<?xml version="1.0" standalone="yes" ?> <H-Inv> <cDNAXML> <CLUSTER-ID>HIX0005159</CLUSTER-ID> <CLUSTER-ID-VERSION>HIX0005159.18</CLUSTER-ID-VERSION> <H-INVITATIONAL-ID>HIT000034397</H-INVITATIONAL-ID> <H-INVITATIONAL-ID-VERSION>HIT000034397.18</H-INVITATIONAL-ID-VERSION> <ACCESSION-NO>BC009483</ACCESSION-NO> <ACCESSION-NO-VERSION>BC009483.2</ACCESSION-NO-VERSION> <GENOME-STATISTICS>build 37.1</GENOME-STATISTICS> <DIVISION>HUM</DIVISION> <MOL-TYPE>mRNA</MOL-TYPE> <CDNA_DATE-CREATE>26-Mar-2013</CDNA_DATE-CREATE> <CDNA_DATE-LAST-MODIFIED>26-Mar-2013</CDNA_DATE-LAST-MODIFIED> <CDNA_H-INV-DB-RELEASE>8.3</CDNA_H-INV-DB-RELEASE> <CDNA_DATE-ANNOTATION-LAST-UPDATE>20-Apr-2012</CDNA_DATE-ANNOTATION-LAST-UPDATE> <CDNA_DATE-ANNOTATION-LAST-MODIFIED>20-Apr-2012</CDNA_DATE-ANNOTATION-LAST-MODIFIED> <CHROMOSOME-NUMBER>5</CHROMOSOME-NUMBER> <CHROMOSOME-BAND>5q31.1</CHROMOSOME-BAND> <CDNA_START>131818780</CDNA_START> <CDNA_END>131826434</CDNA_END> <CDNA_STRAND>-</CDNA_STRAND> 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<CDNA_DB-REFERENCE_REFSEQ>NM_002198</CDNA_DB-REFERENCE_REFSEQ> <CDNA_REP-H-INVITATIONAL>Representative transcript</CDNA_REP-H-INVITATIONAL> <CDNA_PROTEIN_REP_H-INVITATIONAL>Representative transcript</CDNA_PROTEIN_REP_H-INVITATIONAL> <CDNA_SPLICING-ISOFORM_CURATION>Splicing isoform</CDNA_SPLICING-ISOFORM_CURATION> <CDNA_SPLICE-ACCEPTOR>CAGGAG</CDNA_SPLICE-ACCEPTOR> <CDNA_H-INVITATIONAL-PROTEIN-ID>HIP000084307</CDNA_H-INVITATIONAL-PROTEIN-ID> <CDNA_H-INVITATIONAL-PROTEIN-ID-VERSION>HIP000084307.1</CDNA_H-INVITATIONAL-PROTEIN-ID-VERSION> <CDNA_NO_OF_INTERACTION>12</CDNA_NO_OF_INTERACTION> <CDNA_INTERACTION-PARTNER>HIP000026951</CDNA_INTERACTION-PARTNER> <CDNA_INTERACTION-PARTNER>HIP000027985</CDNA_INTERACTION-PARTNER> <CDNA_INTERACTION-PARTNER>HIP000069516</CDNA_INTERACTION-PARTNER> <CDNA_INTERACTION-PARTNER>HIP000085289</CDNA_INTERACTION-PARTNER> <CDNA_INTERACTION-PARTNER>HIP000095247</CDNA_INTERACTION-PARTNER> <CDNA_INTERACTION-PARTNER>HIP000096767</CDNA_INTERACTION-PARTNER> 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<CDNA_DB-REFERENCE_INACT-ID>EBI-2341978</CDNA_DB-REFERENCE_INACT-ID> <JOURNAL_DB-REFERENCE_MEDLINE>15103394</JOURNAL_DB-REFERENCE_MEDLINE> <MRNA-INSPECTION> <CLONE-NUMBER_ORIGINAL>MGC:15355 