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H-Invitational ID: HIT000023222 Accession number: AK098392 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Tubulin polymerization-promoting protein.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AK098392.1 CAGE tag ID NA EST ID NA Clone Number CBR07215 Experimental resources   NBRC ; HGPD ; Antibody (TPPP) ; Catalog (TPPP); Sequence data provider Project:FLJ; Provider:FLJ/IMSUT;  Annotation project H-Invitational FLcDNA Length of cDNA 2043[bp] (No. of exon:5)[A:405 T:348 G:639 C:651] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type brain Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NMD predicted;  Notes NA

GAGCTCCGCTGAGCACCGGGTCGCGCGCGGCCGAGTCGCGGAGGCGCCTC CGCTGCAGTCGCTGCGTCTCCAAGCAACATGGCTGACAAGGCCAAGCCTG CCAAAGCTGCCAACAGGACGCCCCCCAAGTCCCCGGGGGACCCCTCGAAG GACCGGGCAGCCAAGAGGCTGTCGCTGGAATCGGAGGGTGCTGGTGAGGG GGCAGCCGCATCCCCTGAGCTCAGTGCCCTGGAGGAGGCCTTCCGGCGCT TTGCCGTGCACGGGGACGCCAGGGCCACCGGGAGGGAGATGCACGGCAAG AACTGGTCGAAGCTGTGCAAGGACTGCCAGGTGATCGACGGCAGGAACGT GACCGTCACTGACGTGGACATCGTCTTCAGCAAGATCAAAGGGAAGTCTT GCCGGACCATCACCTTTGAGCAGTTCCAGGAGGCGCTGGAGGAGCTCGCC AAGAAGCGATTCAAAGACAAGAGCAGCGAGGAGGCCGTTCGCGAGGTGCA CAGGCTCATCGAGGGCAAGGCGCCCATCATCTCAGGGGTGACGAAAGCCA TCTCGTCGCCCACAGTGTCGAGGCTCACGGACACCACCAAGTTCACGGGC TCCCACAAGGAGCGCTTCGACCCCTCTGGCAAGGGCAAGGGCAAGGCTGG CCGCGTGGATCTGGTGGACGAGTCAGGCTATGTGTCCGGCTACAAGCACG CAGGCACCTACGACCAGAAGGTGCAAGGGGGCAAGTAGCCCCCGCTCCAT GCCTCGCGGCACTGCCGGTGTCCCCAGAGCAGGGACTCTGTCACCTCGCA CTTCATTACATTCCTGTACTAACTGGGGCAGAACTCAGACGGGTGCCCCA GAGGGGGCTGGGGGGCGGCCAGGCCCAGGCCTCCCTCCTGCCCCTCCTCC TACCGGATGCCCCCAGCACTCCCCTCTCAAACCAGGTTTGGGCCCCAGTT CGCTGACCCTCCTAATACACCTGCCTCGTCCTCAGCCATTTCCAAAGTGT CTCGCGGATCACACCACACTGGGCACGTGGTTTGCAGGTCAAAGGGGCGT TTTAAAGCAGCTGGCTGTCATGGCAACAGGAGGCTGTGCTGACCTCCTGA GCGGCAGACACCTTCCAGGAGCCCTGAGGGTGGCAGGAGCTAACCCCAAC CAGCAGGCAACTAACACGGAATTGGCCCCACACCGGACGTGGGAGGTGTC TGTGGGGCCCGAGGCCTGTCCTGTGTGCAGCGGACACCACGGGGCCTTCC TGCTTTCCTGGGCAGAGGGCAGAGTGAGGCCACCTGGCGGGGGTGCTGGG CGCCTGGCACATGTGTGGGGAAGCCGGTCACATGGACACACCTGTGCACA CATGCCTACAGGCCAGCTCTGTGCCAAGGGCAACCTAGGTAAAACGAAAG CCGTCAGGGGCAGTGGGCGGCTTCCCGGCTGACCACAGTGGCTTGGACTG TGAGGGTAGAGTAGGCTCGCTTTGCTTTCCTGAGAAGATGCGGTGGCTGC CTATGTTCTCAGAGCGGGTCTGGGAAGATTCAGAATGTCCGGTCCCTGTG GTGTTGCCAGGCAAGAGACACGAAGTGCCGAGACACTCCTCGCCTCACCG CGTGACAGAGCCTCTGCCCGGCCCTCCCGTTCGCCCGTCCTCACTAGCTG CACCCTGTTTGCTCGCAGACCTCCCATTGCCACAGCCCAAGCACCTTCTT CAACTCTCCCAAAATGGCTCAGCCTAACCTCTCCTGGCCAATCCCCCCCG CCGGAGAGCAGGACACTAGGGAGGACCCCCAGTCCTGCAGTGTCTGTGGG GGTTTCTCTGCCAGCAGGGGGCTGAGCAGAGCCCATCCAGGACACTCCAC ACTGCCAGGACACACCCAGGCGGCCCGCCCTTGCCTGTCTGCACCTGGGG AGAAGCCGGCGCTCCTGCTCCCTCCTGGGGAGGCTGACGGGTGTGGCCAC CCGCTGTCACAATGGCACACTGCTCCTGTGTCTGCTGTCGTTAACATTGT GTGTCAAGTTGGTAAAGTGACAAATAAAGGTGTTAAAACATGG

Gene structure information

H-Inv cluster ID		HIX0004710
Genomic location	Chromosome	5
	Location	5p15.33
	Position	659978- 693466
	Strand	-
Possible duplicated location(s)		NA
Gene structure		5 exon(s)
Database links	RefSeq	NM_007030;
	Ensembl	ENST00000360578;
	Entrez Gene	Entrez Gene ID:11076;
	KEGG GENES	KEGG GENES(11076);
	GeneCard	TPPP;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000024798 Predicted CDS 79..738;  219[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.833 Database links RefSeq NP_008961;  UniProt O94811;  Q4L233;  CCDS CCDS3856;

