H-InvDB x AHG DB
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H-InvDB_8.3 released on March 26, 2013.
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H-Inv cluster ID: HIX0026392 Created date: 26-Mar-2013 Last modified: 20-Apr-2012
Definition: Alpha-2-macroglobulin precursor.
 
 

Gene structure  G-integra H-DBAS
H-Inv cluster ID HIX0026392
Genomic location  G-integra Help Chromosome 12
Location 12p13.31
Position 9220260- 9268825
Strand -
Antisense cluster ID(s) NA
Database links RefSeq NM_000014; 
Ensembl ENST00000546069;  ENST00000495442;  ENST00000542567;  ENST00000467091;  ENST00000495709;  ENST00000404455;  ENST00000539638;  ENST00000497324;  ENST00000545828;  ENST00000540099;  ENST00000543436;  ENST00000318602;  ENST00000472360;  ENST00000462568; 
Entrez Gene Entrez Gene ID:2; 
KEGG GENES KEGG GENES(2); 
GeneCard GeneCardA2M;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Cluster member H-Inv ID(s) HIT000306372;  HIT000052315;  HIT000055976;  HIT000194109;  HIT000329549;  HIT000255654;  HIT000426698;  HIT000431348;  HIT000258991;  HIT000195676;  HIT000300808;  HIT000302090; 
Additional cluster member candidate(s) NA
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA multiple alignmentcDNA-genome multiple alignment;  ORF multiple alignmentORF multiple alignment; 
Mini-G Locus map Locus map

 
TOP 1-10 11-12 LAST 
Cluster member (s)  G-integra H-DBAS
Locus member number 1
H-Inv ID Transcript viewHIT000306372
Accession number CR749334.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Alpha-2-macroglobulin precursor.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_000005)  [Identity/coverage = 99.864%/100.0%] to Homo sapiens protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220311- 9268515
Strand -
Gene structure 36 exons
 
TOP 1-10 11-12 LAST 
Locus member number 2
H-Inv ID Transcript viewHIT000052315
Accession number BC040071.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P01023)  [Identity/coverage = 99.864%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature NA
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220304- 9268497
Strand -
Gene structure 36 exons
 
TOP 1-10 11-12 LAST 
Locus member number 3
H-Inv ID Transcript viewHIT000055976
Accession number BX647329.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; Precursor;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P01023)  [Identity/coverage = 95.252%/45.73%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220309- 9268515
Strand -
Gene structure 19 exons
 
TOP 1-10 11-12 LAST 
Locus member number 4
H-Inv ID Transcript viewHIT000194109
Accession number M11313.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P01023)  [Identity/coverage = 99.864%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature NA
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220310- 9268487
Strand -
Gene structure 36 exons
 
TOP 1-10 11-12 LAST 
Locus member number 5
H-Inv ID Transcript viewHIT000329549
Accession number AB209614.2
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P01023)  [Identity/coverage = 99.864%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature NA
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220304- 9268469
Strand -
Gene structure 36 exons
 
TOP 1-10 11-12 LAST 
Locus member number 6
H-Inv ID Transcript viewHIT000255654
Accession number AY591530.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Alpha-2-macroglobulin precursor.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_000005)  [Identity/coverage = 99.864%/100.0%] to Homo sapiens protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature NA
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220326- 9268491
Strand -
Gene structure 36 exons
 
TOP 1-10 11-12 LAST 
Locus member number 7
H-Inv ID Transcript viewHIT000426698
Accession number AK307832.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Alpha-2-macroglobulin precursor.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_000005)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220371- 9268456
Strand -
Gene structure 35 exons
 
TOP 1-10 11-12 LAST 
Locus member number 8
H-Inv ID Transcript viewHIT000431348
Accession number AK312482.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Alpha-2-macroglobulin precursor.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_000005)  [Identity/coverage = 99.864%/100.0%] to Homo sapiens protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature NA
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220779- 9268459
Strand -
Gene structure 35 exons
 
TOP 1-10 11-12 LAST 
Locus member number 9
H-Inv ID Transcript viewHIT000258991
Accession number BC026246.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; Precursor;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P01023)  [Identity/coverage = 79.31%/46.27%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220309- 9268514
Strand -
Gene structure 20 exons
 
TOP 1-10 11-12 LAST 
Locus member number 10
H-Inv ID Transcript viewHIT000195676
Accession number M36501.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; Precursor;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P01023)  [Identity/coverage = 99.689%/43.62%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature NA
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220310- 9243054
Strand -
Gene structure 17 exons
 
TOP 1-10 11-12 LAST 
Locus member number 11
H-Inv ID Transcript viewHIT000300808
Accession number CR621613.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; Precursor;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P01023)  [Identity/coverage = 100.0%/35.55%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220347- 9232424
Strand -
Gene structure 13 exons
 
TOP 1-10 11-12 LAST 
Locus member number 12
H-Inv ID Transcript viewHIT000302090
Accession number CR622895.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; Precursor;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P01023)  [Identity/coverage = 100.0%/30.73%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Transcript feature NA
Genomic location  G-integra Chromosome 12
Location 12p13.31
Position 9220324- 9231895
Strand -
Gene structure 12 exons

Alternative splicing (AS) information  G-integra H-DBAS
Pattern of alternative splicing isoforms 5' terminal AS;  Internal AS; 
Position of alternative splicing isoforms Cassette;  Internal acceptor site;  Internal donor site;  Mutually exclusive; 
Alternative splicing isoform H-Inv ID(s) Splicing isoformHIT000426698;  Splicing isoformHIT000258991;  Splicing isoformHIT000055976;  Splicing isoformHIT000306372;  Splicing isoformHIT000300808; 
Related H-InvDB links H-DBASH-DBAS;  G-integraG-integra;  cDNA multiple alignmentcDNA-genome multiple alignment;  ORF multiple alignmentORF multiple alignment; 

