H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Invitational ID: HIT000018016 Accession number: AK093149 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Similar to Unconventional myosin-Vb;
 
 

Transcript original information
Accession number AK093149.1
CAGE tag ID NA
EST ID NA
Clone Number TESTI2006465
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ;
Sequence data provider Project:FLJ; Provider:FLJ/HRI; 
Annotation project H-Invitational FLcDNA
Length of cDNA 2727[bp] (No. of exon:17)[A:770 T:670 G:635 C:652]
Devision HUM
Molecular type mRNA
Library origin Cell type NA
Tissue type testis
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA NA
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGGAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0014446
Genomic location  G-integra Help Chromosome 18
Location 18q21.1
Position 47352629- 47623988
Strand -
Possible duplicated location(s) NA
Gene structure 17 exon(s)
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:4645
KEGG GENES KEGG GENES(4645)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA-genome alignmentcDNA-genome alignment

Predicted CDS information
HIP ID HIP000063666
Predicted CDS 353..2542;  729[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.776

Motif information
ORF

length(729),orf(353:2542)
MHWPVTRECTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYP
IDVQRNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYT
YCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMA
RDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASSP
IMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVF
QADDERNYHIFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDD
AEDFEKTRQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAERDGDSCSI
SPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINAR
NALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYGFETFEVNSFE
QFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIE
AKLGILDLLDEECKVPKGTDQNWAQKLYDRHSSSQHFQKPRMSNTAFIIV
HFADKVEYLSDGFLEKNRDTVYEEQINILKAGKFPLVADLFHDDKDPVPA
TTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLSTQQIVKILNL
YTPLNEFEERVTVAFIRTIQAQLQERNDPQQLLLDAKHMFPVLFPFNPSS
LTMDSIHIPACLNLEFLNEVWRCMFPALV*
a.a.
length
InterPro Name
length(629), motif(12:640) 629 IPR027417 P-loop containing nucleoside triphosphate hydrolase [Domain]
length(629), motif(62:690) 629 IPR001609 Myosin head, motor domain [Domain]
length(603), motif(71:673) 603 IPR001609 Myosin head, motor domain [Domain]
length(20), motif(99:118) 20 IPR001609 Myosin head, motor domain [Domain]
length(26), motif(155:180) 26 IPR001609 Myosin head, motor domain [Domain]
length(28), motif(200:227) 28 IPR001609 Myosin head, motor domain [Domain]
length(29), motif(432:460) 29 IPR001609 Myosin head, motor domain [Domain]
length(29), motif(485:513) 29 IPR001609 Myosin head, motor domain [Domain]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000018016
H-Inv cluster ID Locus viewHIX0014446
Accession number AK093149.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Similar to Unconventional myosin-Vb;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (Q9ULV0)  [Identity/coverage = 100.0%/4.55%] to Homo sapiens (Human). protein.
Experimental evidence Protein evidence
PubMed ID 10574461114959081577216116177791174629981866964818724368195422312006823121282656ALL
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol NA
HGNC aliases NA
HGNC name NA
DDBJ NA
UniProt MYO5B
EC number NA
GGDB
(GlycoGene Database)
Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000063666
No. of interaction NA
Interaction partner(s) NA
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:4645
KEGG GENES KEGG GENES(4645)
GeneCard NA *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
FR ID FR216550
Accession
Description
Location
PMID

Gene ontology information
Molecular function ATP binding (GO:0005524);  motor activity (GO:0003774); 
Cellular component myosin complex (GO:0016459); 

Subcellular localization information  Last modified:27-May-2015
WoLF PSORT cytosol;  mitochondria;  nuclear;  Other; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
10 48 1oe9A1 6e-12 71.8 39/50 b.34.3.1
52 653 1b7tA4 e-128 39.5 583/718 c.37.1.9
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsB070322; 
Affymetrix
GeneChip
HG-Focus NA
HG-U133 225301_s_at; 
HG-U133A NA
HG-U133A_2 NA
HG-U133B 225301_s_at; 
HG-U133_Plus_2 225301_s_at; 
HG-U95 63386_at; 
HG-U95A NA
HG-U95B NA
HG-U95C 63386_at; 
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3172327;  3172328;  3172329;  3207850;  3787948;  3787958;  3807597;  3807598;  3807599;  3807603;  3807650;  3807655;  3807656;  3807657;  3807659;  3807661;  3807664;  3807665;  3807668;  3807669;  3807670;  3807678;  3807679;  3807681;  3807688; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 NA
Whole Human Genome Oligo Microarray:PGID247 A_23_P101193; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:27-May-2015
Disease relation Disease name: Microvillus inclusion disease (251850); 
Related information in OMIM OMIM ID:  606540;  Title: MYOSIN VB
Co-localized orphan diseases NA
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(4645)
Disease Entrez Gene ID:(4645)
Substance Entrez Gene ID:(4645)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo ViewerLEGENDALEGENDA

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
179 .. 179 T/C rs73448728 - 5'UTR
275 .. 275 G/A rs139900608 - 5'UTR
283 .. 283 G/A rs145976385 - 5'UTR
328 .. 328 G/T rs115742937 - 5'UTR
377 .. 377 T/G rs16951438 - CDS Nonsynonymous[Cys9Gly]
417 .. 417 G/A rs202129020 - CDS Nonsynonymous[Arg22His]
487 .. 487 G/T rs201403876 - CDS Synonymous[Thr45Thr]
494 .. 494 G/C rs141998504 - CDS Nonsynonymous[Glu48Gln]
516 .. 516 G/T rs138743872 - CDS Nonsynonymous[Arg55Leu]
525 .. 525 T/C rs78626055 - CDS Nonsynonymous[Leu58Pro]
532 .. 532 C/G rs200086960 - CDS Nonsynonymous[Phe60Leu]
546 .. 546 A/C rs117920737 - CDS Nonsynonymous[Asp65Ala]
624 .. 624 G/A rs202205346 - CDS Nonsynonymous[Arg91His]
672 .. 672 T/G rs121908103 + CDS Nonsynonymous[Val107Gly]
725 .. 725 G/A rs1815930 + CDS Nonsynonymous[Ala125Thr]
727 .. 727 C/T rs201531684 - CDS Synonymous[Ala125Ala]
803 .. 803 A/G rs185864408 - CDS Nonsynonymous[Arg151Gly]
859 .. 859 G/A rs199862025 - CDS Synonymous[Thr169Thr]
880 .. 880 G/A rs200687310 - CDS Nonsynonymous[Met176Ile]
1054 .. 1054 C/T rs151001572 - CDS Synonymous[Ile234Ile]
1055 .. 1055 G/A rs200010695 - CDS Nonsynonymous[Gly235Arg]
1235 .. 1235 A/G rs79714279 - CDS Nonsynonymous[Ile295Val]
1237 .. 1237 C/T rs139200179 - CDS Synonymous[Ile295Ile]
1242 .. 1242 G/T rs144305793 - CDS Nonsynonymous[Gly297Val]
1246 .. 1246 G/T rs7240377 - CDS Synonymous[Val298Val]
1270 .. 1270 G/T rs17659179 - CDS Nonsynonymous[Lys306Asn]
1275 .. 1275 G/A rs200142429 - CDS Nonsynonymous[Arg308Gln]
1286 .. 1286 A/G rs182144565 - CDS Nonsynonymous[Thr312Ala]
1301 .. 1301 A/G rs199755279 - CDS Nonsynonymous[Lys317Glu]
1345 .. 1345 C/A rs16951352 - CDS Synonymous[Ile331Ile]
1366 .. 1366 G/A rs139934455 - CDS Synonymous[Ala338Ala]
1380 .. 1380 G/A rs189027956 - CDS Nonsynonymous[Arg343His]
1474 .. 1474 G/A rs121908104 + CDS AA-STOP[Trp374*]
1484 .. 1484 C/T rs190998983 - CDS Nonsynonymous[Arg378Cys]
1503 .. 1503 C/T rs200796610 - CDS Nonsynonymous[Ser384Leu]
1555 .. 1555 C/T rs11082795 - CDS Synonymous[Asn401Asn]
1589 .. 1589 G/A rs200773306 - CDS Nonsynonymous[Gly413Ser]
1603 .. 1603 G/T rs145905243 - CDS Nonsynonymous[Glu417Asp]
1611 .. 1611 A/G rs201374776 - CDS Nonsynonymous[Asn420Ser]
1612 .. 1612 C/G rs202093525 - CDS Nonsynonymous[Asn420Lys]
1841 .. 1841 G/A rs200175136 - CDS Nonsynonymous[Asp497Asn]
1867 .. 1867 C/T rs143987020 - CDS Synonymous[Ile505Ile]
1895 .. 1895 G/A rs192135533 - CDS Nonsynonymous[Val515Ile]