IMAGE:3623414</CLONE-NUMBER_ORIGINAL> <TISSUE-TYPE-ORIGIN_ORIGINAL>Pancreas, adenocarcinoma</TISSUE-TYPE-ORIGIN_ORIGINAL> <DATA-PROVIDER>MGC/NCI</DATA-PROVIDER> <LENGTH-OF-CDNA_ORIGINAL>2061</LENGTH-OF-CDNA_ORIGINAL> <NUMBER-OF-EXON_ORIGINAL>10</NUMBER-OF-EXON_ORIGINAL> <NUMBER-OF-A_ORIGINAL>497</NUMBER-OF-A_ORIGINAL> <NUMBER-OF-T_ORIGINAL>425</NUMBER-OF-T_ORIGINAL> <NUMBER-OF-G_ORIGINAL>556</NUMBER-OF-G_ORIGINAL> <NUMBER-OF-C_ORIGINAL>583</NUMBER-OF-C_ORIGINAL> </MRNA-INSPECTION> <PATHOLOGY> <PATHOLOGY_DATE-LAST-UPDATE>20-Apr-2012</PATHOLOGY_DATE-LAST-UPDATE> <PATHOLOGY_DATE-LAST-MODIFIED>20-Apr-2012</PATHOLOGY_DATE-LAST-MODIFIED> <KNOWN-DISEASE-GENE> <CDNA-OMIM_DB-REFERENCE_OMIM-DISEASE>137215</CDNA-OMIM_DB-REFERENCE_OMIM-DISEASE> <CDNA-OMIM_DISEASE_DISEASE-NAME>Gastric cancer</CDNA-OMIM_DISEASE_DISEASE-NAME> <CDNA-OMIM_DB-REFERENCE_OMIM-DISEASE>153550</CDNA-OMIM_DB-REFERENCE_OMIM-DISEASE> <CDNA-OMIM_DISEASE_DISEASE-NAME>Macrocytic anemia, refractory, of 5q- syndrome</CDNA-OMIM_DISEASE_DISEASE-NAME> <CDNA-OMIM_DISEASE-RELATION>Myelodysplastic syndrome, preleukemic</CDNA-OMIM_DISEASE-RELATION> <CDNA-OMIM_DISEASE-RELATION>Myelogenous leukemia, acute</CDNA-OMIM_DISEASE-RELATION> <CDNA-OMIM_DISEASE-RELATION>Nonsmall cell lung cancer</CDNA-OMIM_DISEASE-RELATION> <CDNA-OMIM_DB-REFERENCE_OMIM>147575</CDNA-OMIM_DB-REFERENCE_OMIM> <CDNA-OMIM_MORBID-MAP_OMIM-TITLE>INTERFERON REGULATORY FACTOR 1</CDNA-OMIM_MORBID-MAP_OMIM-TITLE> </KNOWN-DISEASE-GENE> <ORPHAN-DISEASE_DB-REFERENCE_LOCUS-OMIM>601888</ORPHAN-DISEASE_DB-REFERENCE_LOCUS-OMIM> <ORPHAN-DISEASE_DB-REFERENCE_LOCUS-OMIM>608850</ORPHAN-DISEASE_DB-REFERENCE_LOCUS-OMIM> <ORPHAN-DISEASE_DB-REFERENCE_LOCUS-OMIM>611091</ORPHAN-DISEASE_DB-REFERENCE_LOCUS-OMIM> <ORPHAN-DISEASE_DB-REFERENCE_LOCUS-OMIM>612554</ORPHAN-DISEASE_DB-REFERENCE_LOCUS-OMIM> <ORPHAN-DISEASE_DB-REFERENCE_LOCUS-OMIM>612571</ORPHAN-DISEASE_DB-REFERENCE_LOCUS-OMIM> </PATHOLOGY> <EVOLUTIONARY-FEATURE> <EVOLUTIONARY-FEATURE_DATE-LAST-UPDATE>20-Apr-2012</EVOLUTIONARY-FEATURE_DATE-LAST-UPDATE> <EVOLUTIONARY-FEATURE_DATE-LAST-MODIFIED>20-Apr-2012</EVOLUTIONARY-FEATURE_DATE-LAST-MODIFIED> <ORTHOLOGY> <ACCESSION-NO>AK157347</ACCESSION-NO> <SPECIES>Mus sp. (Mouse)</SPECIES> </ORTHOLOGY> <ORTHOLOGY> <ACCESSION-NO>BC102766</ACCESSION-NO> <SPECIES>Bos sp. (Cow)</SPECIES> </ORTHOLOGY> <ORTHOLOGY> <ACCESSION-NO>ENSGALT00000002244</ACCESSION-NO> <SPECIES>Gallus sp. (Chicken)</SPECIES> </ORTHOLOGY> <ORTHOLOGY> <ACCESSION-NO>ENSMMUT00000011322</ACCESSION-NO> <SPECIES>Macaca sp. (Macaque)</SPECIES> </ORTHOLOGY> <ORTHOLOGY> <ACCESSION-NO>ENSPPYT00000018338</ACCESSION-NO> <SPECIES>Pongo sp. (Orangutan)</SPECIES> </ORTHOLOGY> <ORTHOLOGY> <ACCESSION-NO>ENSPTRT00000031881</ACCESSION-NO> <SPECIES>Pan