H-InvDB x AHG DB
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H-InvDB_8.3 released on March 26, 2013.
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H-Invitational ID: HIT000009200 Accession number: AK025926 Created date: 26-Mar-2013 Last modified: 20-Apr-2012
Definition: Adenylate kinase isoenzyme 4, mitochondrial isoform 7.
 
 

Transcript original information
Accession number AK025926.1
CAGE tag ID NA
EST ID NA
Clone Number HRC03549
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (AK4) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (AK4);
Sequence data provider Project:FLJ; Provider:FLJ/IMSUT; 
Annotation project H-Invitational FLcDNA
Length of cDNA 1732[bp] (No. of exon:5)[A:433 T:465 G:428 C:406]
Devision HUM
Molecular type mRNA
Library origin Cell type primary human renal epithelial cells
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 1715(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) CAGGAG;  TAGAAG; 
Transcript quality feature NA
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0000670
Genomic location  G-integra Help Chromosome 1
Location 1p31.3
Position 65613886- 65692699
Strand +
Possible duplicated location(s) NA
Gene structure 5 exon(s)
Database links RefSeq NM_013410;  NM_001005353;  NM_203464; 
Ensembl ENST00000327299;  ENST00000395334;  ENST00000470888;  ENST00000474968;  ENST00000479060;  ENST00000497030;  ENST00000505168;  ENST00000545314; 
Entrez Gene Entrez Gene ID:205; 
KEGG GENES KEGG GENES(205); 
GeneCard GeneCardAK4;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000033952
Predicted CDS 206..877;  223[aa];  Orientation:+2; 
Codon Adaptation Index (CAI). 0.729
Database links RefSeq NP_001005353;  NP_037542;  NP_982289; 
UniProt P27144; 
CCDS CCDS629; 

Motif information
ORF

length(223),orf(206:877) MASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEV GEMAKQYIEKSLLVPDHVITRLMMSELENRRGQHWLLDGFPRTLGQAEAL DKICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDD VTGEPLVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTETN KIWPYVYTLFSNKITPIQSKEAY* 		a.a.
length		 InterPro Name
length(223), motif(1:223) 223 IPR000850 Adenylate kinase [Family]
length(210), motif(6:215) 210 IPR000850 Adenylate kinase [Family]
length(205), motif(7:211) 205 IPR006259 Adenylate kinase, subfamily [Family]
length(14), motif(9:22) 14 IPR000850 Adenylate kinase [Family]
length(180), motif(10:189) 180 IPR000850 Adenylate kinase [Family]
length(15), motif(37:51) 15 IPR000850 Adenylate kinase [Family]
length(17), motif(85:101) 17 IPR000850 Adenylate kinase [Family]
length(12), motif(85:96) 12 IPR000850 Adenylate kinase [Family]
length(38), motif(125:162) 38 IPR007862 Adenylate kinase, active site lid domain [Domain]
length(36), motif(126:161) 36 IPR007862 Adenylate kinase, active site lid domain [Domain]
length(16), motif(159:174) 16 IPR000850 Adenylate kinase [Family]
length(15), motif(176:190) 15 IPR000850 Adenylate kinase [Family]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000009200
H-Inv cluster ID Locus viewHIX0000670
Accession number AK025926.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Coding potential  Help Protein coding; 
Definition Adenylate kinase isoenzyme 4, mitochondrial isoform 7.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_982289)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Experimental evidence Protein evidence
PubMed ID NA
Gene family/group Gene family H-Inv gene family/group ID HIF0000200
Gene family/group name Putative Adenylate kinase (IPR000850).
Evidence motif (InterPro) ID IPR000850
Gene symbol/name HGNC symbol AK4
HGNC aliases "adenylate kinase 3", "adenylate kinase 3-like 1"
HGNC name adenylate kinase 4
DDBJ NA
UniProt NA
EC number EC 2.7.4.3adenylate kinase; 
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway 00230 :Purine metabolism; 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000033952
No. of interaction 4
Interaction partner(s) HIP000028717;  HIP000056323;  HIP000080319;  HIP000116892; 
BIND NA
DIP NA
MINT NA
HPRD 04070;  04699;  04888; 
IntAct EBI-3909641;  EBI-2820209; 
Database links RefSeq NM_013410;  NM_001005353;  NM_203464; 
Ensembl ENST00000327299;  ENST00000395334;  ENST00000470888;  ENST00000474968;  ENST00000479060;  ENST00000497030;  ENST00000505168;  ENST00000545314; 
Entrez Gene Entrez Gene ID:205; 
KEGG GENES KEGG GENES(205); 
GeneCard GeneCardAK4;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Human curated
Notes NA
Related H-InvDB links Putative Adenylate kinase (IPR000850). Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function ATP binding (GO:0005524);  adenylate kinase activity (GO:0004017);  nucleobase, nucleoside, nucleotide kinase activity (GO:0019205);  nucleotide kinase activity (GO:0019201);  phosphotransferase activity, phosphate group as acceptor (GO:0016776); 
Biological process nucleobase, nucleoside, nucleotide and nucleic acid metabolic process (GO:0006139); 

