H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000035371 Accession number: BC011682 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Cathepsin F; CATSF; EC=3.4.22.41; Precursor;
 
 

Transcript original information
Accession number BC011682.2
CAGE tag ID NA
EST ID NA
Clone Number MGC:19716 IMAGE:3535532
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (CTSF) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (CTSF);
Sequence data provider Provider:MGC/NCI
Annotation project H-Invitational FLcDNA
Length of cDNA 2052[bp] (No. of exon:13)[A:433 T:415 G:607 C:597]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type Lung, small cell carcinoma
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 2010(+) Signal: 1985-1989(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGAAG;  CAGGAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0009840
Genomic location  G-integra Help Chromosome 11
Location 11q13.2
Position 66330934- 66336041
Strand -
Possible duplicated location(s) NA
Gene structure 13 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8722
KEGG GENES KEGG GENES(8722)
GeneCard GeneCardCTSF*GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000031798
Predicted CDS 85..1539;  484[aa];  Orientation:+1; 
Codon Adaptation Index (CAI). 0.826
Database links RefSeq NP_003784
UniProt Q9UBX1
CCDS CCDS8144

Motif information
ORF

length(484),orf(85:1539)
MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMF
NRGRAAGTRAVLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVS
KKTLLCSFQVLDELGRHVLLRKDCGPVDTKVPGAGEPKSAFTQGSAMISS
LSQNHPDNRNETFSSVISLLNEDPLSQDLPVKMASIFKNFVITYNRTYES
KEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLTEEEFRTIYLN
TLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSV
TGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGG
LETEDDYSYQGHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPI
SVAINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSDVPFWAIK
NSWGTDWGEKGYYYLHRGSGACGVNTMASSAVVD*
a.a.
length
InterPro Name
length(444), motif(41:484) 444 IPR013128 Peptidase C1A [Family]
length(58), motif(187:244) 58 IPR013201 Proteinase inhibitor I29, cathepsin propeptide [Domain]
length(212), motif(271:482) 212 IPR000668 Peptidase C1A, papain C-terminal [Domain]
length(210), motif(272:481) 210 IPR000668 Peptidase C1A, papain C-terminal [Domain]
length(16), motif(289:304) 16 IPR000668 Peptidase C1A, papain C-terminal [Domain]
length(12), motif(289:300) 12 IPR000169 Cysteine peptidase, cysteine active site [Active_site]
length(11), motif(429:439) 11 IPR025660 Cysteine peptidase, histidine active site [Active_site]
length(11), motif(431:441) 11 IPR000668 Peptidase C1A, papain C-terminal [Domain]
length(7), motif(446:452) 7 IPR000668 Peptidase C1A, papain C-terminal [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000035371
H-Inv cluster ID Locus viewHIX0009840
Accession number BC011682.2
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript; 
Coding potential  Help Protein coding; 
Definition Cathepsin F; CATSF; EC=3.4.22.41; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (Q9UBX1)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 9822672101982091031878410362521106618721222574914702039154893341797400519159218ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol CTSF
HGNC aliases NA
HGNC name cathepsin F
DDBJ CTSF
UniProt CTSF
EC number EC 3.4.22.41cathepsin F; 
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000031798
No. of interaction 3
Interaction partner(s) HIP000021325HIP000025404HIP000057840
BIND NA
DIP NA
MINT NA
HPRD 00825; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8722
KEGG GENES KEGG GENES(8722)
GeneCard GeneCardCTSF*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Human curated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
FR ID FR042847
Accession
Description
Location
PMID
FR ID FR157191
Accession
Description
Location
PMID