MADKAKPAKAANRTPPKSPGDPSKDRAAKRLSLESEGAGEGAAASPELSA LEEAFRRFAVHGDARATGREMHGKNWSKLCKDCQVIDGRNVTVTDVDIVF SKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPI ISGVTKAISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDLVDESG YVSGYKHAGTYDQKVQGGK*

Motif information

	a.a. length	InterPro	Name
	192	IPR008907	P25-alpha [Family]
	164	IPR008907	P25-alpha [Family]

Gene function information

H-Inv ID		HIT000023222
H-Inv cluster ID		HIX0004710
Accession number		AK098392.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		Representative transcript;  Splicing isoform
Coding potential		Protein coding;
Definition		Tubulin polymerization-promoting protein.
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (NP_008961)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	HIF0001442
	Gene family/group name	P25-alpha (IPR008907).
	Evidence motif (InterPro) ID	IPR008907
Gene symbol/name	HGNC symbol	TPPP
	HGNC aliases	NA
	HGNC name	tubulin polymerization promoting protein
	DDBJ	NA
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000024798
	No. of interaction	2
	Interaction partner(s)	HIP000057699;
	BIND	156043;
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NM_007030;
	Ensembl	ENST00000360578;
	Entrez Gene	Entrez Gene ID:11076;
	KEGG GENES	KEGG GENES(11076);
	GeneCard	TPPP;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Human curated
Notes		NA
Related H-InvDB links		P25-alpha (IPR008907). Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	nuclear;  cytosol;  mitochondria;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 55 179 1wlmA1 2e-26 64.8 125/138 a.39.1.11

Related H-InvDB links GTOP

Gene expression information

Last modified:20-Apr-2012

Tissue-specific expression			neural;
Probe information	AceGene		AGhsB011618;
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	230104_s_at;  230197_s_at;
		HG-U133A	NA
		HG-U133A_2	NA
		HG-U133B	230104_s_at;  230197_s_at;
		HG-U133_Plus_2	230104_s_at;  230197_s_at;
		HG-U95	NA
		HG-U95A	NA
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2798841;  2798842;  2845451;  2845454;  2845455;  2845456;  2845457;  2845458;  2845459;  2845467;  2845473;  2845525;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	NA
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:NA Title:NA
Co-localized orphan diseases		OMIM ID:  601888;  608850;  611091;  612554;  612571;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(11076)
	Disease	Entrez Gene ID:(11076)
	Substance	Entrez Gene ID:(11076)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Evolutionary information

Last modified:20-Apr-2012

Relationship	Species	Accession number	MGI	Links
Orthology	Mus sp. (Mouse)	BC054803	MGI:1920198	G-integra
Orthology	Bos sp. (Cow)	BC133343		G-integra
Orthology	Gallus sp. (Chicken)	BX933510		G-integra
Orthology	Gallus sp. (Chicken)	BX934333		G-integra
Orthology	Equus sp. (Horse)	ENSECAT00000020909		G-integra
Orthology	Oryzias sp. (Medaka)	ENSORLT00000010157		G-integra
Orthology	Pongo sp. (Orangutan)	ENSPPYT00000017791		G-integra
Orthology	Pan sp. (Chimpanzee)	ENSPTRT00000047536		G-integra
Orthology	Tetraodon sp. (Tetraodon)	GSTENT00034086001		G-integra
Orthology	Takifugu sp. (Fugu)	SINFRUT00000145212		G-integra
Orthology	Macaca sp. (Macaque)	XM_001095130		G-integra
Orthology	Monodelphis sp. (Opossum)	XM_001363173		G-integra
Orthology	Rattus sp. (Rat)	XM_341746		G-integra
Orthology	Canis sp. (Dog)	XM_545196		G-integra

Phylogenetic tree [View by ATV]	Neighbor-joining (phb)
Related H-InvDB links	Evola;  dN/dS (under constraction);

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 92 .. 92 C/A rs62330308 - CDS Nonsynonymous[Ala5Asp] 175 .. 175 C/T rs7737452 - CDS Synonymous[Leu33Leu] 192 .. 192 T/C rs450628 - CDS Synonymous[Ala38Ala] 194 .. 194 G/C rs61731452 - CDS Nonsynonymous[Gly39Ala] 205 .. 205 G/T rs61731453 - CDS Nonsynonymous[Ala43Ser] 249 .. 249 C/T rs7737292 - CDS Synonymous[Arg57Arg] 660 .. 660 T/C rs61731455 - CDS Synonymous[Asp194Asp] 675 .. 675 A/G rs1697963 - CDS Synonymous[Ser199Ser] 807 .. 807 T/C rs72707016 - 3'UTR 857 .. 857 G/- rs34019075 - 3'UTR 977 .. 977 C/T rs72707013 - 3'UTR 1003 .. 1003 C/T rs16900955 - 3'UTR 1026 .. 1026 C/T rs77925095 - 3'UTR 1185 .. 1185 G/A rs116639356 - 3'UTR 1196 .. 1196 G/A rs79742881 - 3'UTR 1232 .. 1232 G/A rs114815741 - 3'UTR 1287 .. 1287 G/A rs72707011 - 3'UTR 1632 .. 1632 C/T rs3749611 - 3'UTR 1749 ^ 1750 -/C rs28364690 + 3'UTR 1871 .. 1871 C/T rs28364691 + 3'UTR 1934 .. 1934 C/G rs78298254 - 3'UTR 1951 .. 1951 C/T rs112704282 - 3'UTR 1990 .. 1990 G/A rs114429348 - 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;