H-InvDB x AHG DB
Protein view
H-InvDB_9.0 released on May 27, 2015.
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H-Inv protein ID: HIP000031798 Last modified: 27-May-2015
Definition: Cathepsin F; CATSF; EC=3.4.22.41; Precursor;
[Summery][Full]
[Protein Info][Member][Motif] provide location, ID and descriptions of functional motifs (InterPro)[Function] provide human-curated functional definition, similarity category and related evidences; Gene name; HUGO gene symbols; GO term; EC number; pathway information (KEGG)[PTM][Subcellular loc.] provide subcellular localization prediction by WolfPSORT, Target P, SOSUI, TMHMM and PTS1[Protein Structure][Evolutionary info.] provide orthologs relationships, phylogenic trees and sequence alignments[Polymorphism/repeat] provide polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Protein information
HIP ID HIP000031798
Length 484
Codon Adaptation Index (CAI). 0.826
Database links RefSeq NA
UniProt Q9UBX1 ;
CCDS Q9UBX1;
Original transcript information
Representative H-Inv transcript ID Transcript view HIT000035371
H-Inv cluster ID Locus view HIX0009840
Predicted CDS 85..1539 ; 484[aa] ; Orientation:+1 ;
Genomic location Chromosome 11
Location 11q13.2
CDS position 66330934-66336041
Strand -
Accession number BC011682.2
CAGE tag ID NA
EST ID NA
Clone Number MGC:19716 IMAGE:3535532
Experimental resources NBRC: NITE Biological Resource Center NBRC   HGPD: Human Gene and Protein Database HGPD   Antibody: searching human antibodies at "BIO-kaimono.com" Antibody (CTSF) ;   Catalog: searching experimental product catalogs at "BIO-kaimono.com" Catalog (CTSF) ;
Length of cDNA 2052[bp] (No. of exon:13)[A:433 T:415 G:607 C:597] ;
Database links RefSeq NA
Ensembl NA
Entrez Gene Entrez Gene ID:8722 ;
KEGG GENES KEGG GENES(8722) ;
GeneCard GeneCard CTSF ;
etc H-GOLD Human-Gene diversity Of Life-style related Diseases ;
Protein view

Coresponding transcript member (s)
No.1
H-Inv IDTranscript view HIT000035371
H-Inv cluster IDLocus view HIX0009840
Accession numberBC011682.2
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionCathepsin F; CATSF; EC=3.4.22.41; Precursor;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (Q9UBX1) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help Representative H-Inv IDRepresentative transcript;
Genomic Location G-integra Help Chromosome11
Location11q13.2
CDS position66330934-66336041
Strand-
Gene structure13 exons
No.2
H-Inv IDTranscript view HIT000051703
H-Inv cluster IDLocus view HIX0009840
Accession numberBC036451.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionCathepsin F; CATSF; EC=3.4.22.41; Precursor;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (Q9UBX1) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome11
Location11q13.2
CDS position66330940-66336016
Strand-
Gene structure13 exons
No.3
H-Inv IDTranscript view HIT000068140
H-Inv cluster IDLocus view HIX0009840
Accession numberAF088886.2
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionCathepsin F; CATSF; EC=3.4.22.41; Precursor;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (Q9UBX1) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome11
Location11q13.2
CDS position66330940-66336047
Strand-
Gene structure13 exons
No.4
H-Inv IDTranscript view HIT000088098
H-Inv cluster IDLocus view HIX0009840
Accession numberBC013359.2
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionSimilar to Cathepsin F; CATSF; EC=3.4.22.41; Precursor;
Similarity category HelpSimilar to known protein(Category II).
Similar to known protein (Q9UBX1) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome11
Location11q13.2
CDS position66330934-66336041
Strand-
Gene structure exons
No.5
H-Inv IDTranscript view HIT000244144
H-Inv cluster IDLocus view HIX0009840
Accession numberAJ007331.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionCathepsin F; CATSF; EC=3.4.22.41; Precursor;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (Q9UBX1) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome11
Location11q13.2
CDS position66331393-66335993
Strand-
Gene structure13 exons
No.6
H-Inv IDTranscript view HIT000432523
H-Inv cluster IDLocus view HIX0009840
Accession numberAK313657.1
CAGE tag IDNA
EST IDNA
Coding potential Help Protein coding
DefinitionCathepsin F; CATSF; EC=3.4.22.41; Precursor;
Similarity category HelpIdentical to known human protein(Category I).
Identical to known human protein (Q9UBX1) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Transcript feature Help NA
Genomic Location G-integra Help Chromosome11
Location11q13.2
CDS position66331404-66336015
Strand-
Gene structure13 exons