Gene ontology information
Molecular function cysteine-type peptidase activity (GO:0008234); 
Biological process proteolysis (GO:0006508); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT extracellular;  lysosome; 
Target P signal peptide
SOSUI membrane protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
34 124 1cewI 2e-05 20.9 91/108 d.17.1.2
182 483 1by8A 6e-67 31.8 302/310 d.3.1.1
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsA100305; 
Affymetrix
GeneChip
HG-Focus 203657_s_at; 
HG-U133 203657_s_at; 
HG-U133A 203657_s_at; 
HG-U133A_2 203657_s_at; 
HG-U133B NA
HG-U133_Plus_2 203657_s_at; 
HG-U95 39846_at;  86110_at; 
HG-U95A 39846_at; 
HG-U95B NA
HG-U95C NA
HG-U95D 86110_at; 
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3378345;  3378346;  3378347;  3378349;  3378350;  3378351;  3378352;  3378355;  3378356;  3378357;  3378358;  3378359;  3378360;  3378361;  3378362;  3378365;  3378366;  3378367; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P24433; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P24433; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Evolutionary information  Evola Help Last modified:27-May-2015
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) AF197480 G-integraG-integra
Orthology Rattus sp. (Rat) BC099780 G-integraG-integra
Orthology Danio sp. (Zebrafish) BC124243 G-integraG-integra
Orthology Bos sp. (Cow) ENSBTAT00000014587 G-integraG-integra
Orthology Canis sp. (Dog) ENSCAFT00000019742 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000003620 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000152201 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001379243 G-integraG-integra
Orthology Equus sp. (Horse) XM_001491486 G-integraG-integra
Orthology Macaca sp. (Macaque) XR_013716 G-integraG-integra
Orthology Pan sp. (Chimpanzee) XR_022326 G-integraG-integra
Phylogenetic tree [View by ATV]
Neighbor-joining (phb) 
Related H-InvDB links EvolaEvoladN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
129 .. 129 G/T rs117792851 - CDS Synonymous[Pro15Pro]
210 .. 210 C/T rs1044522 + CDS Synonymous[Pro42Pro]
284 .. 284 G/A rs35342226 - CDS Nonsynonymous[Gly67Asp]
303 .. 303 C/T rs1127894 + CDS Synonymous[Gly73Gly]
310 .. 310 T/G rs200958879 - CDS Nonsynonymous[Ser76Ala]
385 .. 385 A/G rs143077418 - CDS Nonsynonymous[Lys101Glu]
435 .. 435 C/T rs112809338 - CDS Synonymous[His117His]
502 .. 502 G/A rs79274952 - CDS Nonsynonymous[Ala140Thr]
504 .. 504 C/T rs149140177 - CDS Synonymous[Ala140Ala]
542 .. 542 A/G rs11550508 + CDS Nonsynonymous[Gln153Arg]
621 .. 621 G/A rs150481606 - CDS Synonymous[Leu179Leu]
645 .. 645 C/T rs200610855 - CDS Synonymous[Phe187Phe]
648 .. 648 G/C rs140630766 - CDS Nonsynonymous[Lys188Asn]
651 .. 651 C/A rs142743244 - CDS Nonsynonymous[Asn189Lys]
663 .. 663 C/T rs202226607 - CDS Synonymous[Thr193Thr]
667 .. 667 A/G rs146841814 - CDS Nonsynonymous[Asn195Asp]
671 .. 671 G/A rs143814748 - CDS Nonsynonymous[Arg196Gln]
681 .. 681 G/A rs200932066 - CDS Synonymous[Glu199Glu]
698 .. 698 G/T rs142782021 - CDS Nonsynonymous[Arg205Leu]
712 .. 712 G/A rs180808563 - CDS Nonsynonymous[Val210Ile]
723 .. 723 T/A rs146697999 - CDS Nonsynonymous[Asn213Lys]
747 .. 747 C/G rs190243917 - CDS Nonsynonymous[Ile221Met]
760 .. 760 C/T rs143313688 - CDS Nonsynonymous[Arg226Cys]
767 .. 767 C/G rs148611356 - CDS Nonsynonymous[Thr228Arg]
776 .. 776 A/G rs143889283 - CDS Nonsynonymous[Tyr231Cys]
784 .. 784 A/T rs149533017 - CDS Nonsynonymous[Thr234Ser]
820 .. 820 A/G rs201753663 - CDS Nonsynonymous[Thr246Ala]
846 .. 846 A/G/T rs545009 + CDS
864 .. 864 G/A rs140002533 - CDS Synonymous[Lys260Lys]
894 .. 894 C/T rs147398226 - CDS Synonymous[Leu270Leu]
951 .. 951 G/T rs142805637 - CDS Nonsynonymous[Gln289His]
1023 .. 1023 G/A rs114727660 - CDS Synonymous[Gly313Gly]
1089 .. 1089 C/T rs147269500 - CDS Synonymous[Gly335Gly]
1090 .. 1090 G/A rs189862070 - CDS Nonsynonymous[Gly336Ser]
1112 .. 1112 C/T rs200646712 - CDS Nonsynonymous[Ser343Leu]
1175 .. 1175 A/G rs200760567 - CDS Nonsynonymous[Gln364Arg]
1184 .. 1184 A/G rs201500574 - CDS Nonsynonymous[Asn367Ser]
1217 .. 1217 A/G rs148080813 - CDS Nonsynonymous[Asn378Ser]
1224 .. 1224 C/G rs143674429 - CDS Synonymous[Ser380Ser]
1242 .. 1242 C/T rs116329758 - CDS Synonymous[Asn386Asn]
1287 .. 1287 C/T rs139027846 - CDS Synonymous[Ser401Ser]
1322 .. 1322 G/A rs145087378 - CDS Nonsynonymous[Arg413His]
1327 .. 1327 G/A rs200426008 - CDS Nonsynonymous[Gly415Arg]
1337 .. 1337 G/A rs141345438 - CDS Nonsynonymous[Arg418His]
1345 .. 1345 C/T rs28464796 - CDS Nonsynonymous[Arg421Trp]
1346 .. 1346 G/A rs201295932 - CDS Nonsynonymous[Arg421Gln]
1398 .. 1398 C/T rs149687246 - CDS Synonymous[Tyr438Tyr]
1399 .. 1399 G/A rs140795906 - CDS Nonsynonymous[Gly439Ser]
1405 .. 1405 C/T rs150922871 - CDS Nonsynonymous[Arg441Cys]
1418 .. 1418 C/T rs142523550 - CDS Nonsynonymous[Pro445Leu]
1452 .. 1452 C/T rs148155987 - CDS Synonymous[Asp456Asp]
1485 .. 1485 C/T rs572846 + CDS Synonymous[Arg467Arg]
1491 .. 1491 C/T rs144556402 - CDS Synonymous[Ser469Ser]
1492 .. 1492 G/A rs201552564 - CDS Nonsynonymous[Gly470Arg]
1541 .. 1541 G/A rs140501443 - 3'UTR
1677 .. 1677 T/C rs188785271 - 3'UTR
1774 .. 1774 A/G rs13897 + 3'UTR
1880 .. 1880 C/T rs145799081 - 3'UTR
1943 .. 1943 C/T rs4576 + 3'UTR
1986 .. 1986 A/G rs140647918 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer