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H-Invitational ID: HIT000018866 Accession number: AK094009 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Peptidase S1A, chymotrypsin-type family protein.

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Transcript original information Accession number AK094009.1 CAGE tag ID NA EST ID NA Clone Number UTERU2008707 Experimental resources   NBRC ; HGPD ; Sequence data provider Project:FLJ; Provider:FLJ/HRI;  Annotation project H-Invitational FLcDNA Length of cDNA 2580[bp] (No. of exon:0)[A:636 T:620 G:659 C:665] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type uterus Develpmental stage NA

Sequence quality information CDS feature N-truncated Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

ATGTCCTTAAGTCACAGTTAATTCATTTAATGCACACTTTAAGTGTCTAC TGTCAGGCACTGTCCTAGATGTGGGAGGTTCAGTAAAAAGAAACCCACAT AGTCACACAGCCTTTGTGGAGCTCACATTTGAATGTTGCATCAAGTCGAG TTCACCTGATGCATTGTTCTTTACTCCAAGGTGCTTCCAGCTCCATCAGG AGGATTGGGTGGGTGTCCTGGGTCCAGAAGAATGGAGACTACCAACCTCT TTGCTCCTATTACAACCCTCCCTTGCCTGCACCACCCACTGCCCTTACTT TTGCATTTGTTATTCACATCATAGAATTTAAAGCAAGTCACACGGTTTCT CACATTACCTACATTTTACTCAGACGTTCTAGTTCTCATACACATTCTCT TACAACCTTTTCCAGGGCTAACTCCATGGAATGATTTTTGGTCTTTTTGT TTTGTCTTGTTTTGTTTTTGAGAGAGAGTCTTGCTCTGTCACCCAGGCAG TGGCATGGTCTCAGCTCACTGTAAACTCCGCCTCCCAAGTTCAAGTGTTT CTCCTGGATTCAAGCTATTCAAGTGCCTCAGCCACCCGAGTTGCTGGAAT TACAGGCGTGCGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGA CAGGGTTTCTCCATGTTGCCCAGGCTGGTCTCGAACTCCTGGCCTCAAGT GATCCGCCCACCTCAGCCCCCCAAAGTGCTGGGGTTACCGGCGTGAGCCA CTGCACCTGGCCGAATTTTGGTCTTAGTAAAACTTATTCATTTGTCCAGT AACTTTTCATTTCAAAGACTGCCATTTCCTAGTCTTGTCCCTGCTCAATA GCAACAGCACTTCACATACATCAACGTCTCCAGCACCTTTCAAAGCTGCG AGGTGGCTCTAGTATTTTAGGGAAGGCCTCTGTCCTTAGGAAAACTGCAA CCCAGGAGAGATAAAGTGATGCACGCCTGGAGGCAGGGGACACCAGCAAG AGAAACACAGTTCTGCCCTGGAGCACAGGCTTTTGTTTTGATACAGAAAA CACTCAAACGTGGCTTGTGATTTTTTCAAATTACAAATTGTGGGATTCAA CTGGACCTCAGTAGGAACAGGCCACAGTCTAGAGAGAGGATGATCAGGTC TATCAGTTAGCTCTGCTCTGACTTGCTGTGGTGTGGCTCAATGCTCCTGT CTGCAATGGGCTGGGGAGAAGGAAGAAGGAGCCACATCCATGGGGGAGCC ACATCCATGGGGGAGCCACATCCATGGGGGAGCCAAGAGATGTCTTGGTA TTGCCTCCCACTCCTGTGTGGAAAGGGCAGGAAGGGGACCTCCATTGCCT CTTGGCACTGATGGCACCTCTATCCTCTGCTCAACAGGGGAACCAGGTGC TGCATTCCTTCACAGCTGTCTGCCAGGATGATGGCACGTGGCATCGTGCC ATGCCCAGATGCAAGATCAAGGACTGTGGGCAGCCCCGAAACCTGCCTAA TGGTGACTTCCGTTACACCACCACAATGGGAGTGAACACCTACAAGGCCC GTATCCAGTACTACTGCCATGAGCCATATTACAAGATGCAGACCAGAGCT GGCAGCAGGGAGTCTGAGCAAGGGGTGTACACCTGCACAGCACAGGGCAT TTGGAAGAATGAACAGAAGGGAGAGAAGATTCCTCGGTGCTTGCCAGTGT GTGGGAAGCCCGTGAACCCCGTGGAACAGAGGCAGCGCATCATCGGAGGG CAAAAAGCCAAGATGGGCAACTTCCCCTGGCAGGTGTTCACCAACATCCA CGGGCGCGGGGGCGGGGCCCTGCTGGGCGACCGCTGGATCCTCACAGCTG CCCACACCCTGTATCCCAAGGAACACGAAGCGCAAAGCAACGCCTCTTTG GATGTGTTCCTGGGCCACACAAATGTGGAAGAGCTCATGAAGCTAGGAAA TCACCCCATCCGCAGGGTCAGCGTCCACCCGGACTACCGTCAGGATGAGT CCTACAATTTTGAGGGGGACATCGCCCTGCTGGAGCTGGAAAATAGTGTC ACCCTGGGTCCCAACCTCCTCCCCATCTGCCTCCCTGACAACGATACCTT CTACGACCTGGGCTTGATGGGCTATGTCAGTGGCTTCGGGGTCATGGAGG AGAAGATTGCTCATGACCTCAGGTTTGTCCGTCTGCCCGTAGCTAATCCA CAGGCCTGTGAGAACTGGCTCCGGGGAAAGAATAGGATGGATGTGTTCTC TCAAAACATGTTCTGTGCTGGACACCCATCTCTAAAGCAGGACGCCTGCC AGGGGGATAGTGGGGGCGTTTTTGCAGTAAGGGACCCGAACACTGATCGC TGGGTGGCCACGGGCATCGTGTCCTGGGGCATCGGGTGCAGCAGGGGCTA TGGCTTCTACACCAAAGTGCTCAACTACGTGGACTGGATCAAGAAAGAGA TGGAGGAGGAGGACTGAGCCCAGAATTCACTAGGTTCGAATCCAGAGAGC AGTGTGGAAAAAAAAAAACAAAAAACAACTGACCAGTTGTTGATAACCAC TAAGAGTCTCTATTAAAATTACTGATGCAG