Motif information in predicted CDS
ORF

length(485),orf(85:1539) MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMF NRGRAAGTRAVLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVS KKTLLCSFQVLDELGRHVLLRKDCGPVDTKVPGAGEPKSAFTQGSAMISS LSQNHPDNRNETFSSVISLLNEDPLSQDLPVKMASIFKNFVITYNRTYES KEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLTEEEFRTIYLN TLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSV TGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGG LETEDDYSYQGHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPI SVAINAFGMQFYRHGISRPLRPLCSPWLIDHAVLLVGYGNRSDVPFWAIK NSWGTDWGEKGYYYLHRGSGACGVNTMASSAVVD*		 a.a.
length		 InterPro Name
length(444), motif(41:484) 444IPR013128Peptidase C1A [Family]
length(58), motif(187:244) 58IPR013201Proteinase inhibitor I29, cathepsin propeptide [Domain]
length(212), motif(271:482) 212IPR000668Peptidase C1A, papain C-terminal [Domain]
length(210), motif(272:481) 210IPR000668Peptidase C1A, papain C-terminal [Domain]
length(12), motif(289:300) 12IPR000169Cysteine peptidase, cysteine active site [Active_site]
length(16), motif(289:304) 16IPR000668Peptidase C1A, papain C-terminal [Domain]
length(11), motif(429:439) 11IPR025660Cysteine peptidase, histidine active site [Active_site]
length(11), motif(431:441) 11IPR000668Peptidase C1A, papain C-terminal [Domain]
length(7), motif(446:452) 7IPR000668Peptidase C1A, papain C-terminal [Domain]

Protein function information
H-Inv protein ID HIP000031798
Representative H-Inv transcript ID Transcript view HIT000035371
H-Inv cluster ID Locus view HIX0009840
Definition Cathepsin F; CATSF; EC=3.4.22.41; Precursor;
Similarity category Help Identical to known human protein(Category I).
Identical to known human protein (Q9UBX1) [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Gene family/group H-Inv gene family/group ID NA
Gene family/group name NA
Evidence motif (InterPro) ID NA
EC number EC 3.4.22.41 cathepsin F
KEGG metabolic pathway NA
Protein-protein interaction (PPI) PPI viewer No. of interaction 3
Interaction partner(s) HIP000021325; HIP000025404; HIP000057840;
BIND NA
DIP NA
MINT NA
HPRD 00825;
IntAct NA
Database links RefSeq NA
UniProt Q9UBX1 ;
CCDS Q9UBX1;
Gene symbol/name HGNC symbol CTSF
HGNC aliases NA
HGNC name cathepsin F;
Related H-InvDB links G-integraG-integra ; PPI viewer PPI view ; TACT TACT ;

Glycosylation
GPDB (GlycoProtDB)
GPDB 		ID NA
Protein name NA
Organism NA
Length(aa) NA

Subcellular localization information
WoLF PSORT extracellular;
Target P signal peptide
SOSUI membrane protein
TMHMM soluble protein
PTS1 Not targeted
Related H-InvDB links LIFEdb LIFEdb; 
JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Protein structure information (GTOP) GTOP Last modified : 27-May-2015
Start End PDB_ID E-value Identity Coverage SCOP_ID
34 124 1cewI 2e-05 20.9 91/108 d.17.1.2
182 483 1by8A 6e-67 31.8 302/310 d.3.1.1
Related H-InvDB links GTOP GTOP

Evolutionary information
Relationship Species Accession number MGI Links
Orthology Mus sp. (Mouse) AF197480 G-integraG-integra
Orthology Rattus sp. (Rat) BC099780 G-integraG-integra
Orthology Danio sp. (Zebrafish) BC124243 G-integraG-integra
Orthology Bos sp. (Cow) ENSBTAT00000014587 G-integraG-integra
Orthology Canis sp. (Dog) ENSCAFT00000019742 G-integraG-integra
Orthology Pongo sp. (Orangutan) ENSPPYT00000003620 G-integraG-integra
Orthology Takifugu sp. (Fugu) SINFRUT00000152201 G-integraG-integra
Orthology Monodelphis sp. (Opossum) XM_001379243 G-integraG-integra
Orthology Equus sp. (Horse) XM_001491486 G-integraG-integra
Orthology Macaca sp. (Macaque) XR_013716 G-integraG-integra
Orthology Pan sp. (Chimpanzee) XR_022326 G-integraG-integra
Phylogenetic tree [View by ATV] TNeighbor-joining (phb) 
Related H-InvDB links EvolaEvola;  dN/dS; 