sp. (Chimpanzee)</SPECIES> </ORTHOLOGY> <ORTHOLOGY> <ACCESSION-NO>GSTENT00037577001</ACCESSION-NO> <SPECIES>Tetraodon sp. (Tetraodon)</SPECIES> </ORTHOLOGY> <ORTHOLOGY> <ACCESSION-NO>M34253</ACCESSION-NO> <SPECIES>Rattus sp. (Rat)</SPECIES> </ORTHOLOGY> <ORTHOLOGY> <ACCESSION-NO>SINFRUT00000130702</ACCESSION-NO> <SPECIES>Takifugu sp. (Fugu)</SPECIES> </ORTHOLOGY> <ORTHOLOGY> <ACCESSION-NO>XM_001371779</ACCESSION-NO> <SPECIES>Monodelphis sp. (Opossum)</SPECIES> </ORTHOLOGY> <ORTHOLOGY> <ACCESSION-NO>XM_001504445</ACCESSION-NO> <SPECIES>Equus sp. (Horse)</SPECIES> </ORTHOLOGY> <ORTHOLOGY> <ACCESSION-NO>XM_538621</ACCESSION-NO> <SPECIES>Canis sp. (Dog)</SPECIES> </ORTHOLOGY> </EVOLUTIONARY-FEATURE> <CDNA-INFO> <SNP> <SNP_START>22</SNP_START> <SNP_END>22</SNP_END> <SNP_LOCATION-TYPE>..</SNP_LOCATION-TYPE> <SNP_DB-REFERENCE_DBSNP>rs11242115</SNP_DB-REFERENCE_DBSNP> <SNP_BASE-CDNA>G/C</SNP_BASE-CDNA> <SNP_LOCATION>5'UTR</SNP_LOCATION> <SNP_STRAND>+</SNP_STRAND> </SNP> <SNP> <SNP_START>113</SNP_START> <SNP_END>113</SNP_END> <SNP_LOCATION-TYPE>..</SNP_LOCATION-TYPE> <SNP_DB-REFERENCE_DBSNP>rs10900809</SNP_DB-REFERENCE_DBSNP> <SNP_BASE-CDNA>T/C</SNP_BASE-CDNA> <SNP_LOCATION>5'UTR</SNP_LOCATION> <SNP_STRAND>+</SNP_STRAND> </SNP> <SNP> <SNP_START>125</SNP_START> <SNP_END>125</SNP_END> <SNP_LOCATION-TYPE>..</SNP_LOCATION-TYPE> <SNP_DB-REFERENCE_DBSNP>rs960757</SNP_DB-REFERENCE_DBSNP> <SNP_BASE-CDNA>C/T</SNP_BASE-CDNA> <SNP_LOCATION>5'UTR</SNP_LOCATION> <SNP_STRAND>+</SNP_STRAND> </SNP> <SNP> <SNP_START>128</SNP_START> <SNP_END>128</SNP_END> <SNP_LOCATION-TYPE>..</SNP_LOCATION-TYPE> <SNP_DB-REFERENCE_DBSNP>rs111285485</SNP_DB-REFERENCE_DBSNP> <SNP_BASE-CDNA>C/T</SNP_BASE-CDNA> <SNP_LOCATION>5'UTR</SNP_LOCATION> <SNP_STRAND>-</SNP_STRAND> </SNP> <SNP> <SNP_START>172</SNP_START> <SNP_END>172</SNP_END> <SNP_LOCATION-TYPE>..</SNP_LOCATION-TYPE> <SNP_DB-REFERENCE_DBSNP>rs17848393</SNP_DB-REFERENCE_DBSNP> <SNP_BASE-CDNA>G/A</SNP_BASE-CDNA> <SNP_LOCATION>5'UTR</SNP_LOCATION> <SNP_STRAND>+</SNP_STRAND> </SNP> <SNP> <SNP_START>305</SNP_START> <SNP_END>305</SNP_END> <SNP_LOCATION-TYPE>..</SNP_LOCATION-TYPE> <SNP_DB-REFERENCE_DBSNP>rs117282832</SNP_DB-REFERENCE_DBSNP> <SNP_BASE-CDNA>C/T</SNP_BASE-CDNA> <SNP_LOCATION>CDS</SNP_LOCATION> <SNP_TRANSLATION>Synonymous[Phe34Phe]</SNP_TRANSLATION> <SNP_STRAND>-</SNP_STRAND> </SNP> <SNP> <SNP_START>548</SNP_START> <SNP_END>548</SNP_END> <SNP_LOCATION-TYPE>..