1939 .. 1939 C/G rs200469007 - CDS Nonsynonymous[Asp529Glu]
1953 .. 1953 G/A rs202201947 - CDS Nonsynonymous[Ser534Asn]
1986 .. 1986 C/T rs201372185 - CDS Nonsynonymous[Thr545Met]
2004 .. 2004 A/C rs7236435 - CDS Nonsynonymous[His551Pro]
2062 .. 2062 G/C rs185840586 - CDS Synonymous[Thr570Thr]
2104 .. 2104 C/T rs139542376 - CDS Synonymous[Phe584Phe]
2125 .. 2125 T/C rs181890135 - CDS Synonymous[Phe591Phe]
2134 .. 2134 C/A rs199774365 - CDS Nonsynonymous[Asp594Glu]
2135 .. 2135 A/G rs200548362 - CDS Nonsynonymous[Lys595Glu]
2142 .. 2142 C/T rs75107667 + CDS Nonsynonymous[Pro597Leu]
2156 .. 2156 A/G rs201639239 - CDS Nonsynonymous[Thr602Ala]
2166 .. 2166 A/G rs199813207 - CDS Nonsynonymous[Lys605Arg]
2189 .. 2189 G/A rs191746501 - CDS Nonsynonymous[Val613Ile]
2192 .. 2192 C/T rs186494043 - CDS Nonsynonymous[Arg614Cys]
2210 .. 2210 A/G rs200891104 - CDS Nonsynonymous[Met620Val]
2263 .. 2263 C/T rs2276166 + CDS Synonymous[Thr637Thr]
2266 .. 2266 C/A rs200316615 - CDS Synonymous[Ser638Ser]
2312 ^ 2313 -/C rs36114466 - CDS
2343 .. 2343 C/G rs202090244 - CDS Nonsynonymous[Ala664Gly]
2352 .. 2352 G/A rs199948930 - CDS Nonsynonymous[Arg667Gln]
2379 .. 2379 G/C rs201080553 - CDS Nonsynonymous[Arg676Pro]
2401 .. 2401 A/C rs78657366 - CDS Synonymous[Leu683Leu]
2416 .. 2416 C/A rs1058527 + CDS Nonsynonymous[His688Gln]
2417 .. 2417 A/G rs200172993 - CDS Nonsynonymous[Met689Val]
2441 .. 2441 A/C rs1058532 + CDS Nonsynonymous[Asn697His]
2464 .. 2464 C/G rs1058536 + CDS Nonsynonymous[Asp704Glu]
2482 .. 2482 G/A rs1058541 + CDS Synonymous[Ala710Ala]
2497 .. 2497 A/G rs1058543 + CDS Synonymous[Glu715Glu]
2519 .. 2519 T/C rs1058544 + CDS Nonsynonymous[Cys723Arg]
2529 .. 2529 C/T rs200197382 - CDS Nonsynonymous[Pro726Leu]
2539 .. 2539 T/C rs1058548 + CDS Synonymous[Val729Val]
2546 .. 2546 C/G rs200745043 - 3'UTR
2555 .. 2555 G/A rs1058550 + 3'UTR
2559 .. 2559 G/A rs1058551 + 3'UTR
2571 .. 2571 T/G rs1058553 + 3'UTR
2614 .. 2614 A/C rs11874243 - 3'UTR
2623 .. 2623 C/A rs112174362 - 3'UTR
2633 .. 2633 C/T rs200099625 - 3'UTR
2679 .. 2679 T/G rs3208550 + 3'UTR
2681 .. 2681 A/G rs1058554 + 3'UTR
2691 ^ 2692 -/T rs149289525 - 3'UTR
2695 .. 2695 C/A rs1058556 + 3'UTR
2717 .. 2717 T/G rs73436344 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
Type Start End Strand
MARNA 33 175 +
L2b 197 355 -
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD)
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer