H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000049880 Accession number: AK130609 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Ig gamma-2 chain C region;
 
 

Transcript original information
Accession number AK130609.1
CAGE tag ID NA
EST ID NA
Clone Number SPL04664
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider Project:FLJ; Provider:FLJ/IMSUT
Annotation project H-Invitational FLcDNA
Length of cDNA 1578[bp] (No. of exon:7)[A:338 T:283 G:434 C:523]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type spleen
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0012029
Genomic location  G-integra Help Chromosome 14
Location 14q32.33
Position 106109406- 106878091
Strand -
Possible duplicated location(s) NA
Gene structure 7 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene NA
KEGG GENES NA
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000165332
Predicted CDS 26..1444;  472[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.824

Motif information
ORF

length(472),orf(26:1444)
MCKTMKQLWFFLLLVAAPRWVLSQMQLQESGPGLVKPSETLSLTCSVSGD
SISACRHYWGWVRQPPGQTLEWIGSIFCSGSTYYNPSLERRLTISVDTSK
NQMSLNLASVTAADTAVYYCVRLGSAEWLLYGLDVWGKGTTVIVSSASTK
GPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFP
AVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCV
ECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQF
NWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSN
KGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPS
DIAVEWESNGQPENNYKTTPPMLDSDGSFFFYSKLTVDKSRWQQGNVFSC
SVMHEALHNHYTQKSLSLSPGK*
a.a.
length
InterPro Name
length(103), motif(18:120) 103 IPR007110 Immunoglobulin-like domain [Domain]
length(130), motif(22:151) 130 IPR013783 Immunoglobulin-like fold [Domain]
length(119), motif(26:144) 119 IPR013106 Immunoglobulin V-set domain [Domain]
length(98), motif(152:249) 98 IPR013783 Immunoglobulin-like fold [Domain]
length(94), motif(152:245) 94 IPR007110 Immunoglobulin-like domain [Domain]
length(76), motif(163:238) 76 IPR003597 Immunoglobulin C1-set [Domain]
length(72), motif(168:239) 72 IPR003597 Immunoglobulin C1-set [Domain]
length(7), motif(227:233) 7 IPR003006 Immunoglobulin/major histocompatibility complex, conserved site [Conserved_site]
length(106), motif(260:365) 106 IPR013783 Immunoglobulin-like fold [Domain]
length(100), motif(263:362) 100 IPR007110 Immunoglobulin-like domain [Domain]
length(87), motif(272:358) 87 IPR003597 Immunoglobulin C1-set [Domain]
length(99), motif(366:464) 99 IPR013783 Immunoglobulin-like fold [Domain]
length(97), motif(371:467) 97 IPR007110 Immunoglobulin-like domain [Domain]
length(83), motif(378:460) 83 IPR003597 Immunoglobulin C1-set [Domain]
length(74), motif(387:460) 74 IPR003597 Immunoglobulin C1-set [Domain]
length(7), motif(448:454) 7 IPR003006 Immunoglobulin/major histocompatibility complex, conserved site [Conserved_site]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000049880
H-Inv cluster ID Locus viewHIX0012029
Accession number AK130609.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Ig gamma-2 chain C region;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P01859)  [Identity/coverage = 99.387%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 113060118920494047257827076329676677401268049486811139773719012508121150846711915921821269460ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ NA
UniProt IGHG2
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000165332
No. of interaction 1
Interaction partner(s) HIP000167248
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene NA
KEGG GENES NA
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function protein binding (GO:0005515); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT extracellular;  lysosome; 
Target P signal peptide
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
23 144 1yjdC1 2e-18 14.5 117/118 b.1.1.1
168 242 1jrhH2 2e-16 74.1 58/58 b.1.1.2
264 364 1o0vA1 3e-06 18.8 97/104 b.1.1.2
368 462 1o0vA1 3e-10 18.9 95/104 b.1.1.2
Related H-InvDB links GTOP GTOP