</SNP_LOCATION-TYPE> <SNP_DB-REFERENCE_DBSNP>rs17622685</SNP_DB-REFERENCE_DBSNP> <SNP_BASE-CDNA>C/G</SNP_BASE-CDNA> <SNP_LOCATION>CDS</SNP_LOCATION> 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<SNP_TRANSLATION>Synonymous[Gly284Gly]</SNP_TRANSLATION> <SNP_STRAND>-</SNP_STRAND> </SNP> <SNP> <SNP_START>1146</SNP_START> <SNP_END>1146</SNP_END> <SNP_LOCATION-TYPE>..</SNP_LOCATION-TYPE> <SNP_DB-REFERENCE_DBSNP>rs55746618</SNP_DB-REFERENCE_DBSNP> <SNP_BASE-CDNA>T/C</SNP_BASE-CDNA> <SNP_LOCATION>CDS</SNP_LOCATION> <SNP_TRANSLATION>Synonymous[Leu315Leu]</SNP_TRANSLATION> <SNP_STRAND>-</SNP_STRAND> </SNP> <SNP> <SNP_START>1218</SNP_START> <SNP_END>1218</SNP_END> <SNP_LOCATION-TYPE>..</SNP_LOCATION-TYPE> <SNP_DB-REFERENCE_DBSNP>rs56288038</SNP_DB-REFERENCE_DBSNP> <SNP_BASE-CDNA>C/G</SNP_BASE-CDNA> <SNP_LOCATION>3'UTR</SNP_LOCATION> <SNP_STRAND>-</SNP_STRAND> </SNP> <SNP> <SNP_START>1323</SNP_START> <SNP_END>1323</SNP_END> <SNP_LOCATION-TYPE>..</SNP_LOCATION-TYPE> <SNP_DB-REFERENCE_DBSNP>rs17848427</SNP_DB-REFERENCE_DBSNP> <SNP_BASE-CDNA>C/T</SNP_BASE-CDNA> <SNP_LOCATION>3'UTR</SNP_LOCATION> <SNP_STRAND>+</SNP_STRAND> </SNP> <SNP> <SNP_START>1562</SNP_START> <SNP_END>1562</SNP_END> 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<EXON-CDNA_END>198</EXON-CDNA_END> </EXON-CDNA> <EXON-CDNA> <EXON-CDNA_START>199</EXON-CDNA_START> <EXON-CDNA_END>290</EXON-CDNA_END> </EXON-CDNA> <EXON-CDNA> <EXON-CDNA_START>291</EXON-CDNA_START> <EXON-CDNA_END>390</EXON-CDNA_END> </EXON-CDNA> <EXON-CDNA> <EXON-CDNA_START>391</EXON-CDNA_START> <EXON-CDNA_END>567</EXON-CDNA_END> </EXON-CDNA> <EXON-CDNA> <EXON-CDNA_START>568</EXON-CDNA_START> <EXON-CDNA_END>617</EXON-CDNA_END> </EXON-CDNA> <EXON-CDNA> <EXON-CDNA_START>618</EXON-CDNA_START> <EXON-CDNA_END>747</EXON-CDNA_END> </EXON-CDNA> <EXON-CDNA> <EXON-CDNA_START>748</EXON-CDNA_START> <EXON-CDNA_END>870</EXON-CDNA_END> </EXON-CDNA> <EXON-CDNA> <EXON-CDNA_START>871</EXON-CDNA_START> <EXON-CDNA_END>920</EXON-CDNA_END> </EXON-CDNA> <EXON-CDNA> <EXON-CDNA_START>921</EXON-CDNA_START> <EXON-CDNA_END>1056</EXON-CDNA_END> </EXON-CDNA> <EXON-CDNA> <EXON-CDNA_START>1057</EXON-CDNA_START> <EXON-CDNA_END>2061</EXON-CDNA_END> </EXON-CDNA> <EXON-GENOME> <EXON-GENOME_START>131826237</EXON-GENOME_START> <EXON-GENOME_END>131826434</EXON-GENOME_END> </EXON-GENOME> <EXON-GENOME> <EXON-GENOME_START>131825084</EXON-GENOME_START> <EXON-GENOME_END>131825175</EXON-GENOME_END> </EXON-GENOME> <EXON-GENOME> <EXON-GENOME_START>131823618</EXON-GENOME_START> <EXON-GENOME_END>131823717</EXON-GENOME_END> </EXON-GENOME> <EXON-GENOME> <EXON-GENOME_START