Gene structure information

H-Inv cluster ID		HIX0060170
Genomic location	Chromosome	UM
	Location	NA
	Position	NA
	Strand	NA
Possible duplicated location(s)		NA
Gene structure		exon(s)
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:715;
	KEGG GENES	KEGG GENES(715);
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000336703 Predicted CDS 1172..2467;  431[aa];  Orientation:+2;  Codon Adaptation Index (CAI). 0.822

LAVVWLNAPVCNGLGRRKKEPHPWGSHIHGGATSMGEPRDVLVLPPTPVW KGQEGDLHCLLALMAPLSSAQQGNQVLHSFTAVCQDDGTWHRAMPRCKIK DCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQ GVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGN FPWQVFTNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHT NVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELENSVTLGPNLL PICLPDNDTFYDLGLMGYVSGFGVMEEKIAHDLRFVRLPVANPQACENWL RGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGIV SWGIGCSRGYGFYTKVLNYVDWIKKEMEEED*

Motif information

	a.a. length	InterPro	Name
	28	IPR016060	Complement control module [Domain]
	27	IPR016060	Complement control module [Domain]
	76	IPR000436	Sushi/SCR/CCP [Domain]
	82	IPR016060	Complement control module [Domain]
	64	IPR000436	Sushi/SCR/CCP [Domain]
	72	IPR000436	Sushi/SCR/CCP [Domain]
	77	IPR016060	Complement control module [Domain]
	255	IPR009003	Peptidase cysteine/serine, trypsin-like [Domain]
	235	IPR001254	Peptidase S1/S6, chymotrypsin/Hap [Domain]
	234	IPR001254	Peptidase S1/S6, chymotrypsin/Hap [Domain]
	239	IPR001254	Peptidase S1/S6, chymotrypsin/Hap [Domain]
	16	IPR001314	Peptidase S1A, chymotrypsin-type [Family]
	15	IPR001314	Peptidase S1A, chymotrypsin-type [Family]
	13	IPR001314	Peptidase S1A, chymotrypsin-type [Family]
	12	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site [Active_site]

