3597199;  3597200;  3597201;  3597202;  3597203;  3597208;  3597209;  3597211;  3597212;  3597215;  3597216;  3597218;  3597221;  3597226;  3597228;  3597229;  3597231;  3597232;  3597234;  3597235;  3597240;  3597241;  3597246;  3597247;  3597261;  3597263;  3597266;  3597267;  3597268; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P250651; 
Whole Human Genome Oligo Microarray:PGID247 A_24_P347566; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
358 .. 358 C/G rs117175127 + 5'UTR
443 .. 443 T/C rs78491375 + CDS Nonsynonymous[Ile6Thr]
1810 .. 1810 G/A rs115492186 + CDS Nonsynonymous[Ala462Thr]
1940 ^ 1941 -/A rs36019073 + CDS
2047 .. 2047 A/G rs7182971 + CDS Nonsynonymous[Lys541Glu]
2846 .. 2846 C/T rs11633796 + CDS Nonsynonymous[Thr807Ile]
2994 .. 2994 G/A rs35165676 + CDS Synonymous[Thr856Thr]
3122 .. 3122 G/A rs75413920 + CDS AA-STOP[Trp899*]
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
L2c 1144 1339 -
MER33 1783 2060 +
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;