H-InvDB x AHG DB
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H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000061717 Last modified: 27-May-2015
Definition: Flap endonuclease GEN homolog 1; EC=3.1.-.-;
[Summery][Full]
[Protein Info][Member][Motif] 
provide location, ID and descriptions of functional motifs (InterPro)[Function] 
provide human-curated functional definition, similarity
category and related evidences;  Gene name; 
HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] 
provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] 
provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] 
provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000061717
Length 908
Codon Adaptation Index (CAI). 0.683
Database links RefSeq NA
UniProt NA
CCDS NA
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000249675
H-Inv cluster ID Locus view HIX0001847
Predicted CDS 74..2800 ; 908[aa] ; Orientation:+2 ;
Genomic location Chromosome 2
Location 2p24.2
CDS position 17935177-17963430
Strand +
Accession number AK131387.1
CAGE tag ID NA
EST ID NA
Clone Number BRHIP2012360
Experimental resources NBRC: NITE Biological Resource Center NBRC   HGPD: Human Gene and Protein Database HGPD   Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (GEN1) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (GEN1) ;
Length of cDNA 3024[bp] (No. of exon:14)[A:998 T:862 G:611 C:553] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:348654 ;
KEGG GENES KEGG GENES(348654) ;
GeneCard GeneCard GEN1 ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view


Coresponding transcript member (s)
No.1
H-Inv IDTranscript view HIT000249675
H-Inv cluster IDLocus view HIX0001847
Accession numberAK131387.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionFlap endonuclease GEN homolog 1; EC=3.1.-.-;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (Q17RS7) [Identity/coverage = 99.559%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome2
Location2p24.2
CDS position17935177-17963430
Strand+
Gene structure14 exons

Motif information in predicted CDS
ORF

length(909),orf(74:2800)
MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMK
PHLRNLFFRISYLTQMDVKLVFVMEGEPPKLKADVISKRNQTRYGSSGKS
WSQKTGRSHFKSVLRECLHMLECLGIPWVQAAGEAEAMCAYLNAGGHVDG
CLTNDGDTFLYGAQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLDRDALVG
LAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNRWNETSCNSSP
QLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEW
HRTEHDRQLNEVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKVIRYQR
PDLLLFQRFTLEKMEWPNHYACEKLLVLLTHYDMIERKLGSRNSNQLQPI
RIVKTRIRNGVHCFEIEWEKPEHYAMEDKQHGEFALLTIEEESLFEAAYP
EIVAVYQKQKLEIKGKKQKRIKPKENNLPEPDEVMSFQSHMTLKPTCEIF
HKQNSKLNSGISPDPTLPQESISASLNSLLLPKNTPCLNAQEQFMSSLRP
LAIQQIKAVSKSLISESSQPNTSSHNISVIADLHLSTIDWEGTSFSNSPA
IQRNTFSHDLKSEVESELSAIPDGFENIPEQLSCESERYTANIKKVLDED
SDGISPEEHLLSGITDLCLQDLPLKERIFIKLSYPQDNLQPDVNLKTLSI
LSVKESCIANSGSDCTSHLSKDLPGIPLQNESRDSKILKGDQLLQEDYKV
NTSVPYSVSNTVVKTCNVRPPNTALDHSRKVDMQTTRKILMKKSVCLDRH
SSDEQSAPVFGKAKYTTQRMKHSSQKHNSSHFKESGHNKLSSPKIHIKET
EQCVRSYETAENEESCFPDSTKSSLSSLQCHKKENNSGTCLDSPLPLCQR
LKLRFQST*
a.a.
length
InterPro Name
length(93), motif(1:93) 93IPR006085XPG N-terminal [Domain]
length(96), motif(1:96) 96IPR006085XPG N-terminal [Domain]
length(192), motif(1:192) 192IPR029060PIN domain-like [Domain]
length(207), motif(2:208) 207IPR029060PIN domain-like [Domain]
length(72), motif(122:193) 72IPR006086XPG-I domain [Domain]
length(86), motif(123:208) 86IPR006086XPG-I domain [Domain]
length(45), motif(193:237) 45IPR0200455'-3' exonuclease, C-terminal domain [Domain]
length(35), motif(195:229) 35IPR008918Helix-hairpin-helix motif, class 2 [Conserved_site]
length(63), motif(322:384) 63IPR0200455'-3' exonuclease, C-terminal domain [Domain]

