H-InvDB x AHG DB
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H-InvDB_8.3 released on March 26, 2013.
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H-Inv cluster ID: HIX0012987 Created date: 26-Mar-2013 Last modified: 26-Mar-2013
Definition: Integrin alpha-M isoform 1 precursor.
 
 

Gene structure  G-integra H-DBAS
H-Inv cluster ID HIX0012987
Genomic location  G-integra Help Chromosome 16
Location 16p11.2
Position 31271288- 31344213
Strand +
Antisense cluster ID(s) NA
Database links RefSeq NM_001145808
Ensembl ENST00000544665ENST00000287497
Entrez Gene Entrez Gene ID:3684
KEGG GENES KEGG GENES(3684)
GeneCard GeneCardITGAM*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Cluster member H-Inv ID(s) HIT000191220HIT000047510HIT000014463HIT000335636HIT000336076HIT000335634HIT000335635HIT000194612HIT000191245HIT000250933HIT000250932
Additional cluster member candidate(s) NA
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA multiple alignmentcDNA-genome multiple alignment ORF multiple alignmentORF multiple alignment
Mini-G Locus map Locus map

 
TOP 1-10 11-11 LAST 
Cluster member (s)  G-integra H-DBAS
Locus member number 1
H-Inv ID Transcript viewHIT000191220
Accession number J03925.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M isoform 1 precursor.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_001139280)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271321- 31344190
Strand +
Gene structure 30 exons
 
TOP 1-10 11-11 LAST 
Locus member number 2
H-Inv ID Transcript viewHIT000047510
Accession number AK127637.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Integrin alpha-M isoform 1 precursor.
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (NP_001139280)  [Identity/coverage = 100.0%/60.28%] to Homo sapiens protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271331- 31344201
Strand +
Gene structure 21 exons
 
TOP 1-10 11-11 LAST 
Locus member number 3
H-Inv ID Transcript viewHIT000014463
Accession number AK057856.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P11215)  [Identity/coverage = 100.0%/2.26%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271288- 31338744
Strand +
Gene structure 10 exons
 
TOP 1-10 11-11 LAST 
Locus member number 4
H-Inv ID Transcript viewHIT000335636
Accession number BC096348.3
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M isoform 2 precursor.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_000623)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271322- 31343150
Strand +
Gene structure 30 exons
 
TOP 1-10 11-11 LAST 
Locus member number 5
H-Inv ID Transcript viewHIT000336076
Accession number BC099660.3
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M isoform 2 precursor.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_000623)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271322- 31343150
Strand +
Gene structure 30 exons
 
TOP 1-10 11-11 LAST 
Locus member number 6
H-Inv ID Transcript viewHIT000335634
Accession number BC096346.3
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P11215)  [Identity/coverage = 99.826%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271322- 31343150
Strand +
Gene structure 30 exons
 
TOP 1-10 11-11 LAST 
Locus member number 7
H-Inv ID Transcript viewHIT000335635
Accession number BC096347.3
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M isoform 1 precursor.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_001139280)  [Identity/coverage = 99.74%/100.0%] to Homo sapiens protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271322- 31343150
Strand +
Gene structure 30 exons
 
TOP 1-10 11-11 LAST 
Locus member number 8
H-Inv ID Transcript viewHIT000194612
Accession number M18044.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P11215)  [Identity/coverage = 99.826%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271311- 31343089
Strand +
Gene structure 30 exons
 
TOP 1-10 11-11 LAST 
Locus member number 9
H-Inv ID Transcript viewHIT000191245
Accession number J04145.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Integrin alpha-M isoform 1 precursor.
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (NP_001139280)  [Identity/coverage = 100.0%/99.31%] to Homo sapiens protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31273011- 31343706
Strand +
Gene structure 29 exons
 
TOP 1-10 11-11 LAST 
Locus member number 10
H-Inv ID Transcript viewHIT000250933
Accession number AY187248.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P11215)  [Identity/coverage = 100.0%/32.99%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31286913- 31335760
Strand +
Gene structure 9 exons
 
