H-InvDB x AHG DB
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H-InvDB_8.3 released on March 26, 2013.
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H-Invitational ID: HIT000040323 Accession number: BC027866 Created date: 26-Mar-2013 Last modified: 26-Mar-2013
Definition: Similar to CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC=2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialytransferase St8Sia IV; ST8SiaIV;
 
 

Transcript original information
Accession number BC027866.1
CAGE tag ID NA
EST ID NA
Clone Number IMAGE:5203343
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (ST8SIA4) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (ST8SIA4);
Sequence data provider Provider:MGC/NCI
Annotation project H-Invitational FLcDNA
Length of cDNA 1835[bp] (No. of exon:3)[A:620 T:576 G:355 C:284]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Lung, Spleen, fetal, pooled
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 1794(+) Signal: 1769-1773(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0005064
Genomic location  G-integra Help Chromosome 5
Location 5q21.1
Position 100221015- 100238918
Strand -
Possible duplicated location(s) NA
Gene structure 3 exon(s)
Database links RefSeq NM_005668NM_175052
Ensembl ENST00000231461ENST00000451528ENST00000507360ENST00000523381
Entrez Gene Entrez Gene ID:7903
KEGG GENES KEGG GENES(7903)
GeneCard GeneCardST8SIA4*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000094440
Predicted CDS 260..766;  168[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.697
Database links RefSeq NA
UniProt Q8N1F4
CCDS NA

Motif information
ORF

length(168),orf(260:766)
MRSIRKKWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVN
SSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKS
SFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGI
LLDSECGKEIDSHNFVIR*
a.a.
length
InterPro Name
length(77), motif(92:168) 77 IPR001675 Glycosyl transferase, family 29 [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000040323
H-Inv cluster ID Locus viewHIX0005064
Accession number BC027866.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC=2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialytransferase St8Sia IV; ST8SiaIV;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q92187)  [Identity/coverage = 99.405%/46.8%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 762436411279095147020391548933416959974ALL
Gene family/group Gene family H-Inv gene family/group ID HIF0000663
Gene family/group name Sialyltransferase (IPR012163).
Evidence motif (InterPro) ID IPR012163
Gene symbol/name HGNC symbol ST8SIA4
HGNC aliases "sialyltransferase 8 (alpha-2, 8-polysialytransferase) D"
HGNC name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
DDBJ ST8SIA4
UniProt ST8SIA4
EC number EC 2.4.99.-Transferring Other Glycosyl Groups; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000094440
No. of interaction 2
Interaction partner(s) HIP000075301HIP000094440
BIND NA
DIP NA
MINT NA
HPRD 00301;  03970; 
IntAct NA
Database links RefSeq NM_005668NM_175052
Ensembl ENST00000231461ENST00000451528ENST00000507360ENST00000523381
Entrez Gene Entrez Gene ID:7903
KEGG GENES KEGG GENES(7903)
GeneCard GeneCardST8SIA4*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Sialyltransferase (IPR012163). Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function sialyltransferase activity (GO:0008373); 
Biological process protein amino acid glycosylation (GO:0006486); 
Cellular component integral to Golgi membrane (GO:0030173); 

Subcellular localization information  Last modified:26-Mar-2013
WoLF PSORT extracellular;  mitochondria;  peroxisome;  Other; 
Target P signal peptide
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information  H-ANGEL DNAProbeLocator Last modified:26-Mar-2013
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene NA
Affymetrix
GeneChip
HG-Focus NA
HG-U133 NA
HG-U133A NA
HG-U133A_2 NA
HG-U133B NA
HG-U133_Plus_2 1554460_at; 
HG-U95 NA
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2868943;  2868944;  2868946;  2868951;  2868952;  2868953;  2868954; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 A_23_P435601; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:26-Mar-2013
Disease relation Disease name:NA
Related information in OMIM OMIM ID:NA Title:NA
Co-localized orphan diseases OMIM ID:  601888608850611091612554612571
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(7903)
Disease Entrez Gene ID:(7903)
Substance Entrez Gene ID:(7903)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo ViewerLEGENDALEGENDA

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
118 .. 118 T/C rs1428439 - 5'UTR
126 .. 126 T/A rs77888994 - 5'UTR
196 .. 196 G/T rs28617677 - 5'UTR
610 .. 610 A/T rs111610860 - CDS Synonymous[Thr117Thr]
864 .. 864 A/C rs13166792 - 3'UTR
865 .. 865 C/A rs13179860 - 3'UTR
1344 .. 1344 C/T rs11241755 - 3'UTR
1411 .. 1411 A/G rs58824079 - 3'UTR
1439 .. 1439 T/C rs73777433 - 3'UTR
1445 .. 1445 G/C rs57657256 - 3'UTR
1555 .. 1555 A/G rs116786113 - 3'UTR
1620 .. 1620 A/G rs1423380 - 3'UTR
1712 .. 1712 A/C rs6890230 - 3'UTR
1763 .. 1763 A/G rs1541676 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene Repeat mask viewerRepeat Mask Viewer