H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000038249 Accession number: BC018064 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Pseudogene candidate (Proteasome activator complex subunit 3; Activator of multicatalytic protease subunit 3; Proteasome activator 28 subunit gamma; PA28g; PA28gamma;)

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Transcript original information Accession number BC018064.1 CAGE tag ID NA EST ID NA Clone Number IMAGE:4816525 Experimental resources   NBRC ; HGPD ; Sequence data provider Provider:MGC/NCI;  Annotation project H-Invitational FLcDNA Length of cDNA 1377[bp] (No. of exon:1)[A:373 T:352 G:337 C:315] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type Brain, hippocampus Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA Site: 1363(+) Signal: 1336-1340(+) Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

AGCGGTCTGTTGGGAGTTGTGGCGGCGGCGAGGCCCAAGCACAGCTGGCC AAGGCGGGTGTAAAACGCGGGTCGTGTCCACCCCAAAGCTCGACGCCTCT AGAAGCCATGGCTTTTCTGCTGAAGCTAGAGCCGGACATGCAGGGGAAAG TAGATTTGTTTCGAGCCCGTATCGCCCAGGAGGCCGAGGATCTCGTGTCC ACCTTCTTTCCTCAGAAGGTCTTGGAGCTGAATAGCCGAGTTCAGGAGCT CCGGCTGCAAGACCTGTCCAGAATCCATTCGGTGCCAACCTCGGAGCCCC TGGCCACCCCAGGCAACAAGGGAGATGGGCCCAACCAAAATCTGCCAGTT CTGCTGACTCAGTTCTCCATCAAGGTCCCAGCACTGCTTGGCAGCGAGGG ACAGCTTCTGCGGAGCAACCAGCATCTGGTGGAGTTGACTGAGTGGGTGA AACCTGAGATCAAGCTGCTGAGAGAGAAATGCAACACAGTGCACATGTAG GTGCACCCGCTTATCCTGAAGGTGGAGGACGGCAACAACTTCAGGGTGTC TATCCAGGAAGACACTGTGGACCAGCTGTGGACCGTGGATAGCACAGCGG CCTCCTCTCTATGCGGCTTCTCCACCTACTACAACACCCAGGCCAAGTTG GTATCCAAGATAGTGAAGTACCCCCAAGTGGAAGATTATCGCTGCACTGT AGCAGAGGTCGACGAAAACGAGTACCTGAGTGTGCGCCAGATCCTGCTGC ACCTACGGAACGAGTATGCCACCTTGCGTGATGTAATCCTTAAAAACATT GAGAAGATCAAGATCCCTCGGAGCACCAACCGTGATAACCTATACTGATA GCCTTTCTCCACCCCATTTGCCTTCAGGAGTTGGCGGAGCTGTTTAGGCA CCTAGAAGGCTGGTTATTAATGACTCTACAGGTCATGAAATTACTGGAAA TGTGTGTTACCATTTAGAATTTCATACAGCTTATCCTCATACTGAATCAT CTTTTGGTGTAATTTTTATTTGATTTTCCTTTTGTGAGGAGAATGGGGAC AAACCATCAAAAAGAAAAGACTGCCATTTTTAAAAGCAGCTTTATAGATA AATGTTGGCCCAAGGTTTCTTTATTATGGCCTTAGCGACATTGAATGGTT TTAGGGGCTACTTAAAAACTAAATCTTAAAGTTAAATGAAGTTTTTCCTA AAGTTCTGCTATCCGTTGAACTTTGTTCAAACTTACAGAAATGCTCCTTT TACAGCATCATTTTTCTTTTTTGCGAGGAACGGAGTTTAAAGGGATATGT TTAGGTCATTGTATGCCTCCAGTTTAACAGATTGAAATAAAACTTGGTTA TAAAATTTTGTGAAAAAAAAAAAAAAA