Protein function information
H-Inv protein ID HIP000061717
Representative H-Inv transcript ID Transcript view HIT000249675
H-Inv cluster ID Locus view HIX0001847
Definition Flap endonuclease GEN homolog 1; EC=3.1.-.-;
Similarity category Help Identical to known human protein(Category I).
Identical to known human protein (Q17RS7) [Identity/coverage = 99.559%/100.0%] to Homo sapiens (Human). protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number EC 3.1.-.- Acting on Ester Bonds
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer No. of interaction 2
Interaction partner(s) HIP000025861; HIP000070521;
BIND NA
DIP NA
MINT NA
HPRD NA
IntAct NA
Database links RefSeq NA
UniProt NA
CCDS NA
Gene symbol/name HGNC symbol GEN1
HGNC aliases "Gen endonuclease homolog 1 (Drosophila)";
HGNC name GEN1 Holliday junction 5' flap endonuclease;
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

Glycosylation
GPDB (GlycoProtDB)
GPDB
ID NA
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT cytosol;
Target P Other
SOSUI soluble protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified : 27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
2 191 1a76A2 4e-35 24.3 185/207 c.120.1.2
193 241 1a76A1 6e-13 30.6 49/108 a.60.7.1
Related H-InvDB links GTOP GTOP

