Evola  Search ortholog by   Keyword   (Human) Accession number   (All species) Gene symbol   (Human)              (  All species Chimpanzee Orangutan Macaque Mouse Rat Dog Horse Cow Opossum Chicken Zebrafish Medaka Tetraodon Fugu with   All annotation status Manual curation  )

[ Japanese ]

↑ Example: lung cancer (Keyword), AB002303, ENST00000338008, NM_173392 (Accession number), RHEB (Gene symbol)

What is Evola? Evola (http://www.h-invitational.jp/evola/) provides ortholog information between human and fourteen vertebrates. Ortholog is a pair of genes in different species that separated from a common ancestor by speciation. In Evola, orthologs identification is conducted by the computational analysis based on the similarity of genomic and amino acid sequences. The orthologues are also manually curated with molecular evolutionary analysis through the comparison between the species tree and the gene tree. Evola also features the comparison of alternative splicing variants between human and the vertebrate orthologues. [ Sample ]     Evola is available for free of charge. Please cite this publication, if you use Evola.     Matsuya A, Sakate R, Kawahara Y, et al. Nucleic Acids Res. 2008; 36: D787-92.

What's New [03-Dec-2010] Evola release 7.5: Orangutan orthologs have been updated, human transcripts have corresponded to H-InvDB 7.5, methods for molecular phylogeny have been improved, and dN/dS data has been available for download. [16-Oct-2009] A bug that phylogenetic tree viewer (ATV) may erroneously show a previously selected tree was fixed. [11-Aug-2009] Help pages were updated. [27-Apr-2009] Erroneous paralog flags (_) of RefSeq XR in alignments and trees were corrected. [30-Mar-2009] Evola release 6.0: Four species were updated (Mouse, Cow, Horse, Zebrafish). Orthologs of alternative splicing variants were newly available. [30-Sep-2008] All data in the download page were completely updated to Evola release 5.1. [30-Apr-2008] Evola release 5.1: Program bug fix and related ortholog data correction were conducted. [26-Dec-2007] Evola release 5.0: Horse and Medaka were added. Duplicate gene family viewer was released. [27-Sep-2007] Annotation status (Manual curation) and NJ/NJML+ trees were updated. [27-Jun-2007] Evola release 4.1: Ortholog data were updated by a modified detection method. [24-May-2007] dN/dS view was renewed. [30-Mar-2007] Evola release 4.0: Addition of species and new ortholog data supported by computational analysis were available. [28-Sep-2006] Evola release 3.1: Orthologs were classified into manually curated ones and computationally analyzed ones. [23-Jun-2006] Evola release 2.1: Ortholog data were updated due to the update of human representative transcripts in H-InvDB 3.4. [19-May-2006] NJML+ trees were added. [31-Mar-2006] Evola release 2.0: New ortholog data supported by computational analysis were available. [31-Aug-2005] Evola was released.

Evola 7.5 Statistics Species Genes* Human genes* Human  hg19 22,768 - Chimpanzee  panTro2 19,169 19,399 Orangutan  ponAbe2 16,613 16,972 Macaque  rheMac2 17,355 17,659 Mouse  mm9 17,492 17,795 Species Genes* Human genes* Rat  rn4 15,944 16,316 Dog  canFam2 16,414 16,875 Horse  equCab2 15,689 16,250 Cow  bosTau4 15,688 16,030 Opossum  monDom5 15,680 16,039 Species Genes* Human genes* Chicken  galGal3 11,405 11,984 Zebrafish  danRer5 14,009 13,291 Medaka  oryLat2 11,736 11,829 Tetraodon  tetNig1 11,654 11,579 Fugu  fr2 12,509 12,414

* Numbers of "Genes" and "Human genes" are usually different because, besides one-to-one orthologs, one-to-many or many-to-many orthologs may exist.

Yamanoue et al. 2006 (Euteleostei) and Hedges and Kumar 2009 (the others)

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Related site - G-compass: Comparative genome browser