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
2 .. 2 T/G rs111881730 - 5'UTR
22 .. 22 T/C rs4774115 - 5'UTR
26 .. 26 A/C rs4774114 - CDS Nonsynonymous[Met1Leu]
29 .. 29 T/A rs182693461 - CDS Nonsynonymous[Cys2Ser]
36 .. 36 C/A rs190089302 - CDS Nonsynonymous[Thr4Lys]
37 .. 37 A/C rs4774113 - CDS Synonymous[Thr4Thr]
41 .. 41 A/C rs138364008 - CDS Nonsynonymous[Lys6Gln]
45 .. 45 A/G rs187579450 - CDS Nonsynonymous[Gln7Arg]
55 .. 55 C/T rs113208890 - CDS Synonymous[Phe10Phe]
64 .. 64 G/A rs147042410 - CDS Synonymous[Leu13Leu]
73 .. 73 G/A rs113892460 - CDS Synonymous[Ala16Ala]
74 .. 74 G/A rs140461651 - CDS Nonsynonymous[Ala17Thr]
103 .. 103 A/G rs144078801 - CDS Synonymous[Gln26Gln]
115 .. 115 G/C rs201070607 - CDS Synonymous[Ser30Ser]
119 .. 119 C/T rs200099545 - CDS Nonsynonymous[Pro32Ser]
122 .. 122 G/A rs190955722 - CDS Nonsynonymous[Gly33Arg]
124 .. 124 A/G rs184884750 - CDS Synonymous[Gly33Gly]
133 .. 133 G/C rs181228803 - CDS Nonsynonymous[Lys36Asn]
136 .. 136 T/C rs188407917 - CDS Synonymous[Pro37Pro]
139 .. 139 G/A rs201935156 - CDS Synonymous[Ser38Ser]
140 .. 140 G/C rs200764032 - CDS Nonsynonymous[Glu39Gln]
157 .. 157 C/G rs184411901 - CDS Synonymous[Thr44Thr]
161 .. 161 A/G rs113422537 - CDS Nonsynonymous[Ser46Gly]
162 .. 162 G/C rs181859654 - CDS Nonsynonymous[Ser46Thr]
173 .. 173 G/T rs145759866 - CDS Nonsynonymous[Asp50Tyr]
174 .. 174 A/G rs143740707 - CDS Nonsynonymous[Asp50Gly]
179 .. 179 A/T rs190205925 - CDS Nonsynonymous[Ile52Phe]
214 .. 214 C/G rs34195693 - CDS Synonymous[Arg63Arg]
232 .. 232 A/G rs185744941 - CDS Synonymous[Thr69Thr]
238 .. 238 G/A rs193208511 - CDS Synonymous[Glu71Glu]
249 .. 249 G/A rs115523671 - CDS Nonsynonymous[Ser75Asn]
257 .. 257 T/C rs35281264 - CDS Nonsynonymous[Cys78Arg]
268 .. 268 T/C rs183671564 - CDS Synonymous[Ser81Ser]
274 .. 274 C/T/G rs111910988 - CDS
280 .. 280 C/G rs191860623 - CDS Nonsynonymous[Asn85Lys]
287 .. 287 C/T rs112149789 - CDS Nonsynonymous[Leu88Phe]
305 .. 305 A/C rs187288552 - CDS Nonsynonymous[Ile94Leu]
310 .. 310 C/A rs11847691 - CDS Synonymous[Ser95Ser]
362 .. 362 G/A rs191739990 - CDS Nonsynonymous[Ala113Thr]
364 .. 364 A/G rs11851921 - CDS Synonymous[Ala113Ala]
373 .. 373 T/C rs11847603 - CDS Synonymous[Ala116Ala]
384 .. 384 G/A rs188639181 - CDS Nonsynonymous[Cys120Tyr]
388 .. 388 G/A rs138462056 - CDS Synonymous[Val121Val]
392 .. 392 C/G rs11847658 - CDS Nonsynonymous[Leu123Val]
420 .. 420 G/C rs199961915 - CDS Nonsynonymous[Gly132Ala]
437 .. 437 A/C rs1950943 - CDS Nonsynonymous[Lys138Gln]
438 .. 438 A/G rs140411866 - CDS Nonsynonymous[Lys138Arg]
442 .. 442 G/C rs151216698 - CDS Synonymous[Gly139Gly]
455 .. 455 G/A rs142191790 - CDS Nonsynonymous[Val144Ile]
458 .. 458 T/G/C rs111729691 - CDS
460 .. 460 C/T rs181338437 - CDS Synonymous[Ser145Ser]
466 .. 466 C/T rs75377037 - CDS Synonymous[Ala147Ala]