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
118..118 A/T rs139372712 + CDS Nonsynonymous[Gln15His]
157..157 A/T rs147110059 + CDS Synonymous[Ala28Ala]
158..158 G/A rs181124955 + CDS Nonsynonymous[Val29Ile]
215..215 G/A rs202068919 + CDS Nonsynonymous[Val48Ile]
269..269 A/G rs141837989 + CDS Nonsynonymous[Met66Val]
330..330 T/A rs148443734 + CDS Nonsynonymous[Ile86Lys]
347..347 A/T rs1812152 + CDS Nonsynonymous[Thr92Ser]
350..350 C/T rs201492858 + CDS Nonsynonymous[Arg93Trp]
376..376 G/T rs144005627 + CDS Nonsynonymous[Trp101Cys]
437..437 G/A rs201084834 + CDS Nonsynonymous[Glu122Lys]
463..463 G/C rs200681783 + CDS Nonsynonymous[Gln130His]
476..476 G/T rs199545866 + CDS Nonsynonymous[Ala135Ser]
481..481 A/G rs111388449 + CDS Synonymous[Glu136Glu]
501..501 A/G rs16981869 + CDS Nonsynonymous[Asn143Ser]
542..542 G/T rs139099020 + CDS Nonsynonymous[Asp157Tyr]
562..562 C/T rs143444612 + CDS Synonymous[Ala163Ala]
567..567 C/A rs150961964 + CDS Nonsynonymous[Thr165Asn]
568..568 T/C rs201825923 + CDS Synonymous[Thr165Thr]
623..623 A/T rs140068646 + CDS Nonsynonymous[Met184Leu]
639..639 G/A rs116772931 + CDS Nonsynonymous[Ser189Asn]
657^658 -/G rs34478641 + CDS
680..680 A/G rs10177628 + CDS Nonsynonymous[Ile203Val]
693..693 G/C rs138511510 + CDS Nonsynonymous[Cys207Ser]
750..750 T/C rs143219130 + CDS Nonsynonymous[Ile226Thr]
792..792 G/A rs189766183 + CDS Nonsynonymous[Arg240Gln]
822..822 C/T rs141482726 + CDS Nonsynonymous[Pro250Leu]
860..860 G/A rs199991451 + CDS Nonsynonymous[Val263Ile]
876..876 G/T rs139945353 + CDS Nonsynonymous[Gly268Val]
896..896 C/T rs146276503 + CDS Nonsynonymous[Arg275Cys]
897..897 G/A rs202239270 + CDS Nonsynonymous[Arg275His]
931..931 T/C rs201202527 + CDS Synonymous[Tyr286Tyr]
948..948 A/G rs149884551 + CDS Nonsynonymous[Tyr292Cys]
977..977 C/T rs202192107 + CDS Nonsynonymous[Arg302Cys]
978..978 G/A rs148607792 + CDS Nonsynonymous[Arg302His]
1002..1002 A/G rs300175 + CDS Nonsynonymous[Asn310Ser]
1061..1061 G/A rs115591812 + CDS Nonsynonymous[Glu330Lys]
1087..1087 C/T rs150264679 + CDS Synonymous[Asn338Asn]
1136..1136 T/C rs148928887 + CDS Synonymous[Leu355Leu]
1143..1143 A/G rs201049373 + CDS Nonsynonymous[Gln357Arg]
1154..1154 C/T rs200275164 + CDS Nonsynonymous[Leu361Phe]
1181..1181 T/G rs201488023 + CDS Nonsynonymous[Tyr370Asp]
1205..1205 C/T rs141832116 + CDS Nonsynonymous[Leu378Phe]
1310..1310 T/C rs199769297 + CDS Nonsynonymous[Cys413Arg]
1414..1414 A/G rs16983864 + CDS Synonymous[Ala447Ala]
1462..1462 T/G rs201334007 + CDS Nonsynonymous[Ile463Met]
1503..1503 A/G rs148028719 + CDS Nonsynonymous[Asn477Ser]
1599..1599 C/G rs150586336 + CDS Nonsynonymous[Ser509Trp]
1603..1603 G/T rs144151088 + CDS Synonymous[Gly510Gly]
1608..1608 C/T rs192489738 + CDS Nonsynonymous[Ser512Phe]
1711..1711 T/A rs61762986 + CDS Synonymous[Ser546Ser]
1747..1747 T/A rs138268141 + CDS Synonymous[Ala558Ala]
1789..1789 C/T rs151314688 + CDS Synonymous[Thr572Thr]
1833..1833 C/T rs112224689 + CDS Nonsynonymous[Thr587Ile]
1871..1871 G/C rs200602120 + CDS Nonsynonymous[Ala600Pro]
1918..1918 A/G rs202033525 + CDS Synonymous[Glu615Glu]
1970..1970 T/G rs145621452 + CDS Nonsynonymous[Ser633Ala]
1995..1995 C/G rs201918587 + CDS Nonsynonymous[Ala641Gly]
2028..2028 A/C rs141313079 + CDS Nonsynonymous[Asp652Ala]
2044..2044 G/A rs300168 - CDS Synonymous[Glu657Glu]
2103..2103 G/A rs200843544 + CDS Nonsynonymous[Arg677Gln]
2112..2112 T/C rs300169 + CDS Nonsynonymous[Ile680Thr]
2128..2128 T/C rs144098391 + CDS Synonymous[Pro685Pro]
2137..2137 T/C rs139429589 + CDS Synonymous[Asn688Asn]
2150..2150 G/A rs150533023 + CDS Nonsynonymous[Val693Ile]
2171..2171 A/G rs149815077 + CDS Nonsynonymous[Ile700Val]
2184..2184 A/C rs200000475 + CDS Nonsynonymous[Lys704Thr]
2199..2199 C/G rs201307842 + CDS Nonsynonymous[Ala709Gly]
2335..2335 C/T rs111823913 + CDS Synonymous[Val754Val]
2356..2356 A/G rs113795529 + CDS Synonymous[Thr761Thr]
2425..2425 A/G rs139744901 + CDS Synonymous[Gln784Gln]
2454..2454 G/C rs201939375 + CDS Nonsynonymous[Ser794Thr]
2508..2508 A/G rs144368291 + CDS Nonsynonymous[Lys812Arg]
2518..2518 C/T rs148781334 + CDS Synonymous[Tyr815Tyr]
2522..2522 A/G rs77374434 + CDS Nonsynonymous[Thr817Ala]
2588..2588 A/G rs113873109 + CDS Nonsynonymous[Lys839Glu]
2600..2600 C/T rs183886409 + CDS Nonsynonymous[Pro843Ser]
2692..2692 T/G rs57936182 + CDS Nonsynonymous[Ser873Arg]
2703..2703 C/A rs143372639 + CDS Nonsynonymous[Ser877Tyr]
2715..2715 A/C rs201891945 + CDS Nonsynonymous[His881Pro]
2717..2717 A/G rs77424145 + CDS Nonsynonymous[Lys882Glu]
2725..2725 A/C rs141534568 + CDS Nonsynonymous[Glu884Asp]
2728..2728 C/A rs190550780 + CDS Nonsynonymous[Asn885Lys]
2759..2759 C/A rs182439530 + CDS Nonsynonymous[Pro896Thr]
2765..2765 T/C rs17315702 + CDS Nonsynonymous[Cys898Arg]
2766..2766 G/A rs141519917 + CDS Nonsynonymous[Cys898Tyr]
Microsatellite (Short Tandem Repeat, STR)
LocationVariationStrand
No data available
Related H-InvDB links
VaryGeneVaryGene ;