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H-InvDB_9.0 released on May 27, 2015.
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H-Inv cluster ID: HIX0012987 Created date: 26-Mar-2013 Last modified: 27-May-2015
Definition: Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
 
 

Gene structure  G-integra H-DBAS
H-Inv cluster ID HIX0012987
Genomic location  G-integra Help Chromosome 16
Location 16p11.2
Position 31271288- 31344213
Strand +
Antisense cluster ID(s) NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:3684
KEGG GENES KEGG GENES(3684)
GeneCard GeneCardITGAM*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Cluster member H-Inv ID(s) HIT000191220HIT000047510HIT000335636HIT000336076HIT000335634HIT000335635HIT000194612HIT000191245
Additional cluster member candidate(s) NA
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA multiple alignmentcDNA-genome multiple alignment ORF multiple alignmentORF multiple alignment
Mini-G Locus map Locus map

 
TOP 1-8 LAST 
Cluster member (s)  G-integra H-DBAS
Locus member number 1
H-Inv ID Transcript viewHIT000191220
Accession number J03925.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P11215)  [Identity/coverage = 99.913%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature Representative H-Inv IDRepresentative transcript;  Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271321- 31344190
Strand +
Gene structure 30 exons
 
TOP 1-8 LAST 
Locus member number 2
H-Inv ID Transcript viewHIT000047510
Accession number AK127637.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; AltName: CD_antigen=CD11b; Fragment;
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (P11578)  [Identity/coverage = 72.222%/100.0%] to Cavia porcellus (Guinea pig). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature Splicing isoformSplicing isoform
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271331- 31344201
Strand +
Gene structure 21 exons
 
TOP 1-8 LAST 
Locus member number 3
H-Inv ID Transcript viewHIT000335636
Accession number BC096348.3
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P11215)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271322- 31343150
Strand +
Gene structure 30 exons
 
TOP 1-8 LAST 
Locus member number 4
H-Inv ID Transcript viewHIT000336076
Accession number BC099660.3
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P11215)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271322- 31343150
Strand +
Gene structure 30 exons
 
TOP 1-8 LAST 
Locus member number 5
H-Inv ID Transcript viewHIT000335634
Accession number BC096346.3
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P11215)  [Identity/coverage = 99.913%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271322- 31343150
Strand +
Gene structure 30 exons
 
TOP 1-8 LAST 
Locus member number 6
H-Inv ID Transcript viewHIT000335635
Accession number BC096347.3
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P11215)  [Identity/coverage = 99.74%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271322- 31343150
Strand +
Gene structure 30 exons
 
TOP 1-8 LAST 
Locus member number 7
H-Inv ID Transcript viewHIT000194612
Accession number M18044.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P11215)  [Identity/coverage = 99.913%/100.0%] to Homo sapiens (Human). protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31271311- 31343089
Strand +
Gene structure 30 exons
 
TOP 1-8 LAST 
Locus member number 8
H-Inv ID Transcript viewHIT000191245
Accession number J04145.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Similar to Integrin alpha-M isoform 1 precursor.
Similarity category  Help Category: Similar to known protein(Category II).
Similar to known protein (NP_001139280)  [Identity/coverage = 100.0%/99.31%] to Homo sapiens protein.
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Transcript feature NA
Genomic location  G-integra Chromosome 16
Location 16p11.2
Position 31273011- 31343706
Strand +
Gene structure 29 exons

Alternative splicing (AS) information  G-integra H-DBAS
Pattern of alternative splicing isoforms 3' terminal AS;  Internal AS; 
Position of alternative splicing isoforms Cassette;  Internal acceptor site;  Internal donor site; 
Alternative splicing isoform H-Inv ID(s) Splicing isoformHIT000047510Splicing isoformHIT000191220
Related H-InvDB links H-DBASH-DBAS G-integraG-integra cDNA multiple alignmentcDNA-genome multiple alignment ORF multiple alignmentORF multiple alignment

