Human transcript (Homo sapiens)
flag HIT000059426 (AB044805) PFKFB2 471 aa
Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; PFK/FBPase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; Includes: 6-phosphofructo-2-kinase; EC=2.7.1.105; Includes: Fructose-2,6-bisphosphatase; EC=3.1.3.46;
popupCategory II: Similar to known protein O60825
alignment locusmaps

arrow_ot Cross-species mapping
Chimpanzee genome
(Pan troglodytes)		 n/a
Identity / Coverage (amino acid)*: 100.0% / 100.0%
dN/dS in conserved ORF (%length): 0/0 in 100.0% (> 50%)
Window analysis of dN/dS**: No-selection-found
Orangutan genome
(Pongo pygmaeus)		 n/a
Identity / Coverage (amino acid)*: 99.6% / 100.0%
dN/dS in conserved ORF (%length): 0.081 in 16.8% (≤ 50%)
Window analysis of dN/dS**: No-selection-found
Rhesus monkey genome
(Macaca mulatta)		 Protein-coding
[conserved]
Identity / Coverage (amino acid)*: 98.9% / 100.0%
dN/dS in conserved ORF (%length): 0.068 in 100.0% (> 50%)
Window analysis of dN/dS**: Selection-found
* Calculated by FASTY alignment, overriding internal stop codon or frameshift in the primates genome.
** 20-codon with 1-codon step. Fisher's exact test (P < 0.01).

arrow_dl Data download
Sequence (fasta) Transcript, Protein

arrow_go Gene ontology (GO)
Molecular function catalytic activity GO:0003824
ATP binding GO:0005524
6-phosphofructo-2-kinase activity GO:0003873
Biological process metabolic process GO:0008152
fructose 2,6-bisphosphate metabolic process GO:0006003
fructose metabolic process GO:0006000

arrow_ip InterPro
Accession number Short name Sequence region (aa)
IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site 254-263
IPR003094 Fructose-2,6-bisphosphatase 8-464, 124-138, 150-164, 176-190, 230-251, 252-274, 329-345
IPR013078 Histidine phosphatase superfamily, clade-1 251-398
IPR013079 6-phosphofructo-2-kinase 27-249
IPR027417 P-loop containing nucleoside triphosphate hydrolase 38-250, 38-243
IPR029033 Histidine phosphatase superfamily 249-454, 251-448