484 .. 484 G/C/A rs199678915 - CDS
517 .. 517 C/T rs139093355 - CDS Synonymous[Thr164Thr]
520 .. 520 C/T rs189328740 - CDS Synonymous[Ser165Ser]
532 .. 532 G/C rs77047842 - CDS Synonymous[Ala169Ala]
598 .. 598 T/C rs61983197 - CDS Synonymous[Ala191Ala]
625 .. 625 A/G rs11557955 + CDS Synonymous[Pro200Pro]
652 .. 652 C/T rs113491569 - CDS Synonymous[Tyr209Tyr]
665 .. 665 G/A rs139934867 - CDS Nonsynonymous[Val214Met]
677 .. 677 C/A rs11627594 - CDS Nonsynonymous[Pro218Thr]
687 .. 687 A/G rs201580297 - CDS Nonsynonymous[Asn221Ser]
691 .. 691 C/T/G rs200481020 - CDS
787 .. 787 G/A rs117098144 - CDS Synonymous[Pro254Pro]
872 .. 872 G/A rs190914111 - CDS Nonsynonymous[Glu283Lys]
944 .. 944 G/A rs8009156 - CDS Nonsynonymous[Val307Met]
973 .. 973 A/G rs199967809 - CDS Synonymous[Pro316Pro]
1002 .. 1002 G/A rs202145150 - CDS Nonsynonymous[Arg326His]
1021 .. 1021 C/T rs7146603 - CDS Synonymous[Thr332Thr]
1024 .. 1024 T/C rs11160859 - CDS Synonymous[Val333Val]
1025 .. 1025 G/C/A rs113678609 - CDS
1064 .. 1064 A/G rs182705016 - CDS Nonsynonymous[Lys347Glu]
1116 .. 1116 C/T rs200054675 - CDS Nonsynonymous[Thr364Ile]
1154 .. 1154 C/A rs185308159 - CDS Nonsynonymous[Pro377Thr]
1164 .. 1164 G/A rs1045715 + CDS Nonsynonymous[Arg380Gln]
1172 .. 1172 A/C/T rs709590 + CDS
1219 .. 1219 C/T rs201684715 - CDS Synonymous[Tyr398Tyr]
1228 .. 1228 C/T rs200686367 - CDS Synonymous[Asp401Asp]
1232 .. 1232 G/T rs4983499 - CDS Nonsynonymous[Ala403Ser]
1282 .. 1282 A/G rs1049810 + CDS Synonymous[Thr419Thr]
1289 .. 1289 A/G rs75426199 - CDS Nonsynonymous[Met422Val]
1303 .. 1303 C/G rs200897408 - CDS Nonsynonymous[Asp426Glu]
1330 .. 1330 C/A rs1050170 + CDS Synonymous[Leu435Leu]
1355 .. 1355 C/G rs1063434 + CDS Nonsynonymous[Gln444Glu]
1363 .. 1363 C/T rs79786204 - CDS Synonymous[Asn446Asn]
1364 .. 1364 G/A rs1050575 + CDS Nonsynonymous[Val447Ile]
1369 .. 1369 C/T rs1050611 + CDS Synonymous[Phe448Phe]
1394 .. 1394 C/T rs1050859 + CDS Synonymous[Leu457Leu]
1401 .. 1401 A/G rs201183194 - CDS Nonsynonymous[Asn459Ser]
1411 .. 1411 G/A rs28371022 - CDS Synonymous[Thr462Thr]
1411 .. 1411 G/A rs11558031 - CDS Synonymous[Thr462Thr]
1432 .. 1432 T/C rs57885569 - CDS Synonymous[Ser469Ser]
1432 .. 1432 T/C rs17854071 - CDS Synonymous[Ser469Ser]
1434 .. 1434 C/T rs74783140 - CDS Nonsynonymous[Pro470Leu]
1449 .. 1449 C/G rs61045002 - 3'UTR
1449 .. 1449 C/G rs74323548 - 3'UTR
1451 .. 1451 C/T rs200829999 - 3'UTR
1451 .. 1451 C/G rs74485754 - 3'UTR
1456 .. 1456 G/A rs12882905 - 3'UTR
1456 .. 1456 G/A rs74835042 - 3'UTR
1473 .. 1473 C/T rs11557942 - 3'UTR
1474 .. 1474 A/G rs76392983 - 3'UTR
1491 .. 1491 T/C rs112515991 - 3'UTR
1516 .. 1516 G/C rs11626188 - 3'UTR
1529 .. 1529 A/G rs78933770 - 3'UTR
1533 .. 1533 A/G rs191735996 - 3'UTR
1563 .. 1563 G/T rs28485939 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer