H-InvDB x AHG DB
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H-InvDB_8.3 released on March 26, 2013.
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H-Invitational ID: HIT000009143 Accession number: AK025869 Created date: 26-Mar-2013 Last modified: 20-Apr-2012
Definition: Leucine-rich repeat-containing protein 61.
 
 

Transcript original information
Accession number AK025869.1
CAGE tag ID NA
EST ID NA
Clone Number HRC01584
Experimental resources NBRC: NITE Biological Resource Center  NBRC ; HGPD: Human Gene and Protein Database HGPD ; Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (LRRC61) ; Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (LRRC61);
Sequence data provider Project:FLJ; Provider:FLJ/IMSUT; 
Annotation project H-Invitational FLcDNA
Length of cDNA 1483[bp] (No. of exon:2)[A:275 T:286 G:427 C:495]
Devision HUM
Molecular type mRNA
Library origin Cell type primary human renal epithelial cells
Tissue type NA
Develpmental stage NA
Mini-G
Sequence quality information
CDS feature Complete CDS
Kozak sequence NA
PolyA Site: 1465(+) Signal: 1440-1444(+)
Vector/adapter sequence NA
Frame shift NA
Remaining intron NA
Splice site acceptor (NAGNAG) NA
Transcript quality feature Truncation; 
Notes NA

Gene structure information  G-integra H-DBAS cDNA-genome alignment
H-Inv cluster ID HIX0007200
Genomic location  G-integra Help Chromosome 7
Location 7q36.1
Position 150023074- 150035245
Strand +
Possible duplicated location(s) NA
Gene structure 2 exon(s)
Database links RefSeq NM_023942;  NM_001142928; 
Ensembl ENST00000323078;  ENST00000359623;  ENST00000463441;  ENST00000471872;  ENST00000493307; 
Entrez Gene Entrez Gene ID:65999; 
KEGG GENES KEGG GENES(65999); 
GeneCard GeneCardLRRC61;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA-genome alignmentcDNA-genome alignment; 

Predicted CDS information
HIP ID HIP000042096
Predicted CDS 171..950;  259[aa];  Orientation:+3; 
Codon Adaptation Index (CAI). 0.81
Database links RefSeq NP_001136400;  NP_076431; 
UniProt Q9BV99; 
CCDS CCDS5901; 

Motif information
ORF

length(259),orf(171:950) MDPPAEKPGEAGGLQITPQLLKSRTGEFSLESILLLKLRGLGLADLGCLG ECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQ SLNAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAV RELLPGLKVIDGERVIGRGSEFYQLCRDLDSSLRPSSSPGPRATEAQPWV EPGYWESWPSRSSSILEEACRQFQDTLQECWDLDRQASDSLAQAEQVLSS AGPTSSFVF* 		a.a.
length		 InterPro Name
length(20), motif(55:74) 20 IPR001611 Leucine-rich repeat [Repeat]

Gene function information  Gene family PPI viewer Similarity Search Tool TACT
H-Inv ID HIT000009143
H-Inv cluster ID Locus viewHIX0007200
Accession number AK025869.1
CAGE tag ID NA
EST ID NA
Transcript feature  Help NO; 
Coding potential  Help Protein coding; 
Definition Leucine-rich repeat-containing protein 61.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_076431)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Experimental evidence Protein evidence
PubMed ID NA
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol LRRC61
HGNC aliases NA
HGNC name leucine rich repeat containing 61
DDBJ NA
UniProt NA
EC number NA
GGDB
(GlycoGene Database)
 Gene symbol NA
Familly NA
Designation NA
Expression NA
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000042096
No. of interaction 3
Interaction partner(s) HIP000030974;  HIP000064456;  HIP000084610; 
BIND 151676; 
DIP NA
MINT MINT-67408; 
HPRD 02741;  10009;  15979; 
IntAct EBI-756958;  EBI-3050465; 
Database links RefSeq NM_023942;  NM_001142928; 
Ensembl ENST00000323078;  ENST00000359623;  ENST00000463441;  ENST00000471872;  ENST00000493307; 
Entrez Gene Entrez Gene ID:65999; 
KEGG GENES KEGG GENES(65999); 
GeneCard GeneCardLRRC61;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Curation status Auto-annotated
Notes NA
Related H-InvDB links Gene familyGene family;  Similarity Search ToolSimilarity Search Tool;  TACTTACT; 
fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome. 
NA

Gene ontology information
Molecular function protein binding (GO:0005515); 

Subcellular localization information  Last modified:20-Apr-2012
WoLF PSORT cytosol;  nuclear;  extracellular; 
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified:20-Apr-2012
Start End PDB_ID E-value Identity Coverage SCOP_ID
61 165 1a9nA 1e-14 29.3 99/162 c.10.2.4
Related H-InvDB links GTOP GTOP

Gene expression information  H-ANGEL DNAProbeLocator Last modified:20-Apr-2012
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator		 AceGene AGhsA051110;  AGhsB040114; 
Affymetrix
GeneChip		 HG-Focus NA
HG-U133 218907_s_at; 
HG-U133A 218907_s_at; 
HG-U133A_2 218907_s_at; 
HG-U133B NA
HG-U133_Plus_2 218907_s_at; 
HG-U95 63857_at;  78646_at; 
HG-U95A NA
HG-U95B NA
HG-U95C 63857_at; 
HG-U95D NA
HG-U95E 78646_at; 
HG-U95Av2 NA
HuEx-1_0 3031351;  3031352;  3031353;  3031354;  3031355;  3031356;  3031357;  3031358;  3079003;  3079004; 
HuGeneFL NA
Agilent Human 1A Oligo Microarray:PGID215 A_23_P134225; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P134225; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:20-Apr-2012
Disease relation Disease name:NA
Related information in OMIM OMIM ID:NA Title:NA
Co-localized orphan diseases OMIM ID:  605635; 
Disease related mutation NA
Literature-Extracted GENe-Disease Associations (LEGENDA) LEGENDA Gene name Entrez Gene ID:(65999)
Disease Entrez Gene ID:(65999)
Substance Entrez Gene ID:(65999)
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo Viewer;  LEGENDALEGENDA; 

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information  VaryGene Repeat mask viewer
 Single Nucleotide Polymorphism (SNP) and indel  VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
17 .. 17 A/G rs73728117 + 5'UTR
47 .. 47 G/A rs115992259 + 5'UTR
94 .. 94 C/T rs117202313 + 5'UTR
102 .. 102 A/G rs3735171 - 5'UTR
107 .. 107 A/T rs11538924 + 5'UTR
108 .. 108 C/A rs117812897 + 5'UTR
206 .. 206 C/G rs117173805 + CDS Synonymous[Gly12Gly]
285 .. 285 C/T rs75056573 + CDS Nonsynonymous[Arg39Cys]
404 .. 404 T/C rs3735170 - CDS Synonymous[Ala78Ala]
598 .. 598 A/G rs3735169 - CDS Nonsynonymous[Asn143Ser]
753 .. 753 G/A rs61744057 + CDS Nonsynonymous[Glu195Lys]
942 .. 942 G/A rs75914222 + CDS Nonsynonymous[Val258Ile]
953 .. 953 G/A rs111309260 + 3'UTR
1171 .. 1171 G/A rs3735168 - 3'UTR
1182 .. 1182 T/C rs79026194 + 3'UTR
1259 .. 1259 G/A rs116379873 + 3'UTR
1403 .. 1403 C/T/G/A rs11538922 - 3'UTR
 Microsatellite (Short Tandem Repeat, STR)
No data available
 Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD)
No data available
 Repeat  Repeat mask viewer
No data available
Database links H-GOLDHuman-Gene diversity Of Life-style related Diseases(H-GOLD); 
Related H-InvDB links VaryGeneVaryGene;  Repeat mask viewerRepeat Mask Viewer;