Translation polymorphism (SNP) and microsatellite (STR) information

Single Nucleotide Polymorphism (SNP) and indel VaryGene
Location Variation dbSNP ID Strand CDS/UTR Translation
129..129 G/T rs117792851 - CDS Synonymous[Pro15Pro]
210..210 C/T rs1044522 + CDS Synonymous[Pro42Pro]
284..284 G/A rs35342226 - CDS Nonsynonymous[Gly67Asp]
303..303 C/T rs1127894 + CDS Synonymous[Gly73Gly]
310..310 T/G rs200958879 - CDS Nonsynonymous[Ser76Ala]
385..385 A/G rs143077418 - CDS Nonsynonymous[Lys101Glu]
435..435 C/T rs112809338 - CDS Synonymous[His117His]
502..502 G/A rs79274952 - CDS Nonsynonymous[Ala140Thr]
504..504 C/T rs149140177 - CDS Synonymous[Ala140Ala]
542..542 A/G rs11550508 + CDS Nonsynonymous[Gln153Arg]
621..621 G/A rs150481606 - CDS Synonymous[Leu179Leu]
645..645 C/T rs200610855 - CDS Synonymous[Phe187Phe]
648..648 G/C rs140630766 - CDS Nonsynonymous[Lys188Asn]
651..651 C/A rs142743244 - CDS Nonsynonymous[Asn189Lys]
663..663 C/T rs202226607 - CDS Synonymous[Thr193Thr]
667..667 A/G rs146841814 - CDS Nonsynonymous[Asn195Asp]
671..671 G/A rs143814748 - CDS Nonsynonymous[Arg196Gln]
681..681 G/A rs200932066 - CDS Synonymous[Glu199Glu]
698..698 G/T rs142782021 - CDS Nonsynonymous[Arg205Leu]
712..712 G/A rs180808563 - CDS Nonsynonymous[Val210Ile]
723..723 T/A rs146697999 - CDS Nonsynonymous[Asn213Lys]
747..747 C/G rs190243917 - CDS Nonsynonymous[Ile221Met]
760..760 C/T rs143313688 - CDS Nonsynonymous[Arg226Cys]
767..767 C/G rs148611356 - CDS Nonsynonymous[Thr228Arg]
776..776 A/G rs143889283 - CDS Nonsynonymous[Tyr231Cys]
784..784 A/T rs149533017 - CDS Nonsynonymous[Thr234Ser]
820..820 A/G rs201753663 - CDS Nonsynonymous[Thr246Ala]
846..846 A/G/T rs545009 + CDS
864..864 G/A rs140002533 - CDS Synonymous[Lys260Lys]
894..894 C/T rs147398226 - CDS Synonymous[Leu270Leu]
951..951 G/T rs142805637 - CDS Nonsynonymous[Gln289His]
1023..1023 G/A rs114727660 - CDS Synonymous[Gly313Gly]
1089..1089 C/T rs147269500 - CDS Synonymous[Gly335Gly]
1090..1090 G/A rs189862070 - CDS Nonsynonymous[Gly336Ser]
1112..1112 C/T rs200646712 - CDS Nonsynonymous[Ser343Leu]
1175..1175 A/G rs200760567 - CDS Nonsynonymous[Gln364Arg]
1184..1184 A/G rs201500574 - CDS Nonsynonymous[Asn367Ser]
1217..1217 A/G rs148080813 - CDS Nonsynonymous[Asn378Ser]
1224..1224 C/G rs143674429 - CDS Synonymous[Ser380Ser]
1242..1242 C/T rs116329758 - CDS Synonymous[Asn386Asn]
1287..1287 C/T rs139027846 - CDS Synonymous[Ser401Ser]
1322..1322 G/A rs145087378 - CDS Nonsynonymous[Arg413His]
1327..1327 G/A rs200426008 - CDS Nonsynonymous[Gly415Arg]
1337..1337 G/A rs141345438 - CDS Nonsynonymous[Arg418His]
1345..1345 C/T rs28464796 - CDS Nonsynonymous[Arg421Trp]
1346..1346 G/A rs201295932 - CDS Nonsynonymous[Arg421Gln]
1398..1398 C/T rs149687246 - CDS Synonymous[Tyr438Tyr]
1399..1399 G/A rs140795906 - CDS Nonsynonymous[Gly439Ser]
1405..1405 C/T rs150922871 - CDS Nonsynonymous[Arg441Cys]
1418..1418 C/T rs142523550 - CDS Nonsynonymous[Pro445Leu]
1452..1452 C/T rs148155987 - CDS Synonymous[Asp456Asp]
1485..1485 C/T rs572846 + CDS Synonymous[Arg467Arg]
1491..1491 C/T rs144556402 - CDS Synonymous[Ser469Ser]
1492..1492 G/A rs201552564 - CDS Nonsynonymous[Gly470Arg]
Microsatellite (Short Tandem Repeat, STR)
LocationVariationStrand
No data available
Related H-InvDB links
VaryGeneVaryGene ;