Disease related information in H-InvDB is collected in DiseaseInfo Viewer database. To obtain such kind information regarding each H-InvDB locus and transcript, you need to go inside the Locus view or Transcript view at first. There are two types of icon
stand for DiseaseInfo Viewer in both Locus and Transcript view. Either of the icons provide link to DiseaseInfo Viewer.
--- DiseaseInfo Viewer provides two kinds of disease information related to H-Inv loci: (4.6.2) known disease-related genes and (4.6.3) co-localized orphan diseases
cDNA identifiers in each H-Inv locus are listed on the top of the viewer.
If an H-Inv locus is already known as a 'disease-related gene' or a disease relation is suspected, the link to OMIM (Online Mendelian Inheritance in Man) is available.
In case an H-Inv locus is not linked to OMIM, only mapped position, gene symbol, and links to Enterz Gene and GeneLynx are shown.
You also find the cross-reference information between an H-InvDB and a Mutation View. Link via the correspondent Mutation View ID can show you more Gene/Disease Details regarding this locus.
In the second table on the bottom, co-localized orphan diseases are shown. Orphan disease (here) means a disease mapped on the chromosomal region, but whose responsible gene has not been identified yet. Co-localization does not mean direct relationships between gene and disease; however, genes that are cytogenetically co-localized with a disease could be possible candidate genes of that disease.
The number of co-localized H-Inv loci was computed by converting each cytogenetic band into a physical range on the chromosome, with a 1,000,000bp added on each side.
If you click the number of co-localized H-Inv loci of an orphan disease of interest, you will see a new viewer for H-Inv loci within the cytogenetic region.