Gene function information  G-integra PPI viewer H-DBAS Gene family Similarity Search Tool TACT
H-Inv cluster ID HIX0012987
Representative H-Inv ID Representative H-Inv IDHIT000191220
Accession number J03925.1
CAGE tag ID NA
EST ID NA
Coding potential Protein coding; 
Definition Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; AltName: CD_antigen=CD11b; Precursor;
Similarity category  Help Category: Identical to known human protein(Category I).
Identical to known human protein (P11215)  [Identity/coverage = 99.913%/100.0%] to Homo sapiens (Human). protein.
Gene family/group Gene family H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
Gene symbol/name HGNC symbol ITGAM 
HGNC aliases "integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)" 
HGNC name integrin, alpha M (complement component 3 receptor 3 subunit) 
Protein-protein interaction (PPI) PPI viewer H-Inv protein ID HIP000029955
No. of interaction 353
Interaction partner(s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
BIND NA
DIP NA
MINT MINT-72823;  MINT-72825; 
HPRD 00198;  00400;  00554;  00601;  00621;  00772;  00888;  00996;  01421;  01769;  01976;  02235;  02506;  03892;  06042;  12060; 
IntAct NA
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:3684
KEGG GENES KEGG GENES(3684)
GeneCard GeneCardITGAM*GeneCards is provided free to academic non-profit institutions.
etc H-GOLDHuman-Gene diversity Of Life-style related Diseases
Related H-InvDB links G-integraG-integra PPI viewerPPI view H-DBASH-DBAS Gene familyGene family;  Similarity Search ToolSimilarity search tool TACTTACT
Gene expression information   H-ANGEL DNAProbeLocator Last modified:27-May-2015
Tissue-specific expression  H-ANGEL NA
Probe
information DNAProbeLocator
AceGene AGhsB211308; 
Affymetrix
GeneChip
HG-Focus 205786_s_at; 
HG-U133 205785_at;  205786_s_at; 
HG-U133A 205785_at;  205786_s_at; 
HG-U133A_2 205785_at;  205786_s_at; 
HG-U133B NA
HG-U133_Plus_2 205785_at;  205786_s_at; 
HG-U95 38533_s_at;  38534_at; 
HG-U95A 38533_s_at;  38534_at; 
HG-U95B NA
HG-U95C NA
HG-U95D NA
HG-U95E NA
HG-U95Av2 NA
HuEx-1_0 3656991;  3656992;  3656993;  3656994;  3656995;  3656997;  3656998;  3656999;  3657000;  3657001;  3657002;  3657004;  3657005;  3657006;  3657007;  3657011;  3657012;  3657013;  3657014;  3657015;  3657017;  3657018;  3657020;  3657023;  3657025;  3657026;  3657028;  3657029;  3657030;  3657031;  3657033;  3657034;  3657035;  3657036;  3688340;  3688342;  3688344; 
HuGeneFL J03925_at; 
Agilent Human 1A Oligo Microarray:PGID215 A_23_P124108;  A_23_P251749; 
Whole Human Genome Oligo Microarray:PGID247 A_23_P124108; 
Related H-InvDB links H-ANGELH-ANGEL DNAProbeLocatorDNAProbeLocator

Disease/pathology information  DiseaseInfo Viewer LEGENDA Last modified:27-May-2015
Disease relation Disease name: {Systemic lupus erythematous, association with susceptibility to, 6} (609939); 
Related information in OMIM OMIM ID:  120980;  Title: INTEGRIN, ALPHA-M
Co-localized orphan diseases NA
Disease related mutation NA
Co-occurred words and phrases with this gene name in PubMed (LEGENDA) LEGENDA Gene name Entrez Gene ID:(3684); 
Disease Entrez Gene ID:(3684); 
Gene function Entrez Gene ID:(3684); 
Substance Entrez Gene ID:(3684); 
Related H-InvDB links DiseaseInfo ViewerDiseaseInfo ViewerLEGENDALEGENDA