Gene function information  G-integra PPI viewer H-DBAS Gene family Similarity Search Tool TACT
H-Inv cluster ID HIX0026392
Representative H-Inv ID Representative H-Inv IDHIT000306372
Accession number CR749334.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Alpha-2-macroglobulin precursor.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_000005)  [Identity/coverage = 99.864%/100.0%] to Homo sapiens protein.
Gene family/group Gene family H-Inv gene family/group ID HIF0000332
Gene family/group name Putative A-macroglobulin complement component (IPR011626).
Evidence motif (InterPro) ID IPR011626
Gene symbol/name HGNC symbol A2M 
HGNC aliases NA
HGNC name alpha-2-macroglobulin 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000057503
No. of interaction 34
Interaction partner(s) HIP000024120;  HIP000024466;  HIP000025805;  HIP000036736;  HIP000037151;  HIP000038676;  HIP000040935;  HIP000042140;  HIP000048130;  HIP000057652;  HIP000059948;  HIP000061045;  HIP000061387;  HIP000061795;  HIP000073144;  HIP000079240;  HIP000080656;  HIP000082627;  HIP000089868;  HIP000096367;  HIP000096908;  HIP000099978;  HIP000100364;  HIP000100476;  HIP000101851;  HIP000106166;  HIP000107744;  HIP000108912;  HIP000114316;  HIP000141598;  HIP000193291;  HIP000200174;  HIP000337322;  HIP000338791; 
BIND NA
DIP 88119E; 
MINT NA
HPRD 01156;  01530;  01733;  01741;  01991;  02412;  02730;  03183;  03833;  04726;  05009;  05659;  05945;  06040;  07958;  09689;  11055;  12098;  12199;  13154;  14796;  15550;  16186; 
IntAct EBI-3386101;  EBI-3386096;  EBI-3385956;  EBI-3386091;  EBI-3386106;  EBI-3385298;  EBI-3385829;  EBI-3385293;  EBI-3385132;  EBI-3385589;  EBI-3385222;  EBI-3385288;  EBI-3385217;  EBI-3385127;  EBI-3385451;  EBI-3385051;  EBI-3385177;  EBI-2903350;  EBI-3385338;  EBI-3385273;  EBI-3385278;  EBI-3386111;  EBI-3385328;  EBI-3385303;  EBI-3386116;  EBI-3385323;  EBI-3386380;  EBI-3385318;  EBI-3385313;  EBI-3385308; 
Database links RefSeq NM_000014; 
Ensembl ENST00000546069;  ENST00000495442;  ENST00000542567;  ENST00000467091;  ENST00000495709;  ENST00000404455;  ENST00000539638;  ENST00000497324;  ENST00000545828;  ENST00000540099;  ENST00000543436;  ENST00000318602;  ENST00000472360;  ENST00000462568; 
Entrez Gene Entrez Gene ID:2; 
KEGG GENES KEGG GENES(2); 
GeneCard GeneCardA2M;  *GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases; 
Related H-InvDB links G-integraG-integra;  PPI viewerPPI view;  H-DBASH-DBAS;  Putative A-macroglobulin complement component (IPR011626). Similarity Search ToolSimilarity search tool;  TACTTACT; 
Gene expression information   H-ANGEL DNAProbeLocator Last modified:20-Apr-2012
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator		 AceGene AGhsA170913; 
Affymetrix
GeneChip		 HG-Focus 217757_at; 
HG-U133 217757_at; 
HG-U133A 217757_at; 
HG-U133A_2 217757_at; 
HG-U133B NA
HG-U133_Plus_2 217757_at; 
HG-U95 74536_i_at;  74537_f_at;  75187_f_at; 
HG-U95A NA
HG-U95B NA
HG-U95C NA
HG-U95D 74536_i_at;  74537_f_at;  75187_f_at; 
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3404064;  3404066;  3404068;  3404070;  3404071;  3404074;  3404081;  3404083;  3404085;  3404092;  3443355;  3443356;  3443358;  3443362;  3443366;  3443367;  3443368;  3443369;  3443370;  3443374;  3443377;  3443379;  3443381;  3443383;  3443385;  3443386;  3443387;  3443388;  3443392;  3443393;  3443395;  3443396;  3443397;  3443400;  3443402;  3443403;  3443405;  3443406;  3443407;  3443409;  3443410;  3443411;  3443412;  3443413;  3443415;  3443416;  3443419;  3443422;  3443424;  3443425;  3443431;  3443432; 
HuGeneFL M11313_s_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P116898; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P116898; 
Related H-InvDB links H-ANGELH-ANGEL;  DNAProbeLocatorDNAProbeLocator; 

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:20-Apr-2012
Disease relation Disease name: {Alzheimer disease, susceptibility to} (104300); 
Related information in OMIM OMIM ID:  103950;  Title: ALPHA-2-MACROGLOBULIN
Co-localized orphan diseases OMIM ID:  107920;  108600;  130080;  609113;  612372; 
Disease related mutation MutationView:  103950; 
JRE-1.4.0 or later is required.Download JRE at Sun's web site.
Co-occurred words and phrases with this gene name in PubMed (LEGENDA) LEGENDA Gene name Entrez Gene ID:(2); 
Disease Entrez Gene ID:(2); 
Gene function Entrez Gene ID:(2); 
Substance Entrez Gene ID:(2); 
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo Viewer;  LEGENDALEGENDA;