>131822646</EXON-GENOME_START> <EXON-GENOME_END>131822822</EXON-GENOME_END> </EXON-GENOME> <EXON-GENOME> <EXON-GENOME_START>131822487</EXON-GENOME_START> <EXON-GENOME_END>131822536</EXON-GENOME_END> </EXON-GENOME> <EXON-GENOME> <EXON-GENOME_START>131822249</EXON-GENOME_START> <EXON-GENOME_END>131822378</EXON-GENOME_END> </EXON-GENOME> <EXON-GENOME> <EXON-GENOME_START>131821943</EXON-GENOME_START> <EXON-GENOME_END>131822065</EXON-GENOME_END> </EXON-GENOME> <EXON-GENOME> <EXON-GENOME_START>131821359</EXON-GENOME_START> <EXON-GENOME_END>131821408</EXON-GENOME_END> </EXON-GENOME> <EXON-GENOME> <EXON-GENOME_START>131820054</EXON-GENOME_START> <EXON-GENOME_END>131820189</EXON-GENOME_END> </EXON-GENOME> <EXON-GENOME> <EXON-GENOME_START>131818762</EXON-GENOME_START> <EXON-GENOME_END>131819767</EXON-GENOME_END> </EXON-GENOME> <CDS-GENOME-START>131819643</CDS-GENOME-START> <CDS-GENOME-END>131825170</CDS-GENOME-END> </CDNA-INFO> <SEQUENCE> <NUCLEOTIDE_ORIGINAL>GTGCGCCCGAGCCCCGCCGAAGCGAGGCCACCCGGAGCCGTGCCCAGTCCACGCCGGCCGTGCCCGGCGGCCTTAAGAACCCGGCAACCTCTGCCTTCTTCCCTCTTCCACTTGGAGTCGCGCTCCGCGCGCCCTCACTGCAGCCCCTGCGTCGCCGGGACCCTCGCGCGCGACCGCCGAATCGCTCCTGCAGCAGAGCCAACATGCCCATCACTCGGATGCGCATGAGACCCTGGCTAGAGATGCAGATTAATTCCAACCAAATCCCGGGGCTCATCTGGATTAATAAAGAGGAGATGATCTTCCAGATCCCATGGAAGCATGCTGCCAAGCATGGCTGGGACATCAACAAGGATGCCTGTTTGTTCCGGAGCTGGGCCATTCACACAGGCCGATACAAAGCAGGGGAAAAGGAGCCAGATCCCAAGACGTGGAAGGCCAACTTTCGCTGTGCCATGAACTCCCTGCCAGATATCGAGGAGGTGAAAGACCAGAGCAGGAACAAGGGCAGCTCAGCTGTGCGAGTGTACCGGATGCTTCCACCTCTCACCAAGAACCAGAGAAAAGAAAGAAAGTCGAAGTCCAGCCGAGATGCTAAGAGCAAGGCCAAGAGGAAGTCATGTGGGGATTCCAGCCCTGATACCTTCTCTGATGGACTCAGCAGCTCCACTCTGCCTGATGACCACAGCAGCTACACAGTTCCAGGCTACATGCAGGACTTGGAGGTGGAGCAGGCCCTGACTCCAGCACTGTCGCCATGTGCTGTCAGCAGCACTCTCCCCGACTGGCACATCCCAGTGGAAGTTGTGCCGGACAGCACCAGTGATCTGTACAACTTCCAGGTGTCACCCATGCCCTCCACCTCTGAAGCTACAACAGATGAGGATGAGGAAGGGAAATTACCTGAGGACATCATGAAGCTCTTGGAGCAGTCGGAGTGGCAGCCAACAAACGTGGATGGGAAGGGGTACCTACTCAATGAACCTGGAGTCCAGCCCACCTCTGTCTATGGAGACTTTAGCTGTAAGGAGGAGCCAGAAATTGACAGCCCAGGGGGGGATATTGGGCTGAGTCTACAGCGTGTCTTCACAGATCTGAAGAACATGGATGCCACCTGGCTGGACAGCCTGCTGACCCCAGTCCGGTTGCCCTCCATCCAGGCCATTCCCTGTGCACCGTAGCAGGGCCCCTGGGCCCCTCTTATTCCTCTAGGCAAGCAGGACCTGGCATCATGGTGGATATGGTGCAGAGAAGCTGGACTTCTGTGGGCCCCTCAACAGCCAAGTGTGACCCCACTGCCAAGTGGGGATGGGGCCTCCCTCCTTGGGTCATTGACCTCTCAGGGCCTGGCAGGCCAGTGTCTGGGTTTTTCTTGTGGTGTAAAGCTGGCCCTGCCTCCTGGGAAGATGAGGTTCTGAGACCAGTGTATCAGGTCAGGGACTTGGACAGGAGTCAGTGTCTGGCTTTTTCCTCTGAGCCCAGCTGCCTGGAGAGGGTCTCGCTGTCACTGGCTGGCTCCTAGGGGAACAGACCAGTGACCCCAGAAAAGCATAACACCAATCCCAGGGCTGGCTCTGCACTAAGAGAAAATTGCACTAAATGAATCTCGTTCCCAAAGAACTACCCCCTTTTCAGCTGAGCCCTGGGGACTGTTCCAAAGCCAGTGAAATGTGAAGGAAAGTGGGGTCCTTCGGGGCGATGCTCCCTCAGCCTCAGAGGAGCTCTACCCTGCTCCCTGCTTTGGCTGAGGGGCTTGGGAAAAAAACTTGGCACTTTTTCGTGTGGATCTTGCCACATTTCTGATCAGAGGTGTACACTAACATTTCCCCCGAGCTCTTGGCCTTTGCATTTATTTATACAGTGCCTTGCTCGGCGCCCACCACCCCCTCAAGCCCCAGCAGCCCTCAACAGGCCCAGGGAGGGAAGTGTGAGCGCCTTGGTATGACTTAAAATTGGAAATGTCATCTAACCATTAAGTCATGTGTGAACACATAGGACGTGTGTAAATATGTACATTTGTCTTTTTATAAAAAGTAAATTGTTAAAAAAAAAAAAAAAAAA</NUCLEOTIDE_ORIGINAL> </SEQUENCE> <PREDICTED-ORF> <CODING-POTENTIAL>Protein coding</CODING-POTENTIAL> <CDS_SOURCE_START>1</CDS_SOURCE_START> <CDS_SOURCE_END>2061</CDS_SOURCE_END> <CDS_START>204</CDS_START> <CDS_END>1181</CDS_END> <LENGTH-OF-CDS>325</LENGTH-OF-CDS> <ORIENTATION>forward</ORIENTATION> <FRAME>+3</FRAME> <FEATURE>Complete CDS</FEATURE> <CAI>0.823</CAI> </PREDICTED-ORF> <FUNCTION> <DEFINITION> <DATA-SOURCE_DB-REFERENCE_PROTEIN-MOTIF-ID>NP_002189</DATA-SOURCE_DB-REFERENCE_PROTEIN-MOTIF-ID> <DATA-SOURCE_IDENTITY>100.0</DATA-SOURCE_IDENTITY> <DATA-SOURCE_COVERAGE>100.0</DATA-SOURCE_COVERAGE> <DATA-SOURCE_HOMOLOGOUS_SPECIES>Homo sapiens</DATA-SOURCE_HOMOLOGOUS_SPECIES> <DATA-SOURCE_CURATION-STATUS>Human curated</DATA-SOURCE_CURATION-STATUS> <DATA-SOURCE_DEFINITION>Interferon regulatory factor 1.</DATA-SOURCE_DEFINITION> <DATA-SOURCE_SIMILARITY-CATEGORY>Identical to known human protein(Category I).</DATA-SOURCE_SIMILARITY-CATEGORY> <EXP-EVIDENCE>Protein evidence</EXP-EVIDENCE> <EXP-CODE>1</EXP-CODE> <GENENAME-SYMBOL_DDBJ-EMBL-GenBank>IRF1</GENENAME-SYMBOL_DDBJ-EMBL-GenBank> <HGNC> <HUGO-APPROVED-GENE-SYMBOL_GENEW>IRF1</HUGO-APPROVED-GENE-SYMBOL_GENEW> <APPROVED-NAME_GENEW>interferon regulatory factor 1</APPROVED-NAME_GENEW> </HGNC> </DEFINITION> <GENE-ONTOLOGY> <DOMAIN_DB-REFERENCE_INTERPRO>IPR001346</DOMAIN_DB-REFERENCE_INTERPRO> <DOMAIN_NAME>Interferon regulatory factor</DOMAIN_NAME> <DOMAIN_TYPE>Domain</DOMAIN_TYPE> <DOMAIN> <DOMAIN_MOTIF_START>204</DOMAIN_MOTIF_START> <DOMAIN_MOTIF_END>545</DOMAIN_MOTIF_END> <DOMAIN_MOTIF_START>216</DOMAIN_MOTIF_START> <DOMAIN_MOTIF_END>542</DOMAIN_MOTIF_END> <DOMAIN_MOTIF_START>222</DOMAIN_MOTIF_START> <DOMAIN_MOTIF_END>281</DOMAIN_MOTIF_END> <DOMAIN_MOTIF_START>300</DOMAIN_MOTIF_START> <DOMAIN_MOTIF_END>341</DOMAIN_MOTIF_END> <DOMAIN_MOTIF_START>354</DOMAIN_MOTIF_START> <DOMAIN_MOTIF_END>407</DOMAIN_MOTIF_END> <DOMAIN_MOTIF_START>423</DOMAIN_MOTIF_START> <DOMAIN_MOTIF_END>491</DOMAIN_MOTIF_END> <DOMAIN_MOTIF> <GO_ORGANIZING-PRINCIPLE>Molecular