H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000040323 Accession number: BC027866 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Similar to CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC=2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialytransferase St8Sia IV; ST8SiaIV;

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Transcript original information Accession number BC027866.1 CAGE tag ID NA EST ID NA Clone Number IMAGE:5203343 Experimental resources   NBRC ; HGPD ; Antibody (ST8SIA4) ; Catalog (ST8SIA4); Sequence data provider Provider:MGC/NCI;  Annotation project H-Invitational FLcDNA Length of cDNA 1835[bp] (No. of exon:3)[A:620 T:576 G:355 C:284] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type Lung, Spleen, fetal, pooled Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA Site: 1794(+) Signal: 1769-1773(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

AACCTGAGCCCCAGGGAGGCGGCGCGGAGCGACCCTGGCAGAGCTGGCGC AAACAGGGCGAGAGGTCGCTGGGCAGCGTTCGAGGACCAGAGGGAGCTCG GCCACAGAAGACCCCAGTGATCTGATCCCGGGATCCCGGCTCCAAGCTCT CCTCGCATTTTACAGATTTCACCCCCGCGACTATCTCCCCAAAACGGAGC CTTTATATCAAGAGAAGGTGCGGGAGCTGGGGCAACCAGGACTTTCTCGG GCACCCAAGATGCGCTCCATTAGGAAGAAGTGGACGATCTGCACAATAAG TCTGCTCCTGATCTTTTATAAGACAAAAGAAATAGCAAGAACTGAGGAGC ACCAGGAGACGCAACTCATCGGAGATGGTGAATTGTCTTTGAGTCGGTCA CTTGTCAATAGCTCTGATAAAATCATTCGAAAGGCTGGCTCTTCAATCTT CCAGCACAATGTAGAAGGTTGGAAAATCAATTCCTCTTTGGTCCTAGAGA TAAGGAAGAACATACTTCGTTTCTTAGATGCAGAACGAGATGTGTCAGTG GTCAAGAGCAGTTTTAAGCCTGGTGATGTCATACACTATGTGCTTGACAG GCGCCGGACACTAAACATTTCTCATGATCTACATAGCCTCCTACCTGAAG TTTCACCAATGAAGAATCGCAGGTTTAAGACCTGTGCAGTTGTTGGAAAT TCTGGCATTCTGTTAGACAGTGAATGTGGAAAGGAGATTGACAGTCACAA TTTTGTAATAAGGTGAGCTTTCTTCTGCTTTTTGAGATTGTAAGTTTTTC AAAGATATTTTACTTGGGGGTGGAAAACTGTTAGAAAATTTTAAAGTATT ACTAAAACCTCAAACAAATATTTGTCTATGATATCCTTTTCTGTGCAACA TTTAAATTACATTTACCCTGGAATAGAATATTATAATTATTGCGTAGTTG AAAGAAAAAGTGATCCTGTCATAGCAACAAGATTCACACAGCTTTTTTTG GTGAGGTGAGGGGGGAGGCAAATGGCAATTTTATTAAATTTAATATTCCA CACAAACTTTTTTCTTAGTATCTCTTCTTCATACTCATTAGTTTTGTGTG ATTTTATTTGTTGTATAAAGATTATGAATATTACTATGGAATGATGTAAT AGATTTATGTTAATGTTACTTTTTATTAATAATTATCTAGGAGATAGTAA GAACATAGTTTAGCAAGTTTATATTTGATATCCTGAGCCATATTTCTTTA ATTTCTCTTTATATGTGGTATTTGTGTATGTTAGTATATTTGAATTTTAT GTTTTTTTAACATAATTAAGCGTGCATGTTTGTTTTTCATTAACGGTTAA AAGATATTTGATGAATTGTGTGTTTGATTAACCTATTAACTGAAAAAAAC TCAACAGTAGAAATGGAATTATAATCACATCATAAATATAAGCAGTTTTT AATGATCAATTTTTATATCTGTACAGTTTTTTTGGATTGTTTTAGTTCCT TAGAAAAATTAGCTAAATGACAGAAACATGGATATTGAAATATGAAATAG TACAATATAAAGATAGATAGAAAAGTATGCTGAGTTGACATGTTGAAAAA CACAGTCTCTTGAAGATATACTGGAATACATTATTTTTGAATATTTTGAA TATTTTTTGAATATTTTTAAATAAAGTCTTAAAAGCATAAATAGGTAACT ACTTTTAAAAAAAAAGTCATGAGAAATCACACTCAAGCATTATCAAGTGA AGAAAATTCATAATAGCAAATAAAACTGCAAACATTTTACCTTAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0005064
Genomic location	Chromosome	5
	Location	5q21.1
	Position	100221015- 100238918
	Strand	-
Possible duplicated location(s)		NA
Gene structure		3 exon(s)
Database links	RefSeq	NM_005668;  NM_175052;
	Ensembl	ENST00000231461;  ENST00000451528;  ENST00000507360;  ENST00000523381;
	Entrez Gene	Entrez Gene ID:7903;
	KEGG GENES	KEGG GENES(7903);
	GeneCard	ST8SIA4;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000094440 Predicted CDS 260..766;  168[aa];  Orientation:+2;  Codon Adaptation Index (CAI). 0.697 Database links RefSeq NA UniProt Q8N1F4;  CCDS NA

MRSIRKKWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVN SSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKS SFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGI LLDSECGKEIDSHNFVIR*

Motif information

	a.a. length	InterPro	Name
	77	IPR001675	Glycosyl transferase, family 29 [Family]

Gene function information

H-Inv ID		HIT000040323
H-Inv cluster ID		HIX0005064
Accession number		BC027866.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;  Splicing isoform
Coding potential		Protein coding;
Definition		Similar to CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC=2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialytransferase St8Sia IV; ST8SiaIV;
Similarity category		Category: Similar to known protein(Category II).
		Similar to known protein (Q92187)  [Identity/coverage = 99.405%/46.8%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		7624364;  11279095;  14702039;  15489334;  16959974;  ALL;
Gene family/group	H-Inv gene family/group ID	HIF0000663
	Gene family/group name	Sialyltransferase (IPR012163).
	Evidence motif (InterPro) ID	IPR012163
Gene symbol/name	HGNC symbol	ST8SIA4
	HGNC aliases	"sialyltransferase 8 (alpha-2, 8-polysialytransferase) D"
	HGNC name	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
	DDBJ	ST8SIA4
	UniProt	ST8SIA4
EC number		EC 2.4.99.-Transferring Other Glycosyl Groups;
GGDB (GlycoGene Database)	Gene symbol	ST8SIA4
	Familly	Sialyltransferases
	Designation	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
	Expression	fetal brain
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000094440
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NM_005668;  NM_175052;
	Ensembl	ENST00000231461;  ENST00000451528;  ENST00000507360;  ENST00000523381;
	Entrez Gene	Entrez Gene ID:7903;
	KEGG GENES	KEGG GENES(7903);
	GeneCard	ST8SIA4;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Sialyltransferase (IPR012163). Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	sialyltransferase activity (GO:0008373);
Biological process	protein amino acid glycosylation (GO:0006486);
Cellular component	integral to Golgi membrane (GO:0030173);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	extracellular;  mitochondria;  peroxisome;  Other;
Target P	signal peptide
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information

Last modified:20-Apr-2012

Tissue-specific expression			NA
Probe information	AceGene		NA
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	NA
		HG-U133A	NA
		HG-U133A_2	NA
		HG-U133B	NA
		HG-U133_Plus_2	1554460_at;
		HG-U95	NA
		HG-U95A	NA
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2868943;  2868944;  2868946;  2868951;  2868952;  2868953;  2868954;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	A_23_P435601;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:NA Title:NA
Co-localized orphan diseases		OMIM ID:  601888;  608850;  611091;  612554;  612571;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(7903)
	Disease	Entrez Gene ID:(7903)
	Substance	Entrez Gene ID:(7903)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 118 .. 118 T/C rs1428439 - 5'UTR 126 .. 126 T/A rs77888994 - 5'UTR 196 .. 196 G/T rs28617677 - 5'UTR 610 .. 610 A/T rs111610860 - CDS Synonymous[Thr117Thr] 864 .. 864 A/C rs13166792 - 3'UTR 865 .. 865 C/A rs13179860 - 3'UTR 1344 .. 1344 C/T rs11241755 - 3'UTR 1411 .. 1411 A/G rs58824079 - 3'UTR 1439 .. 1439 T/C rs73777433 - 3'UTR 1445 .. 1445 G/C rs57657256 - 3'UTR 1555 .. 1555 A/G rs116786113 - 3'UTR 1620 .. 1620 A/G rs1423380 - 3'UTR 1712 .. 1712 A/C rs6890230 - 3'UTR 1763 .. 1763 A/G rs1541676 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;