Gene function information

H-Inv ID		HIT000018866
H-Inv cluster ID		HIX0060170
Accession number		AK094009.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		Representative transcript;
Coding potential		Protein coding;
Definition		Peptidase S1A, chymotrypsin-type family protein.
Similarity category		Category: IPR domain containing protein(Category III).
		InterPro domain (IPR001314) -containing protein.
Experimental evidence		NA
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	HIF0004019
	Gene family/group name	Peptidase S1 and S6, chymotrypsin/Hap (IPR001254).
	Evidence motif (InterPro) ID	IPR001254
Gene symbol/name	HGNC symbol	NA
	HGNC aliases	NA
	HGNC name	NA
	DDBJ	NA
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000336703
	No. of interaction	89
	Interaction partner(s)	HIP000002695;  HIP000012362;  HIP000021611;  HIP000021611;  HIP000022683;  HIP000022683;  HIP000023224;  HIP000027846;  HIP000028776;  HIP000031121;  HIP000032033;  HIP000032033;  HIP000033567;  HIP000038044;  HIP000038917;  HIP000040104;  HIP000040104;  HIP000040325;  HIP000040325;  HIP000040335;  HIP000040335;  HIP000041964;  HIP000044948;  HIP000045138;  HIP000045138;  HIP000045470;  HIP000047547;  HIP000047547;  HIP000048209;  HIP000048478;  HIP000048478;  HIP000049023;  HIP000051303;  HIP000051303;  HIP000055598;  HIP000055598;  HIP000065041;  HIP000066234;  HIP000067782;  HIP000067782;  HIP000069782;  HIP000069782;  HIP000069885;  HIP000071711;  HIP000078313;  HIP000078313;  HIP000079932;  HIP000079932;  HIP000081613;  HIP000087439;  HIP000087439;  HIP000088108;  HIP000095623;  HIP000095623;  HIP000097730;  HIP000098499;  HIP000109009;  HIP000109009;  HIP000110854;  HIP000110854;  HIP000111022;  HIP000117125;  HIP000117125;  HIP000133002;  HIP000133002;  HIP000146646;  HIP000148859;  HIP000162041;  HIP000162041;  HIP000193974;  HIP000195336;  HIP000195642;  HIP000205642;  HIP000212383;  HIP000219887;  HIP000247333;  HIP000247912;  HIP000251455;  HIP000336295;  HIP000336784;  HIP000345964;  HIP000346720;  HIP000346720;  HIP000349874;  HIP000358744;  HIP000360676;  HIP000360879;  HIP000360879;  HIP000361685;
	BIND	NA
	DIP	100211E;  100366E;  100532E;  100609E;  100625E;  100726E;  101191E;  101443E;  102007E;  102223E;  102293E;  18532E;  47837E;  47898E;  47934E;  48016E;  48443E;  48849E;  48906E;  48953E;  49105E;  49197E;  49199E;  49449E;  50033E;  50141E;  50417E;  50716E;  50760E;  51035E;  51217E;  51254E;  51455E;  51513E;  51558E;  51690E;  51835E;  51967E;  52031E;  52230E;  52250E;  52271E;  52359E;  52870E;  52957E;  53435E;  96492E;  96537E;  96621E;  96987E;  97096E;  97835E;  98140E;  98247E;  98297E;  98317E;  98322E;  98352E;  98475E;  98746E;  98762E;  98906E;  99026E;  99093E;  99178E;  99193E;  99200E;  99222E;  99282E;  99323E;  99378E;  99433E;  99449E;  99484E;  99593E;  99624E;  99764E;  99869E;  99955E;
	MINT	NA
	HPRD	00284;  01677;  03396;  04435;  04471;  04866;  05344;  05728;  06861;  09001;  09490;  12692;  17624;  18253;
	IntAct	EBI-906966;  EBI-880595;  EBI-895331;  EBI-881486;  EBI-879304;  EBI-1147250;  EBI-886936;  EBI-887918;  EBI-883767;  EBI-895222;  EBI-883170;  EBI-883484;  EBI-883046;  EBI-882652;  EBI-881701;  EBI-881754;  EBI-886668;  EBI-883980;  EBI-883848;  EBI-884415;  EBI-886556;  EBI-884810;  EBI-893916;  EBI-887783;  EBI-893650;  EBI-895127;  EBI-894927;  EBI-888366;  EBI-893285;  EBI-893204;  EBI-892264;  EBI-888757;  EBI-891913;  EBI-891424;  EBI-889682;  EBI-891089;  EBI-892437;  EBI-892692;  EBI-887368;  EBI-887304;
Database links	RefSeq	NA
	Ensembl	NA
	Entrez Gene	Entrez Gene ID:715;
	KEGG GENES	KEGG GENES(715);
	GeneCard	NA *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Human curated
Notes		NA
Related H-InvDB links		Peptidase S1 and S6, chymotrypsin/Hap (IPR001254). Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	catalytic activity (GO:0003824);  serine-type endopeptidase activity (GO:0004252);
Biological process	proteolysis (GO:0006508);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	mitochondria;  cytosol;  extracellular;  peroxisome;
Target P	Not predicted
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP)

Last modified:20-Apr-2012

Start End PDB_ID E-value Identity Coverage SCOP_ID 40 66 1gpzA2 2e-05 100.0 27/68 g.18.1.1 67 142 1elvA2 2e-17 40.0 65/66 g.18.1.1 117 395 1qvh.1 1e-32 28.5 267/290 b.47.1.2

Related H-InvDB links GTOP

Gene expression information

Last modified:20-Apr-2012

Tissue-specific expression			NA
Probe information	AceGene		AGhsC080524;
	Affymetrix GeneChip	HG-Focus	212067_s_at;
		HG-U133	212067_s_at;
		HG-U133A	212067_s_at;
		HG-U133A_2	212067_s_at;
		HG-U133B	NA
		HG-U133_Plus_2	212067_s_at;
		HG-U95	39409_at;
		HG-U95A	39409_at;
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	3403217;  3442478;  3442479;  3442480;  3442481;  3442482;  3442483;  3442484;
		HuGeneFL	M14058_at;
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	NA
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  No data available  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  Type Start End Strand L2a 18 135 - AluSz6 442 762 - Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;