Gene structure information

H-Inv cluster ID		HIX0001254
Genomic location	Chromosome	1
	Location	1q23.3
	Position	161860623- 161861986
	Strand	+
Possible duplicated location(s)		NA
Gene structure		1 exon(s)
Database links	RefSeq	NA
	Ensembl	ENST00000457671;  ENST00000458136;
	Entrez Gene	NA
	KEGG GENES	NA
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000026680 Predicted CDS 108..500;  130[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.796

MAFLLKLEPDMQGKVDLFRARIAQEAEDLVSTFFPQKVLELNSRVQELRL QDLSRIHSVPTSEPLATPGNKGDGPNQNLPVLLTQFSIKVPALLGSEGQL LRSNQHLVELTEWVKPEIKLLREKCNTVHM*

Motif information

	a.a. length	InterPro	Name
	129	IPR009077	Proteasome activator pa28, REG alpha/beta subunit [Family]
	126	IPR009077	Proteasome activator pa28, REG alpha/beta subunit [Family]
	54	IPR003185	Proteasome activator pa28, REG alpha subunit [Domain]
	51	IPR003185	Proteasome activator pa28, REG alpha subunit [Domain]

Gene function information

H-Inv ID		HIT000038249
H-Inv cluster ID		HIX0001254
Accession number		BC018064.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		Representative transcript;
Coding potential		Pseudogene candidates;
Definition		Pseudogene candidate (Proteasome activator complex subunit 3; Activator of multicatalytic protease subunit 3; Proteasome activator 28 subunit gamma; PA28g; PA28gamma;)
Similarity category		Category: Pseudogene candidate(Category VII).
		Pseudogene candidate.
Experimental evidence		NA
PubMed ID		15642098;  16287166;  ALL;
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	NA
	HGNC aliases	NA
	HGNC name	NA
	DDBJ	NA
	UniProt	PSME3
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	NA
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NA
	Ensembl	ENST00000457671;  ENST00000458136;
	Entrez Gene	NA
	KEGG GENES	NA
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Human curated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	proteasome activator activity (GO:0008538);
Cellular component	proteasome activator complex (GO:0008537);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	cytosol;  nuclear;  mitochondria;  Other;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 5 130 1avo.1 4e-07 32.6 89/100 a.24.8.1

Related H-InvDB links GTOP

Gene expression information

Last modified:20-Apr-2012

Tissue-specific expression			NA
Probe information	AceGene		NA
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	243581_at;
		HG-U133A	NA
		HG-U133A_2	NA
		HG-U133B	243581_at;
		HG-U133_Plus_2	243581_at;
		HG-U95	47683_at;
		HG-U95A	NA
		HG-U95B	47683_at;
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2363994;  2363995;  2363996;  2363997;  2363998;  2363999;  2364000;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	A_32_P461784;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:NA Title:NA
Co-localized orphan diseases		OMIM ID:  115665;  116600;  155600;  600975;  605225;  605606;  606788;  606852;  606928;  607317;  607671;  608543;  608553;  608995;  610320;  612367;  612596;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	NA
	Disease	NA
	Substance	NA
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Evolutionary information

Last modified:20-Apr-2012

Relationship	Species	Accession number	MGI	Links
Orthology	Monodelphis sp. (Opossum)	XM_001362995		G-integra
Orthology	Bos sp. (Cow)	XM_598451		G-integra
Orthology	Rattus sp. (Rat)	XR_005705		G-integra
Orthology	Mus sp. (Mouse)	XR_032623		G-integra

Phylogenetic tree [View by ATV]	Neighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS (under constraction);

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 92 .. 92 G/C rs79004534 + 5'UTR 318 .. 318 A/G rs12032568 + CDS Nonsynonymous[Lys71Glu] 336 ^ 337 -/A rs34981911 + CDS 525 .. 525 G/C rs10753666 + 3'UTR 707 .. 707 G/A rs111541012 + 3'UTR 800 .. 800 T/C rs78671576 + 3'UTR 888 .. 888 A/C rs113726452 + 3'UTR 898 .. 898 G/T rs112597133 + 3'UTR 976 .. 976 A/T rs111323828 + 3'UTR 1084 .. 1084 A/T rs78056510 + 3'UTR 1277 .. 1277 G/A rs115336828 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;