H-InvDB x AHG DB
Gene family annotation
H-InvDB_8.3 released on March 26, 2013.
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H-InvDB Gene Families/Groups

HIF0000002 MHC: major histocompatibility complex [Download]

Description: The human major histocompatibility complex (MHC), or human leukocyte antigen (HLA), is a gene family located on 6p21.3 containing the most polymorphic genes in the human genome. The HLA molecules play a key role in immune responses by presenting peptides to T-lymphocytes.
We manually annotated functional class I and class II MHC loci by carefully examining human MHC transcripts, using the extended-MHC gene map (http://www.sanger.ac.uk/HGP/Chr6/XMHC/xlist.shtml) as a reference. The dataset of MHC transcripts were collected based on sequence similarity search and keyword search.

<< Chromosome 6 >>
No. HIX Chr. location HGNC gene symbol Definition HIF Gene family/group name
1 HIX0078236 6p21.32 HLA-DRA Major histocompatibility complex, class II, DR alpha precursor. HIF0000002 Major histocompatibility complex (MHC).
2 HIX0018378 6p21.32 HLA-DRB1 HLA class II histocompatibility antigen, DRB1-15 beta chain precursor (MHC class I antigen DRB1*15) (DW2.2/DR2.2). HIF0000002 Major histocompatibility complex (MHC).
3 HIX0027959 6p21.32 HLA-DQA1 HLA class II histocompatibility antigen, DQ(5) alpha chain precursor (DC-1 alpha chain). HIF0000002 Major histocompatibility complex (MHC).
4 HIX0078231 6p21.32 HLA-DQB1 HLA class II histocompatibility antigen, DQ(W1.1) beta chain precursor (DQB1*0501). HIF0000002 Major histocompatibility complex (MHC).
5 HIX0032963 6p21.32 MHC class II, alpha chain, N-terminal domain containing protein. HIF0000002 Major histocompatibility complex (MHC).
6 HIX0078239 6p21.32 HLA-B HLA class I histocompatibility antigen, B-7 alpha chain precursor (MHC class I antigen B*7). HIF0000002 Major histocompatibility complex (MHC).
7 HIX0005684 6p21.32 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain precursor (MHC class I antigen A*3). HIF0000002 Major histocompatibility complex (MHC).
8 HIX0005683 6p21.32 HLA-G HLA class I histocompatibility antigen, alpha chain G precursor (HLA G antigen). HIF0000002 Major histocompatibility complex (MHC).
9 HIX0035763 6p21.32 HLA-F Major histocompatibility complex, class I, F isoform 3 precursor. HIF0000002 Major histocompatibility complex (MHC).
<< Chromosome 6: haplotype cox_hap2 >>
No. HIX Chr. location HGNC gene symbol Definition HIF Gene family/group name
1 HIX0021944 6_cox_hap2 HLA-F HLA class I histocompatibility antigen, alpha chain F; HLA F antigen; Leukocyte antigen F; CDA12; Precursor; HIF0000002 Major histocompatibility complex (MHC).
2 HIX0005767 6_cox_hap2 HLA-DPB1 HLA-DPB1 precursor (MHC class II antigen) (Major histocompatibility complex, class II, DP beta 1) (HLA-DPB1 protein). HIF0000002 Major histocompatibility complex (MHC).
3 HIX0033491 6_cox_hap2 HLA-DRA Major histocompatibility complex, class II, DR alpha precursor. HIF0000002 Major histocompatibility complex (MHC).
4 HIX0078437 6_cox_hap2 HLA class I histocompatibility antigen, B-8 alpha chain precursor (MHC class I antigen B*8). HIF0000002 Major histocompatibility complex (MHC).
5 HIX0005754 6_cox_hap2 HLA-DRB1 Major histocompatibility complex, class II, DR beta 1; MHC class II antigen; HIF0000002 Major histocompatibility complex (MHC).
<< Chromosome 6: haplotype qbl_hap6 >>
No. HIX Chr. location HGNC gene symbol Definition HIF Gene family/group name
1 HIX0023200 6_qbl_hap6 HCG4P6 Pseudogene candidate (MHC class I antigen (Fragment).). HIF0000002 Major histocompatibility complex (MHC).
2 HIX0033011 6_qbl_hap6 HLA-A HLA class I histocompatibility antigen, A-26 alpha chain precursor (MHC class I antigen A*26). HIF0000002 Major histocompatibility complex (MHC).
3 HIX0078608 6_qbl_hap6 HLA-DPB1 MHC class II antigen. HIF0000002 Major histocompatibility complex (MHC).
4 HIX0058200 6_qbl_hap6 HLA-J Pseudogene candidate (Immunoglobulin C1-set domain containing protein.). HIF0000002 Major histocompatibility complex (MHC).
5 HIX0078596 6_qbl_hap6 HLA-DRB1 Major histocompatibility complex, class II, DR beta 1; MHC class II antigen; HIF0000002 Major histocompatibility complex (MHC).
6 HIX0058180 6_qbl_hap6 HLA-DOA Major histocompatibility complex, class II, DO alpha precursor. HIF0000002 Major histocompatibility complex (MHC).
<< Chromosome 6: haplotype mann_hap4 >>
No. HIX Chr. location HGNC gene symbol Definition HIF Gene family/group name
1 HIX0058040 6_mann_hap4 Pseudogene candidate (Leucocyte antigen A (Fragment).). HIF0000002 Major histocompatibility complex (MHC).
2 HIX0057992 6_mann_hap4 HLA-DMB HLA class II histocompatibility antigen, DM beta chain precursor (MHC class II antigen DMB). HIF0000002 Major histocompatibility complex (MHC).
3 HIX0032841 6_mann_hap4 HLA-H MHC class I antigen HLA-H ortholog (Fragment). HIF0000002 Major histocompatibility complex (MHC).
4 HIX0005752 6_mann_hap4 HLA-DRA HLA class II histocompatibility antigen, DR alpha chain precursor (MHC class II antigen DRA). HIF0000002 Major histocompatibility complex (MHC).
5 HIX0078594 6_mann_hap4 HLA-C HLA class I histocompatibility antigen, Cw-16 alpha chain precursor (MHC class I antigen Cw*16). HIF0000002 Major histocompatibility complex (MHC).
<< Chromosome 6: haplotype mcf_hap5 >>
No. HIX Chr. location HGNC gene symbol Definition HIF Gene family/group name
1 HIX0005715 6_mcf_hap5 HLA class I histocompatibility antigen, B-51 alpha chain; MHC class I antigen B*51; Precursor; HIF0000002 Major histocompatibility complex (MHC).
2 HIX0058177 6_mcf_hap5 Major histocompatibility complex, class II, DQ alpha 2. HIF0000002 Major histocompatibility complex (MHC).
<< Chromosome 6: haplotype ssto_hap7 >>
No. HIX Chr. location HGNC gene symbol Definition HIF Gene family/group name
1 HIX0078423 6_ssto_hap7 HLA-A HLA class I histocompatibility antigen, A-32 alpha chain precursor (MHC class I antigen A*32). HIF0000002 Major histocompatibility complex (MHC).