function</GO_ORGANIZING-PRINCIPLE> <GO_DB-REFERENCE_GO>0003700</GO_DB-REFERENCE_GO> <GO_TERM>transcription factor activity</GO_TERM> </DOMAIN_MOTIF> <DOMAIN_MOTIF> <GO_ORGANIZING-PRINCIPLE>Cellular component</GO_ORGANIZING-PRINCIPLE> <GO_DB-REFERENCE_GO>0005634</GO_DB-REFERENCE_GO> <GO_TERM>nucleus</GO_TERM> </DOMAIN_MOTIF> <DOMAIN_MOTIF> <GO_ORGANIZING-PRINCIPLE>Biological process</GO_ORGANIZING-PRINCIPLE> <GO_DB-REFERENCE_GO>0006355</GO_DB-REFERENCE_GO> <GO_TERM>regulation of transcription, DNA-dependent</GO_TERM> </DOMAIN_MOTIF> </DOMAIN> <DOMAIN_DB-REFERENCE_INTERPRO>IPR011991</DOMAIN_DB-REFERENCE_INTERPRO> <DOMAIN_NAME>Winged helix-turn-helix transcription repressor DNA-binding</DOMAIN_NAME> <DOMAIN_TYPE>Domain</DOMAIN_TYPE> <DOMAIN> <DOMAIN_MOTIF_START>207</DOMAIN_MOTIF_START> <DOMAIN_MOTIF_END>542</DOMAIN_MOTIF_END> </DOMAIN> <DOMAIN_DB-REFERENCE_INTERPRO>IPR017431</DOMAIN_DB-REFERENCE_INTERPRO> <DOMAIN_NAME>Interferon regulatory factor-1/2</DOMAIN_NAME> <DOMAIN_TYPE>Family</DOMAIN_TYPE> <DOMAIN> <DOMAIN_MOTIF_START>204</DOMAIN_MOTIF_START> <DOMAIN_MOTIF_END>1148</DOMAIN_MOTIF_END> </DOMAIN> <DOMAIN_DB-REFERENCE_INTERPRO>IPR019817</DOMAIN_DB-REFERENCE_INTERPRO> <DOMAIN_NAME>Interferon regulatory factor, conserved site</DOMAIN_NAME> <DOMAIN_TYPE>Conserved_site</DOMAIN_TYPE> <DOMAIN> <DOMAIN_MOTIF_START>279</DOMAIN_MOTIF_START> <DOMAIN_MOTIF_END>380</DOMAIN_MOTIF_END> </DOMAIN> </GENE-ONTOLOGY> <CELLULAR-LOCATION> <CELLULAR-LOCATION_DATE-LAST-UPDATE>20-Apr-2012</CELLULAR-LOCATION_DATE-LAST-UPDATE> <CELLULAR-LOCATION_DATE-LAST-MODIFIED>20-Apr-2012</CELLULAR-LOCATION_DATE-LAST-MODIFIED> <LOCATION_WPSORT>nuclear</LOCATION_WPSORT> <TARGET-P>Not predicted</TARGET-P> <SOSUI>soluble protein</SOSUI> <TMHMM>soluble protein</TMHMM> <PTS1> <CSEQ>RLPSIQAIPCAP</CSEQ> <SCORE>-29.964</SCORE> <LOCATION>Not targeted</LOCATION> </PTS1> </CELLULAR-LOCATION> </FUNCTION> <PROTEIN-STRUCTURE> <PROTEIN-STRUCTURE_DATE-LAST-UPDATE>20-Apr-2012</PROTEIN-STRUCTURE_DATE-LAST-UPDATE> <PROTEIN-STRUCTURE_DATE-LAST-MODIFIED>20-Apr-2012</PROTEIN-STRUCTURE_DATE-LAST-MODIFIED> <SECONDARY-TERTIARY-STRUCTURE> <STRUCTURE_START>7</STRUCTURE_START> <STRUCTURE_END>111</STRUCTURE_END> <STRUCTURE_DB-REFERENCE_PDB>1if1A</STRUCTURE_DB-REFERENCE_PDB> <STRUCTURE_EVALUE>9e-47</STRUCTURE_EVALUE> <STRUCTURE_IDENTITY>100.0</STRUCTURE_IDENTITY> <STRUCTURE_COVERAGE>105/105</STRUCTURE_COVERAGE> <STRUCTURE_DOMAIN_DB-REFERENCE_SCOP>a.4.5.23</STRUCTURE_DOMAIN_DB-REFERENCE_SCOP> <STRUCTURE_DOMAIN_ANOMALOUS-STRUCTURE>YES</STRUCTURE_DOMAIN_ANOMALOUS-STRUCTURE> </SECONDARY-TERTIARY-STRUCTURE> </PROTEIN-STRUCTURE> <SEQUENCE_TRANSLATION>MPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTKNQRKERKSKSSRDAKSKAKRKSCGDSSPDTFSDGLSSSTLPDDHSSYTVPGYMQDLEVEQALTPALSPCAVSSTLPDWHIPVEVVPDSTSDLYNFQVSPMPSTSEATTDEDEEGKLPEDIMKLLEQSEWQPTNVDGKGYLLNEPGVQPTSVYGDFSCKEEPEIDSPGGDIGLSLQRVFTDLKNMDATWLDSLLTPVRLPSIQAIPCAP*</SEQUENCE_TRANSLATION> <EXPRESSION> <EXPRESSION_DATE-LAST-UPDATE>20-Apr-2012</EXPRESSION_DATE-LAST-UPDATE> <EXPRESSION_DATE-LAST-MODIFIED>20-Apr-2012</EXPRESSION_DATE-LAST-MODIFIED> <PROBE-MAPPING> <PLATFORM> <PLATFORM-TYPE>AceGene</PLATFORM-TYPE> <PROBE> <PROBE-TYPE>AceGene</PROBE-TYPE> <PROBE-ID>AGhsA220418</PROBE-ID> </PROBE> </PLATFORM> <PLATFORM> <PLATFORM-TYPE>Affymetrix GeneChip</PLATFORM-TYPE> <PROBE> <PROBE-TYPE>HG-Focus</PROBE-TYPE> <PROBE-ID>202531_at</PROBE-ID> </PROBE> <PROBE> <PROBE-TYPE>HG-U133</PROBE-TYPE> <PROBE-ID>202531_at</PROBE-ID> </PROBE> <PROBE> <PROBE-TYPE>HG-U133A</PROBE-TYPE> <PROBE-ID>202531_at</PROBE-ID> </PROBE> <PROBE> <PROBE-TYPE>HG-U133A_2</PROBE-TYPE> <PROBE-ID>202531_at</PROBE-ID> </PROBE> <PROBE> <PROBE-TYPE>HG-U133_Plus_2</PROBE-TYPE> <PROBE-ID>202531_at</PROBE-ID> </PROBE> <PROBE> <PROBE-TYPE>HG-U95</PROBE-TYPE> <PROBE-ID>669_s_at</PROBE-ID> </PROBE> <PROBE> <PROBE-TYPE>HG-U95A</PROBE-TYPE> <PROBE-ID>669_s_at</PROBE-ID> </PROBE> <PROBE> <PROBE-TYPE>HG_U95Av2</PROBE-TYPE> <PROBE-ID>669_s_at</PROBE-ID> </PROBE> <PROBE> <PROBE-TYPE>HuEx-1_0</PROBE-TYPE> <PROBE-ID>2828595</PROBE-ID> <PROBE-ID>2875350</PROBE-ID> <PROBE-ID>2875351</PROBE-ID> <PROBE-ID>2875353</PROBE-ID> <PROBE-ID>2875356</PROBE-ID> <PROBE-ID>2875358</PROBE-ID> <PROBE-ID>2875360</PROBE-ID> <PROBE-ID>2875362</PROBE-ID> <PROBE-ID>2875363</PROBE-ID> <PROBE-ID>2875364</PROBE-ID> <PROBE-ID>2875365</PROBE-ID> <PROBE-ID>2875366</PROBE-ID> <PROBE-ID>2875372</PROBE-ID> <PROBE-ID>2875375</PROBE-ID> </PROBE> <PROBE> <PROBE-TYPE>HuGeneFL</PROBE-TYPE> <PROBE-ID>L05072_s_at</PROBE-ID> </PROBE> </PLATFORM> <PLATFORM> <PLATFORM-TYPE>Agilent probe set</PLATFORM-TYPE> <PROBE> <PROBE-TYPE>Human 1A Oligo Microarray:PGID215</PROBE-TYPE> <PROBE-ID>A_23_P41765</PROBE-ID> </PROBE> <PROBE> <PROBE-TYPE>Whole Human Genome Oligo Microarray:PGID247</PROBE-TYPE> <PROBE-ID>A_23_P41765</PROBE-ID> </PROBE> </PLATFORM> </PROBE-MAPPING> </EXPRESSION> </cDNAXML> </H-Inv>
H-InvDB_8.3 released on March 26, 2013.
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