TOP 1-10 11-11 LAST 
Locus member number 11
H-Inv ID Transcript viewHIT000250932
Accession number AY187247.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P11215)  [Identity/coverage = 98.693%/17.45%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31286913- 31335760
Strand +
Gene structure 5 exons

Alternative splicing (AS) information  G-integra H-DBAS
Pattern of alternative splicing isoforms 3' terminal AS;  Internal AS; 
Position of alternative splicing isoforms Cassette;  Internal acceptor site;  Internal donor site; 
Alternative splicing isoform H-Inv ID(s) Splicing isoformHIT000047510Splicing isoformHIT000014463Splicing isoformHIT000191220
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA multiple alignmentcDNA-genome multiple alignment ORF multiple alignmentORF multiple alignment

Gene function information  G-integra PPI viewer H-DBAS Gene family Similarity Search Tool TACT
H-Inv cluster ID HIX0012987
Representative H-Inv ID Representative H-Inv IDHIT000191220
Accession number J03925.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M isoform 1 precursor.
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (NP_001139280)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Gene family/group Gene family H-Inv gene family/group ID HIF0000158
Gene family/group name Putative Integrin alpha-2 (IPR013649).
Evidence motif (InterPro) ID IPR013649
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000029955
No. of interaction 17
Interaction partner(s) HIP000027325HIP000031656HIP000048035HIP000056885HIP000060632HIP000072382HIP000080514HIP000095774HIP000096799HIP000096803HIP000102812HIP000104980HIP000107068HIP000112468HIP000168538HIP000192502HIP000308527
BIND NA
DIP NA
MINT MINT-72823;  MINT-72825; 
HPRD 00198;  00400;  00554;  00601;  00621;  00772;  00888;  00996;  01421;  01769;  01976;  02235;  02506;  03892;  06042;  12060; 
IntAct EBI-2568294; 
Database links RefSeq NM_001145808
Ensembl ENST00000544665ENST00000287497
Entrez Gene Entrez Gene ID:3684
KEGG GENES KEGG GENES(3684)
GeneCard GeneCardITGAM*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Related H-InvDB links G-integraG-integra PPI viewerPPI view H-DBASH-DBAS Putative Integrin alpha-2 (IPR013649). Similarity Search ToolSimilarity search tool TACTTACT
Gene expression information   H-ANGEL DNAProbeLocator Last modified:26-Mar-2013
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsB211308; 
Affymetrix
GeneChip
HG-Focus 205786_s_at; 
HG-U133 205785_at;  205786_s_at; 
HG-U133A 205785_at;  205786_s_at; 
HG-U133A_2 205785_at;  205786_s_at; 
HG-U133B NA
HG-U133_Plus_2 205785_at;  205786_s_at; 
HG-U95 38533_s_at;  38534_at; 
HG-U95A 38533_s_at;  38534_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3656991;  3656992;  3656993;  3656994;  3656995;  3656997;  3656998;  3656999;  3657000;  3657001;  3657002;  3657004;  3657005;  3657006;  3657007;  3657011;  3657012;  3657013;  3657014;  3657015;  3657017;  3657018;  3657020;  3657023;  3657025;  3657026;  3657028;  3657029;  3657030;  3657031;  3657033;  3657034;  3657035;  3657036;  3688340;  3688342;  3688344; 
HuGeneFL J03925_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P124108;  A_23_P251749; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P124108; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:26-Mar-2013
Disease relation Disease name: {Systemic lupus erythematous, association with susceptibility to, 6} (609939); 
Related information in OMIM OMIM ID:  120980;  Title: INTEGRIN, ALPHA-M
Co-localized orphan diseases OMIM ID:  128200157700602066605751606668608105611096611913
Disease related mutation NA
Co-occurred words and phrases with this gene name in PubMed (LEGENDA) LEGENDA Gene name Entrez Gene ID:(3684); 
Disease Entrez Gene ID:(3684); 
Gene function Entrez Gene ID:(3684); 
Substance Entrez Gene ID:(3684); 
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo ViewerLEGENDALEGENDA