Subcellular localization information  Last modified:20-Apr-2012
WoLF PSORT mitochondria;  cytosol;  nuclear; 
Target P Not predicted
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:20-Apr-2012
Start End PDB_ID E-value Identity Coverage SCOP_ID
7 174 1knqA 8e-23 20.5 161/171 c.37.1.17
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:20-Apr-2012
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator		 AceGene AGhsA011623; 
Affymetrix
GeneChip		 HG-Focus 204348_s_at; 
HG-U133 204348_s_at; 
HG-U133A 204348_s_at; 
HG-U133A_2 204348_s_at; 
HG-U133B NA
HG-U133_Plus_2 204348_s_at; 
HG-U95 32331_at;  48822_s_at; 
HG-U95A 32331_at; 
HG-U95B 48822_s_at; 
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 2340318;  2340319;  2340320;  2340326;  2340330;  2340331;  2340333;  2340334;  2340335;  2416721;  2416746;  2857292;  2857293;  3449880;  3449881;  3449882;  3449883;  3449884;  3449885;  3717257;  3717258;  3717260;  3717262;  3717264;  3717266;  3717268;  3717270;  3752281;  3752282; 
HuGeneFL X60673_rna1_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P200522; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P200524;  A_32_P108655; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:20-Apr-2012
Disease relation Disease name:NA
Related information in OMIM OMIM ID:NA Title:NA
Co-localized orphan diseases OMIM ID:  115665;  116600;  155600;  600975;  605225;  605606;  606788;  606852;  606928;  607317;  607671;  608543;  608553;  608995;  610320;  612367;  612596; 
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(205)
Disease Entrez Gene ID:(205)
Substance Entrez Gene ID:(205)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo Viewer;  LEGENDALEGENDA; 

Evolutionary information  Evola Help Last modified:20-Apr-2012
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) AK154374 MGI:3553260 G-integraG-integra
Orthology Danio sp. (Zebrafish) BC068387 G-integraG-integra
Orthology Rattus sp. (Rat) BC087024 G-integraG-integra
Orthology Bos sp. (Cow) BC120077 G-integraG-integra
Orthology Gallus sp. (Chicken) BX932222 G-integraG-integra
Orthology Pongo sp. (Orangutan) CR861439 G-integraG-integra
Orthology Equus sp. (Horse) ENSECAT00000019552 G-integraG-integra
Orthology Oryzias sp. (Medaka) ENSORLT00000012536 G-integraG-integra
Orthology Pan sp. (Chimpanzee) ENSPTRT00000001569 G-integraG-integra
Orthology Tetraodon sp. (Tetraodon) GSTENT00033599001 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000127770 G-integraG-integra
Orthology Macaca sp. (Macaque) XM_001089466 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001364867 G-integraG-integra
Orthology Canis sp. (Dog) XM_546674 G-integraG-integra
Phylogenetic tree [View by ATV]
 Neighbor-joining (phb) 
Related H-InvDB links EvolaEvola;  dN/dS (under constraction); 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
16 .. 16 C/T rs114871912 + 5'UTR
78 .. 78 G/- rs34080963 + 5'UTR
149 .. 149 T/C rs57193680 + 5'UTR
174 .. 174 C/G rs61781805 + 5'UTR
269 .. 269 T/A rs17853973 + CDS Nonsynonymous[Cys22Ser]
655 .. 655 C/T rs34248479 - CDS Synonymous[Asp150Asp]
670 .. 670 A/G rs4915685 + CDS Synonymous[Pro155Pro]
1475 .. 1475 T/C rs55657410 + 3'UTR
1572 .. 1572 T/C rs9092 + 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;